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  Domain Name: Noggin
Noggin. This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation.
No pairwise interactions found for the domain Noggin

Total Mutations Found: 16
Total Disease Mutations Found: 16
This domain occurred 1 times on human genes (2 proteins).



  BRACHYDACTYLY, TYPE B2
  BRACHYDACTYLY, TYPE B2, INCLUDED;;
  MULTIPLE SYNOSTOSES SYNDROME 1
  STAPES ANKYLOSIS SYNDROME WITHOUT SYMPHALANGISM
  STAPES ANKYLOSIS WITH BROAD THUMB AND TOES, INCLUDED
  SYMPHALANGISM, PROXIMAL 1A (SYM1A)
  SYMPHALANGISM, PROXIMAL, 1A
  SYMPHALANGISM, PROXIMAL, 1A, INCLUDED
  TARSAL-CARPAL COALITION SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Noggin










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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