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  Domain Name: Peptidase_C19
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 36
Total Disease Mutations Found: 6
This domain occurred 67 times on human genes (105 proteins).



  BROOKE-SPIEGLER SYNDROME, INCLUDED
  CYLINDROMATOSIS, FAMILIAL
  TRICHOEPITHELIOMA, MULTIPLE FAMILIAL, 1
  TRICHOEPITHELIOMA, MULTIPLE FAMILIAL, 1, INCLUDED;;


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   Protein ID            Protein Position