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  Domain Name: Peptidase_S8
Subtilase family. Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.

Total Mutations Found: 18
Total Disease Mutations Found: 8
This domain occurred 10 times on human genes (25 proteins).



  HYPERCHOLESTEROLEMIA, FAMILIAL, 3
  OBESITY, SUSCEPTIBILITY TO
  PROPROTEIN CONVERTASE 1/3 DEFICIENCY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Peptidase_S8
























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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