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  Domain Name: RING
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in mediating protein-protein interactions; identified in a proteins with a wide range of functions such as viral replication, signal transduction, and development; has two variants, the C3HC4-type and a C3H2C3-type (RING-H2 finger), which have different cysteine/histidine pattern; a subset of RINGs are associated with B-Boxes (C-X2-H-X7-C-X7-C-X2-C-H-X2-H)
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 83
Total Disease Mutations Found: 14
This domain occurred 237 times on human genes (394 proteins).



  BREAST CANCER (BC)
  BREAST-OVARIAN CANCER, FAMILIAL, 1 (BROVCA1)
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
  MOYAMOYA DISEASE 2, SUSCEPTIBILITY TO
  NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
  NOONAN SYNDROME-LIKE DISORDER WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA
  PRECOCIOUS PUBERTY, CENTRAL, 2


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
cross-brace motif










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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