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  Domain Name: RING
Ring finger. E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)
No pairwise interactions found for the domain RING

Total Mutations Found: 74
Total Disease Mutations Found: 14
This domain occurred 247 times on human genes (453 proteins).



  BREAST CANCER (BC)
  BREAST-OVARIAN CANCER, FAMILIAL, 1 (BROVCA1)
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
  EPILEPSY, PROGRESSIVE MYOCLONIC 2B
  MOYAMOYA DISEASE 2, SUSCEPTIBILITY TO
  NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
  NOONAN SYNDROME-LIKE DISORDER WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA
  PEROXISOMAL BIOGENESIS DISORDER 3B


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for RING







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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