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  Domain Name: RNA_pol_B_RPB2
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 15
Total Disease Mutations Found: 12
This domain occurred 2 times on human genes (4 proteins).



  HYPOGONADISM
  LEUKODYSTROPHY, HYPOMYELINATING, 8, WITH HYPODONTIA AND HYPOGONADOTROPIC
  LEUKODYSTROPHY, HYPOMYELINATING, 8, WITHOUT HYPODONTIA AND WITH HYPOGONADOTROPIC
  LEUKODYSTROPHY, HYPOMYELINATING, 8, WITHOUT HYPODONTIA OR HYPOGONADOTROPIC


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
RPB1 interaction site
RPB3 interaction site
RPB10 interaction site
RPB11 interaction site
RPB12 interaction site
















































































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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