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  Domain Name: Rad51_DMC1_radA
Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 26
Total Disease Mutations Found: 14
This domain occurred 7 times on human genes (18 proteins).



  BREAST CANCER, FAMILIAL
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 4
  FANCONI ANEMIA, COMPLEMENTATION GROUP O
  MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 6
  MIRROR MOVEMENTS 2, SUSCEPTIBILITY TO
  VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
ATP binding site
Walker A motif
Walker B motif
multimer (BRC) interface


















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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