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  Domain Name: Reprolysin
Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
No pairwise interactions found for the domain Reprolysin

Total Mutations Found: 39
Total Disease Mutations Found: 8
This domain occurred 38 times on human genes (75 proteins).



  CONE-ROD DYSTROPHY 9
  THROMBOTIC THROMBOCYTOPENIC PURPURA, CONGENITAL
  WEILL-MARCHESANI SYNDROME 1
  WEILL-MARCHESANI-LIKE SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Reprolysin










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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