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  Domain Name: TGFB
Transforming growth factor-beta (TGF-beta) family. Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.
No pairwise interactions found for the domain TGFB

Total Mutations Found: 24
Total Disease Mutations Found: 17
This domain occurred 34 times on human genes (57 proteins).



  BRACHYDACTYLY, TYPE A2, INCLUDED
  BRACHYDACTYLY, TYPE C
  COLOBOMA, OCULAR, INCLUDED
  FIBULAR HYPOPLASIA AND COMPLEX BRACHYDACTYLY
  HETEROTAXY, VISCERAL, 5, AUTOSOMAL
  KLIPPEL-FEIL SYNDROME 3, AUTOSOMAL DOMINANT
  LEFT-RIGHT AXIS MALFORMATIONS
  LOEYS-DIETZ SYNDROME, TYPE 4
  MICROPHTHALMIA, ISOLATED 7
  MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 6
  MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 6, INCLUDED
  MULTIPLE SYNOSTOSES SYNDROME 2
  MULTIPLE SYNOSTOSES SYNDROME 2, INCLUDED
  OROFACIAL CLEFT 11
  RIENHOFF SYNDROME (1 FAMILY)
  SYMPHALANGISM, PROXIMAL, 1B
  TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 5


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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TGFB








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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