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  Domain Name: TGc
Transglutaminase/protease-like homologues. Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.
No pairwise interactions found for the domain TGc

Total Mutations Found: 12
Total Disease Mutations Found: 10
This domain occurred 11 times on human genes (18 proteins).



  FACTOR XIII, A SUBUNIT, DEFICIENCY OF
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 1
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 1, WITH BATHING SUIT DISTRIBUTION
  SPHEROCYTOSIS, TYPE 5, DUE TO PROTEIN 4.2-TOZEUR
  SPINOCEREBELLAR ATAXIA 35


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TGc







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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