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  Domain Name: TPR
Tetratricopeptide repeats. Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.
No pairwise interactions found for the domain TPR

Total Mutations Found: 17
Total Disease Mutations Found: 5
This domain occurred 89 times on human genes (192 proteins).



  CHUDLEY-MCCULLOUGH SYNDROME
  CILIARY DYSKINESIA, PRIMARY, 28, WITH SITUS INVERSUS
  GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME B-POSITIVE,
  INTESTINAL ATRESIA, MULTIPLE
  TYPE II


Tips:
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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TPR





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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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