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  Domain Name: Transglut_core
Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.
No pairwise interactions found for the domain Transglut_core

Total Mutations Found: 18
Total Disease Mutations Found: 13
This domain occurred 11 times on human genes (15 proteins).



  FACTOR XIII, A SUBUNIT, DEFICIENCY OF
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 1
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 1, WITH BATHING SUIT DISTRIBUTION
  SPHEROCYTOSIS, TYPE 5, DUE TO PROTEIN 4.2-TOZEUR
  SPINOCEREBELLAR ATAXIA 35


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Transglut_core













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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