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  Domain Name: ZnMc_ADAM_like
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 36
Total Disease Mutations Found: 8
This domain occurred 37 times on human genes (74 proteins).



  CONE-ROD DYSTROPHY 9
  THROMBOTIC THROMBOCYTOPENIC PURPURA, CONGENITAL
  WEILL-MARCHESANI SYNDROME 1
  WEILL-MARCHESANI-LIKE SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
active site
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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