| Interacting Domains ↕ | CD ↕ Accession (External Link) | Description ↕ |
|---|
zf-C3HC4 | pfam00097 | Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway. | HEAT | pfam02985 | HEAT repeat. The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). | TIP120 | pfam08623 | TATA-binding protein interacting (TIP20). TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription. | Skp1 | smart00512 | SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones] | F-box | pfam00646 | F-box domain. This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. |
