Results for the protein: Q9UK32

Results for the Protein: Q9UK32

11133131

27330

RPS6KA6

NCBI, UniProt

KS6A6_HUMAN RecName: Full=Ribosomal protein S6 kinase alpha-6; Short=S6K-alpha-6; AltName: Full=90 kDa ribosomal protein S6 kinase 6; Short=p90-RSK 6; Short=p90RSK6; AltName: Full=Ribosomal S6 kinase 4; Short=RSK-4; AltName: Full=pp90RSK4

			0 3 0 1 2

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Swiss-Prot Protein: Q9UK32

Identical to: NP_055311

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_VEGFR3	cd05102	0.0001	7	332
STKc_ROCK2	cd05621	4.6e-39	29	392
STKc_ROCK1	cd05622	5.2e-39	29	393
STKc_ROCK	cd05596	1.5e-48	43	392
STKc_PAK_I	cd06647	2.7e-07	48	345
STKc_PAK2	cd06655	9.5e-08	48	348
STKc_myosinIIIB	cd06639	7.5e-08	52	325
STKc_PAK5	cd06658	5.2e-07	52	340
PTKc_FGFR4	cd05099	3.7e-07	55	350
STKc_myosinIIIA	cd06638	3.3e-09	55	330
PTKc_PDGFR	cd05055	0.00048	57	328
STKc_PAK6	cd06659	3.4e-10	57	353
STKc_TAO	cd06607	5.4e-06	58	344
STKc_STK10_LOK	cd06644	4.1e-19	59	351
PTKc_FGFR1	cd05098	7.1e-06	60	335
STKc_MAP4K4_6	cd06636	1e-06	60	322
STKc_PAK4	cd06657	1.4e-07	61	345
STKc_CDK9	cd07865	2.1e-10	61	330
STKc_ASK	cd06624	1.4e-14	63	330
STKc_MAP4K5	cd06646	3.3e-08	63	329
PTKc_FGFR2	cd05101	7.4e-07	64	335
STKc_MAP4K3	cd06645	2.8e-09	64	329
STKc_PCTAIRE2	cd07872	2.1e-07	64	363
STKc_PCTAIRE1	cd07873	1.8e-06	64	343
PTKc_InsR_like	cd05032	4.3e-10	65	326
PTKc_Src_like	cd05034	9.2e-11	65	324
PTKc_InsR	cd05061	4.4e-07	65	335
PTKc_IGF-1R	cd05062	1.1e-06	65	326
PTKc_EGFR_like	cd05057	6.3e-07	65	334
PTKc_Jak1_rpt2	cd05079	8.7e-06	65	329
PTKc_Tie2	cd05088	1.3e-07	65	335
PTKc_EGFR	cd05108	7.3e-07	65	376
PTKc_HER2	cd05109	5e-07	65	334
PTKc_HER4	cd05110	4.9e-05	65	355
PKc_MKK4	cd06616	5.7e-09	65	328
STKc_PCTAIRE_like	cd07844	3.6e-10	65	358
STKc_PFTAIRE1	cd07869	2.4e-06	65	366
STKc_PCTAIRE3	cd07871	3.5e-08	65	340
PTKc_ALK_LTK	cd05036	3.5e-10	66	326
PTKc_DDR	cd05051	0.00011	66	332
PTKc_FAK	cd05056	6.2e-09	66	333
PKc_MEK2	cd06649	6.6e-09	66	419
PKc_MEK1	cd06650	2.7e-07	66	423
PTKc_Ror	cd05048	2.7e-09	67	319
PTKc_Trk	cd05049	2.5e-10	67	330
PTKc_Musk	cd05050	1.8e-08	67	327
PTKc_Abl	cd05052	3e-08	67	329
PTKc_FGFR	cd05053	4e-07	67	329
PTKc_EphR_A10	cd05064	8.3e-06	67	329
PTKc_Lck_Blk	cd05067	3.6e-06	67	328
PTKc_Frk_like	cd05068	1.7e-12	67	328
PTKc_Lyn	cd05072	2.1e-07	67	328
PTKc_Hck	cd05073	1e-07	67	328
PTKc_EphR_A2	cd05063	3.9e-07	67	329
PTKc_Fyn_Yrk	cd05070	1.6e-05	67	328
PTKc_Csk	cd05082	5.8e-06	67	328
PTKc_Ror2	cd05091	4e-06	67	328
PTKc_TrkA	cd05092	2.9e-08	67	331
PTKc_TrkB	cd05093	2.2e-07	67	336
PTKc_TrkC	cd05094	0.00041	67	336
PTKc_Ror1	cd05090	2.2e-07	67	328
PTKc_DDR_like	cd05097	0.00052	67	330
STKc_TNIK	cd06637	2e-08	67	330
PTKc_EphR	cd05033	5.8e-08	68	307
PTKc_Tec_like	cd05059	6.2e-09	68	325
PTKc_EphR_B	cd05065	1.8e-07	68	329
PTKc_EphR_A	cd05066	2.6e-07	68	329
PTKc_FGFR3	cd05100	2.4e-05	68	361
PTKc_Itk	cd05112	1.4e-08	68	325
PTKc_Btk_Bmx	cd05113	8.7e-11	68	325
PTKc_Tec_Rlk	cd05114	3.5e-11	68	325
STKc_SLK_like	cd06611	6.3e-14	68	345
STKc_SLK	cd06643	2e-15	68	349
STKc_PFTAIRE2	cd07870	1.2e-06	68	347
PTK_Ryk	cd05043	2.6e-07	69	290
PTKc_Chk	cd05083	1.6e-06	69	327
PTKc_Tie1	cd05089	9.4e-06	69	334
STKc_myosinIII_like	cd06608	1.6e-13	69	330
PKc_MAPKK_Byr1_like	cd06620	3.2e-10	69	361
STKc_MST4	cd06640	8.8e-09	69	351
STKc_MST3	cd06641	1.3e-08	69	351
STKc_STK25-YSK1	cd06642	3.8e-09	69	351
PTKc_Csk_like	cd05039	8.1e-05	70	293
PTKc_Yes	cd05069	1.6e-06	70	328
PTKc_Src	cd05071	3e-05	70	330
STKc_MASTL	cd05610	3.5e-06	70	697
STKc_MEKK3_like	cd06625	2.5e-18	70	330
STKc_MEKK3	cd06651	1.9e-11	70	333
STKc_MEKK2	cd06652	4.2e-08	70	331
STKc_MEKK3_like_1	cd06653	7.9e-10	70	330
STKc_TEY_MAPK_plant	cd07858	3.5e-08	70	393
PTKc_Jak_rpt2	cd05038	1.2e-08	71	328
PTK_CCK4	cd05046	2.3e-06	71	326
STKc_ROCK_NDR_like	cd05573	1.1e-89	71	391
STKc_phototropin_lik	cd05574	5.4e-86	71	356
STKc_PKA	cd05580	2e-107	71	363
STKc_PDK1	cd05581	5e-77	71	330
STKc_DMPK_like	cd05597	2.6e-69	71	391
STKc_LATS	cd05598	1.1e-64	71	391
STKc_NDR_like	cd05599	9.4e-42	71	389
STKc_CRIK	cd05601	8.4e-56	71	391
STKc_Sid2p_Dbf2p	cd05600	1e-34	71	392
STKc_MAST	cd05609	8e-64	71	361
STKc_PRKX_like	cd05612	3.7e-87	71	362
STKc_MRCK_alpha	cd05623	9.4e-57	71	392
STKc_MRCK_beta	cd05624	8.9e-53	71	391
STKc_LATS1	cd05625	7.5e-46	71	389
STKc_NDR2	cd05627	1.8e-61	71	423
STKc_NDR1	cd05628	1.6e-55	71	403
STKc_NDR_like_fungal	cd05629	4.2e-59	71	394
STKc_LATS2	cd05626	1.1e-43	71	396
PKc_MAPKK	cd06605	7.9e-15	71	335
STKc_MAP4K3_like	cd06613	1.9e-14	71	329
PKc_MEK	cd06615	5.2e-11	71	403
PKc_MKK3_6	cd06617	2e-11	71	344
PKc_MAPKK_Pek1_like	cd06621	8.1e-12	71	335
PKc_MAPKK_PBS2_like	cd06622	2e-08	71	388
PKc_MAPKK_plant_like	cd06623	2.5e-25	71	335
PKc_MKK5	cd06619	5e-06	71	342
STKc_CdkB_plant	cd07837	2.5e-12	71	331
STKc_CDKL1_4	cd07847	6.5e-09	71	369
STKc_CDK6	cd07862	4.3e-07	71	356
STKc_Nek6_Nek7	cd08224	2.2e-11	71	330
STKc_Nek7	cd08229	2.5e-12	71	330
STKc_Nek6	cd08228	7.2e-11	71	330
SPS1	COG0515	4.6e-63	71	420
PTKc_RET	cd05045	3.2e-07	72	332
PKc_STE	cd05122	1.9e-35	72	329
STKc_Yank1	cd05578	4.8e-85	72	330
STKc_MSK_N	cd05583	1.4e-130	72	349
STKc_cPKC	cd05587	1.6e-95	72	392
STKc_GRK4_like	cd05605	3.2e-62	72	351
STKc_MSK2_N	cd05614	7.6e-124	72	393
STKc_cPKC_alpha	cd05615	8.6e-81	72	392
STKc_cPKC_beta	cd05616	1.7e-81	72	392
STKc_MSK1_N	cd05613	6.9e-108	72	349
STKc_GRK6	cd05630	1.2e-54	72	351
STKc_GRK4	cd05631	1.3e-50	72	351
STKc_GRK5	cd05632	2.2e-53	72	351
STKc_MAPKKK	cd06606	2e-40	72	330
STKc_MEKK4	cd06626	5e-15	72	330
STKc_Cdc7_like	cd06627	2.6e-19	72	330
STKc_MAPKKK_Byr2_lik	cd06628	5.1e-30	72	330
STKc_MEKK1	cd06630	8.8e-10	72	331
STKc_YSK4	cd06631	3.2e-11	72	330
STKc_Pho85	cd07836	5.3e-15	72	364
STKc_CCRK	cd07832	7.4e-15	72	331
STKc_CDK5	cd07839	3.2e-08	72	330
STKc_CDK7	cd07841	8.4e-16	72	339
STKc_TDY_MAPK_plant	cd07859	1.4e-08	72	414
STKc_CDK2_3	cd07860	1.2e-07	72	361
STKc_CDK1_euk	cd07861	2.7e-11	72	364
STKc_Nek	cd08215	1.6e-54	72	329
STKc_Nek1	cd08218	5.5e-41	72	330
STKc_Nek3	cd08219	1.9e-32	72	329
STKc_Nek8	cd08220	3.5e-13	72	330
STKc_Nek9	cd08221	5.6e-12	72	329
STKc_Nek11	cd08222	2.1e-22	72	330
STKc_Nek4	cd08223	4.4e-30	72	330
STKc_Nek5	cd08225	4.7e-35	72	330
STKc_Nek2	cd08217	1e-17	72	330
STKc_Nek10	cd08528	3.8e-15	72	327
STKc_FA2-like	cd08529	4.8e-15	72	316
STKc_CNK2-like	cd08530	2.4e-18	72	321
PTKc_Axl_like	cd05035	2e-06	73	328
PTKc_Tyro3	cd05074	4.4e-07	73	329
PTKc_Axl	cd05075	0.00012	73	328
PTKc_Tyk2_rpt2	cd05080	3e-06	73	330
PTKc_Jak2_Jak3_rpt2	cd05081	1.8e-07	73	325
STKc_CMGC	cd05118	4.1e-16	73	330
PTKc_Srm_Brk	cd05148	5.9e-09	73	319
STKc_PKN	cd05589	5.8e-104	73	391
STKc_MAPKKK_Bck1_lik	cd06629	3.9e-13	73	330
STKc_MAK_like	cd07830	1e-15	73	330
STKc_CDK1_like	cd07835	1.7e-11	73	364
STKc_CDK9_like	cd07840	8.2e-14	73	330
STKc_RSK_N	cd05582	1.4e-250	76	391
STKc_p70S6K	cd05584	1.3e-146	76	393
STKc_Rim15_like	cd05611	5.7e-22	76	336
PTKc	cd00192	6.8e-14	77	329
PTKc_Ack_like	cd05040	5.6e-10	77	326
PTKc_Fes_like	cd05041	1.6e-11	77	326
PTKc_Aatyk	cd05042	7.6e-05	77	327
PTKc_c-ros	cd05044	5.2e-08	77	327
PTKc_Tie	cd05047	1.6e-06	77	329
PTKc_Met_Ron	cd05058	2.5e-07	77	330
PTKc_Syk_like	cd05060	2e-09	77	330
PTK_Jak1_rpt1	cd05077	0.00022	77	325
PTK_Jak2_Jak3_rpt1	cd05078	1e-06	77	329
PTKc_Fes	cd05084	1.9e-08	77	327
PTKc_Fer	cd05085	1.9e-09	77	330
PTKc_Aatyk1_Aatyk3	cd05087	0.0008	77	330
PTKc_Syk	cd05116	2.5e-11	77	330
STKc_PKC	cd05570	4.7e-100	77	391
STKc_PKB	cd05571	9.5e-106	77	393
STKc_SGK	cd05575	1.7e-110	77	391
STKc_aPKC	cd05588	2.4e-79	77	392
STKc_nPKC_eta	cd05590	1.8e-90	77	392
STKc_nPKC_theta_delt	cd05592	1.1e-92	77	393
STKc_PKB_gamma	cd05593	7.9e-86	77	396
STKc_PKB_alpha	cd05594	1.3e-87	77	394
STKc_PKB_beta	cd05595	2.7e-90	77	393
STKc_SGK1	cd05602	2.4e-89	77	393
STKc_SGK2	cd05603	1.7e-99	77	392
STKc_SGK3	cd05604	8.5e-93	77	398
STKc_nPKC_epsilon	cd05591	2.2e-90	77	392
STKc_aPKC_zeta	cd05617	4.4e-68	77	392
STKc_aPKC_iota	cd05618	3.3e-64	77	392
STKc_nPKC_theta	cd05619	1.7e-85	77	393
STKc_nPKC_delta	cd05620	7.2e-73	77	393
STKc_MEKK1_plant	cd06632	1.8e-16	77	330
STKc_beta_ARK	cd05606	2.8e-71	78	350
STKc_GRK3	cd05633	4.8e-62	78	351
PKc	cd00180	1.5e-76	79	328
PTKc_Zap-70	cd05115	1.7e-09	79	330
STKc_AGC	cd05123	1.9e-150	79	330
STKc_cGK_PKG	cd05572	4.8e-91	79	337
STKc_GRK	cd05577	5e-64	79	350
STKc_YPK1_like	cd05585	1.2e-106	79	390
STKc_Sck1_like	cd05586	1.7e-94	79	422
STKc_MAST_like	cd05579	7.4e-78	79	335
STKc_GRK7	cd05607	3.4e-49	79	350
STKc_GRK1	cd05608	2.8e-54	79	350
STKc_PAK_II	cd06648	3.5e-12	396	696
STKc_myosinIIIB	cd06639	1.2e-08	399	684
STKc_PAK5	cd06658	2.2e-08	400	696
STKc_PAK6	cd06659	2.5e-11	401	702
STKc_JNK1	cd07875	4.9e-06	401	723
STKc_PAK4	cd06657	2.1e-08	402	700
STKc_PAK	cd06614	3.4e-18	403	692
STKc_JNK2	cd07876	1.4e-07	404	724
STKc_PAK1	cd06654	7.1e-11	405	706
STKc_TAO2	cd06634	8.5e-06	406	721
STKc_PAK_I	cd06647	3.1e-19	406	704
STKc_PAK3	cd06656	3.9e-11	406	708
STKc_PAK2	cd06655	4.6e-10	406	707
STKc_JNK3	cd07874	3e-06	408	732
STKc_p38alpha_MAPK14	cd07877	1e-08	408	721
STKc_JNK	cd07850	1.7e-09	409	719
STKc_myosinIIIA	cd06638	7e-09	410	683
STKc_p38	cd07851	1.5e-14	410	721
STKc_p38delta_MAPK13	cd07879	3.6e-05	410	721
STKc_TAO1	cd06635	6e-06	411	720
STKc_MAP4K4_6	cd06636	1.1e-06	411	683
PK_STRAD_alpha	cd08227	0.00034	411	745
PKc_MKK7	cd06618	1.9e-11	412	709
STKc_TAO3	cd06633	0.00016	412	720
STKc_CDK8_like	cd07842	3.4e-11	412	683
STKc_p38gamma_MAPK12	cd07880	3.7e-09	412	721
STKc_p70S6K	cd05584	9.7e-13	413	745
STKc_p38beta_MAPK11	cd07878	4.6e-08	414	721
STKc_Sty1_Hog1	cd07856	1.4e-11	415	711
STKc_MAPK4_6	cd07854	3.4e-08	416	718
STKc_TNIK	cd06637	2.1e-08	419	683
STKc_CDK12	cd07864	1.1e-09	419	683
PTK_HER3	cd05111	1.9e-05	420	676
PTKc_Itk	cd05112	9.6e-08	420	682
PTKc_Btk_Bmx	cd05113	3.3e-08	420	682
PTKc_Tec_Rlk	cd05114	1.3e-06	420	682
STKc_ERK1_2_like	cd07849	2e-11	420	724
STKc_TEY_MAPK_plant	cd07858	1.9e-11	420	727
STKc_MST4	cd06640	7.9e-09	421	704
STKc_MST3	cd06641	1.7e-08	421	698
STKc_STK25-YSK1	cd06642	6.8e-10	421	698
STKc_ERK5	cd07855	6.2e-12	421	717
STKc_BUR1	cd07866	1.8e-08	421	683
STKc_ASK	cd06624	1.3e-09	422	683
STKc_PCTAIRE_like	cd07844	5.1e-08	422	719
STKc_CDK10	cd07845	4.4e-11	423	694
SPS1	COG0515	3e-46	423	745
PTKc_Frk_like	cd05068	1.2e-07	424	685
STKc_PKA	cd05580	4.5e-17	424	705
STKc_PDK1	cd05581	2e-22	424	683
STKc_DMPK_like	cd05597	9.7e-09	424	732
STKc_MAST	cd05609	1.5e-09	424	733
STKc_PRKX_like	cd05612	1.2e-16	424	712
STKc_MST3_like	cd06609	8.7e-16	424	700
STKc_OSR1_SPAK	cd06610	3.6e-17	424	683
STKc_MST1_2	cd06612	2.1e-16	424	683
PKc_MAPKK_plant_like	cd06623	7.7e-17	424	688
STKc_NAK1_like	cd06917	2.8e-12	424	704
STKc_CDKL	cd07833	2.2e-13	424	683
STKc_CDC2L1	cd07843	3.6e-13	424	683
STKc_CDKL2_3	cd07846	4.6e-11	424	683
STKc_CDKL1_4	cd07847	1.4e-16	424	683
STKc_CDKL5	cd07848	3.7e-06	424	683
STKc_Nek6_Nek7	cd08224	4.9e-10	424	686
STKc_Nek6	cd08228	2.1e-07	424	686
PKc_STE	cd05122	1.3e-24	425	682
STKc_Yank1	cd05578	8.5e-20	425	683
STKc_GRK4_like	cd05605	5.8e-10	425	727
STKc_MSK1_N	cd05613	9.5e-10	425	705
STKc_MAPKKK	cd06606	2.3e-28	425	683
STKc_Cdc7_like	cd06627	9e-21	425	683
STKc_MAPKKK_Byr2_lik	cd06628	7.2e-17	425	683
STKc_MAPK	cd07834	9.2e-16	425	710
STKc_Pho85	cd07836	1.6e-09	425	683
STKc_CCRK	cd07832	7.2e-16	425	684
STKc_NLK	cd07853	7.1e-09	425	745
STKc_MPK1	cd07857	5.7e-11	425	722
STKc_TDY_MAPK_plant	cd07859	8.9e-10	425	727
STKc_CDK2_3	cd07860	2.5e-07	425	683
STKc_CDK4	cd07863	1.3e-07	425	683
STKc_CDC2L6	cd07867	1.8e-07	425	683
STKc_CDK8	cd07868	4.8e-07	425	683
STKc_Nek	cd08215	2.9e-23	425	683
STKc_Nek1	cd08218	5.8e-19	425	683
STKc_Nek3	cd08219	9.5e-15	425	683
STKc_Nek8	cd08220	5.4e-09	425	683
STKc_Nek4	cd08223	1.3e-09	425	683
STKc_Nek5	cd08225	6.1e-15	425	683
STKc_Nek10	cd08528	4.5e-08	425	686
STKc_CNK2-like	cd08530	8.8e-13	425	683
STKc_CMGC	cd05118	1.5e-24	426	683
STKc_MSK_N	cd05583	1.8e-10	426	705
STKc_cPKC	cd05587	3.1e-08	426	738
STKc_PKN	cd05589	8.4e-10	426	745
STKc_MSK2_N	cd05614	2e-10	426	740
STKc_CDK_like	cd07829	1.3e-19	426	683
STKc_MOK	cd07831	9.2e-15	426	683
STKc_CDK1_like	cd07835	7.4e-09	426	683
STKc_CDK4_6_like	cd07838	5.7e-13	426	683
STKc_MAPK15	cd07852	2.4e-12	426	714
STKc_CDK1_euk	cd07861	8.2e-10	426	683
STKc_Nek11	cd08222	3e-08	426	683
PK_STRAD	cd08216	8.8e-06	427	691
PK_STRAD_beta	cd08226	0.00011	427	725
STKc_RSK_N	cd05582	1.5e-14	429	738
STKc_SGK	cd05575	7e-10	430	743
STKc_aPKC	cd05588	6e-10	430	738
STKc_nPKC_eta	cd05590	2.7e-08	430	744
STKc_nPKC_theta_delt	cd05592	3.8e-09	430	744
STKc_PKB_alpha	cd05594	1.9e-10	430	743
STKc_PKB_beta	cd05595	4.7e-08	430	745
STKc_SGK2	cd05603	2.8e-11	430	739
STKc_SGK3	cd05604	1.9e-06	430	745
STKc_nPKC_epsilon	cd05591	4.2e-09	430	744
PKc	cd00180	8e-73	432	681
STKc_AGC	cd05123	8.1e-30	432	683
STKc_PKB	cd05571	9.6e-12	432	745
STKc_cGK_PKG	cd05572	7.5e-16	432	687
STKc_YPK1_like	cd05585	6.4e-13	432	744
STKc_Sck1_like	cd05586	1.3e-08	432	744
STKc_SGK1	cd05602	2.1e-09	432	734
STKc_beta_ARK	cd05606	4.3e-08	432	704
STKc_GRK7	cd05607	1.1e-07	432	704
STKc_GRK1	cd05608	1.9e-09	432	710
STKc_MEKK3_like	cd06625	4.2e-12	432	683
Pkinase	pfam00069	3.4e-91	73	330
Pkinase_C	pfam00433	2.2e-09	350	394
Pkinase	pfam00069	2.3e-102	426	683
Pkinase_Tyr	pfam07714	1.4e-17	73	324
TyrKc	smart00219	5.6e-16	73	325
STYKc	smart00221	4.1e-93	73	330
S_TKc	smart00220	1.9e-104	83	330
S_TK_X	smart00133	1.6e-18	331	392
TyrKc	smart00219	3e-14	426	683
STYKc	smart00221	4.9e-84	426	683
S_TKc	smart00220	1.2e-95	436	683
KIND	smart00750	2e-05	506	691

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs6616890	Polymorphism	p.ASP692ASN	N/A
Swiss-Prot	VAR_040638	Polymorphism	p.SER258THR	N/A
Swiss-Prot	VAR_040637	Polymorphism	p.TYR140CYS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258