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Results for the Protein: P37173
116242818

TGFR2_HUMAN RecName: Full=TGF-beta receptor type-2; Short=TGFR-2; AltName: Full=TGF-beta type II receptor; AltName: Full=Transforming growth factor-beta receptor type II; Short=TGF-beta receptor type II; Short=TbetaR-II; Flags: Precursor

Known Diseases associated with this Protein:
  COLON CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6, SOMATIC, INCLUDED
  COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6
  ESOPHAGEAL CANCER (ESCR)
  ESOPHAGEAL CANCER, SOMATIC
  HEREDITARY NON-POLYPOSIS COLORECTAL CANCER 6 (HNPCC6)
  LOEYS-DIETZ SYNDROME 1B (LDS1B)
  LOEYS-DIETZ SYNDROME 2B (LDS2B)
  LOEYS-DIETZ SYNDROME, TYPE 1B
  LOEYS-DIETZ SYNDROME, TYPE 1B, INCLUDED
  LOEYS-DIETZ SYNDROME, TYPE 2B
36
12
16
0
32
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

ecTbetaR2 - pfam08917
STKc_myosinIIIA - cd06638
STKc_myosinIIIB - cd06639
STKc_PAK - cd06614
PTKc_FGFR2 - cd05101
STKc_MAP4K4_6 - cd06636
STKc_p38 - cd07851
PTKc_FGFR - cd05053
PKc_MKK7 - cd06618
PTKc_EGFR_like - cd05057
PTK_HER3 - cd05111
PTKc_HER2 - cd05109
STKc_MAP4K5 - cd06646
STKc_MAP4K3 - cd06645
STKc_ASK - cd06624
PTK_CCK4 - cd05046
STKc_STK10_LOK - cd06644
PTKc_FGFR1 - cd05098
STKc_PCTAIRE_like - cd07844
STKc_CDK12 - cd07864
PTKc_Chk - cd05083
PTKc_Csk - cd05082
PTKc_FAK - cd05056
PTKc_Frk_like - cd05068
PTKc_Fyn_Yrk - cd05070
PTKc_Abl - cd05052
PTKc_Hck - cd05073
PTKc_Tie2 - cd05088
PTKc_Ror - cd05048
PTKc_Trk - cd05049
PTKc_EphR - cd05033
PTKc_EphR_A - cd05066
PKc_MKK3_6 - cd06617
PTKc_ALK_LTK - cd05036
PTKc_EphR_B - cd05065
PTKc_EphR_A2 - cd05063
PTKc_InsR_like - cd05032
STKc_Nek7 - cd08229
STKc_Nek6_Nek7 - cd08224
STKc_Nek6 - cd08228
STKc_SLK - cd06643
PTKc_Btk_Bmx - cd05113
PTKc_Itk - cd05112
STKc_SLK_like - cd06611
PTKc_Srm_Brk - cd05148
STKc_myosinIII_like - cd06608
PTKc_FGFR4 - cd05099
PTKc_Src - cd05071
PTKc_Jak_rpt2 - cd05038
PTKc_DDR2 - cd05095
PTK_Ryk - cd05043
PTKc_Yes - cd05069
STKc_MEKK3 - cd06651
STKc_MAPK - cd07834
STKc_MEKK3_like_1 - cd06653
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
PTKc_Ror2 - cd05091
STKc_MEKK3_like - cd06625
STKc_CDKL1_4 - cd07847
STKc_TNIK - cd06637
TyrKc - smart00219
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
PKc_MAPKK - cd06605
STYKc - smart00221
PKc_MAPKK_plant_like - cd06623
PTKc_Musk - cd05050
PTKc_Axl_like - cd05035
PTKc_Src_like - cd05034
PTKc_Tyro3 - cd05074
PTKc_Csk_like - cd05039
PTKc_Tie1 - cd05089
PTKc_Jak1_rpt2 - cd05079
PTKc_Tyk2_rpt2 - cd05080
STKc_CDKL2_3 - cd07846
STKc_CDK9_like - cd07840
STKc_CNK2-like - cd08530
STKc_CDK7 - cd07841
STKc_Nek - cd08215
STKc_Nek2 - cd08217
STKc_PDK1 - cd05581
STKc_OSR1_SPAK - cd06610
STKc_CRIK - cd05601
STKc_MST1_2 - cd06612
PKc_STE - cd05122
STKc_MAP4K3_like - cd06613
STKc_CdkB_plant - cd07837
STKc_CDKL - cd07833
STKc_CDK_like - cd07829
STKc_CDK4_6_like - cd07838
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK4 - cd06626
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_c-ros - cd05044
PTKc - cd00192
PTKc_Ack_like - cd05040
PTKc_Tie - cd05047
PTKc_Met_Ron - cd05058
PTKc_Jak2_Jak3_rpt2 - cd05081
STKc_NAK1_like - cd06917
STKc_MEKK1_plant - cd06632
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CMGC - cd05118
PTKc_Syk_like - cd05060
PKc - cd00180
STKc_AGC - cd05123
STKc_CCRK - cd07832
STKc_MAST_like - cd05579
STKc_GRK7 - cd05607
STKc_MAK_like - cd07830
S_TKc - smart00220
STKc_PAK_II - cd06648
PKc_MEK - cd06615


Swiss-Prot Protein: P37173
Identical to: NP_003233
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
STKc_myosinIIIBcd066390.00033224511
STKc_PAKcd066142.9e-07227542
PTKc_FGFR2cd051010.00018228555
STKc_MAP4K4_6cd066360.00033230510
STKc_p38cd078510.00026230562
PTKc_FGFRcd050534.2e-06231548
PTKc_EGFR_likecd050570.00012233555
PTK_HER3cd051110.00073233550
PKc_MKK7cd066180.00029233544
PTKc_HER2cd051097.8e-05234555
STKc_MAP4K3cd066450.00039234535
STKc_MAP4K5cd066460.001234509
PTK_CCK4cd050460.0005235540
STKc_STK10_LOKcd066440.00024235555
STKc_ASKcd066240.00041235539
PTKc_Ablcd050527.5e-05237542
PTKc_FAKcd050566.8e-06237546
PTKc_Frk_likecd050688.8e-06237541
PTKc_Fyn_Yrkcd050700.00043237538
PTKc_Hckcd050730.00012237538
PTKc_Cskcd050825.1e-05237541
PTKc_Chkcd050830.00015237541
PTKc_FGFR1cd050980.00013237555
STKc_PCTAIRE_likecd078440.00091237558
STKc_CDK12cd078647.2e-05237539
PTKc_Rorcd050481.8e-06238541
PTKc_Trkcd050492e-07238540
PTKc_Tie2cd050880.00035238536
PTKc_EphRcd050337.4e-07239542
PTKc_ALK_LTKcd050361.1e-05239540
PTKc_EphR_Bcd050650.00011239511
PTKc_EphR_Acd050660.00063239517
PKc_MKK3_6cd066177.1e-06239519
PTKc_InsR_likecd050321.1e-06240540
PTKc_EphR_A2cd050633.2e-05240542
PTKc_Itkcd051120.00034241539
PTKc_Btk_Bmxcd051130.00014241539
STKc_SLK_likecd066119.1e-06241555
STKc_SLKcd066435.8e-05241557
STKc_Nek6_Nek7cd082246.5e-05241515
STKc_Nek6cd082280.00013241514
STKc_Nek7cd082290.00011241543
PTKc_Jak_rpt2cd050381.4e-08242542
PTK_Rykcd050432.5e-05242541
PTKc_Yescd050690.00099242538
PTKc_Srccd050710.00066242540
PTKc_DDR2cd050950.00077242540
PTKc_FGFR4cd050991.7e-05242559
PTKc_Srm_Brkcd051482.3e-08242541
STKc_myosinIII_likecd066085.6e-08242484
PTKc_Ror2cd050910.00047243541
STKc_MAPKKKcd066064.7e-12243484
STKc_MEKK3_likecd066255.5e-07243510
STKc_Cdc7_likecd066271.1e-08243484
STKc_MEKK3cd066511.1e-05243512
STKc_MEKK3_like_1cd066530.00013243526
STKc_MAPKcd078344.9e-05243560
PTKc_Src_likecd050342.2e-05244541
PTKc_Axl_likecd050350.00012244542
PTKc_Csk_likecd050391.8e-05244485
PTKc_Muskcd050502.3e-06244540
PTKc_Tyro3cd050740.00071244542
PTKc_Jak1_rpt2cd050790.00057244542
PTKc_Tyk2_rpt2cd050807.9e-06244543
PTKc_Tie1cd050890.00093244527
PKc_MAPKKcd066051.1e-06244515
PKc_MAPKK_plant_likecd066232.8e-06244540
STKc_TNIKcd066374.5e-05244510
STKc_CDKL1_4cd078470.0008244540
PKc_STEcd051224.3e-10245538
STKc_PDK1cd055811.9e-08245504
STKc_CRIKcd056010.0005245557
STKc_OSR1_SPAKcd066106.6e-06245484
STKc_MST1_2cd066121.7e-05245484
STKc_MAP4K3_likecd066131.7e-07245538
STKc_CDK_likecd078293.9e-05245539
STKc_CDKLcd078330.00025245539
STKc_CdkB_plantcd078370.00032245540
STKc_CDK4_6_likecd078380.00019245484
STKc_CDK7cd078415.1e-05245558
STKc_CDKL2_3cd078460.00015245539
STKc_CDK9_likecd078400.00052245538
STKc_Nekcd082157.8e-08245540
STKc_Nek2cd082170.00013245510
STKc_CNK2-likecd085300.00023245541
STKc_MEKK4cd066262.3e-06247533
STKc_MAPKKK_Byr2_likcd066280.00034247522
PTKccd001921.6e-12248539
PTKc_Ack_likecd050403.9e-06248540
PTKc_c-roscd050440.00037248540
PTKc_Tiecd050470.0006248515
PTKc_Met_Roncd050580.00097248544
PTKc_Jak2_Jak3_rpt2cd050814.8e-06248542
PTKc_Aatyk1_Aatyk3cd050870.001248540
STKc_MAPKKK_Bck1_likcd066297.1e-07249510
STKc_MEKK1_plantcd066320.0001249534
STKc_NAK1_likecd069174.7e-05249548
PKccd001808e-46250541
PTKc_Syk_likecd050600.00099250543
STKc_CMGCcd051182e-07250539
STKc_AGCcd051231.1e-06250544
STKc_MAST_likecd055790.00021250543
STKc_GRK7cd056070.00076250559
STKc_MAK_likecd078300.00062250539
STKc_CCRKcd078320.00017250539
STKc_PAK_IIcd066480.00089268557
PKc_MEKcd066153.9e-05309555
Pkinasepfam000692.7e-52244538
ecTbetaR2pfam089173.7e-7447153
Pkinase_Tyrpfam077141.8e-17244538
STYKcsmart002211.9e-24244522
TyrKcsmart002192.3e-15244538
S_TKcsmart002209.7e-26254539

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_022353Diseasep.ALA355PROLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_029760Diseasep.ARG460CYSLoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_022360Diseasep.ARG528CYSLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_022362Diseasep.ARG537CYSLoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_029761Diseasep.ARG460HISLoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_022361Diseasep.ARG528HISLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_022356Polymorphismp.ASN435SERN/A
Swiss-ProtVAR_041417Polymorphismp.ASN490SERN/A
Swiss-ProtVAR_066725Diseasep.ASP446ASNLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_066730Diseasep.CYS514ARGLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_041414Polymorphismp.CYS61ARGN/A
Swiss-ProtVAR_015816Diseasep.GLU526GLNEsophageal cancer (ESCR)
Swiss-ProtVAR_022354Diseasep.GLY357TRPLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_066727Diseasep.GLY509VALLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_066724Diseasep.HIS377ARGLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_041415Polymorphismp.HIS328TYRN/A
Swiss-ProtVAR_066728Diseasep.ILE510PHELoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_066729Diseasep.ILE510SERLoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_036070Polymorphismp.ILE73VALN/A
Swiss-ProtVAR_022359Polymorphismp.LEU452METN/A
Swiss-ProtVAR_022351Diseasep.LEU308PROLoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_041416Polymorphismp.MET373ILEN/A
Swiss-ProtVAR_066726Diseasep.MET457LYSLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_020510Polymorphismp.MET36VALN/A
Swiss-ProtVAR_022358Diseasep.SER449PHELoeys-Dietz syndrome 2B (LDS2B)
Swiss-ProtVAR_008156Diseasep.THR315METHereditary non-polyposis colorectal cancer 6 (HNPCC6)
Swiss-ProtVAR_066731Diseasep.TRP521ARGLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_022352Diseasep.TYR336ASNLoeys-Dietz syndrome 1B (LDS1B)
Swiss-ProtVAR_028063Polymorphismp.VAL439ALAN/A
Swiss-ProtVAR_022357Polymorphismp.VAL447ALAN/A
Swiss-ProtVAR_017606Polymorphismp.VAL191ILEN/A
Swiss-ProtVAR_022355Polymorphismp.VAL387METN/A
OMIM190182.0009 Diseasep.ALA330PROLOEYS-DIETZ SYNDROME, TYPE 1B
OMIM190182.0014 Diseasep.ARG435CYSLOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0012 Diseasep.ARG503CYSLOEYS-DIETZ SYNDROME, TYPE 1B
OMIM190182.0007 Diseasep.ARG512CYSLOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0015 Diseasep.ARG435HISLOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0011 Diseasep.ARG503HISLOEYS-DIETZ SYNDROME, TYPE 1B||COLON CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6, SOMATIC, INCLUDED
OMIM190182.0019 Diseasep.ARG470TERLOEYS-DIETZ SYNDROME, TYPE 1B
OMIM190182.0004 Diseasep.GLN483GLNLOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0003 Diseasep.GLU501GLNESOPHAGEAL CANCER, SOMATIC
OMIM190182.0010 Diseasep.GLY332TRPLOEYS-DIETZ SYNDROME, TYPE 1B
OMIM190182.0005 Diseasep.LEU283PROLOEYS-DIETZ SYNDROME, TYPE 2B||LOEYS-DIETZ SYNDROME, TYPE 1B, INCLUDED
OMIM190182.0017 Diseasep.MET400VALLOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0018 Diseasep.PRO402LEULOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0006 Diseasep.SER424PHELOEYS-DIETZ SYNDROME, TYPE 2B
OMIM190182.0002 Diseasep.THR290METCOLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6
OMIM190182.0008 Diseasep.TYR311ASNLOEYS-DIETZ SYNDROME, TYPE 1B



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