Results for the protein: P42681

Results for the Protein: P42681

116242835

7294

TXK

NCBI, UniProt

TXK_HUMAN RecName: Full=Tyrosine-protein kinase TXK; AltName: Full=Protein-tyrosine kinase 4; AltName: Full=Resting lymphocyte kinase

			0 3 0 2 1

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Swiss-Prot Protein: P42681

Identical to: NP_003319

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_Kit	cd05104	2.3e-13	136	524
SH2	cd00173	3.3e-34	149	246
PTKc_VEGFR	cd05054	4.1e-21	152	527
STKc_PAK_I	cd06647	2.8e-05	235	525
STKc_PAK2	cd06655	4.2e-05	235	527
PTK_Tyk2_rpt1	cd05076	3.5e-07	236	521
PTKc_PDGFR_alpha	cd05105	5.4e-14	241	526
PTKc_PDGFR_beta	cd05107	8.7e-10	241	525
PTKc_CSF-1R	cd05106	5e-20	241	525
PTKc_PDGFR	cd05055	6.6e-19	244	524
STKc_myosinIIIB	cd06639	0.00013	248	523
STKc_Sty1_Hog1	cd07856	0.0004	248	524
STKc_PAK6	cd06659	4.5e-07	251	524
PTKc_FGFR4	cd05099	1.1e-33	253	526
PTKc_FGFR3	cd05100	9.2e-20	253	526
STKc_myosinIIIA	cd06638	6.6e-06	253	522
STKc_PAK	cd06614	2.5e-15	254	527
STKc_TAO	cd06607	1.8e-05	254	526
STKc_TAO2	cd06634	1.9e-06	254	525
STKc_TAO1	cd06635	4.6e-05	254	525
PKc_MKK7	cd06618	8.1e-09	256	526
STKc_PAK1	cd06654	3.9e-05	256	527
PTKc_FGFR1	cd05098	2.6e-32	258	525
STKc_PAK5	cd06658	4.6e-06	258	527
STKc_STK10_LOK	cd06644	2.5e-07	259	526
PTKc_FGFR2	cd05101	1.8e-31	260	526
STKc_PAK4	cd06657	4.8e-05	260	527
STKc_PAK3	cd06656	0.00012	261	525
STKc_PCTAIRE_like	cd07844	0.00036	261	522
STKc_p38	cd07851	0.00065	261	525
STKc_CDK12	cd07864	1.6e-08	261	522
PTKc_FGFR	cd05053	7.2e-36	262	525
STKc_ASK	cd06624	1.1e-08	262	522
STKc_MAP4K3	cd06645	6.5e-06	262	521
STKc_MAP4K5	cd06646	7.3e-05	262	521
STKc_CDKL2_3	cd07846	1.5e-08	262	522
PTKc_VEGFR3	cd05102	3.9e-20	263	527
PTKc_VEGFR2	cd05103	9.5e-19	263	527
PTKc_EGFR_like	cd05057	9.2e-73	263	526
PTKc_InsR_like	cd05032	2.5e-57	264	522
PTKc_Src_like	cd05034	2.8e-117	264	523
PTKc_ALK_LTK	cd05036	5.9e-75	264	522
PTKc_Csk_like	cd05039	1e-74	264	523
PTKc_Abl	cd05052	7.6e-96	264	524
PTKc_FAK	cd05056	6.8e-67	264	526
PTKc_InsR	cd05061	1.1e-41	264	525
PTKc_IGF-1R	cd05062	9.5e-48	264	522
PTKc_Lck_Blk	cd05067	9.4e-90	264	524
PTKc_Frk_like	cd05068	1.7e-104	264	523
PTKc_Yes	cd05069	1.5e-79	264	524
PTKc_Fyn_Yrk	cd05070	3.1e-88	264	524
PTKc_Src	cd05071	4.9e-81	264	526
PTKc_Lyn	cd05072	5.6e-88	264	523
PTKc_Hck	cd05073	5e-86	264	524
PTKc_Csk	cd05082	2.1e-74	264	523
PTKc_Chk	cd05083	1e-65	264	523
PTKc_Tie1	cd05089	1e-24	264	526
PTKc_Srm_Brk	cd05148	1.7e-76	264	523
PTK_CCK4	cd05046	8.2e-54	265	522
PTKc_Ror	cd05048	4.3e-39	265	520
PTKc_Musk	cd05050	1.3e-54	265	522
PTKc_DDR	cd05051	6.2e-47	265	522
PTKc_Trk	cd05049	2.3e-56	265	519
PTKc_EphR_A2	cd05063	4.3e-69	265	524
PTKc_EphR_A10	cd05064	1.9e-52	265	524
PTKc_Ror1	cd05090	1.2e-36	265	520
PTKc_Ror2	cd05091	3.5e-32	265	520
PTKc_TrkA	cd05092	7.8e-53	265	526
PTKc_TrkC	cd05094	7.9e-33	265	526
PTKc_DDR2	cd05095	1.7e-46	265	522
PTKc_DDR1	cd05096	8.4e-39	265	522
PTKc_DDR_like	cd05097	9.5e-45	265	522
PTKc_TrkB	cd05093	3.5e-48	265	526
PKc_MAPKK_Byr1_like	cd06620	7.8e-08	265	524
STKc_MAP4K4_6	cd06636	5.8e-05	265	522
STKc_TNIK	cd06637	7.8e-07	265	522
STKc_PAK_II	cd06648	4.8e-08	265	527
PTKc_EphR	cd05033	1.1e-79	266	524
PTKc_Jak_rpt2	cd05038	7.3e-58	266	524
PTK_Ryk	cd05043	3.2e-20	266	527
PTKc_Tec_like	cd05059	1.9e-225	266	521
PTKc_EphR_B	cd05065	2.6e-67	266	524
PTKc_EphR_A	cd05066	3.5e-69	266	524
PTKc_Jak1_rpt2	cd05079	1.2e-36	266	524
PTKc_Jak2_Jak3_rpt2	cd05081	1e-44	266	524
PTKc_Tie2	cd05088	2.8e-26	266	526
PTKc_EGFR	cd05108	1.9e-30	266	526
PTKc_HER2	cd05109	7.5e-48	266	525
PTK_HER3	cd05111	8e-44	266	526
PTKc_Itk	cd05112	1.5e-157	266	521
PTKc_Tec_Rlk	cd05114	2e-204	266	521
PTKc_Btk_Bmx	cd05113	6.8e-159	266	521
PTKc_HER4	cd05110	1.3e-37	266	526
STKc_SLK_like	cd06611	4.8e-10	266	525
STKc_SLK	cd06643	3.8e-07	266	526
STKc_myosinIII_like	cd06608	1.2e-09	267	518
STKc_MST4	cd06640	7.9e-08	267	527
STKc_MST3	cd06641	5.7e-08	267	527
STKc_STK25-YSK1	cd06642	2e-08	267	527
STKc_CDK9	cd07865	1.6e-05	267	513
STKc_BUR1	cd07866	1.9e-05	267	513
STKc_PFTAIRE2	cd07870	0.00029	267	527
STKc_MST1_2	cd06612	1.5e-10	268	518
STKc_MAP4K3_like	cd06613	1.6e-10	268	521
STKc_MEKK3_like	cd06625	1.1e-11	268	522
STKc_MEKK3	cd06651	1.6e-08	268	523
STKc_MEKK2	cd06652	8.6e-06	268	523
STKc_MEKK3_like_1	cd06653	2.3e-07	268	522
STKc_ROCK_NDR_like	cd05573	6.6e-05	269	514
STKc_phototropin_lik	cd05574	0.00015	269	525
STKc_PKA	cd05580	4.9e-06	269	499
STKc_PDK1	cd05581	1.1e-10	269	518
STKc_PRKX_like	cd05612	8.1e-06	269	526
PKc_MAPKK	cd06605	3.9e-09	269	522
STKc_MST3_like	cd06609	1e-10	269	527
STKc_OSR1_SPAK	cd06610	1.2e-11	269	522
PKc_MEK	cd06615	1.1e-06	269	527
PKc_MKK4	cd06616	5.9e-05	269	524
PKc_MKK3_6	cd06617	1.2e-07	269	525
PKc_MAPKK_Pek1_like	cd06621	0.00015	269	527
PKc_MAPKK_PBS2_like	cd06622	3.8e-06	269	527
PKc_MAPKK_plant_like	cd06623	1.1e-13	269	525
STKc_CdkB_plant	cd07837	2e-06	269	527
STKc_CDK10	cd07845	1.1e-05	269	514
STKc_CDKL1_4	cd07847	1.9e-06	269	522
STKc_MAPK4_6	cd07854	0.00095	269	526
STKc_Nek6_Nek7	cd08224	3.4e-08	269	525
STKc_Nek6	cd08228	2.3e-06	269	525
STKc_Nek7	cd08229	3.8e-08	269	525
SPS1	COG0515	0.00014	269	525
PTKc_RET	cd05045	2.8e-31	270	527
PKc_STE	cd05122	9.8e-16	270	518
STKc_MSK_N	cd05583	0.00078	270	523
STKc_cPKC	cd05587	0.00034	270	527
STKc_Yank1	cd05578	4e-07	270	526
STKc_Cdc7_like	cd06627	4.7e-14	270	518
STKc_CCRK	cd07832	6.9e-07	270	521
STKc_MAPK	cd07834	2.4e-06	270	523
STKc_Pho85	cd07836	0.0001	270	527
STKc_CDK5	cd07839	1.2e-05	270	527
STKc_CDK7	cd07841	1.7e-08	270	518
STKc_CDK8_like	cd07842	3.7e-06	270	520
STKc_MPK1	cd07857	8.9e-05	270	523
STKc_CDK2_3	cd07860	0.00014	270	527
STKc_CDK1_euk	cd07861	0.00013	270	527
STKc_Nek2	cd08217	4.6e-11	270	523
STKc_Nek1	cd08218	5.2e-08	270	522
STKc_Nek3	cd08219	8.6e-12	270	521
STKc_Nek8	cd08220	3.2e-07	270	521
STKc_Nek11	cd08222	3.9e-10	270	522
STKc_Nek4	cd08223	3.2e-12	270	522
STKc_Nek5	cd08225	6.2e-10	270	522
STKc_Nek10	cd08528	3.8e-07	270	522
STKc_CNK2-like	cd08530	2e-08	270	520
PTKc_Axl_like	cd05035	3.4e-45	271	524
PTKc_Tyro3	cd05074	1.2e-41	271	524
PTKc_Axl	cd05075	3.5e-38	271	524
PTKc_Tyk2_rpt2	cd05080	6.8e-27	271	525
STKc_PKN	cd05589	0.00012	271	526
STKc_MAPKKK_Bck1_lik	cd06629	9.5e-12	271	522
STKc_CDK1_like	cd07835	3.5e-05	271	527
STKc_MAPKKK	cd06606	1.3e-19	272	522
STKc_MAPKKK_Byr2_lik	cd06628	1.6e-17	272	522
PK_STRAD	cd08216	4.5e-05	272	519
STKc_CDK_like	cd07829	2.3e-11	273	519
STKc_MAK_like	cd07830	1.4e-12	273	518
STKc_MOK	cd07831	7.5e-07	273	518
STKc_CDKL	cd07833	1.1e-06	273	518
STKc_CMGC	cd05118	1.1e-10	274	518
STKc_CDK4_6_like	cd07838	6.4e-05	274	513
STKc_CDK9_like	cd07840	1.2e-10	274	520
STKc_Nek	cd08215	1.7e-16	274	522
STKc_Nek9	cd08221	6.1e-09	274	522
STKc_FA2-like	cd08529	6.7e-12	274	522
PTKc	cd00192	4.4e-122	275	521
PTK_Jak_rpt1	cd05037	4e-12	275	521
PTKc_Ack_like	cd05040	2.8e-79	275	522
PTKc_Fes_like	cd05041	9.1e-82	275	522
PTKc_Aatyk	cd05042	1.6e-23	275	522
PTKc_c-ros	cd05044	1.6e-53	275	522
PTKc_Met_Ron	cd05058	7.6e-61	275	526
PTKc_Syk_like	cd05060	2.6e-63	275	525
PTK_Jak1_rpt1	cd05077	6.5e-09	275	521
PTK_Jak2_Jak3_rpt1	cd05078	3.8e-13	275	521
PTKc_Fes	cd05084	2.6e-71	275	522
PTKc_Fer	cd05085	2.4e-72	275	522
PTKc_Aatyk2	cd05086	5.2e-26	275	522
PTKc_Aatyk1_Aatyk3	cd05087	1.8e-32	275	522
PTKc_Syk	cd05116	1.2e-50	275	525
STKc_PKC	cd05570	1.3e-06	275	521
STKc_nPKC_theta_delt	cd05592	0.001	275	526
STKc_nPKC_theta	cd05619	0.00016	275	527
STKc_MEKK4	cd06626	1.9e-09	275	519
STKc_MEKK1	cd06630	8e-08	275	521
STKc_MEKK1_plant	cd06632	1.1e-10	275	520
PTKc_Zap-70	cd05115	6.8e-49	276	525
STKc_CDC2L1	cd07843	1.6e-05	276	513
PKc	cd00180	2.8e-66	277	520
PTKc_Tie	cd05047	1.7e-37	277	525
STKc_AGC	cd05123	4.7e-09	277	519
STKc_cGK_PKG	cd05572	3.3e-08	277	515
STKc_MAST_like	cd05579	2.7e-09	277	513
STKc_YSK4	cd06631	4.2e-09	277	522
STKc_NAK1_like	cd06917	1.2e-08	277	527
SH3_1	pfam00018	6.3e-15	88	134
SH2	pfam00017	7.8e-35	150	231
Pkinase	pfam00069	5.3e-40	271	520
SH3	smart00326	2.8e-15	83	140
SH2	smart00252	3.5e-32	148	237
Pkinase_Tyr	pfam07714	9e-145	271	520
TyrKc	smart00219	2.3e-132	271	520
STYKc	smart00221	2.3e-60	271	522
S_TKc	smart00220	2e-49	281	524

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041869	Polymorphism	p.ARG63CYS	N/A
dbSNP	rs11724347	Polymorphism	p.ARG336GLN	N/A
dbSNP	rs7658300	Polymorphism	p.ARG45HIS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258