Results for the protein: P42679

Results for the Protein: P42679

1169123

4145

MATK

NCBI, UniProt

MATK_HUMAN RecName: Full=Megakaryocyte-associated tyrosine-protein kinase; AltName: Full=CSK homologous kinase; Short=CHK; AltName: Full=Hematopoietic consensus tyrosine-lacking kinase; AltName: Full=Protein kinase HYL; AltName: Full=Tyrosine-protein kinase CTK

			0 3 0 1 2

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: P42679

Identical to: NP_647612

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_VEGFR	cd05054	8.4e-30	116	485
PTKc_Kit	cd05104	2.4e-21	120	482
PTKc_PDGFR_beta	cd05107	3.5e-10	120	483
SH2	cd00173	1.2e-31	121	211
PTKc_PDGFR_alpha	cd05105	1.1e-14	196	484
PTKc_CSF-1R	cd05106	1e-27	198	483
PTKc_PDGFR	cd05055	5.3e-21	208	482
STKc_PAK6	cd06659	7.7e-07	212	501
PKc_MKK5	cd06619	0.00058	215	503
PTK_Tyk2_rpt1	cd05076	8.3e-07	218	479
STKc_PAK5	cd06658	1.3e-05	218	499
STKc_PAK1	cd06654	2.3e-06	218	500
PTKc_FGFR1	cd05098	3.3e-58	219	495
STKc_PAK	cd06614	7.5e-13	219	482
STKc_PAK_I	cd06647	1.2e-05	219	498
STKc_PAK2	cd06655	4.4e-06	219	501
STKc_PAK3	cd06656	1.3e-06	219	502
PTKc_FGFR2	cd05101	1.5e-54	220	489
STKc_TAO	cd06607	0.00059	220	505
STKc_PAK_II	cd06648	1.9e-08	220	495
STKc_TAO2	cd06634	0.00022	220	506
STKc_PAK4	cd06657	1.8e-05	220	501
STKc_p38gamma_MAPK12	cd07880	0.00089	220	507
STKc_STK10_LOK	cd06644	3.7e-06	221	491
PKc_MKK7	cd06618	1.6e-05	222	494
STKc_MAP4K3	cd06645	0.0001	222	479
STKc_MAP4K5	cd06646	3.2e-05	222	479
STKc_CDK9	cd07865	7.3e-06	222	471
STKc_myosinIIIA	cd06638	0.001	223	480
STKc_PFTAIRE2	cd07870	6.6e-06	223	502
PTKc_FGFR4	cd05099	3.8e-56	224	503
PTKc_FGFR3	cd05100	4.1e-49	224	506
STKc_ASK	cd06624	2.5e-09	226	480
PTKc_VEGFR3	cd05102	1.5e-32	227	485
PTKc_VEGFR2	cd05103	9.6e-28	227	485
PTK_HER3	cd05111	2.2e-45	227	492
STKc_CDK10	cd07845	1.2e-06	227	452
PTKc_InsR_like	cd05032	1.1e-58	228	480
PTKc_Src_like	cd05034	1.1e-92	228	481
PTKc_Csk_like	cd05039	3.8e-203	228	481
PTKc_Abl	cd05052	4.9e-85	228	482
PTKc_FGFR	cd05053	3.1e-68	228	483
PTKc_FAK	cd05056	1e-68	228	486
PTKc_InsR	cd05061	4.5e-48	228	491
PTKc_IGF-1R	cd05062	3.1e-43	228	480
PTKc_Lck_Blk	cd05067	9.5e-76	228	481
PTKc_Yes	cd05069	1.9e-69	228	481
PTKc_Fyn_Yrk	cd05070	1.5e-73	228	481
PTKc_Frk_like	cd05068	7.1e-81	228	481
PTKc_Src	cd05071	1.2e-71	228	483
PTKc_Lyn	cd05072	5.4e-70	228	481
PTKc_Hck	cd05073	2.2e-74	228	481
PTKc_Csk	cd05082	2.5e-126	228	481
PTKc_Chk	cd05083	4.2e-204	228	481
PTKc_Srm_Brk	cd05148	2.5e-79	228	481
STKc_CDK12	cd07864	1.3e-06	228	502
PTK_CCK4	cd05046	1.7e-36	229	480
PTKc_Ror	cd05048	1.1e-45	229	482
PTKc_Trk	cd05049	2.6e-54	229	480
PTKc_DDR	cd05051	4.5e-28	229	480
PTKc_EGFR_like	cd05057	4.7e-56	229	492
PTKc_Tie2	cd05088	2.3e-46	229	496
PTKc_EGFR	cd05108	1.4e-32	229	507
PTKc_HER2	cd05109	2.2e-40	229	492
PTKc_HER4	cd05110	3.4e-33	229	507
STKc_SLK	cd06643	6.6e-06	229	489
STKc_PCTAIRE3	cd07871	2.6e-05	229	505
PTKc_EphR	cd05033	9.7e-74	230	482
PTKc_Jak_rpt2	cd05038	1.7e-66	230	482
PTK_Ryk	cd05043	4.5e-22	230	482
PTKc_Musk	cd05050	2e-49	230	480
PTKc_Tec_like	cd05059	2.1e-83	230	479
PTKc_EphR_A2	cd05063	1.9e-60	230	482
PTKc_EphR_A10	cd05064	1.2e-58	230	482
PTKc_EphR_B	cd05065	8.3e-59	230	482
PTKc_EphR_A	cd05066	1.2e-61	230	482
PTKc_Jak1_rpt2	cd05079	3.8e-38	230	482
PTKc_Tyk2_rpt2	cd05080	1.1e-37	230	483
PTKc_Jak2_Jak3_rpt2	cd05081	3.8e-45	230	482
PTKc_Ror1	cd05090	2.6e-43	230	481
PTKc_Ror2	cd05091	2.2e-41	230	481
PTKc_TrkA	cd05092	1.5e-43	230	488
PTKc_TrkB	cd05093	3.2e-37	230	492
PTKc_TrkC	cd05094	4e-17	230	492
PTKc_DDR2	cd05095	1.2e-24	230	480
PTKc_DDR1	cd05096	7.3e-21	230	480
PTKc_DDR_like	cd05097	3.1e-32	230	480
PTKc_Itk	cd05112	3.1e-74	230	479
PTKc_Btk_Bmx	cd05113	1.1e-75	230	479
PTKc_Tec_Rlk	cd05114	3.9e-69	230	479
STKc_SLK_like	cd06611	3.8e-07	230	485
PKc_MKK4	cd06616	4.6e-08	230	497
PKc_MAPKK_Byr1_like	cd06620	0.00013	230	485
STKc_GRK4	cd05631	0.00042	231	507
STKc_MAP4K3_like	cd06613	2.1e-08	231	479
STKc_Pho85	cd07836	3.3e-05	231	502
STKc_PCTAIRE_like	cd07844	9.5e-07	231	502
STKc_CDK2_3	cd07860	5.2e-06	231	502
STKc_BUR1	cd07866	0.00033	231	471
STKc_PCTAIRE1	cd07873	0.00073	231	503
PTKc_Tie1	cd05089	2.4e-52	232	495
STKc_Nek6_Nek7	cd08224	3.4e-08	232	484
STKc_Nek6	cd08228	3.9e-07	232	484
STKc_Nek7	cd08229	1.8e-08	232	484
PTKc_ALK_LTK	cd05036	1.1e-70	233	480
PTK_Jak_rpt1	cd05037	1.7e-12	233	479
PTK_Jak1_rpt1	cd05077	1.2e-09	233	479
STKc_phototropin_lik	cd05574	0.00028	233	495
STKc_PKA	cd05580	1.5e-06	233	504
STKc_ROCK_NDR_like	cd05573	0.00031	233	502
STKc_PRKX_like	cd05612	2.4e-06	233	507
PKc_MAPKK	cd06605	2.3e-07	233	481
STKc_MST3_like	cd06609	1.4e-09	233	487
PKc_MEK	cd06615	1.3e-05	233	492
PKc_MKK3_6	cd06617	1.3e-06	233	496
PKc_MAPKK_Pek1_like	cd06621	4e-07	233	483
STKc_OSR1_SPAK	cd06610	1.3e-11	233	480
PKc_MAPKK_PBS2_like	cd06622	7.1e-06	233	507
PKc_MAPKK_plant_like	cd06623	7.1e-12	233	477
STKc_MST4	cd06640	6e-06	233	503
STKc_MST3	cd06641	1.4e-06	233	503
STKc_STK25-YSK1	cd06642	2.1e-06	233	485
STKc_MEKK2	cd06652	0.00047	233	485
STKc_MEKK3_like_1	cd06653	0.0001	233	484
STKc_CDK8_like	cd07842	1.1e-05	233	471
STKc_CDKL1_4	cd07847	0.00018	233	480
STKc_CDK6	cd07862	2.6e-05	233	505
STKc_ERK1_2_like	cd07849	0.00047	233	484
SPS1	COG0515	5.8e-06	233	504
PTKc_RET	cd05045	6.3e-43	234	485
STKc_CMGC	cd05118	1.6e-09	234	472
PKc_STE	cd05122	8.1e-14	234	471
STKc_Yank1	cd05578	4.1e-06	234	472
STKc_cPKC	cd05587	0.00051	234	503
STKc_GRK4_like	cd05605	1.2e-06	234	507
STKc_cPKC_alpha	cd05615	0.00076	234	503
STKc_GRK6	cd05630	0.00016	234	507
STKc_GRK5	cd05632	0.00015	234	490
STKc_MSK_N	cd05583	1.6e-05	234	507
STKc_MAPKKK	cd06606	1.8e-20	234	472
STKc_Cdc7_like	cd06627	5e-13	234	474
STKc_MAPKKK_Byr2_lik	cd06628	4.4e-15	234	480
STKc_MEKK1	cd06630	2.3e-07	234	480
STKc_YSK4	cd06631	4.3e-08	234	478
STKc_MEKK3	cd06651	2.9e-06	234	482
STKc_CCRK	cd07832	1.4e-07	234	473
STKc_MAPK	cd07834	5.5e-06	234	506
STKc_CDK7	cd07841	6.6e-09	234	479
STKc_MPK1	cd07857	0.0002	234	491
STKc_CDK1_euk	cd07861	0.00088	234	504
STKc_CDK4	cd07863	0.00017	234	502
STKc_Nek	cd08215	1.4e-14	234	480
STKc_Nek1	cd08218	3.7e-07	234	480
STKc_Nek3	cd08219	3.6e-11	234	483
STKc_Nek11	cd08222	6.4e-07	234	479
STKc_Nek4	cd08223	1.5e-05	234	480
STKc_Nek5	cd08225	1.3e-09	234	480
STKc_Nek10	cd08528	1.5e-06	234	480
STKc_FA2-like	cd08529	1.1e-09	234	480
STKc_CNK2-like	cd08530	1.4e-08	234	479
PTKc_Axl_like	cd05035	7e-58	235	482
PTKc_Tyro3	cd05074	1.8e-52	235	482
PTKc_Axl	cd05075	2.7e-47	235	482
STKc_PKN	cd05589	0.00011	235	506
STKc_CDK_like	cd07829	5e-11	235	472
STKc_MAK_like	cd07830	1.1e-08	235	471
STKc_CDK1_like	cd07835	4.8e-06	235	502
STKc_CDK4_6_like	cd07838	5.2e-08	235	442
STKc_MAPK4_6	cd07854	2.4e-05	235	495
STKc_myosinIII_like	cd06608	9.4e-06	236	462
STKc_MEKK3_like	cd06625	2e-09	236	480
STKc_CDKL	cd07833	6.5e-07	236	472
STKc_CDKL2_3	cd07846	8.2e-06	236	483
STKc_Sty1_Hog1	cd07856	0.001	236	505
PK_STRAD	cd08216	0.00015	236	484
STKc_PDK1	cd05581	7.2e-11	237	471
STKc_MEKK4	cd06626	2.1e-09	237	472
STKc_MAPKKK_Bck1_lik	cd06629	5.9e-11	238	472
STKc_MEKK1_plant	cd06632	1.1e-09	238	472
PTKc	cd00192	1.3e-113	239	479
PTKc_Ack_like	cd05040	1.1e-68	239	480
PTKc_Fes_like	cd05041	9.5e-92	239	480
PTKc_Aatyk	cd05042	5.7e-14	239	480
PTKc_c-ros	cd05044	1.8e-56	239	480
PTKc_Tie	cd05047	6.4e-57	239	483
PTKc_Met_Ron	cd05058	8.4e-62	239	484
PTKc_Syk_like	cd05060	1.1e-74	239	483
PTK_Jak2_Jak3_rpt1	cd05078	2.8e-13	239	479
PTKc_Fes	cd05084	1.9e-77	239	480
PTKc_Fer	cd05085	1.3e-78	239	480
PTKc_Aatyk2	cd05086	3e-10	239	484
PTKc_Aatyk1_Aatyk3	cd05087	1.1e-18	239	480
PTKc_Zap-70	cd05115	2.2e-54	239	483
PTKc_Syk	cd05116	8.5e-59	239	483
STKc_PKC	cd05570	1.7e-06	239	483
STKc_nPKC_theta_delt	cd05592	6.7e-05	239	507
STKc_nPKC_delta	cd05620	0.00082	239	507
STKc_nPKC_theta	cd05619	9.6e-06	239	507
STKc_MOK	cd07831	4.8e-05	239	476
STKc_CDK5	cd07839	1.2e-05	239	505
STKc_CDK9_like	cd07840	4.3e-08	239	472
STKc_Nek2	cd08217	1.8e-07	239	480
STKc_CdkB_plant	cd07837	3.4e-05	240	481
PKc	cd00180	5.1e-57	241	478
STKc_AGC	cd05123	1.3e-07	241	473
STKc_cGK_PKG	cd05572	6.1e-06	241	478
STKc_GRK	cd05577	0.00019	241	489
STKc_GRK1	cd05608	9.9e-05	241	506
STKc_MAST_like	cd05579	4.8e-07	241	471
STKc_MST1_2	cd06612	1.5e-09	241	472
STKc_NAK1_like	cd06917	4.3e-08	241	494
STKc_CDC2L1	cd07843	0.00013	241	471
STKc_Nek8	cd08220	5.8e-07	241	479
STKc_Nek9	cd08221	4.6e-07	241	480
SH2	pfam00017	6.5e-32	122	196
Pkinase	pfam00069	6.2e-30	235	478
SH3	smart00326	2.3e-09	49	108
SH2	smart00252	1.9e-30	120	202
Pkinase_Tyr	pfam07714	1.6e-129	235	478
TyrKc	smart00219	6.3e-126	235	482
STYKc	smart00221	1.5e-48	235	471
S_TKc	smart00220	9.9e-40	245	482
KIND	smart00750	1.5e-05	310	484

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041679	Polymorphism	p.ALA354THR	N/A
dbSNP	rs35351680	Polymorphism	p.ALA496THR	N/A
Swiss-Prot	VAR_041681	Polymorphism	p.ARG503GLN	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258