Results for the protein: P43403

Results for the Protein: P43403

1177044

7535

ZAP70

NCBI, UniProt

ZAP70_HUMAN RecName: Full=Tyrosine-protein kinase ZAP-70; AltName: Full=70 kDa zeta-chain associated protein; AltName: Full=Syk-related tyrosine kinase

Known Diseases associated with this Protein:
SELECTIVE T-CELL DEFECT
SELECTIVE T-CELL DEFECT (STCD)

8

4

2

0

10

Tips:

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Swiss-Prot Protein: P43403

Identical to: NP_001070

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	1.6e-28	162	254
PTKc_VEGFR	cd05054	7.9e-13	220	600
PTKc_PDGFR_beta	cd05107	3.5e-08	229	598
PTKc_CSF-1R	cd05106	8.6e-13	304	598
STKc_myosinIIIA	cd06638	4.4e-07	307	595
PTKc_Kit	cd05104	3.2e-12	308	597
PTKc_PDGFR_alpha	cd05105	6.6e-12	308	599
STKc_myosinIIIB	cd06639	1.5e-06	314	599
PTKc_PDGFR	cd05055	3.7e-16	315	597
STKc_TAO1	cd06635	0.0003	317	617
PTKc_FGFR1	cd05098	8.2e-31	319	605
STKc_PAK	cd06614	4.3e-10	320	604
STKc_PAK1	cd06654	0.00058	320	614
PTKc_FGFR2	cd05101	2.6e-31	321	605
STKc_TAO2	cd06634	1.7e-05	321	615
STKc_MST4	cd06640	1.6e-07	321	597
STKc_MST3	cd06641	5.8e-07	321	596
STKc_STK25-YSK1	cd06642	1.8e-08	321	596
STKc_CDK9	cd07865	3.2e-05	321	598
PTKc_EGFR_like	cd05057	2.1e-70	322	603
STKc_PAK_II	cd06648	2.2e-05	322	600
STKc_PAK6	cd06659	0.00094	323	618
STKc_MAP4K4_6	cd06636	0.00021	323	598
STKc_TAO	cd06607	6.8e-05	324	613
PKc_MKK7	cd06618	4.5e-08	324	614
PTKc_FGFR	cd05053	6.6e-31	326	595
PTKc_FGFR4	cd05099	3.5e-40	326	610
PTKc_FGFR3	cd05100	3.6e-21	326	619
STKc_PAK2	cd06655	0.00084	327	615
STKc_PAK3	cd06656	0.00081	327	612
PTKc_Jak1_rpt2	cd05079	6e-51	328	597
PTKc_VEGFR3	cd05102	4.4e-12	329	600
PTKc_VEGFR2	cd05103	1.1e-12	329	600
STKc_ASK	cd06624	4.1e-08	329	598
STKc_MEKK3	cd06651	1.4e-05	329	600
PTK_Ryk	cd05043	5.7e-23	330	600
PTKc_FAK	cd05056	3.5e-94	330	601
PTKc_Chk	cd05083	1.6e-59	330	596
PTKc_EGFR	cd05108	7.8e-50	330	619
PTK_CCK4	cd05046	3.3e-20	331	595
PTKc_Trk	cd05049	1.3e-33	331	595
PTKc_Tyk2_rpt2	cd05080	3.6e-36	331	598
PTKc_Jak2_Jak3_rpt2	cd05081	4.6e-48	331	597
PTKc_Tie2	cd05088	2.6e-31	331	618
PTKc_TrkA	cd05092	5.3e-41	331	599
PTKc_TrkB	cd05093	2.3e-35	331	607
PTKc_HER2	cd05109	3.3e-55	331	605
PTKc_TrkC	cd05094	1.1e-17	331	605
PTKc_HER4	cd05110	1e-48	331	616
PTK_HER3	cd05111	2.7e-51	331	603
PKc_MKK4	cd06616	5e-08	331	617
STKc_STK10_LOK	cd06644	5.8e-06	331	616
STKc_PCTAIRE_like	cd07844	7.7e-05	331	619
STKc_CDK12	cd07864	1.5e-06	331	605
STKc_PCTAIRE3	cd07871	0.00022	331	598
STKc_PCTAIRE2	cd07872	0.00078	331	617
STKc_PCTAIRE1	cd07873	0.00025	331	609
PTKc_InsR_like	cd05032	1.4e-43	332	595
PTKc_EphR	cd05033	7.4e-78	332	597
PTKc_ALK_LTK	cd05036	5.3e-50	332	595
PTKc_Jak_rpt2	cd05038	1.1e-67	332	597
PTKc_Musk	cd05050	4.1e-53	332	595
PTKc_Abl	cd05052	3.1e-68	332	597
PTKc_InsR	cd05061	2.9e-31	332	606
PTKc_IGF-1R	cd05062	1.1e-33	332	595
PTKc_EphR_A10	cd05064	1.3e-55	332	597
PTKc_EphR_A	cd05066	4.9e-69	332	597
PTKc_Lck_Blk	cd05067	9.5e-59	332	596
PTKc_Frk_like	cd05068	3.1e-74	332	596
PTKc_Yes	cd05069	1.6e-44	332	597
PTKc_Fyn_Yrk	cd05070	1.5e-49	332	597
PTKc_Src	cd05071	8.9e-49	332	599
PTKc_Lyn	cd05072	8.7e-52	332	596
PTKc_Hck	cd05073	2.8e-51	332	596
PTKc_Csk	cd05082	3.6e-51	332	596
PTKc_DDR2	cd05095	2.3e-36	332	595
PTKc_DDR1	cd05096	3.6e-31	332	595
PTKc_DDR_like	cd05097	8.8e-40	332	595
PTKc_Itk	cd05112	4.4e-59	332	594
PTKc_Btk_Bmx	cd05113	1.6e-60	332	594
PTKc_Tec_Rlk	cd05114	2.7e-58	332	594
STKc_MAP4K3_like	cd06613	9.3e-10	332	591
PKc_MAPKK_Byr1_like	cd06620	9.9e-08	332	604
STKc_SLK	cd06643	1.7e-06	332	618
STKc_MAP4K3	cd06645	0.00041	332	597
PKc_MEK1	cd06650	0.00076	332	617
STKc_PFTAIRE2	cd07870	7.7e-05	332	619
PTK_Tyk2_rpt1	cd05076	2.1e-07	333	594
STKc_TNIK	cd06637	7.4e-05	333	598
PTKc_DDR	cd05051	6.2e-27	334	589
PTKc_EphR_A2	cd05063	1.8e-64	334	597
STKc_cPKC_alpha	cd05615	0.00011	334	619
STKc_OSR1_SPAK	cd06610	1.9e-08	334	587
PKc_MEK2	cd06649	4.8e-05	334	611
STKc_MEKK3_like_1	cd06653	0.00076	334	596
PTKc_Tie1	cd05089	3.5e-30	335	612
STKc_ROCK_NDR_like	cd05573	0.00011	335	613
STKc_PKA	cd05580	0.00013	335	554
STKc_CRIK	cd05601	0.00099	335	610
STKc_PRKX_like	cd05612	0.00021	335	618
STKc_MST3_like	cd06609	3.8e-10	335	598
PKc_MKK5	cd06619	0.00079	335	618
PKc_MAPKK_Pek1_like	cd06621	2.4e-07	335	597
PKc_MAPKK_PBS2_like	cd06622	2.6e-07	335	611
PKc_MAPKK_plant_like	cd06623	6.4e-12	335	592
PKc_MKK3_6	cd06617	1.4e-08	335	592
PKc_MAPKK	cd06605	2.9e-10	335	591
STKc_CdkB_plant	cd07837	9.4e-07	335	599
STKc_Nek4	cd08223	7e-08	335	598
STKc_Nek6	cd08228	6.9e-06	335	595
PTKc_Src_like	cd05034	8.5e-62	336	596
PTKc_Ror	cd05048	2.5e-35	336	596
PTKc_EphR_B	cd05065	2.6e-67	336	597
PTKc_Ror1	cd05090	4e-42	336	596
PTKc_Ror2	cd05091	3.4e-36	336	596
STKc_MSK_N	cd05583	1.2e-06	336	611
STKc_MSK1_N	cd05613	0.00019	336	610
PKc_MEK	cd06615	1.2e-07	336	593
STKc_Cdc7_like	cd06627	1.4e-13	336	587
STKc_MAPK	cd07834	0.00052	336	598
STKc_CDKL1_4	cd07847	0.0002	336	610
STKc_Nek3	cd08219	1.7e-08	336	595
STKc_Nek6_Nek7	cd08224	4.5e-06	336	598
STKc_Nek5	cd08225	2.1e-05	336	595
STKc_Nek10	cd08528	9.5e-07	336	595
PTKc_RET	cd05045	2.6e-32	337	596
PKc_STE	cd05122	1.3e-13	337	597
STKc_MAPKKK_Byr2_lik	cd06628	7.3e-13	337	598
STKc_Nek7	cd08229	9.5e-07	337	595
PTKc_Axl_like	cd05035	2.1e-52	338	597
PTKc_Tec_like	cd05059	2.7e-46	338	594
PTKc_Axl	cd05075	6.2e-46	338	597
PTKc_Tyro3	cd05074	1.6e-53	338	597
STKc_Pho85	cd07836	2.8e-05	338	619
STKc_CDK2_3	cd07860	0.00034	338	598
STKc_Nek1	cd08218	1.4e-05	338	595
STKc_Nek11	cd08222	1.1e-06	338	595
PTKc_Csk_like	cd05039	6.4e-50	339	596
STKc_CDK1_like	cd07835	1.6e-05	339	619
STKc_CDK7	cd07841	4.1e-07	339	617
STKc_CDK1_euk	cd07861	0.00065	339	598
STKc_FA2-like	cd08529	5.7e-09	339	595
STKc_myosinIII_like	cd06608	2.2e-07	340	587
STKc_SLK_like	cd06611	2.1e-07	340	590
STKc_CDK5	cd07839	2.1e-05	340	617
PTKc_Tie	cd05047	4.8e-39	341	595
STKc_MAPKKK	cd06606	6.5e-16	341	587
PTKc	cd00192	2.1e-108	342	594
PTK_Jak_rpt1	cd05037	2.1e-16	342	594
PTKc_Ack_like	cd05040	1.9e-80	342	595
PTKc_Fes_like	cd05041	2.2e-58	342	595
PTKc_Aatyk	cd05042	4.1e-13	342	598
PTKc_Syk_like	cd05060	2.1e-205	342	598
PTKc_Zap-70	cd05115	2.2e-212	342	598
PTKc_Syk	cd05116	3.4e-156	342	598
STKc_NAK1_like	cd06917	3.5e-08	342	605
PTK_Jak1_rpt1	cd05077	3.1e-10	343	594
PTK_Jak2_Jak3_rpt1	cd05078	1.2e-14	343	594
PTKc_Fes	cd05084	1.1e-65	343	595
PTKc_Aatyk2	cd05086	1.2e-09	343	598
PTKc_Aatyk1_Aatyk3	cd05087	2.3e-18	343	595
STKc_CMGC	cd05118	4.8e-11	343	598
PTKc_Srm_Brk	cd05148	3.6e-45	343	596
STKc_phototropin_lik	cd05574	0.00051	343	572
STKc_PDK1	cd05581	1.2e-09	343	577
STKc_MAPKKK_Bck1_lik	cd06629	4.3e-09	343	587
STKc_MAK_like	cd07830	7.9e-08	343	598
STKc_CDKL	cd07833	0.00096	343	598
STKc_CDK4_6_like	cd07838	4.1e-05	343	541
STKc_CDK9_like	cd07840	8.4e-07	343	598
STKc_Nek2	cd08217	8.1e-09	343	593
STKc_Nek	cd08215	3.7e-15	343	595
STKc_CNK2-like	cd08530	2.1e-07	343	595
PKc	cd00180	2.8e-54	344	593
PTKc_c-ros	cd05044	9.5e-47	344	595
PTKc_Met_Ron	cd05058	1.6e-56	344	599
PTKc_Fer	cd05085	1.1e-64	344	595
STKc_AGC	cd05123	2.6e-10	344	598
STKc_PKC	cd05570	6.6e-06	344	599
STKc_cGK_PKG	cd05572	1.8e-05	344	582
STKc_MAST_like	cd05579	8.8e-07	344	576
STKc_RSK_N	cd05582	5.7e-05	344	619
STKc_p70S6K	cd05584	0.00037	344	619
STKc_PKN	cd05589	0.0005	344	619
STKc_GRK	cd05577	7.1e-06	344	609
STKc_nPKC_theta_delt	cd05592	0.00057	344	618
STKc_GRK4_like	cd05605	2.1e-05	344	613
STKc_GRK7	cd05607	4e-05	344	612
STKc_GRK1	cd05608	1e-05	344	612
STKc_nPKC_theta	cd05619	0.0003	344	619
STKc_GRK4	cd05631	0.00041	344	613
STKc_GRK5	cd05632	0.00017	344	613
STKc_MEKK3_like	cd06625	2.5e-09	344	598
STKc_MEKK4	cd06626	1.8e-06	344	577
STKc_MEKK1	cd06630	3.9e-06	344	587
STKc_YSK4	cd06631	3.1e-08	344	587
STKc_MEKK1_plant	cd06632	3.8e-09	344	587
STKc_MST1_2	cd06612	3.5e-13	344	587
STKc_MOK	cd07831	1.2e-06	344	598
STKc_CCRK	cd07832	1.7e-08	344	599
STKc_Nek8	cd08220	5.8e-07	344	577
STKc_Nek9	cd08221	3.2e-07	344	595
STKc_Yank1	cd05578	8.9e-10	345	598
STKc_CDK10	cd07845	4.8e-05	347	608
STKc_CDKL2_3	cd07846	6.4e-05	348	592
STKc_CDK_like	cd07829	6e-09	349	587
SH2	pfam00017	7.6e-28	10	87
SH2	pfam00017	1e-28	163	239
Pkinase	pfam00069	3.3e-28	338	593
SH2	smart00252	1.6e-23	8	93
SH2	smart00252	9.7e-28	161	245
Pkinase_Tyr	pfam07714	1e-128	338	593
TyrKc	smart00219	3.3e-128	338	593
STYKc	smart00221	4.3e-48	338	595
S_TKc	smart00220	1.9e-41	348	598

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_065625	Disease	p.ALA507VAL	Selective T-cell defect (STCD)
Swiss-Prot	VAR_065624	Disease	p.ARG465CYS	Selective T-cell defect (STCD)
Swiss-Prot	VAR_015538	Disease	p.ARG465HIS	Selective T-cell defect (STCD)
Swiss-Prot	VAR_041846	Polymorphism	p.ARG175LEU	N/A
Swiss-Prot	VAR_065626	Disease	p.CYS564ARG	Selective T-cell defect (STCD)
Swiss-Prot	VAR_041848	Polymorphism	p.GLY448GLU	N/A
Swiss-Prot	VAR_065623	Disease	p.LEU337ARG	Selective T-cell defect (STCD)
Swiss-Prot	VAR_041847	Polymorphism	p.PRO191LEU	N/A
Swiss-Prot	VAR_006351	Disease	p.SER518ARG	Selective T-cell defect (STCD)
Swiss-Prot	VAR_041849	Polymorphism	p.TRP523LEU	N/A
OMIM	176947.0005	Disease	p.ARG465HIS	SELECTIVE T-CELL DEFECT
OMIM	176947.0003	Disease	p.SER518ARG	SELECTIVE T-CELL DEFECT

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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