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Results for the Protein: P04626
119533

ERBB2_HUMAN RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=Metastatic lymph node gene 19 protein; Short=MLN 19; AltName: Full=Proto-oncogene Neu; AltName: Full=Proto-oncogene c-ErbB-2; AltName: Full=Tyrosine kinase-type cell surface receptor HER2; AltName: Full=p185erbB2; AltName: CD_antigen=CD340; Flags: Precursor

Known Diseases associated with this Protein:
  ADENOCARCINOMA OF LUNG, SOMATIC
  GASTRIC CANCER, SOMATIC
  GLIOBLASTOMA, SOMATIC
  OVARIAN CANCER, SOMATIC
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10
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6
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

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Default View:

Recep_L_domain - pfam01030
Furin-like - pfam00757
FU - smart00261
FU - cd00064
PTKc_Kit - cd05104
PTKc_PDGFR_beta - cd05107
PTKc_VEGFR - cd05054
PTKc_VEGFR3 - cd05102
PTKc_VEGFR2 - cd05103
PTKc_CSF-1R - cd05106
PTKc_PDGFR_alpha - cd05105
STKc_PAK1 - cd06654
STKc_PAK2 - cd06655
STKc_PAK3 - cd06656
STKc_PAK_I - cd06647
PTKc_FGFR1 - cd05098
STKc_myosinIIIB - cd06639
PKc_MKK7 - cd06618
PTKc_FGFR2 - cd05101
PTK_Tyk2_rpt1 - cd05076
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
STKc_myosinIIIA - cd06638
STKc_p38 - cd07851
STKc_TAO - cd06607
STKc_PAK - cd06614
STKc_PAK_II - cd06648
PTKc_DDR - cd05051
STKc_STK10_LOK - cd06644
PTKc_PDGFR - cd05055
STKc_CDK10 - cd07845
STKc_MAP4K5 - cd06646
STKc_MAP4K3 - cd06645
STKc_Sty1_Hog1 - cd07856
STKc_ASK - cd06624
PTKc_FAK - cd05056
PTK_Ryk - cd05043
PTKc_Lck_Blk - cd05067
PTKc_EGFR_like - cd05057
PTKc_Tie2 - cd05088
PTKc_EGFR - cd05108
PTKc_Hck - cd05073
PTKc_Lyn - cd05072
PTK_HER3 - cd05111
PTKc_Fyn_Yrk - cd05070
PTKc_HER4 - cd05110
PTKc_HER2 - cd05109
PTKc_Yes - cd05069
PTKc_Src - cd05071
STKc_MAP4K4_6 - cd06636
PTKc_ALK_LTK - cd05036
PTKc_Ror - cd05048
STKc_SLK - cd06643
PTKc_Csk - cd05082
PTKc_Chk - cd05083
PTK_CCK4 - cd05046
PTKc_Trk - cd05049
PTKc_Csk_like - cd05039
PTKc_Src_like - cd05034
PTKc_InsR_like - cd05032
PTKc_Tec_Rlk - cd05114
PTKc_Itk - cd05112
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_Btk_Bmx - cd05113
PKc_MEK2 - cd06649
PTKc_DDR_like - cd05097
STKc_TNIK - cd06637
PKc_MAPKK_Byr1_like - cd06620
STKc_myosinIII_like - cd06608
PKc_MKK4 - cd06616
PKc_MEK1 - cd06650
PTKc_EphR_A10 - cd05064
PTKc_EphR_B - cd05065
PTKc_Jak_rpt2 - cd05038
PTKc_Tec_like - cd05059
PTKc_FGFR - cd05053
PTKc_Abl - cd05052
PTKc_EphR - cd05033
PTKc_EphR_A - cd05066
PTKc_Frk_like - cd05068
PTKc_TrkC - cd05094
PTKc_DDR2 - cd05095
PTKc_DDR1 - cd05096
PTKc_TrkA - cd05092
PTKc_Ror1 - cd05090
PTKc_Jak1_rpt2 - cd05079
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Musk - cd05050
STKc_OSR1_SPAK - cd06610
STKc_MAP4K3_like - cd06613
PTKc_Srm_Brk - cd05148
STKc_PFTAIRE1 - cd07869
STKc_MST1_2 - cd06612
STKc_PCTAIRE_like - cd07844
STKc_PFTAIRE2 - cd07870
STKc_MEKK3_like_1 - cd06653
STKc_MSK_N - cd05583
PTKc_InsR - cd05061
STKc_MST4 - cd06640
STKc_MST3 - cd06641
PTKc_Ror2 - cd05091
STKc_STK25-YSK1 - cd06642
STKc_MEKK3 - cd06651
STKc_MEKK2 - cd06652
STKc_CDK12 - cd07864
STKc_CDKL1_4 - cd07847
STKc_CDKL2_3 - cd07846
STKc_Nek6 - cd08228
STKc_CdkB_plant - cd07837
SPS1 - COG0515
STKc_Nek6_Nek7 - cd08224
STKc_Nek7 - cd08229
PKc_MEK - cd06615
PKc_MAPKK - cd06605
STKc_MST3_like - cd06609
STKc_PRKX_like - cd05612
STKc_MAST - cd05609
STKc_PKA - cd05580
STKc_NAK1_like - cd06917
PTKc_Tie1 - cd05089
PKc_MKK3_6 - cd06617
STKc_MEKK3_like - cd06625
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_plant_like - cd06623
PKc_MAPKK_Pek1_like - cd06621
PKc_MKK5 - cd06619
STKc_CDK4 - cd07863
STKc_Nek2 - cd08217
STKc_TDY_MAPK_plant - cd07859
STKc_CDK7 - cd07841
STKc_Nek1 - cd08218
STKc_NLK - cd07853
STKc_CDK2_3 - cd07860
STKc_Nek5 - cd08225
STKc_Nek10 - cd08528
STKc_CDK5 - cd07839
STKc_Nek9 - cd08221
STKc_Nek4 - cd08223
STKc_Nek8 - cd08220
STKc_Nek3 - cd08219
STKc_Pho85 - cd07836
STKc_GRK4_like - cd05605
STKc_MSK2_N - cd05614
STKc_cPKC_alpha - cd05615
STKc_MAPK - cd07834
STKc_cPKC - cd05587
STKc_Yank1 - cd05578
PTKc_RET - cd05045
PTKc_IGF-1R - cd05062
PKc_STE - cd05122
STKc_GRK6 - cd05630
STKc_MSK1_N - cd05613
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK1 - cd06630
STKc_YSK4 - cd06631
STKc_CCRK - cd07832
STKc_GRK4 - cd05631
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_GRK5 - cd05632
STKc_CDK9_like - cd07840
STYKc - smart00221
TyrKc - smart00219
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
STKc_CDK4_6_like - cd07838
STKc_CMGC - cd05118
PTKc_Tyk2_rpt2 - cd05080
PTKc_Axl - cd05075
STKc_PKN - cd05589
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CDK1_like - cd07835
STKc_MOK - cd07831
STKc_CDK_like - cd07829
PTKc_Axl_like - cd05035
PTKc_Tyro3 - cd05074
STKc_Nek11 - cd08222
STKc_Nek - cd08215
STKc_MEKK1_plant - cd06632
STKc_MEKK4 - cd06626
STKc_FA2-like - cd08529
STKc_CDK8_like - cd07842
STKc_MAK_like - cd07830
STKc_PDK1 - cd05581
STKc_p70S6K - cd05584
STKc_CNK2-like - cd08530
STKc_RSK_N - cd05582
STKc_nPKC_theta_delt - cd05592
STKc_PKB - cd05571
PTKc_Aatyk1_Aatyk3 - cd05087
STKc_nPKC_theta - cd05619
STKc_SGK2 - cd05603
PTK_Jak1_rpt1 - cd05077
PTKc_Tie - cd05047
PTKc_Met_Ron - cd05058
PTKc_Syk_like - cd05060
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc - cd00192
PTKc_Ack_like - cd05040
PTKc_Fes_like - cd05041
PTKc_Syk - cd05116
PTKc_Fes - cd05084
PTKc_Fer - cd05085
PTK_Jak_rpt1 - cd05037
PTKc_Aatyk2 - cd05086
PKc - cd00180
STKc_GRK1 - cd05608
PTKc_Zap-70 - cd05115
STKc_MAST_like - cd05579
STKc_AGC - cd05123
STKc_GRK - cd05577
STKc_cGK_PKG - cd05572
S_TKc - smart00220
KIND - smart00750


Swiss-Prot Protein: P04626
Identical to: NP_004439
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
FUcd000641.4e-14235296
FUcd000642.8e-10510561
FUcd000645.2e-14562624
PTKc_PDGFR_betacd051073.4e-09610981
PTKc_Kitcd051045e-12610980
PTKc_VEGFRcd050544.1e-23614983
PTKc_VEGFR3cd051021.4e-21657983
PTKc_VEGFR2cd051033.9e-14661983
PTKc_CSF-1Rcd051068.6e-14684981
PTKc_PDGFR_alphacd051058.2e-12685982
STKc_PAK1cd066549.7e-06692998
STKc_PAK2cd066552.1e-05693998
STKc_PAK3cd066563e-06693999
STKc_PAK_Icd066471e-05693995
PTKc_FGFR1cd050982.1e-37701984
PKc_MKK7cd066184.4e-08704992
STKc_myosinIIIBcd066390.00025704978
PTK_Tyk2_rpt1cd050763.7e-05705977
PTKc_FGFR2cd051016.3e-42705993
PTKc_FGFR4cd050991.6e-44706997
PTKc_FGFR3cd051003.8e-397061017
STKc_myosinIIIAcd066381.8e-05706977
STKc_p38cd078513.3e-067061013
STKc_TAOcd066070.000567071010
STKc_PAKcd066146.5e-10707990
PTKc_DDRcd050512.2e-27708978
STKc_STK10_LOKcd066440.00012708995
STKc_PAK_IIcd066480.00049708990
PTKc_PDGFRcd050551.3e-17709980
STKc_MAP4K3cd066450.00034710976
STKc_MAP4K5cd066460.00024710977
STKc_CDK10cd078455.6e-05710999
PTK_Rykcd050435e-25712980
PTKc_EGFR_likecd050572.4e-216712990
PTKc_FAKcd050569.4e-85712984
PTKc_Lck_Blkcd050671.5e-48712976
PTKc_Yescd050692.7e-43712979
PTKc_Fyn_Yrkcd050703e-48712979
PTKc_Srccd050711.5e-46712981
PTKc_Lyncd050721.2e-41712979
PTKc_Hckcd050737.2e-41712979
PTKc_EGFRcd051084.9e-2307121026
PTKc_HER2cd051094.1e-250712990
PTKc_HER4cd051104.6e-2097121013
PTK_HER3cd051112.3e-158712990
PTKc_Tie2cd050882.8e-357121002
STKc_ASKcd066244.5e-07712978
STKc_Sty1_Hog1cd078560.000167121021
PTKc_ALK_LTKcd050361.6e-55713978
PTKc_Rorcd050482.4e-34713979
STKc_MAP4K4_6cd066360.00028713979
PTKc_InsR_likecd050321.2e-55714978
PTKc_Src_likecd050349.6e-62714979
PTKc_Csk_likecd050393.7e-39714979
PTK_CCK4cd050467.5e-19714978
PTKc_Trkcd050491.3e-35714978
PTKc_Cskcd050829.9e-52714979
PTKc_Chkcd050831.1e-52714979
STKc_SLKcd066431.6e-05714993
PTKc_Jak_rpt2cd050385.9e-66715980
PTKc_Muskcd050502.6e-36715978
PTKc_Ablcd050526.7e-69715980
PTKc_FGFRcd050533.1e-49715981
PTKc_Tec_likecd050597.1e-52715977
PTKc_EphR_A10cd050643.9e-45715980
PTKc_EphR_Bcd050651.4e-60715980
PTKc_EphR_Acd050662.9e-62715980
PTKc_Frk_likecd050684.8e-71715979
PTKc_Jak1_rpt2cd050791e-42715980
PTKc_Jak2_Jak3_rpt2cd050812e-52715980
PTKc_Ror1cd050903.6e-34715979
PTKc_TrkAcd050922.9e-33715986
PTKc_TrkCcd050942.6e-12715988
PTKc_DDR2cd050955.7e-28715978
PTKc_DDR1cd050961.6e-21715978
PTKc_EphRcd050333.7e-64715980
PTKc_DDR_likecd050977.2e-29715978
PTKc_TrkBcd050932.3e-28715988
PTKc_EphR_A2cd050636.3e-63715980
PTKc_Itkcd051121.5e-62715977
PTKc_Tec_Rlkcd051147.4e-62715977
PTKc_Btk_Bmxcd051138.8e-60715977
PKc_MKK4cd066161.5e-06715995
STKc_myosinIII_likecd066089.2e-07715977
PKc_MAPKK_Byr1_likecd066201.4e-07715987
STKc_TNIKcd066379.1e-05715977
PKc_MEK2cd066496.6e-057151030
PKc_MEK1cd066509.6e-067151041
PTKc_Srm_Brkcd051481.8e-50716979
STKc_OSR1_SPAKcd066108.3e-09716976
STKc_MAP4K3_likecd066136.2e-08716976
STKc_MST1_2cd066122.3e-09716946
STKc_PCTAIRE_likecd078441.9e-057161005
STKc_PFTAIRE2cd078703e-067161031
STKc_PFTAIRE1cd078690.000547161026
PTKc_InsRcd050614.9e-41717989
PTKc_Ror2cd050912.7e-24717979
STKc_MSK_Ncd055831.6e-057171026
STKc_MST3cd066419.3e-07717997
STKc_STK25-YSK1cd066422.7e-08717998
STKc_MEKK3cd066516e-09717979
STKc_MEKK2cd066522.3e-05717978
STKc_MST4cd066409.6e-077171008
STKc_MEKK3_like_1cd066532.7e-05717978
PTKc_Tie1cd050891e-357181001
STKc_PKAcd055804.3e-05718979
STKc_MASTcd056090.000377181032
STKc_PRKX_likecd056127.1e-057181021
PKc_MAPKKcd066053e-09718982
STKc_MST3_likecd066091.9e-08718958
PKc_MEKcd066151.6e-05718989
PKc_MKK3_6cd066172.2e-07718992
PKc_MKK5cd066196.2e-057181012
PKc_MAPKK_Pek1_likecd066218.6e-05718989
PKc_MAPKK_PBS2_likecd066223.8e-067181027
PKc_MAPKK_plant_likecd066237.8e-12718982
STKc_MEKK3_likecd066255.5e-10718978
STKc_NAK1_likecd069176.6e-07718977
STKc_CdkB_plantcd078374.1e-067181006
STKc_CDKL2_3cd078460.00095718977
STKc_CDKL1_4cd078471.3e-057181014
STKc_CDK12cd078640.000127181005
STKc_Nek6cd082286.2e-05718982
STKc_Nek7cd082298.7e-07718981
STKc_Nek6_Nek7cd082241.3e-06718985
SPS1COG05152.5e-277181176
PTKc_RETcd050457.1e-51719983
PTKc_IGF-1Rcd050625.8e-38719978
PKc_STEcd051227e-12719976
STKc_Yank1cd055781.9e-06719979
STKc_cPKCcd055879.4e-057191047
STKc_GRK4_likecd056058.1e-067191013
STKc_MSK2_Ncd056147e-067191052
STKc_cPKC_alphacd056150.000217191034
STKc_MSK1_Ncd056131.7e-057191006
STKc_GRK6cd056300.00067191002
STKc_GRK4cd056310.000617191035
STKc_GRK5cd056320.000677191008
STKc_MAPKKKcd066061.9e-15719977
STKc_Cdc7_likecd066275.3e-12719973
STKc_MAPKKK_Byr2_likcd066282.3e-08719978
STKc_MEKK1cd066308.8e-08719977
STKc_YSK4cd066314e-09719977
STKc_CCRKcd078322e-07719970
STKc_Pho85cd078360.000137191031
STKc_MAPKcd078344.6e-067191012
STKc_CDK5cd078390.000147191005
STKc_CDK7cd078414.2e-06719973
STKc_NLKcd078530.000697191043
STKc_CDK2_3cd078600.000337191005
STKc_CDK4cd078630.000317191005
STKc_TDY_MAPK_plantcd078590.000717191048
STKc_Nek2cd082171.4e-06719979
STKc_Nek1cd082183.9e-05719978
STKc_Nek3cd082193.3e-08719978
STKc_Nek8cd082209.9e-06719978
STKc_Nek4cd082232e-05719978
STKc_Nek5cd082253.1e-05719978
STKc_Nek9cd082213.9e-05719978
STKc_Nek10cd085280.00021719978
PTKc_Axl_likecd050351.6e-55720980
PTKc_Tyro3cd050742.7e-49720980
PTKc_Axlcd050754.2e-42720980
PTKc_Tyk2_rpt2cd050801.5e-27720981
STKc_CMGCcd051181.2e-07720969
STKc_PKNcd055890.000227201031
STKc_MAPKKK_Bck1_likcd066295.8e-07720977
STKc_CDK_likecd078292.5e-06720977
STKc_MOKcd078311.4e-05720976
STKc_CDK1_likecd078351.9e-067201005
STKc_CDK4_6_likecd078382.1e-05720924
STKc_CDK9_likecd078409.8e-08720986
STKc_MEKK1_plantcd066328.9e-08721973
STKc_Nekcd082159.1e-12721978
STKc_Nek11cd082221.1e-05721977
STKc_MEKK4cd066261.2e-06722977
STKc_CDK8_likecd078420.000317221005
STKc_FA2-likecd085299e-08722978
STKc_PDK1cd055811.8e-09723976
STKc_RSK_Ncd055821.4e-057231053
STKc_p70S6Kcd055843e-067231035
STKc_MAK_likecd078301.4e-05723946
STKc_CNK2-likecd085301e-06723978
PTKccd001921e-121724977
PTKc_Ack_likecd050402.7e-78724978
PTKc_Fes_likecd050411.6e-42724978
PTKc_Aatykcd050422.4e-12724975
PTKc_c-roscd050441.3e-51724978
PTKc_Tiecd050478.2e-42724981
PTKc_Met_Roncd050584.8e-71724982
PTKc_Syk_likecd050601.9e-90724981
PTK_Jak2_Jak3_rpt1cd050789.1e-11724977
PTKc_Fescd050843e-45724978
PTKc_Fercd050856.9e-51724978
PTK_Jak_rpt1cd050371.5e-10724977
PTKc_Aatyk2cd050862.7e-07724978
PTK_Jak1_rpt1cd050772.2e-07724977
PTKc_Sykcd051161.3e-62724981
PTKc_Aatyk1_Aatyk3cd050878.5e-11724978
STKc_PKBcd055710.000157241058
STKc_nPKC_theta_deltcd055920.000137241035
STKc_SGK2cd056030.000647241037
STKc_nPKC_thetacd056194.5e-057241026
PKccd001803e-53726976
PTKc_Zap-70cd051152.7e-63726981
STKc_AGCcd051231e-06726979
STKc_cGK_PKGcd055720.0004726944
STKc_GRKcd055770.000837261034
STKc_MAST_likecd055794.8e-06726951
STKc_GRK1cd056087.4e-057261007
Recep_L_domainpfam010303.1e-5052173
Furin-likepfam007571.5e-69189343
Recep_L_domainpfam010301.1e-28366486
Pkinasepfam000695.5e-33720976
FUsmart002612.2e-07232276
FUsmart002615.5e-09501552
FUsmart002613.3e-09557606
Pkinase_Tyrpfam077141.1e-131720976
TyrKcsmart002195.9e-128720976
STYKcsmart002217.1e-47720987
S_TKcsmart002209.9e-37730980
KINDsmart007500.000458071002

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_042100Polymorphismp.ALA1216ASPN/A
dbSNPrs28933370 Polymorphismp.ASN857SERN/A
Swiss-ProtVAR_055435Polymorphismp.GLU914LYSN/A
Swiss-ProtVAR_042098Polymorphismp.GLY776SERN/A
Swiss-ProtVAR_004077Polymorphismp.ILE654VALN/A
dbSNPrs1136201 Polymorphismp.ILE655VALN/A
Swiss-ProtVAR_055432Polymorphismp.LEU755PRON/A
Swiss-ProtVAR_042097Polymorphismp.LEU768SERN/A
dbSNPrs61552325 Polymorphismp.PRO1170ALAN/A
dbSNPrs4252633 Polymorphismp.TRP452CYSN/A
OMIM164870.0008 Diseasep.ASN857SEROVARIAN CANCER, SOMATIC
OMIM164870.0006 Diseasep.GLU914LYSGLIOBLASTOMA, SOMATIC
OMIM164870.0007 Diseasep.GLY776SERGASTRIC CANCER, SOMATIC
OMIM164870.0005 Diseasep.LEU755PROADENOCARCINOMA OF LUNG, SOMATIC



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