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Results for the Protein: P07948
125480
LYN

LYN_HUMAN RecName: Full=Tyrosine-protein kinase Lyn; AltName: Full=Lck/Yes-related novel protein tyrosine kinase; AltName: Full=V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; AltName: Full=p53Lyn; AltName: Full=p56Lyn
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Tips:
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SH3 - smart00326
SH3_2 - pfam07653
SH3 - cd00174
SH3_1 - pfam00018
SH2 - smart00252
SH2 - cd00173
SH2 - pfam00017
PTKc_CSF-1R - cd05106
PTKc_PDGFR_beta - cd05107
PTKc_PDGFR - cd05055
PTKc_Kit - cd05104
PTKc_PDGFR_alpha - cd05105
STKc_myosinIIIB - cd06639
PTKc_FGFR1 - cd05098
STKc_TAO - cd06607
STKc_PAK - cd06614
STKc_TAO1 - cd06635
STKc_myosinIIIA - cd06638
STKc_MAP4K4_6 - cd06636
PTKc_FGFR2 - cd05101
STKc_p38gamma_MAPK12 - cd07880
PTKc_FGFR3 - cd05100
PTKc_FGFR - cd05053
PTKc_FGFR4 - cd05099
STKc_STK10_LOK - cd06644
STKc_p38 - cd07851
PKc_MKK7 - cd06618
STKc_ASK - cd06624
STKc_TAO2 - cd06634
STKc_PAK_II - cd06648
PTK_Tyk2_rpt1 - cd05076
STKc_PAK6 - cd06659
STKc_CDK9 - cd07865
PTKc_VEGFR3 - cd05102
PTK_HER3 - cd05111
PTKc_VEGFR2 - cd05103
PTKc_EGFR_like - cd05057
PTKc_VEGFR - cd05054
STKc_MAP4K3 - cd06645
STKc_PCTAIRE2 - cd07872
STKc_Sty1_Hog1 - cd07856
STKc_PCTAIRE1 - cd07873
PTKc_EGFR - cd05108
PTKc_Csk - cd05082
PTKc_Chk - cd05083
PTKc_HER2 - cd05109
PTKc_Hck - cd05073
STKc_CDK12 - cd07864
STKc_TNIK - cd06637
PTKc_Srm_Brk - cd05148
PTKc_HER4 - cd05110
STKc_ERK1_2_like - cd07849
PTKc_Lyn - cd05072
PTKc_InsR - cd05061
PTKc_Abl - cd05052
PTKc_Csk_like - cd05039
PTKc_Src_like - cd05034
PTKc_ALK_LTK - cd05036
PTKc_InsR_like - cd05032
PTKc_FAK - cd05056
PTKc_Fyn_Yrk - cd05070
PTKc_IGF-1R - cd05062
PTKc_Yes - cd05069
PTKc_Src - cd05071
PTKc_Frk_like - cd05068
PTKc_Lck_Blk - cd05067
PTKc_DDR1 - cd05096
PTKc_DDR_like - cd05097
STKc_SLK_like - cd06611
STKc_SLK - cd06643
PTKc_DDR2 - cd05095
STKc_MAP4K5 - cd06646
PKc_MAPKK_Byr1_like - cd06620
PTKc_Ror2 - cd05091
PTKc_Musk - cd05050
PTKc_DDR - cd05051
PTKc_Trk - cd05049
PTKc_Ror - cd05048
PTK_CCK4 - cd05046
PTKc_TrkC - cd05094
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_EphR_A10 - cd05064
PTKc_TrkA - cd05092
PTKc_Ror1 - cd05090
PTKc_Tec_Rlk - cd05114
STKc_BUR1 - cd07866
PTKc_Btk_Bmx - cd05113
PTKc_EphR_A - cd05066
PTKc_Jak_rpt2 - cd05038
PTKc_EphR_B - cd05065
PTKc_EphR - cd05033
PTK_Ryk - cd05043
PTKc_Itk - cd05112
PTKc_Tie2 - cd05088
PTKc_Jak1_rpt2 - cd05079
PTKc_Tec_like - cd05059
STKc_PFTAIRE2 - cd07870
STKc_MST3 - cd06641
STKc_MST1_2 - cd06612
STKc_myosinIII_like - cd06608
STKc_MAP4K3_like - cd06613
STKc_MST4 - cd06640
STKc_STK25-YSK1 - cd06642
STKc_PCTAIRE_like - cd07844
STKc_PCTAIRE3 - cd07871
STKc_Nek6_Nek7 - cd08224
STKc_MEKK2 - cd06652
PKc_MKK4 - cd06616
STKc_MEKK3_like_1 - cd06653
STKc_CDKL1_4 - cd07847
STKc_CDKL2_3 - cd07846
STKc_CDK10 - cd07845
STKc_CDK6 - cd07862
STKc_CdkB_plant - cd07837
SPS1 - COG0515
STKc_FA2-like - cd08529
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
STKc_OSR1_SPAK - cd06610
STKc_CDKL - cd07833
PKc_MAPKK - cd06605
STKc_PRKX_like - cd05612
STKc_phototropin_lik - cd05574
PTKc_Tie1 - cd05089
STKc_ROCK_NDR_like - cd05573
STKc_MST3_like - cd06609
STKc_PKA - cd05580
PKc_MAPKK_plant_like - cd06623
PKc_MKK3_6 - cd06617
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_Pek1_like - cd06621
PKc_MKK5 - cd06619
PKc_MEK - cd06615
STKc_Nek - cd08215
STKc_CDK1_euk - cd07861
STKc_CDK4 - cd07863
STKc_Nek3 - cd08219
STKc_Nek10 - cd08528
STKc_CDK2_3 - cd07860
STKc_Nek5 - cd08225
STKc_Nek4 - cd08223
STKc_Nek8 - cd08220
STKc_Nek1 - cd08218
STKc_cPKC - cd05587
STKc_MSK_N - cd05583
STKc_GRK4_like - cd05605
STKc_cPKC_alpha - cd05615
STKc_MPK1 - cd07857
STKc_GRK5 - cd05632
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_CDK8_like - cd07842
STKc_CDC2L1 - cd07843
PTKc_RET - cd05045
STKc_Pho85 - cd07836
STKc_MEKK3 - cd06651
STKc_MAPK - cd07834
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
TyrKc - smart00219
STKc_MAPKKK_Bck1_lik - cd06629
PTKc_Axl - cd05075
STYKc - smart00221
PTKc_Axl_like - cd05035
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Tyro3 - cd05074
PTKc_Tyk2_rpt2 - cd05080
STKc_CDK1_like - cd07835
STKc_PKN - cd05589
STKc_MAPK15 - cd07852
PK_STRAD - cd08216
STKc_CNK2-like - cd08530
STKc_Nek2 - cd08217
STKc_CDK9_like - cd07840
STKc_CDK4_6_like - cd07838
STKc_Yank1 - cd05578
STKc_CDK7 - cd07841
PKc_STE - cd05122
STKc_MEKK3_like - cd06625
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MAK_like - cd07830
STKc_CDK_like - cd07829
STKc_NAK1_like - cd06917
STKc_CMGC - cd05118
STKc_PDK1 - cd05581
STKc_CDK5 - cd07839
STKc_MOK - cd07831
STKc_CCRK - cd07832
STKc_Nek11 - cd08222
STKc_CRIK - cd05601
STKc_Nek9 - cd08221
STKc_MAPK4_6 - cd07854
STKc_RSK_N - cd05582
STKc_PKC - cd05570
STKc_nPKC_theta_delt - cd05592
STKc_MEKK1 - cd06630
STKc_MEKK1_plant - cd06632
STKc_nPKC_theta - cd05619
PTKc_Syk - cd05116
PTKc_Fer - cd05085
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Aatyk - cd05042
PTKc_c-ros - cd05044
PTKc_Syk_like - cd05060
PTKc_Tie - cd05047
PTK_Jak_rpt1 - cd05037
PTKc - cd00192
PTKc_Fes - cd05084
PTKc_Aatyk2 - cd05086
PTKc_Aatyk1_Aatyk3 - cd05087
PTK_Jak2_Jak3_rpt1 - cd05078
PTK_Jak1_rpt1 - cd05077
PTKc_Met_Ron - cd05058
STKc_MEKK4 - cd06626
PTKc_Zap-70 - cd05115
STKc_MAST_like - cd05579
STKc_AGC - cd05123
PKc - cd00180
STKc_cGK_PKG - cd05572
STKc_GRK - cd05577
STKc_GRK1 - cd05608
STKc_GRK7 - cd05607
STKc_YSK4 - cd06631
S_TKc - smart00220


Swiss-Prot Protein: P07948
Identical to: NP_002341
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
SH2cd001732.2e-32128226
PTKc_CSF-1Rcd051063e-36210502
PTKc_PDGFRcd050552.7e-29211501
PTKc_Kitcd051042.7e-21211501
PTKc_PDGFR_betacd051071.1e-22211502
PTKc_PDGFR_alphacd051051.1e-16219503
PTKc_FGFR1cd050984.7e-48226508
STKc_myosinIIIBcd066390.0008226503
STKc_TAOcd066073.1e-05228511
STKc_PAKcd066141.5e-11229511
STKc_TAO1cd066350.00017229511
STKc_myosinIIIAcd066381.8e-06229498
PTKc_FGFR2cd051012.6e-46230508
STKc_MAP4K4_6cd066364.8e-05230497
STKc_p38gamma_MAPK12cd078800.00044232512
PTKc_FGFRcd050532.3e-61234502
PTKc_FGFR4cd050995.2e-52234511
PTKc_FGFR3cd051001.2e-30234511
STKc_STK10_LOKcd066440.00011235508
PKc_MKK7cd066183.8e-08236510
STKc_ASKcd066241.7e-09236501
STKc_TAO2cd066341.1e-05236511
STKc_p38cd078511.6e-06236512
PTK_Tyk2_rpt1cd050761.6e-06237498
STKc_PAK_IIcd066489.8e-07237501
STKc_PAK6cd066592.1e-05237511
STKc_CDK9cd078659.3e-07238501
PTKc_VEGFRcd050541.9e-24239504
PTKc_EGFR_likecd050572.3e-60239505
PTKc_VEGFR3cd051022e-26239504
PTKc_VEGFR2cd051037.1e-22239504
PTK_HER3cd051117.1e-34239511
STKc_MAP4K3cd066454.3e-07239497
STKc_Sty1_Hog1cd078564.3e-05239510
STKc_PCTAIRE2cd078724.3e-05239511
STKc_PCTAIRE1cd078734e-05239505
PTKc_InsR_likecd050322.1e-73240499
PTKc_Src_likecd050349.8e-218240500
PTKc_ALK_LTKcd050361.2e-65240499
PTKc_Csk_likecd050391.8e-93240500
PTKc_Ablcd050522.3e-109240501
PTKc_FAKcd050568e-78240505
PTKc_InsRcd050611.4e-53240508
PTKc_IGF-1Rcd050622.1e-55240499
PTKc_Lck_Blkcd050672.6e-183240500
PTKc_Frk_likecd050682.9e-153240500
PTKc_Yescd050697.9e-160240500
PTKc_Fyn_Yrkcd050706.3e-163240500
PTKc_Srccd050716e-157240502
PTKc_Lyncd050721.2e-232240500
PTKc_Hckcd050739e-203240500
PTKc_Chkcd050838.7e-79240500
PTKc_Cskcd050822e-81240500
PTKc_EGFRcd051086.7e-27240512
PTKc_HER2cd051099.2e-37240511
PTKc_HER4cd051101.3e-28240509
PTKc_Srm_Brkcd051481e-125240500
STKc_TNIKcd066374.4e-06240501
STKc_ERK1_2_likecd078493.9e-05240510
STKc_CDK12cd078648.6e-09240512
PTK_CCK4cd050465.9e-36241499
PTKc_Rorcd050486e-45241500
PTKc_Trkcd050498.4e-49241506
PTKc_Muskcd050501.2e-49241499
PTKc_DDRcd050514.2e-34241495
PTKc_EphR_A2cd050632e-75241501
PTKc_EphR_A10cd050641.4e-62241501
PTKc_Ror1cd050902e-43241500
PTKc_Ror2cd050914.4e-38241500
PTKc_TrkAcd050922.3e-52241499
PTKc_TrkBcd050932.5e-43241509
PTKc_TrkCcd050946.8e-32241509
PTKc_DDR2cd050955.1e-39241499
PTKc_DDR1cd050964.3e-30241499
PTKc_DDR_likecd050975.1e-39241499
STKc_SLK_likecd066111.1e-07241510
PKc_MAPKK_Byr1_likecd066205.8e-06241501
STKc_SLKcd066431.5e-05241512
STKc_MAP4K5cd066468.6e-06241498
PTKc_EphRcd050331.5e-93242501
PTKc_Jak_rpt2cd050383.2e-62242501
PTK_Rykcd050432.4e-25242504
PTKc_Tec_likecd050597.6e-109242498
PTKc_EphR_Bcd050659.8e-75242501
PTKc_EphR_Acd050661.5e-77242501
PTKc_Jak1_rpt2cd050794.4e-44242501
PTKc_Tie2cd050882.3e-33242508
PTKc_Itkcd051122.3e-96242498
PTKc_Btk_Bmxcd051133e-95242498
PTKc_Tec_Rlkcd051141.3e-92242498
STKc_BUR1cd078661.9e-08242490
STKc_myosinIII_likecd066084e-07243493
STKc_MST1_2cd066122.7e-13243501
STKc_MAP4K3_likecd066137.1e-11243498
STKc_MST4cd066401.7e-07243504
STKc_MST3cd066417.5e-08243512
STKc_STK25-YSK1cd066422.1e-08243504
STKc_PCTAIRE_likecd078447.5e-07243509
STKc_PFTAIRE2cd078703.2e-06243512
PKc_MKK4cd066169.3e-07244512
STKc_MEKK2cd066521.6e-06244503
STKc_MEKK3_like_1cd066533e-08244501
STKc_PCTAIRE3cd078712.7e-05244509
STKc_Nek6_Nek7cd082245.6e-10244502
PTKc_Tie1cd050892.4e-38245507
STKc_ROCK_NDR_likecd055735e-05245509
STKc_phototropin_likcd055747.4e-05245505
STKc_PKAcd055801.7e-06245503
STKc_PRKX_likecd056122.3e-06245509
PKc_MAPKKcd066051.8e-09245498
STKc_MST3_likecd066092.3e-11245512
STKc_OSR1_SPAKcd066101.4e-12245497
PKc_MKK3_6cd066175.2e-08245498
PKc_MKK5cd066190.00049245511
PKc_MEKcd066158.2e-06245512
PKc_MAPKK_Pek1_likecd066213.1e-08245497
PKc_MAPKK_PBS2_likecd066221.2e-06245511
PKc_MAPKK_plant_likecd066231.2e-15245504
STKc_CDKLcd078334.7e-06245493
STKc_CdkB_plantcd078372.3e-07245510
STKc_CDK10cd078451.3e-06245491
STKc_CDKL2_3cd078466.9e-08245501
STKc_CDKL1_4cd078473.1e-06245509
STKc_CDK6cd078620.00066245509
STKc_Nek6cd082282.9e-08245502
STKc_Nek7cd082291.7e-10245502
STKc_FA2-likecd085295.6e-11245497
SPS1COG05151.9e-09245512
PTKc_RETcd050451.3e-51246504
STKc_MSK_Ncd055830.00023246512
STKc_cPKCcd055870.00023246510
STKc_GRK4_likecd056052.6e-05246512
STKc_cPKC_alphacd056150.00019246510
STKc_GRK5cd056320.00038246512
STKc_MAPKKKcd066064.3e-32246493
STKc_Cdc7_likecd066271.3e-18246490
STKc_MEKK3cd066515.2e-09246503
STKc_MAPKcd078345.1e-07246500
STKc_Pho85cd078361.5e-06246512
STKc_CDK8_likecd078422.2e-05246501
STKc_CDC2L1cd078437.8e-06246501
STKc_MPK1cd078572.4e-05246511
STKc_CDK2_3cd078604.9e-06246509
STKc_CDK4cd078630.00025246509
STKc_CDK1_eukcd078615.5e-05246512
STKc_Nekcd082152.4e-15246498
STKc_Nek1cd082186.5e-09246502
STKc_Nek3cd082192.3e-11246497
STKc_Nek8cd082201.9e-06246497
STKc_Nek4cd082231.3e-09246502
STKc_Nek5cd082258.8e-14246502
STKc_Nek10cd085289.3e-08246499
PTKc_Axl_likecd050352e-53247501
PTKc_Tyro3cd050741.1e-48247501
PTKc_Axlcd050754.8e-47247501
PTKc_Jak2_Jak3_rpt2cd050815.7e-46247501
PTKc_Tyk2_rpt2cd050801.2e-34247502
STKc_PKNcd055895.9e-05247509
STKc_MAPKKK_Bck1_likcd066294.7e-10247491
STKc_CDK1_likecd078353e-06247509
STKc_CMGCcd051181.6e-11248493
PKc_STEcd051222.1e-15248492
STKc_PDK1cd055817.9e-10248501
STKc_Yank1cd055782.9e-09248502
STKc_MEKK3_likecd066253.2e-13248499
STKc_MAPKKK_Byr2_likcd066287.9e-20248501
STKc_NAK1_likecd069172e-10248505
STKc_CDK_likecd078291e-13248502
STKc_MAK_likecd078301e-12248500
STKc_MOKcd078313e-06248490
STKc_CCRKcd078321.3e-08248502
STKc_CDK4_6_likecd078380.00015248493
STKc_CDK5cd078391e-06248509
STKc_CDK7cd078412.3e-09248494
STKc_CDK9_likecd078403e-12248493
STKc_MAPK15cd078522e-05248511
PK_STRADcd082160.00043248499
STKc_Nek2cd082171.9e-09248496
STKc_CNK2-likecd085303.6e-08248498
STKc_CRIKcd056010.0002249509
STKc_Nek11cd082224e-08249498
STKc_RSK_Ncd055820.00043250512
STKc_MAPK4_6cd078547e-05250512
STKc_Nek9cd082212.6e-07250502
PTKccd001922.4e-125251498
PTK_Jak_rpt1cd050372.7e-10251498
PTKc_Ack_likecd050403.5e-73251499
PTKc_Fes_likecd050413.5e-85251499
PTKc_Aatykcd050424e-13251499
PTKc_c-roscd050444e-63251499
PTKc_Tiecd050479.8e-45251502
PTKc_Met_Roncd050583.7e-62251503
PTKc_Syk_likecd050604.3e-72251502
PTK_Jak1_rpt1cd050774.9e-09251498
PTK_Jak2_Jak3_rpt1cd050784.4e-09251498
PTKc_Fescd050842.5e-66251499
PTKc_Aatyk2cd050861e-08251499
PTKc_Aatyk1_Aatyk3cd050871.3e-19251499
PTKc_Fercd050852.8e-73251499
PTKc_Sykcd051167.4e-56251502
STKc_PKCcd055701.5e-06251502
STKc_nPKC_theta_deltcd055920.00069251512
STKc_nPKC_thetacd056198.4e-05251505
STKc_MEKK1cd066305.8e-07251499
STKc_MEKK1_plantcd066321.2e-12251496
PTKc_Zap-70cd051155e-54252502
STKc_MEKK4cd066261.6e-10252502
PKccd001801.1e-65253497
STKc_AGCcd051235.4e-10253493
STKc_cGK_PKGcd055724.1e-08253494
STKc_GRKcd055777.4e-05253499
STKc_MAST_likecd055799.7e-08253498
STKc_GRK7cd056078.2e-05253511
STKc_GRK1cd056080.00032253512
STKc_YSK4cd066311.4e-11253501
SH3_1pfam000181.8e-2169115
SH2pfam000179.8e-41129211
Pkinasepfam000691.6e-44247497
SH3smart003262.5e-2164121
SH3_2pfam076532.5e-0567120
SH2smart002526.4e-33127217
Pkinase_Tyrpfam077143.6e-152247497
TyrKcsmart002192.2e-133247497
STYKcsmart002211.1e-57247490
S_TKcsmart002201.8e-49257501

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_041737Polymorphismp.ASP385TYRN/A



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