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Results for the Protein: P19525
125527

E2AK2_HUMAN RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Short=eIF-2A protein kinase 2; AltName: Full=Interferon-inducible RNA-dependent protein kinase; AltName: Full=P1/eIF-2A protein kinase; AltName: Full=Protein kinase RNA-activated; Short=PKR; AltName: Full=Tyrosine-protein kinase EIF2AK2; AltName: Full=p68 kinase
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Default View:

DSRM - cd00048
dsrm - pfam00035
DSRM - smart00358
PTKc_PDGFR_alpha - cd05105
PTKc_VEGFR - cd05054
PTKc_Kit - cd05104
STKc_TAO1 - cd06635
STKc_MAP4K4_6 - cd06636
STKc_JNK - cd07850
STKc_PAK5 - cd06658
STKc_myosinIIIB - cd06639
STKc_p38 - cd07851
STKc_PAK4 - cd06657
STKc_myosinIIIA - cd06638
STKc_TAO2 - cd06634
PKc_MKK7 - cd06618
PTKc_DDR2 - cd05095
STKc_TAO - cd06607
STKc_CDK9 - cd07865
PTKc_HER2 - cd05109
STKc_PAK6 - cd06659
PTKc_EGFR_like - cd05057
STKc_PAK_II - cd06648
STKc_PAK - cd06614
PTKc_PDGFR - cd05055
PTKc_Tie2 - cd05088
PTKc_FGFR - cd05053
STKc_STK10_LOK - cd06644
STKc_MAP4K5 - cd06646
STKc_MAP4K3 - cd06645
PTKc_Jak_rpt2 - cd05038
PTKc_Tyk2_rpt2 - cd05080
PTKc_Jak1_rpt2 - cd05079
STKc_TNIK - cd06637
STKc_MAPK15 - cd07852
PTKc_VEGFR2 - cd05103
STKc_CDK12 - cd07864
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_Trk - cd05049
STKc_ASK - cd06624
STKc_CDK10 - cd07845
PTKc_VEGFR3 - cd05102
PTKc_Ror - cd05048
STKc_SLK - cd06643
STKc_Nek11 - cd08222
STKc_BUR1 - cd07866
STKc_ERK5 - cd07855
STKc_MAPK4_6 - cd07854
STKc_PCTAIRE_like - cd07844
STKc_Sty1_Hog1 - cd07856
PKc_MKK4 - cd06616
STKc_PCTAIRE1 - cd07873
STKc_PCTAIRE3 - cd07871
STKc_PFTAIRE2 - cd07870
STKc_PFTAIRE1 - cd07869
PTKc_InsR_like - cd05032
PTKc_Abl - cd05052
PTKc_Src_like - cd05034
PTKc_FAK - cd05056
PTKc_InsR - cd05061
STKc_MAP4K3_like - cd06613
PTKc_IGF-1R - cd05062
PTKc_EphR_B - cd05065
PTKc_Chk - cd05083
PTKc_Csk - cd05082
PTKc_Lyn - cd05072
PTKc_Frk_like - cd05068
PTKc_Yes - cd05069
STKc_MEKK3_like_1 - cd06653
STKc_MEKK2 - cd06652
STKc_ERK1_2_like - cd07849
PTKc_TrkA - cd05092
STKc_MEKK3 - cd06651
PTK_HER3 - cd05111
PTKc_Musk - cd05050
STKc_MEKK3_like - cd06625
STKc_myosinIII_like - cd06608
PKc_MAPKK_plant_like - cd06623
STKc_NAK1_like - cd06917
STKc_MST3_like - cd06609
PKc_MKK3_6 - cd06617
PKc_MEK - cd06615
STKc_SLK_like - cd06611
STKc_Nek6 - cd08228
SPS1 - COG0515
STKc_Nek7 - cd08229
STKc_Nek6_Nek7 - cd08224
STKc_CDK6 - cd07862
STKc_CDKL5 - cd07848
STKc_CDKL1_4 - cd07847
PTKc_Itk - cd05112
PTKc_Btk_Bmx - cd05113
PTKc_Tec_Rlk - cd05114
PTKc_EphR - cd05033
PTKc_Tec_like - cd05059
PTKc_Ror1 - cd05090
PTKc_Hck - cd05073
PTKc_EphR_A - cd05066
STKc_OSR1_SPAK - cd06610
PTKc_Srm_Brk - cd05148
STKc_PRKX_like - cd05612
PKc_MAPKK - cd06605
STKc_PDK1 - cd05581
STKc_MAST - cd05609
STKc_PKA - cd05580
STKc_ROCK_NDR_like - cd05573
STKc_phototropin_lik - cd05574
STKc_CDK2_3 - cd07860
STKc_CDK1_euk - cd07861
STKc_Nek - cd08215
STKc_CDK4 - cd07863
STKc_CDK7 - cd07841
STKc_Nek2 - cd08217
STKc_CDK8_like - cd07842
STKc_CDC2L1 - cd07843
STKc_MPK1 - cd07857
STKc_Nek4 - cd08223
STKc_Nek10 - cd08528
STKc_CNK2-like - cd08530
STKc_CDK5 - cd07839
STKc_Nek5 - cd08225
STKc_Nek9 - cd08221
STKc_Nek3 - cd08219
STKc_Nek8 - cd08220
STKc_Nek1 - cd08218
STKc_FA2-like - cd08529
STKc_Yank1 - cd05578
STKc_MSK_N - cd05583
STKc_GRK6 - cd05630
STKc_GRK4 - cd05631
PKc_STE - cd05122
PTKc_Lck_Blk - cd05067
STKc_CdkB_plant - cd07837
PTKc_RET - cd05045
PTK_CCK4 - cd05046
PTKc_Tie1 - cd05089
STKc_GRK5 - cd05632
STKc_GRK4_like - cd05605
STKc_MAPKKK - cd06606
STKc_CCRK - cd07832
STKc_MAPK - cd07834
STKc_Pho85 - cd07836
STKc_MEKK1 - cd06630
STKc_YSK4 - cd06631
STKc_MST1_2 - cd06612
STKc_MAPKKK_Byr2_lik - cd06628
PKc_MAPKK_Byr1_like - cd06620
STKc_Cdc7_like - cd06627
STKc_CDKL2_3 - cd07846
STKc_CDC2L6 - cd07867
STYKc - smart00221
STKc_CDK_like - cd07829
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
STKc_CDK9_like - cd07840
TyrKc - smart00219
STKc_PKN - cd05589
STKc_MST4 - cd06640
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CMGC - cd05118
PTKc_Jak2_Jak3_rpt2 - cd05081
STKc_MST3 - cd06641
STKc_STK25-YSK1 - cd06642
STKc_CDK1_like - cd07835
STKc_CDKL - cd07833
STKc_MOK - cd07831
STKc_MAK_like - cd07830
STKc_CDK4_6_like - cd07838
PKc_MAPKK_Pek1_like - cd06621
PKc_MAPKK_PBS2_like - cd06622
PTKc_ALK_LTK - cd05036
PTKc_Ror2 - cd05091
PTKc_Zap-70 - cd05115
PTKc_Aatyk - cd05042
STKc_MEKK1_plant - cd06632
PTKc_c-ros - cd05044
PTKc_Ack_like - cd05040
PTKc - cd00192
STKc_MEKK4 - cd06626
STKc_SGK - cd05575
PTKc_Syk_like - cd05060
PTKc_Met_Ron - cd05058
PTKc_Tie - cd05047
PTKc_Fes - cd05084
PTKc_Fer - cd05085
STKc_PKC - cd05570
PTKc_Syk - cd05116
PTKc_Aatyk2 - cd05086
PTKc_Fes_like - cd05041
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
PKc - cd00180
STKc_GRK1 - cd05608
STKc_GRK - cd05577
STKc_MAST_like - cd05579
STKc_GRK7 - cd05607
S_TKc - smart00220


Swiss-Prot Protein: P19525
Identical to: NP_002750, NP_001129123
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
DSRMcd000481.4e-22975
DSRMcd000481.5e-15100165
PTKc_PDGFR_alphacd051050.00064162539
PTKc_VEGFRcd050540.00086185543
PTKc_Kitcd051045.2e-05233540
STKc_TAO1cd066351.9e-05239550
STKc_MAP4K4_6cd066369.7e-07241538
STKc_PAK5cd066580.00047246548
STKc_JNKcd078505.9e-05246547
STKc_myosinIIIBcd066399.4e-05247539
STKc_p38cd078515.1e-07247543
STKc_PAK4cd066570.00037248550
STKc_myosinIIIAcd066388.9e-08249538
STKc_TAO2cd066341.6e-05250546
PTKc_DDR2cd050950.00036251538
STKc_TAOcd066078.7e-06251547
PKc_MKK7cd066186.2e-09251547
STKc_CDK9cd078652.8e-11251538
PTKc_EGFR_likecd050573.2e-06252550
PTKc_HER2cd051098.2e-05252550
STKc_PAK6cd066596.2e-06252551
STKc_PAK_IIcd066484.1e-07253551
PTKc_PDGFRcd050553e-06254540
STKc_PAKcd066143.2e-15254542
PTKc_FGFRcd050531.4e-06257537
PTKc_Tie2cd050881.7e-07257551
STKc_STK10_LOKcd066442.8e-05257548
STKc_MAP4K5cd066468.2e-07258537
STKc_MAP4K3cd066454e-07258537
PTKc_Jak_rpt2cd050387.3e-10259540
PTKc_Jak1_rpt2cd050790.0001259540
PTKc_Tyk2_rpt2cd050804.9e-07259541
STKc_TNIKcd066375.8e-09259538
STKc_MAPK15cd078525.4e-07259550
PTKc_VEGFR2cd051035.6e-06260543
STKc_CDK12cd078647.6e-11260538
PTKc_Trkcd050497.2e-08261538
PTKc_EphR_A2cd050630.00067261540
PTKc_TrkBcd050930.0002261547
STKc_ASKcd066241.4e-07261538
PTKc_Rorcd050484e-06262539
PTKc_VEGFR3cd051026.7e-05262543
STKc_SLKcd066433.9e-05262550
STKc_CDK10cd078455e-09262550
STKc_BUR1cd078665.8e-10262534
STKc_Nek11cd082226e-11262538
PTKc_InsR_likecd050323.6e-07263538
PTKc_Src_likecd050342.1e-07263539
PTKc_Ablcd050528.8e-07263540
PTKc_FAKcd050566.6e-08263544
PTKc_InsRcd050610.00012263549
PTKc_IGF-1Rcd050620.00051263538
PTKc_EphR_Bcd050650.00075263540
PTKc_Frk_likecd050682.2e-06263539
PTKc_Yescd050690.0008263539
PTKc_Lyncd050722.7e-05263539
PTKc_Cskcd050820.00084263539
PTKc_Chkcd050830.00023263539
STKc_MAP4K3_likecd066132.1e-14263537
PKc_MKK4cd066163.7e-06263551
STKc_PCTAIRE_likecd078441.2e-05263538
STKc_MAPK4_6cd078541.8e-07263548
STKc_ERK5cd078552.1e-05263550
STKc_Sty1_Hog1cd078560.00022263546
STKc_PFTAIRE1cd078690.0006263550
STKc_PFTAIRE2cd078700.00029263538
STKc_PCTAIRE3cd078710.00017263538
STKc_PCTAIRE1cd078730.0007263544
PTKc_Muskcd050502.6e-08264538
PTKc_TrkAcd050929.5e-05264546
PTK_HER3cd051111.9e-05264550
STKc_myosinIII_likecd066081.7e-09264538
STKc_MEKK3_likecd066253.8e-11264538
STKc_MEKK3cd066512.4e-08264540
STKc_MEKK2cd066525e-07264539
STKc_MEKK3_like_1cd066538.4e-07264538
STKc_ERK1_2_likecd078495.1e-06264551
PTKc_EphRcd050339.6e-06265540
PTKc_Tec_likecd050594.6e-09265537
PTKc_Hckcd050731.2e-05265539
PTKc_Ror1cd050900.00057265539
PTKc_Itkcd051127.5e-09265537
PTKc_Btk_Bmxcd051139.4e-08265537
PTKc_Tec_Rlkcd051141.4e-06265537
PTKc_EphR_Acd050660.00051265540
PTKc_Srm_Brkcd051484.5e-06265539
STKc_ROCK_NDR_likecd055731.5e-05265550
STKc_phototropin_likcd055741.3e-05265545
STKc_PKAcd055804.5e-09265532
STKc_PDK1cd055811.5e-15265534
STKc_MASTcd056090.00014265551
STKc_PRKX_likecd056121.2e-05265550
PKc_MAPKKcd066055.8e-12265544
STKc_OSR1_SPAKcd066109.7e-12265538
PKc_MEKcd066153.9e-07265551
STKc_SLK_likecd066111.2e-08265547
PKc_MKK3_6cd066173.2e-07265538
STKc_MST3_likecd066094.5e-12265540
PKc_MAPKK_plant_likecd066239.6e-16265544
STKc_NAK1_likecd069171.8e-08265541
STKc_CDKL1_4cd078479.3e-09265538
STKc_CDKL5cd078487.3e-05265538
STKc_CDK6cd078627.1e-05265538
STKc_Nek6_Nek7cd082248.8e-11265544
STKc_Nek6cd082281.2e-07265541
STKc_Nek7cd082292.2e-08265541
SPS1COG05151.5e-22265551
PTKc_RETcd050450.00031266542
PTK_CCK4cd050461.5e-05266538
PTKc_Lck_Blkcd050670.00092266539
PTKc_Tie1cd050893e-05266550
PKc_STEcd051227.1e-23266534
STKc_Yank1cd055786e-10266540
STKc_MSK_Ncd055831.4e-05266546
STKc_GRK4_likecd056052.8e-07266545
STKc_GRK6cd056309.8e-05266548
STKc_GRK4cd056315e-05266545
STKc_GRK5cd056329.4e-05266548
STKc_MAPKKKcd066064.9e-19266533
STKc_MST1_2cd066121.8e-12266532
PKc_MAPKK_Byr1_likecd066201.7e-06266544
STKc_Cdc7_likecd066278.7e-14266534
STKc_MAPKKK_Byr2_likcd066282.7e-08266538
STKc_MEKK1cd066307.6e-07266535
STKc_YSK4cd066313.9e-07266538
STKc_CCRKcd078327.6e-15266537
STKc_MAPKcd078342.9e-08266547
STKc_Pho85cd078364.1e-05266538
STKc_CdkB_plantcd078373.6e-10266540
STKc_CDK5cd078395.8e-08266538
STKc_CDK7cd078416.6e-12266543
STKc_CDK8_likecd078421.9e-07266534
STKc_CDC2L1cd078435.3e-10266534
STKc_MPK1cd078579.6e-06266550
STKc_CDK2_3cd078601.3e-05266538
STKc_CDK1_eukcd078611.2e-05266538
STKc_CDK4cd078633e-06266538
STKc_Nekcd082153.3e-44266538
STKc_Nek2cd082172e-18266538
STKc_Nek1cd082185e-29266538
STKc_Nek3cd082191.3e-16266538
STKc_Nek8cd082206.7e-14266538
STKc_Nek9cd082215.2e-13266538
STKc_Nek4cd082235.1e-28266538
STKc_Nek5cd082258.7e-25266538
STKc_Nek10cd085281.5e-07266538
STKc_CNK2-likecd085301.3e-12266538
STKc_FA2-likecd085296.8e-16266538
PTKc_Jak2_Jak3_rpt2cd050814.7e-08267540
STKc_CMGCcd051183.6e-14267534
STKc_PKNcd055890.00031267550
STKc_MAPKKK_Bck1_likcd066291.9e-10267538
STKc_MST4cd066401.5e-06267550
STKc_MST3cd066411.7e-06267550
STKc_STK25-YSK1cd066422.4e-06267550
STKc_MAK_likecd078306.8e-14267538
STKc_MOKcd078315.7e-10267539
STKc_CDKLcd078332.8e-11267536
STKc_CDK1_likecd078358.4e-07267551
STKc_CDK4_6_likecd078381.5e-13267534
STKc_CDK9_likecd078401.3e-12267538
STKc_CDKL2_3cd078466.5e-09267538
STKc_CDK_likecd078291.2e-16267534
STKc_CDC2L6cd078670.00011267538
PTKc_ALK_LTKcd050367.9e-06268538
PKc_MAPKK_Pek1_likecd066212.9e-10268551
PKc_MAPKK_PBS2_likecd066227.1e-05268549
PTKc_Ror2cd050910.00047269539
PTKc_Zap-70cd051152e-06270541
PTKccd001921.2e-10271537
PTKc_Ack_likecd050404.6e-08271538
PTKc_Fes_likecd050412.4e-08271538
PTKc_Aatykcd050421.4e-05271538
PTKc_c-roscd050443.8e-06271538
PTKc_Tiecd050473e-06271541
PTKc_Met_Roncd050588.9e-05271542
PTKc_Syk_likecd050604.2e-07271541
PTKc_Fescd050842.4e-06271538
PTKc_Fercd050851.5e-06271538
PTKc_Aatyk2cd050860.00029271538
PTKc_Sykcd051165.6e-05271541
STKc_PKCcd055708.5e-07271550
STKc_SGKcd055750.00098271551
STKc_MEKK4cd066265.8e-12271538
STKc_MEKK1_plantcd066324.2e-12271538
PKccd001803.4e-69273536
STKc_AGCcd051233.4e-11273532
STKc_cGK_PKGcd055724.2e-09273541
STKc_GRKcd055772.5e-07273544
STKc_MAST_likecd055792.9e-10273535
STKc_GRK7cd056071.2e-05273547
STKc_GRK1cd056082e-07273547
dsrmpfam000355.8e-191075
dsrmpfam000353.6e-14101165
Pkinasepfam000691.1e-52267536
DSRMsmart003582.4e-231076
DSRMsmart003581.6e-17101167
Pkinase_Tyrpfam077146.6e-15267536
TyrKcsmart002196.7e-14267536
STYKcsmart002215.7e-53267538
S_TKcsmart002205.5e-55277540

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_040476Polymorphismp.ILE506VALN/A
Swiss-ProtVAR_040475Polymorphismp.LEU439VALN/A
Swiss-ProtVAR_040474Polymorphismp.VAL428GLUN/A



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