Results for the protein: P19525

Results for the Protein: P19525

125527

5610

EIF2AK2

NCBI, UniProt

E2AK2_HUMAN RecName: Full=Interferon-induced, double-stranded RNA-activated protein kinase; AltName: Full=Eukaryotic translation initiation factor 2-alpha kinase 2; Short=eIF-2A protein kinase 2; AltName: Full=Interferon-inducible RNA-dependent protein kinase; AltName: Full=P1/eIF-2A protein kinase; AltName: Full=Protein kinase RNA-activated; Short=PKR; AltName: Full=Tyrosine-protein kinase EIF2AK2; AltName: Full=p68 kinase

			0 3 0 0 3

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Swiss-Prot Protein: P19525

Identical to: NP_002750, NP_001129123

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
DSRM	cd00048	1.5e-15	100	165
PTKc_PDGFR_alpha	cd05105	0.00064	162	539
PTKc_VEGFR	cd05054	0.00086	185	543
PTKc_Kit	cd05104	5.2e-05	233	540
STKc_TAO1	cd06635	1.9e-05	239	550
STKc_MAP4K4_6	cd06636	9.7e-07	241	538
STKc_PAK5	cd06658	0.00047	246	548
STKc_JNK	cd07850	5.9e-05	246	547
STKc_myosinIIIB	cd06639	9.4e-05	247	539
STKc_p38	cd07851	5.1e-07	247	543
STKc_PAK4	cd06657	0.00037	248	550
STKc_myosinIIIA	cd06638	8.9e-08	249	538
STKc_TAO2	cd06634	1.6e-05	250	546
PTKc_DDR2	cd05095	0.00036	251	538
STKc_TAO	cd06607	8.7e-06	251	547
PKc_MKK7	cd06618	6.2e-09	251	547
STKc_CDK9	cd07865	2.8e-11	251	538
PTKc_EGFR_like	cd05057	3.2e-06	252	550
PTKc_HER2	cd05109	8.2e-05	252	550
STKc_PAK6	cd06659	6.2e-06	252	551
STKc_PAK_II	cd06648	4.1e-07	253	551
PTKc_PDGFR	cd05055	3e-06	254	540
STKc_PAK	cd06614	3.2e-15	254	542
PTKc_FGFR	cd05053	1.4e-06	257	537
PTKc_Tie2	cd05088	1.7e-07	257	551
STKc_STK10_LOK	cd06644	2.8e-05	257	548
STKc_MAP4K5	cd06646	8.2e-07	258	537
STKc_MAP4K3	cd06645	4e-07	258	537
PTKc_Jak_rpt2	cd05038	7.3e-10	259	540
PTKc_Jak1_rpt2	cd05079	0.0001	259	540
PTKc_Tyk2_rpt2	cd05080	4.9e-07	259	541
STKc_TNIK	cd06637	5.8e-09	259	538
STKc_MAPK15	cd07852	5.4e-07	259	550
PTKc_VEGFR2	cd05103	5.6e-06	260	543
STKc_CDK12	cd07864	7.6e-11	260	538
PTKc_Trk	cd05049	7.2e-08	261	538
PTKc_EphR_A2	cd05063	0.00067	261	540
PTKc_TrkB	cd05093	0.0002	261	547
STKc_ASK	cd06624	1.4e-07	261	538
PTKc_Ror	cd05048	4e-06	262	539
PTKc_VEGFR3	cd05102	6.7e-05	262	543
STKc_SLK	cd06643	3.9e-05	262	550
STKc_CDK10	cd07845	5e-09	262	550
STKc_BUR1	cd07866	5.8e-10	262	534
STKc_Nek11	cd08222	6e-11	262	538
PTKc_InsR_like	cd05032	3.6e-07	263	538
PTKc_Src_like	cd05034	2.1e-07	263	539
PTKc_Abl	cd05052	8.8e-07	263	540
PTKc_FAK	cd05056	6.6e-08	263	544
PTKc_InsR	cd05061	0.00012	263	549
PTKc_IGF-1R	cd05062	0.00051	263	538
PTKc_EphR_B	cd05065	0.00075	263	540
PTKc_Frk_like	cd05068	2.2e-06	263	539
PTKc_Yes	cd05069	0.0008	263	539
PTKc_Lyn	cd05072	2.7e-05	263	539
PTKc_Csk	cd05082	0.00084	263	539
PTKc_Chk	cd05083	0.00023	263	539
STKc_MAP4K3_like	cd06613	2.1e-14	263	537
PKc_MKK4	cd06616	3.7e-06	263	551
STKc_PCTAIRE_like	cd07844	1.2e-05	263	538
STKc_MAPK4_6	cd07854	1.8e-07	263	548
STKc_ERK5	cd07855	2.1e-05	263	550
STKc_Sty1_Hog1	cd07856	0.00022	263	546
STKc_PFTAIRE1	cd07869	0.0006	263	550
STKc_PFTAIRE2	cd07870	0.00029	263	538
STKc_PCTAIRE3	cd07871	0.00017	263	538
STKc_PCTAIRE1	cd07873	0.0007	263	544
PTKc_Musk	cd05050	2.6e-08	264	538
PTKc_TrkA	cd05092	9.5e-05	264	546
PTK_HER3	cd05111	1.9e-05	264	550
STKc_myosinIII_like	cd06608	1.7e-09	264	538
STKc_MEKK3_like	cd06625	3.8e-11	264	538
STKc_MEKK3	cd06651	2.4e-08	264	540
STKc_MEKK2	cd06652	5e-07	264	539
STKc_MEKK3_like_1	cd06653	8.4e-07	264	538
STKc_ERK1_2_like	cd07849	5.1e-06	264	551
PTKc_EphR	cd05033	9.6e-06	265	540
PTKc_Tec_like	cd05059	4.6e-09	265	537
PTKc_Hck	cd05073	1.2e-05	265	539
PTKc_Ror1	cd05090	0.00057	265	539
PTKc_Itk	cd05112	7.5e-09	265	537
PTKc_Btk_Bmx	cd05113	9.4e-08	265	537
PTKc_Tec_Rlk	cd05114	1.4e-06	265	537
PTKc_EphR_A	cd05066	0.00051	265	540
PTKc_Srm_Brk	cd05148	4.5e-06	265	539
STKc_ROCK_NDR_like	cd05573	1.5e-05	265	550
STKc_phototropin_lik	cd05574	1.3e-05	265	545
STKc_PKA	cd05580	4.5e-09	265	532
STKc_PDK1	cd05581	1.5e-15	265	534
STKc_MAST	cd05609	0.00014	265	551
STKc_PRKX_like	cd05612	1.2e-05	265	550
PKc_MAPKK	cd06605	5.8e-12	265	544
STKc_OSR1_SPAK	cd06610	9.7e-12	265	538
PKc_MEK	cd06615	3.9e-07	265	551
STKc_SLK_like	cd06611	1.2e-08	265	547
PKc_MKK3_6	cd06617	3.2e-07	265	538
STKc_MST3_like	cd06609	4.5e-12	265	540
PKc_MAPKK_plant_like	cd06623	9.6e-16	265	544
STKc_NAK1_like	cd06917	1.8e-08	265	541
STKc_CDKL1_4	cd07847	9.3e-09	265	538
STKc_CDKL5	cd07848	7.3e-05	265	538
STKc_CDK6	cd07862	7.1e-05	265	538
STKc_Nek6_Nek7	cd08224	8.8e-11	265	544
STKc_Nek6	cd08228	1.2e-07	265	541
STKc_Nek7	cd08229	2.2e-08	265	541
SPS1	COG0515	1.5e-22	265	551
PTKc_RET	cd05045	0.00031	266	542
PTK_CCK4	cd05046	1.5e-05	266	538
PTKc_Lck_Blk	cd05067	0.00092	266	539
PTKc_Tie1	cd05089	3e-05	266	550
PKc_STE	cd05122	7.1e-23	266	534
STKc_Yank1	cd05578	6e-10	266	540
STKc_MSK_N	cd05583	1.4e-05	266	546
STKc_GRK4_like	cd05605	2.8e-07	266	545
STKc_GRK6	cd05630	9.8e-05	266	548
STKc_GRK4	cd05631	5e-05	266	545
STKc_GRK5	cd05632	9.4e-05	266	548
STKc_MAPKKK	cd06606	4.9e-19	266	533
STKc_MST1_2	cd06612	1.8e-12	266	532
PKc_MAPKK_Byr1_like	cd06620	1.7e-06	266	544
STKc_Cdc7_like	cd06627	8.7e-14	266	534
STKc_MAPKKK_Byr2_lik	cd06628	2.7e-08	266	538
STKc_MEKK1	cd06630	7.6e-07	266	535
STKc_YSK4	cd06631	3.9e-07	266	538
STKc_CCRK	cd07832	7.6e-15	266	537
STKc_MAPK	cd07834	2.9e-08	266	547
STKc_Pho85	cd07836	4.1e-05	266	538
STKc_CdkB_plant	cd07837	3.6e-10	266	540
STKc_CDK5	cd07839	5.8e-08	266	538
STKc_CDK7	cd07841	6.6e-12	266	543
STKc_CDK8_like	cd07842	1.9e-07	266	534
STKc_CDC2L1	cd07843	5.3e-10	266	534
STKc_MPK1	cd07857	9.6e-06	266	550
STKc_CDK2_3	cd07860	1.3e-05	266	538
STKc_CDK1_euk	cd07861	1.2e-05	266	538
STKc_CDK4	cd07863	3e-06	266	538
STKc_Nek	cd08215	3.3e-44	266	538
STKc_Nek2	cd08217	2e-18	266	538
STKc_Nek1	cd08218	5e-29	266	538
STKc_Nek3	cd08219	1.3e-16	266	538
STKc_Nek8	cd08220	6.7e-14	266	538
STKc_Nek9	cd08221	5.2e-13	266	538
STKc_Nek4	cd08223	5.1e-28	266	538
STKc_Nek5	cd08225	8.7e-25	266	538
STKc_Nek10	cd08528	1.5e-07	266	538
STKc_CNK2-like	cd08530	1.3e-12	266	538
STKc_FA2-like	cd08529	6.8e-16	266	538
PTKc_Jak2_Jak3_rpt2	cd05081	4.7e-08	267	540
STKc_CMGC	cd05118	3.6e-14	267	534
STKc_PKN	cd05589	0.00031	267	550
STKc_MAPKKK_Bck1_lik	cd06629	1.9e-10	267	538
STKc_MST4	cd06640	1.5e-06	267	550
STKc_MST3	cd06641	1.7e-06	267	550
STKc_STK25-YSK1	cd06642	2.4e-06	267	550
STKc_MAK_like	cd07830	6.8e-14	267	538
STKc_MOK	cd07831	5.7e-10	267	539
STKc_CDKL	cd07833	2.8e-11	267	536
STKc_CDK1_like	cd07835	8.4e-07	267	551
STKc_CDK4_6_like	cd07838	1.5e-13	267	534
STKc_CDK9_like	cd07840	1.3e-12	267	538
STKc_CDKL2_3	cd07846	6.5e-09	267	538
STKc_CDK_like	cd07829	1.2e-16	267	534
STKc_CDC2L6	cd07867	0.00011	267	538
PTKc_ALK_LTK	cd05036	7.9e-06	268	538
PKc_MAPKK_Pek1_like	cd06621	2.9e-10	268	551
PKc_MAPKK_PBS2_like	cd06622	7.1e-05	268	549
PTKc_Ror2	cd05091	0.00047	269	539
PTKc_Zap-70	cd05115	2e-06	270	541
PTKc	cd00192	1.2e-10	271	537
PTKc_Ack_like	cd05040	4.6e-08	271	538
PTKc_Fes_like	cd05041	2.4e-08	271	538
PTKc_Aatyk	cd05042	1.4e-05	271	538
PTKc_c-ros	cd05044	3.8e-06	271	538
PTKc_Tie	cd05047	3e-06	271	541
PTKc_Met_Ron	cd05058	8.9e-05	271	542
PTKc_Syk_like	cd05060	4.2e-07	271	541
PTKc_Fes	cd05084	2.4e-06	271	538
PTKc_Fer	cd05085	1.5e-06	271	538
PTKc_Aatyk2	cd05086	0.00029	271	538
PTKc_Syk	cd05116	5.6e-05	271	541
STKc_PKC	cd05570	8.5e-07	271	550
STKc_SGK	cd05575	0.00098	271	551
STKc_MEKK4	cd06626	5.8e-12	271	538
STKc_MEKK1_plant	cd06632	4.2e-12	271	538
PKc	cd00180	3.4e-69	273	536
STKc_AGC	cd05123	3.4e-11	273	532
STKc_cGK_PKG	cd05572	4.2e-09	273	541
STKc_GRK	cd05577	2.5e-07	273	544
STKc_MAST_like	cd05579	2.9e-10	273	535
STKc_GRK7	cd05607	1.2e-05	273	547
STKc_GRK1	cd05608	2e-07	273	547
dsrm	pfam00035	5.8e-19	10	75
dsrm	pfam00035	3.6e-14	101	165
Pkinase	pfam00069	1.1e-52	267	536
DSRM	smart00358	2.4e-23	10	76
DSRM	smart00358	1.6e-17	101	167
Pkinase_Tyr	pfam07714	6.6e-15	267	536
TyrKc	smart00219	6.7e-14	267	536
STYKc	smart00221	5.7e-53	267	538
S_TKc	smart00220	5.5e-55	277	540

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040476	Polymorphism	p.ILE506VAL	N/A
Swiss-Prot	VAR_040475	Polymorphism	p.LEU439VAL	N/A
Swiss-Prot	VAR_040474	Polymorphism	p.VAL428GLU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258