Results for the protein: P21439

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
COG1123	COG1123	6.7e-12	167	638
ABCC_SUR2	cd03288	8.3e-22	310	632
ABCC_CFTR1	cd03291	1.4e-09	363	654
ModF	COG1119	2.6e-13	367	614
TagH	COG1134	3.3e-08	374	635
MglA	COG1129	8.9e-08	386	794
ABCC_TAP	cd03248	1.6e-86	387	608
PstB	COG1117	9.6e-19	387	625
YhbG	COG1137	4.5e-12	387	627
Ttg2A	COG1127	3.1e-14	389	647
LivG	COG0411	3.1e-12	390	623
CcmA	COG1131	1.2e-34	390	703
ABCG_EPDR	cd03213	6.8e-14	391	612
ABCG_PDR_domain1	cd03233	1.8e-07	391	612
ABCG_White	cd03234	3.5e-11	391	612
ABCG_PDR_domain2	cd03232	1.6e-08	391	626
ABCC_NFT1	cd03369	1.4e-21	391	614
sufC	COG0396	7.3e-12	391	635
Uup	COG0488	1.5e-07	391	889
TauB	COG1116	3.5e-14	391	635
ZnuC	COG1121	1.4e-12	391	640
CbiO	COG1122	2.7e-44	391	626
DppF	COG1124	5.8e-22	391	638
ABCC_MRP_domain2	cd03244	3.1e-63	392	614
ABCC_bacteriocin_exp	cd03245	8.7e-65	392	612
ABCC_Glucan_exporter	cd03254	1.9e-114	392	622
ABCC_CFTR2	cd03289	2.1e-11	392	653
CysA	COG1118	4.1e-14	392	723
FepC	COG1120	2e-18	392	655
GlnQ	COG1126	9.6e-22	392	629
ABC_RNaseL_inhibitor	cd03236	2e-05	393	640
ABC_NikE_OppD_transp	cd03257	2.3e-36	393	612
ABC_MetN_methionine_	cd03258	4.1e-21	393	622
ABC_CysA_sulfate_imp	cd03296	3.2e-20	393	632
LivF	COG0410	2.4e-15	393	630
DppD	COG0444	5.5e-13	393	666
OpuBA	COG1125	9e-14	393	739
SalX	COG1136	2.5e-36	393	615
AbcC	COG1135	1.5e-17	393	705
ABC_Carb_Monos_I	cd03216	1.3e-18	394	611
ABC_Carb_Monos_II	cd03215	5.5e-10	394	608
ABC_FeS_Assembly	cd03217	1e-09	394	624
ABC_YhbG	cd03218	2.1e-10	394	623
ABC_Mj1267_LivG_bran	cd03219	9.7e-16	394	623
ABC_KpsT_Wzt	cd03220	8.6e-11	394	612
ABC_RNaseL_inhibitor	cd03222	3.1e-05	394	626
ABCD_peroxisomal_ALD	cd03223	2.7e-11	394	608
ABCF_EF-3	cd03221	1.3e-08	394	607
ABCC_MRP_Like	cd03228	5.3e-126	394	607
ABC_Class3	cd03229	1.1e-47	394	607
ABC_DR_subfamily_A	cd03230	8.7e-35	394	608
ABC_TM1139_LivF_bran	cd03224	2.6e-16	394	620
ABC_UvrA	cd03238	1.6e-05	394	612
ABCC_Protease_Secret	cd03246	6.3e-61	394	608
ABCC_cytochrome_bd	cd03247	4.2e-62	394	612
ABC_MTABC3_MDL1_MDL2	cd03249	1.2e-177	394	631
ABCC_MRP_domain1	cd03250	2.6e-18	394	607
ABCC_MsbA	cd03251	2.8e-130	394	628
ABCC_Hemolysin	cd03252	4.1e-102	394	631
ABC_MJ0796_LolCDE_Ft	cd03255	4.3e-29	394	608
ABCC_ATM1_transporte	cd03253	3e-119	394	631
ABC_Carb_Solutes_lik	cd03259	2e-31	394	612
ABC_PstB_phosphate_t	cd03260	5.8e-41	394	617
ABC_Org_Solvent_Resi	cd03261	9.3e-18	394	625
ABC_HisP_GlnQ	cd03262	3e-21	394	608
ABC_subfamily_A	cd03263	2.2e-14	394	618
ABC_NatA_sodium_expo	cd03266	9.7e-12	394	612
ABC_NatA_like	cd03267	4.6e-07	394	606
ABC_BcrA_bacitracin_	cd03268	7.6e-11	394	612
ABC_putative_ATPase	cd03269	9.2e-11	394	612
ABC_drug_resistance_	cd03264	1.4e-11	394	612
ABC_PhnC_transporter	cd03256	8.3e-17	394	624
ABCC_SUR1_N	cd03290	3.4e-14	394	607
ABC_FtsE_transporter	cd03292	1e-17	394	608
ABC_NrtD_SsuB_transp	cd03293	1.8e-19	394	607
ABC_Pro_Gly_Betaine	cd03294	1.6e-17	394	628
ABC_OpuCA_Osmoprotec	cd03295	1e-16	394	634
ABC_PotA_N	cd03300	8.4e-16	394	617
ABC_MalK_N	cd03301	2.6e-14	394	612
ABC_ThiQ_thiamine_tr	cd03298	3.3e-11	394	612
ABC_ATPase	cd00267	7.9e-69	395	607
ABC_Iron-Siderophore	cd03214	2.9e-18	395	612
ABC_cobalt_CbiO_doma	cd03225	1.1e-46	395	607
ABC_cobalt_CbiO_doma	cd03226	8e-15	395	609
ABC_Metallic_Cations	cd03235	2e-17	395	611
ABC_RNaseL_inhibitor	cd03237	0.00069	403	634
ABC_CcmA_heme_export	cd03231	1.1e-06	405	604
ABC_UvrA_II	cd03271	6.6e-06	405	614
ABC_ModC_molybdenum_	cd03297	3.2e-13	406	612
ABC_ModC_like	cd03299	2.7e-14	406	628
ABC_DrrA	cd03265	2.3e-12	407	618
MdlB	COG1132	3.2e-165	694	1283
ABCC_SUR2	cd03288	7.8e-21	963	1283
ABCC_TAP	cd03248	1.5e-89	1025	1257
PstB	COG1117	1.8e-12	1027	1282
CcmA	COG1131	5.9e-16	1030	1286
ABCG_EPDR	cd03213	2.5e-11	1031	1261
ABCC_NFT1	cd03369	1e-17	1031	1263
TauB	COG1116	2.7e-12	1031	1283
CbiO	COG1122	4.1e-36	1031	1275
DppF	COG1124	5.2e-14	1031	1276
ABCC_MRP_domain2	cd03244	3.3e-50	1032	1263
ABCC_bacteriocin_exp	cd03245	1.1e-57	1032	1261
ABCC_Glucan_exporter	cd03254	4.6e-111	1032	1271
ABCC_CFTR2	cd03289	2.1e-06	1032	1286
FepC	COG1120	2.1e-12	1032	1282
ABC_NikE_OppD_transp	cd03257	5.2e-23	1033	1261
ABC_MetN_methionine_	cd03258	9.5e-18	1033	1271
ABC_CysA_sulfate_imp	cd03296	2.6e-17	1033	1281
PhnK	COG1101	6.8e-09	1033	1268
SalX	COG1136	1.1e-22	1033	1263
ABC_Carb_Monos_I	cd03216	1.6e-16	1034	1260
ABCD_peroxisomal_ALD	cd03223	1.3e-13	1034	1257
ABCF_EF-3	cd03221	1.3e-08	1034	1256
ABCC_MRP_Like	cd03228	1.4e-109	1034	1256
ABC_Class3	cd03229	9.6e-36	1034	1256
ABC_DR_subfamily_A	cd03230	6.3e-23	1034	1257
ABCC_Protease_Secret	cd03246	1.1e-62	1034	1257
ABCC_cytochrome_bd	cd03247	1.6e-54	1034	1261
ABC_MTABC3_MDL1_MDL2	cd03249	1.1e-171	1034	1280
ABCC_MRP_domain1	cd03250	3.4e-19	1034	1256
ABCC_MsbA	cd03251	3.3e-115	1034	1277
ABCC_Hemolysin	cd03252	9.1e-91	1034	1280
ABC_MJ0796_LolCDE_Ft	cd03255	2.3e-15	1034	1257
ABCC_ATM1_transporte	cd03253	2.9e-103	1034	1280
ABC_Carb_Solutes_lik	cd03259	3.1e-18	1034	1261
ABC_PstB_phosphate_t	cd03260	7.8e-32	1034	1266
ABC_Org_Solvent_Resi	cd03261	2.1e-15	1034	1272
ABC_HisP_GlnQ	cd03262	4.6e-17	1034	1257
ABCC_SUR1_N	cd03290	1.3e-18	1034	1256
ABC_FtsE_transporter	cd03292	3.6e-14	1034	1257
ABC_NrtD_SsuB_transp	cd03293	1.4e-18	1034	1265
ABC_MalK_N	cd03301	8.4e-12	1034	1261
ABC_ThiQ_thiamine_tr	cd03298	5.3e-10	1034	1261
ABC_ATPase	cd00267	1.2e-54	1035	1256
ABC_Iron-Siderophore	cd03214	4.5e-13	1035	1261
ABC_cobalt_CbiO_doma	cd03225	5.5e-34	1035	1256
ABC_cobalt_CbiO_doma	cd03226	3.7e-13	1035	1258
ABC_Metallic_Cations	cd03235	2.4e-12	1035	1261
ABC_ModC_molybdenum_	cd03297	1.9e-12	1048	1261
SunT	COG2274	2.2e-66	7	632
COG4178	COG4178	5.6e-05	12	611
ABC_membrane	pfam00664	2.4e-90	57	350
PvdE	COG4615	3.1e-09	59	626
CydD	COG4988	7.6e-40	76	639
CydC	COG4987	4.7e-13	81	631
ArpD	COG4618	1.1e-17	96	641
ATM1	COG5265	5e-77	133	630
COG4172	COG4172	6.4e-08	255	628
COG4586	COG4586	1.9e-06	364	701
PhnK	COG4107	8.7e-05	388	635
HisP	COG4598	2e-20	388	631
PotA	COG3842	7.9e-15	389	749
COG4181	COG4181	2.5e-12	389	612
COG3845	COG3845	3.7e-05	390	749
SapF	COG4167	4.5e-07	390	640
ProV	COG4175	5.6e-09	390	732
COG3638	COG3638	3.8e-15	391	648
MalK	COG3839	1.1e-14	391	742
CcmA	COG4133	1.9e-07	392	608
COG4136	COG4136	1.6e-07	392	611
COG4152	COG4152	2e-05	392	654
TauB	COG4525	6.4e-12	392	644
FtsE	COG2884	8.5e-14	393	616
ThiQ	COG3840	2.9e-11	393	631
ArtP	COG4161	2.4e-21	393	631
COG4559	COG4559	6.5e-06	393	641
AppF	COG4608	2.4e-14	393	656
BtuD	COG4138	1.4e-06	394	640
NatA	COG4555	6.4e-16	394	637
COG4619	COG4619	3.1e-18	394	622
CeuD	COG4604	2.9e-09	394	626
ModC	COG4148	1.3e-07	408	720
ABC_tran	pfam00005	1.3e-38	436	561
SunT	COG2274	2.8e-65	633	1281
CydD	COG4988	4.5e-19	710	1286
ABC_membrane	pfam00664	1.4e-81	715	990
CydC	COG4987	1e-11	742	1280
ATM1	COG5265	1.7e-66	771	1279
HisP	COG4598	7.4e-15	1028	1280
PhnK	COG4107	3.9e-07	1030	1285
FtsE	COG2884	1.9e-12	1033	1265
ThiQ	COG3840	4.6e-11	1033	1280
ArtP	COG4161	2.6e-17	1033	1280
NatA	COG4555	1.3e-13	1034	1285
COG4619	COG4619	1.3e-10	1034	1268
PhnL	COG4778	2.1e-08	1043	1251
COG4674	COG4674	2.5e-05	1044	1265
ABC_tran	pfam00005	3e-33	1076	1210
AAA	smart00382	4.1e-39	421	613
AAA	smart00382	9.7e-34	1061	1256

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_023503	Disease	p.ALA546ASP	Cholestasis of pregnancy, intrahepatic 3 (ICP3)
Swiss-Prot	VAR_043102	Disease	p.ALA934THR	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_043095	Polymorphism	p.ARG590GLN	N/A
Swiss-Prot	VAR_024359	Polymorphism	p.ARG788GLN	N/A
dbSNP	rs2230028	Polymorphism	p.ARG652GLY	N/A
Swiss-Prot	VAR_043081	Disease	p.ARG150LYS	Cholestasis of pregnancy, intrahepatic 3 (ICP3)
dbSNP	rs8187801	Polymorphism	p.ARG788PRO	N/A
Swiss-Prot	VAR_043078	Polymorphism	p.ASP87GLU	N/A
Swiss-Prot	VAR_043094	Disease	p.ASP564GLY	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
dbSNP	rs8187797	Polymorphism	p.GLU528ASP	N/A
Swiss-Prot	VAR_043086	Disease	p.GLU395GLY	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_043089	Polymorphism	p.GLU450GLY	N/A
Swiss-Prot	VAR_043091	Disease	p.GLY535ASP	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_043099	Disease	p.GLY762GLU	Cholestasis of pregnancy, intrahepatic 3 (ICP3)
Swiss-Prot	VAR_043098	Polymorphism	p.GLY742SER	N/A
Swiss-Prot	VAR_043103	Disease	p.GLY983SER	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_043100	Polymorphism	p.ILE764LEU	N/A
Swiss-Prot	VAR_043092	Disease	p.ILE541PHE	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_030763	Polymorphism	p.ILE263VAL	N/A
Swiss-Prot	VAR_043085	Polymorphism	p.ILE367VAL	N/A
Swiss-Prot	VAR_043093	Disease	p.LEU556ARG	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_043104	Polymorphism	p.LEU1082GLN	N/A
Swiss-Prot	VAR_043096	Disease	p.LEU591GLN	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_020223	Polymorphism	p.LEU238VAL	N/A
Swiss-Prot	VAR_043083	Disease	p.MET301THR	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_043082	Disease	p.PHE165ILE	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_043097	Disease	p.PHE711SER	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_023504	Disease	p.PRO1168SER	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_043079	Polymorphism	p.PRO95SER	N/A
Swiss-Prot	VAR_043084	Disease	p.SER346ILE	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_023502	Disease	p.SER320PHE	Gallbladder disease 1 (GBD1)
Swiss-Prot	VAR_023501	Polymorphism	p.THR175ALA	N/A
Swiss-Prot	VAR_043087	Disease	p.THR424ALA	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_030765	Polymorphism	p.THR651ASN	N/A
Swiss-Prot	VAR_043101	Polymorphism	p.THR775MET	N/A
Swiss-Prot	VAR_043080	Disease	p.TRP138ARG	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
Swiss-Prot	VAR_043088	Disease	p.VAL425MET	Cholestasis, progressive familial intrahepatic, 3 (PFIC3)
OMIM	171060.0004	Disease	p.ALA546ASP	CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY, 3
OMIM	171060.0012	Disease	p.ARG590GLN	CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY, 3\|\|GALLBLADDER DISEASE 1, INCLUDED
OMIM	171060.0013	Disease	p.ARG545GLY	GALLBLADDER DISEASE 1
OMIM	171060.0011	Disease	p.ARG144TER	CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY, 3
OMIM	171060.0002	Disease	p.ARG957TER	CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC 3\|\|CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY, 3, INCLUDED
OMIM	171060.0007	Disease	p.PRO1161SER	GALLBLADDER DISEASE 1
OMIM	171060.0005	Disease	p.SER320PHE	GALLBLADDER DISEASE 1\|\|CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY, 3, INCLUDED
OMIM	171060.0006	Disease	p.THR175VAL	GALLBLADDER DISEASE 1
OMIM	171060.0010	Disease	p.TYR403HIS	CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC 3

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258