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Results for the Protein: Q13873
12643724
659

BMPR2_HUMAN RecName: Full=Bone morphogenetic protein receptor type-2; Short=BMP type-2 receptor; Short=BMPR-2; AltName: Full=Bone morphogenetic protein receptor type II; Short=BMP type II receptor; Short=BMPR-II; Flags: Precursor

Known Diseases associated with this Protein:
  PULMONARY HYPERTENSION, PRIMARY, 1
  PULMONARY HYPERTENSION, PRIMARY, 1 (PPH1)
  PULMONARY HYPERTENSION, PRIMARY, 1, WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA
  PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED, INCLUDED
  PULMONARY HYPERTENSION, PRIMARY, FENFLURAMINE-ASSOCIATED
  PULMONARY VENOOCCLUSIVE DISEASE
35
2
19
0
18
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Activin_recp - pfam01064
STKc_PAK_II - cd06648
STKc_myosinIIIA - cd06638
STKc_myosinIIIB - cd06639
PTKc_FGFR1 - cd05098
STKc_p38gamma_MAPK12 - cd07880
STKc_JNK3 - cd07874
STKc_JNK - cd07850
STKc_p38 - cd07851
PKc_MKK7 - cd06618
STKc_CDK9 - cd07865
STKc_MAP4K5 - cd06646
PTKc_FGFR4 - cd05099
PTKc_FGFR - cd05053
STKc_TNIK - cd06637
STKc_PAK - cd06614
STKc_ASK - cd06624
STKc_MST1_2 - cd06612
STKc_CDK10 - cd07845
PTKc_ALK_LTK - cd05036
PTKc_Tie2 - cd05088
PTKc_DDR2 - cd05095
PTKc_TrkC - cd05094
PTKc_Ror - cd05048
PTKc_DDR_like - cd05097
STKc_CDK12 - cd07864
PTKc_TrkA - cd05092
PTKc_EphR_A2 - cd05063
PTKc_Lyn - cd05072
PTKc_Lck_Blk - cd05067
STKc_TEY_MAPK_plant - cd07858
PTKc_FAK - cd05056
PTKc_Musk - cd05050
PTKc_Abl - cd05052
PTKc_Csk - cd05082
PTK_CCK4 - cd05046
PTKc_Trk - cd05049
PTKc_Hck - cd05073
PTKc_InsR - cd05061
PTKc_Frk_like - cd05068
PTKc_EphR_A10 - cd05064
PTKc_IGF-1R - cd05062
PTKc_Tec_Rlk - cd05114
PTKc_HER2 - cd05109
PTKc_Btk_Bmx - cd05113
PTKc_EGFR - cd05108
STKc_phototropin_lik - cd05574
PTKc_Chk - cd05083
PKc_MKK4 - cd06616
PTKc_HER4 - cd05110
PTK_HER3 - cd05111
PTKc_Itk - cd05112
PTKc_EphR - cd05033
PTKc_Src_like - cd05034
PTKc_InsR_like - cd05032
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Jak_rpt2 - cd05038
PTKc_Csk_like - cd05039
PTKc_Jak1_rpt2 - cd05079
PTKc_EphR_A - cd05066
PTKc_EphR_B - cd05065
PTKc_EGFR_like - cd05057
PTKc_Tec_like - cd05059
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
STKc_PCTAIRE3 - cd07871
STKc_PCTAIRE_like - cd07844
STKc_PFTAIRE2 - cd07870
STKc_MST4 - cd06640
STKc_MAP4K3_like - cd06613
STKc_STK25-YSK1 - cd06642
STKc_Nek6_Nek7 - cd08224
STKc_NAK1_like - cd06917
PKc_MAPKK - cd06605
STKc_MEKK3_like - cd06625
STKc_CdkB_plant - cd07837
STKc_CDKL1_4 - cd07847
SPS1 - COG0515
PKc_MAPKK_plant_like - cd06623
STKc_CDKL2_3 - cd07846
STKc_PRKX_like - cd05612
STKc_MAST - cd05609
STKc_PDK1 - cd05581
PKc_MAPKK_PBS2_like - cd06622
STKc_myosinIII_like - cd06608
STKc_DMPK_like - cd05597
STKc_MST3_like - cd06609
PKc_MEK - cd06615
PKc_MKK3_6 - cd06617
STKc_OSR1_SPAK - cd06610
STKc_CDK2_3 - cd07860
STKc_CDK1_euk - cd07861
STKc_MPK1 - cd07857
STKc_NLK - cd07853
STKc_CDK8_like - cd07842
STKc_CDK4 - cd07863
STKc_CNK2-like - cd08530
STKc_CDK7 - cd07841
STKc_FA2-like - cd08529
STKc_Nek8 - cd08220
STKc_Nek - cd08215
STKc_Nek2 - cd08217
STKc_Pho85 - cd07836
STKc_MSK_N - cd05583
STKc_CDK5 - cd07839
STKc_Yank1 - cd05578
PKc_STE - cd05122
PTKc_RET - cd05045
STKc_MSK2_N - cd05614
STKc_MSK1_N - cd05613
STKc_MAPK - cd07834
STKc_MAPKKK - cd06606
STKc_CCRK - cd07832
STKc_Cdc7_like - cd06627
STKc_MEKK3 - cd06651
STKc_MAK_like - cd07830
Pkinase - pfam00069
STYKc - smart00221
TyrKc - smart00219
Pkinase_Tyr - pfam07714
PTKc_Tyk2_rpt2 - cd05080
STKc_CMGC - cd05118
STKc_CDK1_like - cd07835
STKc_CDK4_6_like - cd07838
STKc_CDK9_like - cd07840
PTKc_Axl_like - cd05035
STKc_CDK_like - cd07829
PTKc_Srm_Brk - cd05148
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK4 - cd06626
PTKc_Zap-70 - cd05115
STKc_MAPKKK_Bck1_lik - cd06629
STKc_MEKK1 - cd06630
STKc_MEKK1_plant - cd06632
PTKc_Syk - cd05116
STKc_YSK4 - cd06631
PTKc_Fes - cd05084
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Ack_like - cd05040
PTKc - cd00192
PTKc_Aatyk2 - cd05086
PTKc_Fer - cd05085
PTKc_Syk_like - cd05060
PTKc_Fes_like - cd05041
STKc_MAST_like - cd05579
STKc_AGC - cd05123
PKc - cd00180
S_TKc - smart00220


Swiss-Prot Protein: Q13873
Identical to: NP_001195
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
STKc_PAK_IIcd066483.3e-05179505
STKc_myosinIIIAcd066380.00018181471
PTKc_FGFR1cd050980.0009182478
STKc_myosinIIIBcd066394.4e-05182503
STKc_JNK3cd078740.00089184573
STKc_p38gamma_MAPK12cd078800.00099184545
STKc_JNKcd078500.00034185559
STKc_p38cd078510.00016186510
PKc_MKK7cd066180.00058188491
STKc_MAP4K5cd066460.00018190473
STKc_CDK9cd078650.00019190499
PTKc_FGFR4cd050990.00062191524
PTKc_FGFRcd050537.1e-05192454
STKc_PAKcd066143.5e-08193480
STKc_TNIKcd066370.00024193471
STKc_ASKcd066249.6e-06194481
PTKc_ALK_LTKcd050364.3e-06196468
PTKc_Tie2cd050880.00044196494
STKc_MST1_2cd066121.7e-06196446
STKc_CDK10cd078450.00013196509
PTKc_Muskcd050506.1e-07197455
PTKc_Ablcd050524.1e-05197473
PTKc_Trkcd050491.6e-08197503
PTKc_FAKcd050562.4e-07197488
PTK_CCK4cd050460.00021197471
PTKc_InsRcd050611.2e-05197467
PTKc_IGF-1Rcd050621.1e-05197478
PTKc_EphR_A10cd050640.00072197473
PTKc_Frk_likecd050682.1e-05197504
PTKc_Hckcd050730.00033197483
PTKc_Cskcd050828.6e-06197473
PTKc_TrkAcd050920.00047197506
PTKc_Rorcd050481.7e-06197452
PTKc_TrkCcd050940.00038197553
PTKc_DDR2cd050950.00031197503
PTKc_DDR_likecd050974.5e-05197471
PTKc_Lck_Blkcd050678.8e-05197504
PTKc_Lyncd050727e-05197504
PTKc_EphR_A2cd050633.3e-05197473
STKc_TEY_MAPK_plantcd078580.00058197554
STKc_CDK12cd078642e-06197506
PTKc_InsR_likecd050321.1e-07198478
PTKc_Src_likecd050347.5e-06198483
PTKc_EphRcd050334.7e-09198457
PTKc_Jak_rpt2cd050381.3e-10198505
PTKc_Csk_likecd050392.1e-07198456
PTKc_EGFR_likecd050570.00013198481
PTKc_Tec_likecd050592.6e-06198497
PTKc_EphR_Bcd050651.2e-05198505
PTKc_EphR_Acd050660.00029198505
PTKc_Jak1_rpt2cd050790.00025198505
PTKc_Jak2_Jak3_rpt2cd050812.9e-07198505
PTKc_Chkcd050837.8e-06198478
PTKc_EGFRcd051080.00029198522
PTKc_HER2cd051098.3e-05198481
PTKc_Itkcd051121.9e-06198470
PTKc_Tec_Rlkcd051140.00046198470
PTKc_Btk_Bmxcd051132.7e-06198502
PTK_HER3cd051110.00014198481
PTKc_HER4cd051100.00028198509
STKc_phototropin_likcd055740.00024198506
PKc_MKK4cd066160.00053198489
STKc_MAP4K3_likecd066137.6e-06199470
STKc_MST4cd066400.00059199512
STKc_STK25-YSK1cd066420.00077199515
STKc_PCTAIRE_likecd078443.5e-06199503
STKc_PFTAIRE2cd078704.9e-05199525
STKc_PCTAIRE3cd078710.00069199503
STKc_PCTAIRE2cd078720.00018199524
STKc_PCTAIRE1cd078730.00083199506
STKc_Nek6_Nek7cd082240.00016200477
STKc_PDK1cd055812.7e-08201508
STKc_DMPK_likecd055970.001201552
STKc_MASTcd056090.00014201535
STKc_PRKX_likecd056120.00059201509
STKc_myosinIII_likecd066085.5e-05201412
STKc_MST3_likecd066092.5e-05201461
STKc_OSR1_SPAKcd066102.1e-06201446
PKc_MEKcd066158.3e-05201501
PKc_MKK3_6cd066173.6e-05201482
PKc_MAPKK_PBS2_likecd066220.00043201512
PKc_MAPKK_plant_likecd066236.1e-06201512
STKc_MEKK3_likecd066254.3e-06201471
PKc_MAPKKcd066055.2e-05201477
STKc_NAK1_likecd069175.8e-06201509
STKc_CdkB_plantcd078374e-08201503
STKc_CDKL2_3cd078460.00013201505
STKc_CDKL1_4cd078473.8e-05201505
SPS1COG05152.7e-24201693
PTKc_RETcd050450.00051202475
PKc_STEcd051222.5e-07202494
STKc_Yank1cd055788.1e-05202472
STKc_MSK_Ncd055830.00018202498
STKc_MSK1_Ncd056138.9e-05202498
STKc_MSK2_Ncd056140.00038202565
STKc_MAPKKKcd066069.5e-12202446
STKc_Cdc7_likecd066272.5e-09202417
STKc_MEKK3cd066510.00063202483
STKc_CCRKcd078322.2e-07202472
STKc_MAPKcd078340.00017202528
STKc_Pho85cd078360.00013202509
STKc_CDK5cd078395.4e-06202503
STKc_CDK7cd078414.1e-05202502
STKc_CDK8_likecd078420.00019202485
STKc_NLKcd078531.8e-05202592
STKc_MPK1cd078570.00032202510
STKc_CDK2_3cd078606.4e-05202503
STKc_CDK1_eukcd078617.6e-05202503
STKc_CDK4cd078630.00033202503
STKc_Nek2cd082170.00067202429
STKc_Nekcd082158.6e-09202471
STKc_Nek8cd082200.00027202471
STKc_FA2-likecd085293.3e-05202471
STKc_CNK2-likecd085303.4e-05202476
PTKc_Axl_likecd050351.4e-05203505
PTKc_Tyk2_rpt2cd050801.1e-06203506
STKc_CMGCcd051181.6e-06203497
STKc_CDK_likecd078296e-06203497
STKc_CDK1_likecd078353.1e-06203503
STKc_CDK4_6_likecd078387.8e-06203497
STKc_CDK9_likecd078400.00014203505
STKc_MAK_likecd078300.00051203502
PTKc_Srm_Brkcd051485.1e-05204473
STKc_MAPKKK_Byr2_likcd066285.4e-05204481
STKc_MEKK4cd066261.1e-07205505
PTKc_Zap-70cd051154.4e-05206506
PTKccd001921.9e-10207502
PTKc_Ack_likecd050406.8e-07207503
PTKc_Fes_likecd050411e-08207471
PTKc_Aatykcd050423.5e-06207503
PTKc_c-roscd050445e-05207503
PTKc_Syk_likecd050601.1e-06207458
PTKc_Fercd050856.9e-07207471
PTKc_Aatyk2cd050860.00057207503
PTKc_Aatyk1_Aatyk3cd050876.1e-05207471
PTKc_Fescd050840.00012207471
PTKc_Sykcd051160.00039207506
STKc_MAPKKK_Bck1_likcd066291.5e-07207496
STKc_MEKK1cd066301.5e-05207447
STKc_YSK4cd066310.00015207471
STKc_MEKK1_plantcd066325.6e-07207495
PKccd001803.2e-32209504
STKc_AGCcd051235.1e-08209506
STKc_MAST_likecd055793.1e-05209451
Activin_recppfam010642.2e-2832131
Pkinasepfam000691e-38203501
Pkinase_Tyrpfam077144.2e-14203501
TyrKcsmart002196.8e-12203501
STYKcsmart002212.3e-24203485
S_TKcsmart002209.4e-18213506

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_013680Diseasep.ARG491GLNPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_033111Diseasep.ARG899PROPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013681Diseasep.ARG491TRPPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013683Diseasep.ASN519LYSPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013679Diseasep.ASP485GLYPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013673Diseasep.CYS123ARGPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013677Diseasep.CYS420ARGPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013678Diseasep.CYS483ARGPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013674Diseasep.CYS123SERPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013672Diseasep.CYS118TRPPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013671Diseasep.CYS117TYRPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013676Diseasep.CYS347TYRPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013670Diseasep.CYS60TYRPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_033109Diseasep.GLN82HISPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013675Polymorphismp.GLU224ASPN/A
Swiss-ProtVAR_033110Diseasep.GLY182ASPPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_013682Diseasep.LYS512THRPulmonary hypertension, primary, 1 (PPH1)
Swiss-ProtVAR_019996Polymorphismp.SER775ASNN/A
OMIM600799.0013 Diseasep.ARG491GLNPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0018 Diseasep.ARG899PROPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0019 Diseasep.ARG211TERPULMONARY HYPERTENSION, PRIMARY, 1||PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED, INCLUDED
OMIM600799.0017 Diseasep.ARG332TERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0012 Diseasep.ARG873TERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0002 Diseasep.ARG899TERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0008 Diseasep.ARG491TRPPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0027 Diseasep.ASN202TYRPULMONARY VENOOCCLUSIVE DISEASE
OMIM600799.0007 Diseasep.ASP485GLYPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0015 Diseasep.CYS123ARGPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0016 Diseasep.CYS123SERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0011 Diseasep.CYS169TERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0005 Diseasep.CYS118TRPPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0006 Diseasep.CYS347TYRPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0026 Diseasep.GLN433TERPULMONARY HYPERTENSION, PRIMARY, 1, WITH HEREDITARY HEMORRHAGIC TELANGIECTASIA
OMIM600799.0028 Diseasep.GLU195TERPULMONARY VENOOCCLUSIVE DISEASE
OMIM600799.0020 Diseasep.GLY182ASPPULMONARY HYPERTENSION, PRIMARY, FENFLURAMINE-ASSOCIATED
OMIM600799.0003 Diseasep.SER73TERPULMONARY HYPERTENSION, PRIMARY, 1
OMIM600799.0022 Diseasep.TYR40TERPULMONARY VENOOCCLUSIVE DISEASE



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