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Results for the Protein: Q92851
12644463
843

CASPA_HUMAN RecName: Full=Caspase-10; Short=CASP-10; AltName: Full=Apoptotic protease Mch-4; AltName: Full=FAS-associated death domain protein interleukin-1B-converting enzyme 2; Short=FLICE2; AltName: Full=ICE-like apoptotic protease 4; Contains: RecName: Full=Caspase-10 subunit p23/17; Contains: RecName: Full=Caspase-10 subunit p12; Flags: Precursor

Known Diseases associated with this Protein:
  AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME 2A (ALPS2A)
  AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
  FAMILIAL NON-HODGKIN LYMPHOMA (NHL)
  GASTRIC CANCER (GASC)
  GASTRIC CANCER, SOMATIC
  GASTRIC CANCER, SOMATIC, INCLUDED
  NON-HODGKIN LYMPHOMA, SOMATIC
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

DED - smart00031
DED_Caspase_10_repea - cd08341
DED_FADD - cd08336
DED - pfam01335
DED_Caspase_8_10_rep - cd08792
DED_Caspase_8_repeat - cd08333
DED - cd00045
DED_Caspase-like_rep - cd08776
DED_Caspase_10_repea - cd08814
DED_Caspase_8_10_rep - cd08334
DED_Caspase_8_repeat - cd08813
CASc - cd00032
CASc - smart00115
Peptidase_C14 - pfam00656


Swiss-Prot Protein: Q92851
Identical to: NP_116756
   Default View:










Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
DED_FADDcd083363e-061899
DED_Caspase_10_repeacd083411.4e-581899
DEDcd000451.4e-112096
DED_Caspase_8_repeatcd083331.4e-1020100
DED_Caspase-like_repcd087760.000462095
DED_Caspase_8_10_repcd087921e-222096
DED_Caspase_8_10_repcd083341.9e-35112190
DED_Caspase_8_repeatcd088133.4e-06112190
DED_Caspase_10_repeacd088144.1e-54112190
DEDcd000459.5e-07115182
CASccd000323.8e-98275510
DEDpfam013358.1e-2720102
DEDpfam013352.8e-27115193
Peptidase_C14pfam006562.2e-54284508
DEDsmart000314.9e-281897
DEDsmart000319.4e-25113188
CAScsmart001152.3e-113276517

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_037430Diseasep.ALA414VALFamilial non-Hodgkin lymphoma (NHL)
Swiss-ProtVAR_065234Polymorphismp.ARG21CYSN/A
Swiss-ProtVAR_037429Diseasep.ILE406LEUAutoimmune lymphoproliferative syndrome 2A (ALPS2A)
Swiss-ProtVAR_014071Diseasep.LEU285PHEAutoimmune lymphoproliferative syndrome 2A (ALPS2A)
Swiss-ProtVAR_065235Polymorphismp.LEU285PRON/A
Swiss-ProtVAR_065233Polymorphismp.LYS14THRN/A
Swiss-ProtVAR_037428Diseasep.MET147THRGastric cancer (GASC)
Swiss-ProtVAR_055362Polymorphismp.PRO444SERN/A
Swiss-ProtVAR_055361Polymorphismp.SER239CYSN/A
dbSNPrs17860405 Polymorphismp.TYR446CYSN/A
dbSNPrs13010627 Polymorphismp.VAL410ILEN/A
OMIM601762.0003 Diseasep.ALA414VALNON-HODGKIN LYMPHOMA, SOMATIC
OMIM601762.0004 Diseasep.GLN257TERNON-HODGKIN LYMPHOMA, SOMATIC||GASTRIC CANCER, SOMATIC, INCLUDED
OMIM601762.0007 Diseasep.ILE406LEUAUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
OMIM601762.0001 Diseasep.LEU285PHEAUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
OMIM601762.0006 Diseasep.MET147THRGASTRIC CANCER, SOMATIC



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