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Results for the Protein: P16234
129892

PGFRA_HUMAN RecName: Full=Platelet-derived growth factor receptor alpha; Short=PDGF-R-alpha; Short=PDGFR-alpha; AltName: Full=Alpha platelet-derived growth factor receptor; AltName: Full=Alpha-type platelet-derived growth factor receptor; AltName: Full=CD140 antigen-like family member A; AltName: Full=CD140a antigen; AltName: Full=Platelet-derived growth factor alpha receptor; AltName: Full=Platelet-derived growth factor receptor 2; Short=PDGFR-2; AltName: CD_antigen=CD140a; Flags: Precursor

Known Diseases associated with this Protein:
  GASTROINTESTINAL STROMAL TUMOR (GIST)
  GASTROINTESTINAL STROMAL TUMOR, FAMILIAL
  GASTROINTESTINAL STROMAL TUMOR, FAMILIAL, INCLUDED
  GASTROINTESTINAL STROMAL TUMOR, SOMATIC
  HYPEREOSINOPHILIC SYNDROME, IDIOPATHIC, RESISTANT TO IMATINIB
  VARIANT OF UNKNOWN SIGNIFICANCE
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21
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2
20
Tips:
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Default View:

IG - smart00409
IG_like - smart00410
IGc2 - smart00408
Ig1_VEGFR - cd05862
Ig1_PDGFR-alphabeta - cd05861
Ig1_VEGFR_like - cd05742
Ig4_PDGFR-alpha - cd05859
Ig4_SCFR_like - cd04975
Ig4_SCFR - cd05860
I-set - pfam07679
Ig2_VEGFR - cd04976
Ig - cd00096
Ig_TrkABC_d4 - cd04972
PTKc_CSF-1R - cd05106
PTKc_Kit - cd05104
PTKc_PDGFR_alpha - cd05105
PTKc_PDGFR - cd05055
PTKc_PDGFR_beta - cd05107
PTKc_FGFR1 - cd05098
PTKc_FGFR2 - cd05101
PTKc_EGFR_like - cd05057
PTKc_FGFR - cd05053
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
PTKc_VEGFR2 - cd05103
PTKc_VEGFR - cd05054
PTKc_VEGFR3 - cd05102
PTKc_Csk - cd05082
PTKc_Hck - cd05073
PTKc_Tie1 - cd05089
PTKc_Lyn - cd05072
PTKc_Srm_Brk - cd05148
PTKc_Chk - cd05083
PTKc_ALK_LTK - cd05036
PTKc_Abl - cd05052
PTKc_Fyn_Yrk - cd05070
PTKc_Csk_like - cd05039
PTKc_Src_like - cd05034
PTKc_InsR_like - cd05032
PTKc_IGF-1R - cd05062
PTKc_InsR - cd05061
PTKc_Src - cd05071
PTKc_FAK - cd05056
PTKc_Yes - cd05069
PTKc_Frk_like - cd05068
PTKc_Lck_Blk - cd05067
PTKc_Ror2 - cd05091
PTKc_DDR2 - cd05095
PTKc_EphR_A10 - cd05064
PTKc_DDR_like - cd05097
PTKc_TrkA - cd05092
PTKc_TrkB - cd05093
PTKc_Ror - cd05048
PTK_CCK4 - cd05046
PTKc_DDR - cd05051
PTKc_Musk - cd05050
PTKc_Ror1 - cd05090
PTKc_TrkC - cd05094
PTKc_Trk - cd05049
PTKc_DDR1 - cd05096
PTKc_Tec_Rlk - cd05114
PTKc_EphR_B - cd05065
PTKc_EphR - cd05033
PTKc_Jak_rpt2 - cd05038
PTKc_EphR_A - cd05066
PTKc_Tie2 - cd05088
PTKc_Btk_Bmx - cd05113
STKc_myosinIII_like - cd06608
STKc_PDK1 - cd05581
SPS1 - COG0515
STKc_Cdc7_like - cd06627
PTKc_RET - cd05045
STKc_Nek - cd08215
STKc_MAPKKK - cd06606
Pkinase_Tyr - pfam07714
TyrKc - smart00219
STYKc - smart00221
Pkinase - pfam00069
PTKc_Tyro3 - cd05074
PTKc_Tec_like - cd05059
PTKc_Axl - cd05075
PTKc_Axl_like - cd05035
PTKc - cd00192
PTKc_Syk_like - cd05060
PTKc_Tie - cd05047
PTKc_c-ros - cd05044
PTKc_Fes_like - cd05041
PTKc_Fer - cd05085
PTKc_Aatyk2 - cd05086
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Aatyk - cd05042
PKc - cd00180
STKc_AGC - cd05123
S_TKc - smart00220
STKc_Nek11 - cd08222
STKc_Nek10 - cd08528
PTKc_Met_Ron - cd05058
PTKc_Jak1_rpt2 - cd05079
STKc_PAK_II - cd06648
PTK_HER3 - cd05111
PTKc_HER2 - cd05109
PTKc_HER4 - cd05110
PTKc_EGFR - cd05108
STKc_Nek6 - cd08228
PTKc_Itk - cd05112
PTKc_Jak2_Jak3_rpt2 - cd05081
STKc_MST4 - cd06640
STKc_CdkB_plant - cd07837
STKc_CDK4 - cd07863
STKc_Nek7 - cd08229
STKc_PCTAIRE_like - cd07844
STKc_nPKC_theta - cd05619
PKc_MAPKK_PBS2_like - cd06622
STKc_CDKL1_4 - cd07847
STKc_Pho85 - cd07836
STKc_MAPKKK_Byr2_lik - cd06628
PKc_MKK7 - cd06618
PTKc_EphR_A2 - cd05063
STKc_SLK_like - cd06611
STKc_CDK5 - cd07839
PTK_Jak1_rpt1 - cd05077
STKc_CDK12 - cd07864
PTK_Jak_rpt1 - cd05037
STKc_Nek8 - cd08220
PTK_Ryk - cd05043
STKc_MAP4K3_like - cd06613
STKc_Nek6_Nek7 - cd08224
STKc_CDKL2_3 - cd07846
STKc_MEKK3_like - cd06625
STKc_OSR1_SPAK - cd06610
STKc_Nek2 - cd08217
STKc_Nek4 - cd08223
STKc_MPK1 - cd07857
STKc_FA2-like - cd08529
STKc_Nek3 - cd08219
STKc_CNK2-like - cd08530
STKc_PKN - cd05589
STKc_MOK - cd07831
STKc_CMGC - cd05118
PTKc_Zap-70 - cd05115
STKc_nPKC_theta_delt - cd05592
STKc_MEKK1_plant - cd06632
PTKc_Syk - cd05116
PTKc_Fes - cd05084
STKc_YPK1_like - cd05585
PTK_Jak2_Jak3_rpt1 - cd05078
STKc_MEKK1 - cd06630
STKc_CDKL - cd07833
STKc_MAPKKK_Bck1_lik - cd06629
PTKc_Ack_like - cd05040
STKc_MAPK - cd07834
STKc_CDK_like - cd07829
PTKc_Tyk2_rpt2 - cd05080
STKc_YSK4 - cd06631
STKc_CDK7 - cd07841
STKc_Nek9 - cd08221
STKc_NAK1_like - cd06917
PKc_STE - cd05122
STKc_PAK - cd06614
STKc_MAPK15 - cd07852
PKc_MKK4 - cd06616
PKc_MAPKK_plant_like - cd06623
STKc_MEKK4 - cd06626
STKc_CDC2L1 - cd07843
STKc_MST3_like - cd06609
STKc_MST1_2 - cd06612
STKc_Yank1 - cd05578
STKc_CDK9_like - cd07840
STKc_MAST_like - cd05579
STKc_PKC - cd05570


Swiss-Prot Protein: P16234
Identical to: NP_006197
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
Ig1_VEGFR_likecd057428.6e-41228308
Ig1_PDGFR-alphabetacd058614.8e-58228311
Ig1_VEGFRcd058620.00012228311
Ig4_SCFR_likecd049753e-57313413
Ig4_SCFRcd058602.5e-06313415
Ig4_PDGFR-alphacd058591.6e-74313413
Ig2_VEGFRcd049760.00096333411
Igcd000965.7e-06335408
Ig_TrkABC_d4cd049723.2e-33415497
PTKc_CSF-1Rcd051061.2e-174552955
PTKc_PDGFRcd05055555954
PTKc_Kitcd051049.8e-180555954
PTKc_PDGFR_alphacd05105555956
PTKc_PDGFR_betacd051071e-241555955
PTKc_FGFR1cd050982.7e-83575961
PTKc_FGFR2cd051011.1e-79577961
PTKc_EGFR_likecd050573.5e-29578962
PTKc_FGFRcd050533.2e-111580955
PTKc_FGFR3cd051005.8e-70580989
PTKc_FGFR4cd050991.5e-81580975
PTKc_VEGFRcd050542e-150585957
PTKc_VEGFR3cd051026.7e-136585957
PTKc_VEGFR2cd051032.1e-125585957
PTKc_InsR_likecd050322.1e-48586955
PTKc_Src_likecd050341.7e-51586953
PTKc_ALK_LTKcd050362.5e-41586952
PTKc_Csk_likecd050393.7e-35586953
PTKc_Ablcd050521.9e-42586954
PTKc_InsRcd050611.4e-30586962
PTKc_IGF-1Rcd050624e-30586952
PTKc_FAKcd050561.9e-39586958
PTKc_Lck_Blkcd050676.4e-34586953
PTKc_Frk_likecd050683.5e-47586953
PTKc_Yescd050697e-27586953
PTKc_Srccd050711.7e-27586955
PTKc_Fyn_Yrkcd050706.7e-30586953
PTKc_Lyncd050726.2e-34586953
PTKc_Hckcd050732.1e-36586953
PTKc_Cskcd050824.1e-35586953
PTKc_Tie1cd050891.8e-42586978
PTKc_Chkcd050832.8e-41586953
PTKc_Srm_Brkcd051481.8e-37586953
PTKc_Trkcd050498.3e-40587955
PTKc_Muskcd050507.9e-53587952
PTKc_DDRcd050519e-18587952
PTKc_Rorcd050481.2e-32587953
PTK_CCK4cd050468e-17587952
PTKc_TrkAcd050926.5e-32587956
PTKc_TrkBcd050939.8e-25587968
PTKc_TrkCcd050942e-12587964
PTKc_Ror1cd050903.1e-18587953
PTKc_DDR1cd050969e-27587952
PTKc_DDR_likecd050973.2e-26587952
PTKc_Ror2cd050918.1e-21587953
PTKc_DDR2cd050954.5e-24587952
PTKc_EphR_A10cd050641.7e-09587954
PTKc_Jak_rpt2cd050383.2e-31588954
PTKc_EphRcd050331.3e-21588954
PTKc_EphR_Bcd050655.8e-17588954
PTKc_EphR_Acd050666e-19588954
PTKc_Tie2cd050884.2e-38588979
PTKc_Btk_Bmxcd051134.9e-37588951
PTKc_Tec_Rlkcd051142.4e-29588951
STKc_myosinIII_likecd066082.4e-05589949
STKc_PDK1cd055814.2e-07591944
SPS1COG05156e-105911089
PTKc_RETcd050456.8e-83592957
STKc_MAPKKKcd066063.9e-13592944
STKc_Cdc7_likecd066271.8e-08592943
STKc_Nekcd082153.9e-08592950
PTKc_Axl_likecd050356.2e-41593954
PTKc_Tec_likecd050593.6e-28593951
PTKc_Tyro3cd050747e-39593954
PTKc_Axlcd050755.7e-34593954
PTKccd001921.4e-135597954
PTKc_Fes_likecd050416.8e-36597952
PTKc_c-roscd050442.4e-37597952
PTKc_Tiecd050471.6e-48597955
PTKc_Syk_likecd050608e-26597955
PTKc_Fercd050852e-37597955
PTKc_Aatyk2cd050860.00013597952
PTKc_Aatyk1_Aatyk3cd050871.3e-06597952
PKccd001801.6e-34599953
PTKc_Aatykcd050424.1e-10599956
STKc_AGCcd051234.1e-07599944
STKc_Nek11cd082220.0002671955
STKc_Nek10cd085280.00083675952
PTKc_Met_Roncd050583.7e-39684956
PTKc_Jak1_rpt2cd050799.3e-19684954
STKc_PAK_IIcd066480.00039690954
PTK_HER3cd051111.8e-14691966
PTKc_EGFRcd051082.9e-14694996
PTKc_HER2cd051092.8e-16694966
PTKc_HER4cd051101.3e-10694998
STKc_Nek6cd082280.00044694955
PTKc_Jak2_Jak3_rpt2cd050811.3e-14697954
PTKc_Itkcd051122e-29697951
STKc_MST4cd066400.00065697974
STKc_CdkB_plantcd078370.00032699945
STKc_CDK4cd078630.00056700977
STKc_Nek7cd082291.8e-06702955
STKc_nPKC_thetacd056194.5e-057031021
STKc_PCTAIRE_likecd078440.00038703993
PKc_MAPKK_PBS2_likecd066220.000127061010
STKc_Pho85cd078360.00026706993
STKc_CDKL1_4cd078470.00012706993
STKc_MAPKKK_Byr2_likcd066286.3e-06707954
PTKc_EphR_A2cd050631e-20709954
PKc_MKK7cd066180.0004709964
STKc_SLK_likecd066116.6e-05710964
STKc_CDK5cd078390.00029710993
PTK_Jak1_rpt1cd050772.5e-05711950
STKc_CDK12cd078640.00041713950
PTK_Jak_rpt1cd050374.3e-06715950
STKc_Nek8cd082200.00092715950
PTK_Rykcd050433.9e-19716953
STKc_MAP4K3_likecd066139.8e-05716950
STKc_Nek6_Nek7cd082248.7e-05717955
STKc_OSR1_SPAKcd066101.4e-05718944
STKc_MEKK3_likecd066250.0009718952
STKc_CDKL2_3cd078461.5e-05718950
STKc_MPK1cd078570.0001719981
STKc_Nek3cd082199.9e-06719954
STKc_Nek4cd082230.00042719949
STKc_Nek2cd082171.3e-05719950
STKc_FA2-likecd085298.1e-05719949
STKc_CNK2-likecd085305.4e-05719950
STKc_CMGCcd051181.6e-07720959
STKc_PKNcd055899.4e-057201019
STKc_MOKcd078317.4e-05720943
PTKc_Sykcd051163.2e-25721959
PTKc_Zap-70cd051154.6e-23721955
STKc_nPKC_theta_deltcd055927e-057211021
STKc_MEKK1_plantcd066329e-06721949
PTKc_Fescd050843.8e-28723955
STKc_YPK1_likecd055850.000877231018
PTK_Jak2_Jak3_rpt1cd050787.1e-05726951
STKc_MEKK1cd066300.00054727946
STKc_MAPKKK_Bck1_likcd066295.4e-06727944
STKc_CDKLcd078330.00099727943
PTKc_Ack_likecd050402.5e-21728955
STKc_MAPKcd078340.00038730985
PTKc_Tyk2_rpt2cd050801.1e-10731955
STKc_CDK_likecd078291.5e-07731943
STKc_YSK4cd066311.2e-05735954
STKc_CDK7cd078417.1e-05741955
STKc_Nek9cd082216.4e-05741955
STKc_NAK1_likecd069173e-06744981
PKc_STEcd051223.1e-08745948
STKc_PAKcd066143.9e-07746961
STKc_MAPK15cd078527.4e-05749998
PKc_MKK4cd066160.001753977
PKc_MAPKK_plant_likecd066231.2e-05755964
STKc_MEKK4cd066268.3e-05758944
STKc_CDC2L1cd078430.00025759943
STKc_MST3_likecd066095.4e-05760962
STKc_MST1_2cd066123.3e-05766944
STKc_Yank1cd055788.1e-05767953
STKc_CDK9_likecd078409.4e-06768943
STKc_MAST_likecd055790.00036769943
STKc_PKCcd055700.00019771994
Pkinasepfam000692.7e-14593950
IGsmart004092.4e-07220310
IG_likesmart004102.4e-07220310
IGc2smart004080.001227297
I-setpfam076798.9e-06319413
IGsmart004091.1e-05322412
IG_likesmart004101.1e-05322412
Pkinase_Tyrpfam077141.7e-189593953
TyrKcsmart002191.1e-132593950
STYKcsmart002217.4e-43593923
S_TKcsmart002204.1e-24603954

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_042034Polymorphismp.ARG764CYSN/A
dbSNPrs77524207 Polymorphismp.ARG340GLNN/A
Swiss-ProtVAR_066460Polymorphismp.ARG481GLYN/A
Swiss-ProtVAR_066469Polymorphismp.ARG748GLYN/A
Swiss-ProtVAR_066466Polymorphismp.ASN659LYSN/A
Swiss-ProtVAR_066467Polymorphismp.ASN659SERN/A
Swiss-ProtVAR_042037Polymorphismp.ASP1071ASNN/A
Swiss-ProtVAR_066472Polymorphismp.ASP842TYRN/A
Swiss-ProtVAR_066471Polymorphismp.ASP842VALN/A
Swiss-ProtVAR_042036Polymorphismp.GLU996LYSN/A
Swiss-ProtVAR_042035Polymorphismp.GLY829ARGN/A
Swiss-ProtVAR_042033Polymorphismp.GLY426ASPN/A
Swiss-ProtVAR_042032Polymorphismp.GLY79ASPN/A
Swiss-ProtVAR_066464Polymorphismp.HIS570ARGN/A
Swiss-ProtVAR_066465Polymorphismp.HIS650GLNN/A
Swiss-ProtVAR_066463Polymorphismp.ILE562METN/A
Swiss-ProtVAR_066461Polymorphismp.LEU507PRON/A
Swiss-ProtVAR_066468Polymorphismp.LEU705PRON/A
dbSNPrs35597368 Polymorphismp.SER478PRON/A
Swiss-ProtVAR_066474Diseasep.TYR849CYSGastrointestinal stromal tumor (GIST)
Swiss-ProtVAR_066475Polymorphismp.TYR849SERN/A
Swiss-ProtVAR_066462Polymorphismp.VAL561ASPN/A
OMIM173490.0011 Diseasep.ALA401ASPVARIANT OF UNKNOWN SIGNIFICANCE
OMIM173490.0009 Diseasep.ASP846TYRGASTROINTESTINAL STROMAL TUMOR, FAMILIAL
OMIM173490.0001 Diseasep.ASP842VALGASTROINTESTINAL STROMAL TUMOR, SOMATIC
OMIM173490.0008 Diseasep.THR674ILEHYPEREOSINOPHILIC SYNDROME, IDIOPATHIC, RESISTANT TO IMATINIB
OMIM173490.0013 Diseasep.THR1052METVARIANT OF UNKNOWN SIGNIFICANCE
OMIM173490.0010 Diseasep.TYR555CYSGASTROINTESTINAL STROMAL TUMOR, FAMILIAL
OMIM173490.0012 Diseasep.VAL544ALAVARIANT OF UNKNOWN SIGNIFICANCE
OMIM173490.0004 Diseasep.VAL561ASPGASTROINTESTINAL STROMAL TUMOR, SOMATIC||GASTROINTESTINAL STROMAL TUMOR, FAMILIAL, INCLUDED



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