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Results for the Protein: P01116
131875

RASK_HUMAN RecName: Full=GTPase KRas; AltName: Full=K-Ras 2; AltName: Full=Ki-Ras; AltName: Full=c-K-ras; AltName: Full=c-Ki-ras; Contains: RecName: Full=GTPase KRas, N-terminally processed; Flags: Precursor

Known Diseases associated with this Protein:
  BLADDER CANCER, SOMATIC, INCLUDED
  BLADDER CANCER, TRANSITIONAL CELL, SOMATIC
  BREAST ADENOCARCINOMA, SOMATIC
  CARDIOFACIOCUTANEOUS SYNDROME 2
  CARDIOFACIOCUTANEOUS SYNDROME 2 (CFC2)
  EPIDERMAL NEVUS, SOMATIC, INCLUDED;;
  GASTRIC CANCER (GASC)
  GASTRIC CANCER, SOMATIC
  GASTRIC CANCER, SOMATIC, INCLUDED;;
  LUNG CANCER, SOMATIC
  LUNG CANCER, SQUAMOUS CELL, SOMATIC
  NEVUS SEBACEOU
  NEVUS SEBACEOUS, SOMATIC, INCLUDED
  NOONAN SYNDROME 3
  NOONAN SYNDROME 3 (NS3)
  PANCREATIC CARCINOMA, SOMATIC
  PILOCYTIC ASTROCYTOMA, SOMATIC
36
11
20
0
27
Tips:
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Default View:

small_GTPase - smart00010
Rab2 - cd01866
COG1100 - COG1100
Rab30 - cd04114
RhoG - cd01875
Rit_Rin_Ric - cd04141
M_R_Ras_like - cd04145
RhoBTB - cd01873
Rab8_Rab10_Rab13_lik - cd01867
H_N_K_Ras_like - cd04138
RheB - cd04137
ARHI_like - cd04140
RSR1 - cd04177
Rap_like - cd04136
Rap2 - cd04176
Rap1 - cd04175
RhoA_like - cd01870
Rab3 - cd01865
Rop_like - cd04133
Rab5_related - cd01860
Rac1_like - cd01871
Rnd - cd04131
Cdc42 - cd01874
Rho2 - cd04129
Rab21 - cd04123
RabL2 - cd04124
Rab14 - cd04122
Rab24 - cd04118
Rab15 - cd04117
- cd04125
RJL - cd04119
Rab12 - cd04120
RRP22 - cd04142
RAS - smart00173
RAB - smart00175
Rab9 - cd04116
RGK - cd04148
Rhes_like - cd04143
Rho4_like - cd04132
Tc10 - cd04135
RalA_RalB - cd04139
Wrch_1 - cd04130
Rab28 - cd04109
Rab7 - cd01862
Rab18 - cd01863
Rab19 - cd01864
Rab6 - cd01861
Rab33B_Rab33A - cd04115
Ran - cd00877
Rab - cd00154
Rho - cd00157
Rab11_like - cd01868
Rab1_Ypt1 - cd01869
Rab39 - cd04111
Rab26 - cd04112
Rab4 - cd04113
Rab35 - cd04110
RabL4 - cd04101
Centaurin_gamma - cd04103
Rab23_like - cd04106
Rab32_Rab38 - cd04107
Rab36_Rab34 - cd04108
Ras - pfam00071
Miro - pfam08477
Ras_dva - cd04147
Ras - cd00876
Rab27A - cd04127
Miro1 - cd01893
Arf_Arl - cd00878
RERG_RasL11_like - cd04146
Rho3 - cd04134
Ras2 - cd04144
RHO - smart00174
Era_like - cd00880
Ras_like_GTPase - cd00882
RAN - smart00176


Swiss-Prot Protein: P01116
Identical to: NP_203524
   Default View:














































































Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
Rab2cd018661.6e-301166
RhoGcd018751.4e-181183
Rab30cd041143.5e-181164
COG1100COG11004.8e-401188
Rab8_Rab10_Rab13_likcd018672.8e-372166
RhoBTBcd018730.000572163
Rit_Rin_Riccd041411.1e-722172
M_R_Ras_likecd041451.4e-832164
Rab5_relatedcd018605.7e-213164
Rab3cd018651.4e-203166
RhoA_likecd018701.3e-193164
Rac1_likecd018716.8e-193179
Cdc42cd018746.1e-133163
Rho2cd041291.8e-133183
Rndcd041310.000273165
Rop_likecd041333.2e-093167
Rap_likecd041368.3e-923164
RheBcd041377.6e-523189
H_N_K_Ras_likecd041383.2e-1133164
ARHI_likecd041405.1e-373164
Rap1cd041752.2e-773165
Rap2cd041765.2e-693164
RSR1cd041777e-573189
Rhocd001578.5e-294162
Rabcd001548.3e-494161
Rancd008773.2e-134171
Rab6cd018612.1e-224163
Rab7cd018628.2e-174169
Rab18cd018631e-284163
Rab19cd018645.5e-124163
Rab11_likecd018682.3e-244164
Rab1_Ypt1cd018693.8e-354166
Centaurin_gammacd041031.9e-054163
Rab23_likecd041069.4e-214163
Rab32_Rab38cd041074.5e-124180
Rab36_Rab34cd041087e-054181
RabL4cd041014.6e-124164
Rab28cd041092.9e-104189
Rab35cd041104.8e-224188
Rab39cd041112.3e-104180
Rab26cd041121.4e-104186
Rab4cd041132.4e-144163
Rab33B_Rab33Acd041152e-214165
Rab9cd041161.6e-214163
Rab15cd041173e-204163
Rab24cd041182.8e-084186
RJLcd041196.3e-114165
Rab12cd041201.5e-054186
Rab14cd041225.3e-244166
Rab21cd041232.8e-234164
RabL2cd041241.6e-064167
cd041251.5e-144189
Wrch_1cd041301.1e-124163
Rho4_likecd041322.5e-154189
Tc10cd041351.8e-124160
RalA_RalBcd041391.9e-1044166
RRP22cd041421.4e-074189
Rhes_likecd041431.3e-134189
RGKcd041484.3e-094188
Rascd008761.9e-1005163
Arf_Arlcd008784.4e-055162
Miro1cd018937.7e-065158
Rab27Acd041279.9e-205168
Rho3cd041341.5e-075183
Ras2cd041447.9e-765189
RERG_RasL11_likecd041469.9e-335165
Ras_dvacd041475.2e-155189
Era_likecd008805.3e-058167
Ras_like_GTPasecd008825.5e-578161
Raspfam000711.8e-955165
small_GTPasesmart000105.3e-551171
RASsmart001733.5e-1214166
RABsmart001752.6e-384166
Miropfam084776.4e-195119
RHOsmart001742.6e-126166
RANsmart001768.4e-059189

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_036308Polymorphismp.ALA146THRN/A
Swiss-ProtVAR_016030Diseasep.ALA59THRGastric cancer (GASC)
Swiss-ProtVAR_064851Diseasep.GLN22ARGNoonan syndrome 3 (NS3)
Swiss-ProtVAR_036306Polymorphismp.GLN61ARGN/A
Swiss-ProtVAR_064850Diseasep.GLN22GLUCardiofaciocutaneous syndrome 2 (CFC2)
Swiss-ProtVAR_006841Polymorphismp.GLN61HISN/A
Swiss-ProtVAR_036305Polymorphismp.GLY12ALAN/A
Swiss-ProtVAR_016027Polymorphismp.GLY12ARGN/A
Swiss-ProtVAR_065145Polymorphismp.GLY13ARGN/A
Swiss-ProtVAR_026112Diseasep.GLY60ARGCardiofaciocutaneous syndrome 2 (CFC2)
Swiss-ProtVAR_016026Polymorphismp.GLY12ASPN/A
Swiss-ProtVAR_016029Diseasep.GLY13ASPGastric cancer (GASC)
Swiss-ProtVAR_006839Polymorphismp.GLY12CYSN/A
Swiss-ProtVAR_016028Polymorphismp.GLY12SERN/A
Swiss-ProtVAR_065146Diseasep.GLY60SERNoonan syndrome 3 (NS3)
Swiss-ProtVAR_006840Polymorphismp.GLY12VALN/A
Swiss-ProtVAR_064854Diseasep.ILE36METNoonan syndrome 3 (NS3)
Swiss-ProtVAR_036307Polymorphismp.LYS117ASNN/A
Swiss-ProtVAR_064849Diseasep.LYS5ASNGastric cancer (GASC)
Swiss-ProtVAR_069785Diseasep.LYS147GLUCardiofaciocutaneous syndrome 2 (CFC2)
Swiss-ProtVAR_065144Diseasep.LYS5GLUNoonan syndrome 3 (NS3)
Swiss-ProtVAR_026110Diseasep.PRO34ARGCardiofaciocutaneous syndrome 2 (CFC2)
Swiss-ProtVAR_064853Diseasep.PRO34GLNNoonan syndrome 3 (NS3)
Swiss-ProtVAR_064852Diseasep.PRO34LEUNoonan syndrome 3 (NS3)
Swiss-ProtVAR_026111Diseasep.THR58ILENoonan syndrome 3 (NS3)
Swiss-ProtVAR_069784Diseasep.TYR71HISCardiofaciocutaneous syndrome 2 (CFC2)
Swiss-ProtVAR_026109Diseasep.VAL14ILENoonan syndrome 3 (NS3)
OMIM190070.0004 Diseasep.ALA59THRBLADDER CANCER, TRANSITIONAL CELL, SOMATIC
OMIM190070.0010 190070.0015 Diseasep.ASP153VALNOONAN SYNDROME 3
OMIM190070.0002 Diseasep.GLY12ARGLUNG CANCER, SQUAMOUS CELL, SOMATIC||BLADDER CANCER, SOMATIC, INCLUDED
OMIM190070.0016 Diseasep.GLY13ARGPILOCYTIC ASTROCYTOMA, SOMATIC
OMIM190070.0009 Diseasep.GLY60ARGCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0005 Diseasep.GLY12ASPPANCREATIC CARCINOMA, SOMATIC||GASTRIC CANCER, SOMATIC, INCLUDED;;||EPIDERMAL NEVUS, SOMATIC, INCLUDED;;||NEVUS SEBACEOU
OMIM190070.0003 Diseasep.GLY13ASPBREAST ADENOCARCINOMA, SOMATIC
OMIM190070.0001 Diseasep.GLY12CYSLUNG CANCER, SOMATIC
OMIM190070.0007 Diseasep.GLY12SERGASTRIC CANCER, SOMATIC
OMIM190070.0020 Diseasep.GLY60SERNOONAN SYNDROME 3
OMIM190070.0006 Diseasep.GLY12VALPANCREATIC CARCINOMA, SOMATIC||NEVUS SEBACEOUS, SOMATIC, INCLUDED
OMIM190070.0017 Diseasep.LYS5ASNCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0022 Diseasep.LYS147GLUCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0019 Diseasep.LYS5GLUNOONAN SYNDROME 3
OMIM190070.0018 Diseasep.PHE156LEUCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0013 Diseasep.PRO34ARGCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0011 Diseasep.THR58ILENOONAN SYNDROME 3
OMIM190070.0021 Diseasep.TYR71HISCARDIOFACIOCUTANEOUS SYNDROME 2
OMIM190070.0014 Diseasep.VAL152GLYNOONAN SYNDROME 3
OMIM190070.0012 Diseasep.VAL14ILENOONAN SYNDROME 3



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