Results for the protein: P01111

Results for the Protein: P01111

131883

4893

NRAS

NCBI, UniProt

RASN_HUMAN RecName: Full=GTPase NRas; AltName: Full=Transforming protein N-Ras; Flags: Precursor

Known Diseases associated with this Protein:
  AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME 4 (ALPS4)
  AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IV
  EPIDERMAL NEVUS, SOMATIC
  EPIDERMAL NEVUS, SOMATIC, INCLUDED
  JUVENILE MYELOMONOCYTIC LEUKEMIA, INCLUDED;;
  NOONAN SYNDROME 6
  NOONAN SYNDROME 6 (NS6)
  NOONAN SYNDROME 6, INCLU
  RECTAL CANCER, SOMATIC
  THYROID CARCINOMA, FOLLICULAR, SOMATIC

10

4

7

0

7

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Swiss-Prot Protein: P01111

Identical to: NP_002515

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
RhoG	cd01875	5.5e-18	1	184
Rab30	cd04114	2.5e-17	1	164
COG1100	COG1100	1.1e-38	1	183
Rab8_Rab10_Rab13_lik	cd01867	2e-35	2	166
RhoBTB	cd01873	0.00011	2	163
Rit_Rin_Ric	cd04141	5.3e-72	2	172
M_R_Ras_like	cd04145	4.7e-82	2	164
Rab5_related	cd01860	2.6e-20	3	164
Rab3	cd01865	4.4e-20	3	166
RhoA_like	cd01870	2.8e-20	3	164
Rac1_like	cd01871	3.1e-18	3	163
Cdc42	cd01874	3.3e-12	3	163
Rop_like	cd04133	2.6e-09	3	167
Rap_like	cd04136	3.4e-90	3	164
RheB	cd04137	2.9e-49	3	189
H_N_K_Ras_like	cd04138	3.9e-113	3	164
ARHI_like	cd04140	1.7e-35	3	164
Rap1	cd04175	5e-75	3	165
Rap2	cd04176	6.4e-68	3	164
RSR1	cd04177	9.9e-56	3	189
Rho2	cd04129	3.2e-12	3	189
Rnd	cd04131	7.4e-05	3	165
Rab	cd00154	1.4e-48	4	161
Rho	cd00157	6.8e-29	4	162
Ran	cd00877	6.2e-13	4	171
Rab6	cd01861	1.5e-21	4	163
Rab7	cd01862	4.2e-17	4	169
Rab18	cd01863	2.9e-28	4	163
Rab19	cd01864	2e-10	4	163
Rab11_like	cd01868	1.7e-23	4	164
Rab1_Ypt1	cd01869	5e-34	4	166
RabL4	cd04101	1.9e-09	4	164
Centaurin_gamma	cd04103	4e-05	4	163
Rab23_like	cd04106	2.5e-21	4	163
Rab32_Rab38	cd04107	1.7e-12	4	181
Rab36_Rab34	cd04108	0.00014	4	187
Rab28	cd04109	1.8e-09	4	189
Rab35	cd04110	4e-20	4	188
Rab39	cd04111	2.9e-09	4	181
Rab26	cd04112	7e-10	4	186
Rab4	cd04113	2.3e-14	4	163
Rab33B_Rab33A	cd04115	2.1e-20	4	165
Rab9	cd04116	3.5e-21	4	163
Rab15	cd04117	6e-19	4	163
Rab24	cd04118	8e-08	4	186
RJL	cd04119	4.8e-11	4	165
Rab12	cd04120	9.1e-05	4	187
Tc10	cd04135	7.4e-13	4	160
RalA_RalB	cd04139	5.8e-105	4	166
RRP22	cd04142	7.3e-07	4	189
RGK	cd04148	2.7e-08	4	189
Rhes_like	cd04143	2.3e-12	4	189
Rab21	cd04123	3e-26	4	164
Rab14	cd04122	2.8e-24	4	166
RabL2	cd04124	1.8e-06	4	167
	cd04125	1e-12	4	175
Wrch_1	cd04130	3.5e-10	4	163
Rho4_like	cd04132	5.7e-15	4	189
Arf_Arl	cd00878	1.7e-05	5	162
Ras	cd00876	2.1e-97	5	163
Miro1	cd01893	2.1e-05	5	158
Rho3	cd04134	8.8e-08	5	189
Ras2	cd04144	6.6e-69	5	189
RERG_RasL11_like	cd04146	4.6e-31	5	165
Ras_dva	cd04147	7e-14	5	186
Rab27A	cd04127	3.6e-19	5	168
Era_like	cd00880	6.8e-05	8	163
Ras_like_GTPase	cd00882	2.6e-56	8	161
Ras	pfam00071	8.7e-94	5	165
small_GTPase	smart00010	8.9e-54	1	167
RAS	smart00173	3.5e-119	4	166
RAB	smart00175	2.1e-37	4	166
Miro	pfam08477	1.9e-18	5	119
RHO	smart00174	2.5e-12	6	166
RAN	smart00176	0.00068	9	177

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_006847	Polymorphism	p.GLN61ARG	N/A
Swiss-Prot	VAR_006846	Polymorphism	p.GLN61LYS	N/A
Swiss-Prot	VAR_006845	Polymorphism	p.GLY13ARG	N/A
Swiss-Prot	VAR_063084	Disease	p.GLY13ASP	Autoimmune lymphoproliferative syndrome 4 (ALPS4)
Swiss-Prot	VAR_021194	Polymorphism	p.GLY12CYS	N/A
Swiss-Prot	VAR_063086	Disease	p.GLY60GLU	Noonan syndrome 6 (NS6)
Swiss-Prot	VAR_063085	Disease	p.THR50ILE	Noonan syndrome 6 (NS6)
OMIM	164790.0002	Disease	p.GLN61ARG	THYROID CARCINOMA, FOLLICULAR, SOMATIC\|\|EPIDERMAL NEVUS, SOMATIC, INCLUDED
OMIM	164790.0001	Disease	p.GLY13ARG	RECTAL CANCER, SOMATIC
OMIM	164790.0007	Disease	p.GLY12ASP	EPIDERMAL NEVUS, SOMATIC
OMIM	164790.0003	Disease	p.GLY13ASP	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IV\|\|JUVENILE MYELOMONOCYTIC LEUKEMIA, INCLUDED;;\|\|NOONAN SYNDROME 6, INCLU
OMIM	164790.0005	Disease	p.GLY60GLU	NOONAN SYNDROME 6
OMIM	164790.0006	Disease	p.PRO34LEU	EPIDERMAL NEVUS, SOMATIC
OMIM	164790.0004	Disease	p.THR50ILE	NOONAN SYNDROME 6

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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