Results for the protein: P20794

Results for the Protein: P20794

13432166

4117

MAK

NCBI, UniProt

MAK_HUMAN RecName: Full=Serine/threonine-protein kinase MAK; AltName: Full=Male germ cell-associated kinase

Known Diseases associated with this Protein:
RETINITIS PIGMENTOSA 62
RETINITIS PIGMENTOSA 62 (RP62)

9

7

4

1

11

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: P20794

Identical to: NP_005897

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_EphR	cd05033	3.7e-09	1	250
PTKc_Csk_like	cd05039	2e-05	1	237
PTK_CCK4	cd05046	7.9e-06	1	236
PTKc_Ror	cd05048	1.2e-09	1	249
PTKc_Trk	cd05049	2.9e-09	1	248
PTKc_Abl	cd05052	6.4e-09	1	250
PTKc_EGFR_like	cd05057	0.00023	1	245
PTKc_InsR	cd05061	0.00027	1	258
PTKc_IGF-1R	cd05062	6e-05	1	256
PTKc_EphR_A10	cd05064	1.3e-05	1	249
PTKc_EphR_B	cd05065	1.2e-06	1	250
PTKc_EphR_A	cd05066	1.2e-05	1	250
PTKc_Lck_Blk	cd05067	2.7e-06	1	283
PTKc_Frk_like	cd05068	4.5e-13	1	253
PTKc_Fyn_Yrk	cd05070	1.3e-06	1	283
PTKc_Lyn	cd05072	5.9e-08	1	246
PTKc_Hck	cd05073	4.1e-08	1	265
PTKc_Tyk2_rpt2	cd05080	6.6e-07	1	251
PTKc_Csk	cd05082	8.1e-06	1	286
PTKc_Chk	cd05083	1.7e-06	1	256
PTKc_Tie2	cd05088	0.00012	1	260
PTKc_Ror1	cd05090	2.3e-05	1	249
PTKc_Ror2	cd05091	7e-05	1	249
PTKc_TrkA	cd05092	1.5e-05	1	263
PTKc_TrkB	cd05093	1.9e-06	1	262
PTKc_TrkC	cd05094	7.3e-05	1	329
PTKc_FGFR1	cd05098	0.0002	1	257
PTKc_FGFR4	cd05099	5e-06	1	270
PTKc_FGFR3	cd05100	0.00012	1	282
PTKc_FGFR2	cd05101	8.8e-06	1	257
PTKc_Btk_Bmx	cd05113	1.4e-10	1	254
PTKc_DDR_like	cd05097	1.1e-05	1	285
PTKc_DDR2	cd05095	2.7e-05	1	262
STKc_MAP4K3_like	cd06613	5.3e-13	1	283
STKc_TAO1	cd06635	6.8e-08	1	285
STKc_ASK	cd06624	1.5e-07	1	284
STKc_myosinIIIA	cd06638	2.8e-05	1	284
STKc_myosinIIIB	cd06639	5.9e-05	1	285
STKc_MAP4K3	cd06645	1.2e-08	1	283
STKc_MAP4K5	cd06646	5.6e-08	1	283
STKc_PAK_I	cd06647	2.3e-05	1	304
STKc_PAK1	cd06654	9.1e-05	1	307
STKc_PAK3	cd06656	9.9e-05	1	308
STKc_PAK2	cd06655	5.5e-05	1	307
STKc_PCTAIRE_like	cd07844	1.3e-72	1	284
STKc_CDK10	cd07845	1.9e-52	1	295
STKc_JNK	cd07850	1.6e-29	1	321
STKc_MAPK15	cd07852	2.5e-36	1	320
STKc_TEY_MAPK_plant	cd07858	4.3e-62	1	337
STKc_CDK12	cd07864	4.8e-50	1	284
STKc_CDK9	cd07865	2.6e-25	1	284
STKc_BUR1	cd07866	6e-33	1	284
STKc_CDC2L6	cd07867	2.2e-18	1	284
STKc_PFTAIRE1	cd07869	1.8e-43	1	299
STKc_PFTAIRE2	cd07870	1.1e-54	1	284
STKc_PCTAIRE3	cd07871	3e-65	1	284
STKc_PCTAIRE2	cd07872	1.5e-61	1	307
STKc_PCTAIRE1	cd07873	2.3e-55	1	299
STKc_JNK3	cd07874	5.9e-13	1	352
STKc_JNK1	cd07875	5.8e-11	1	331
STKc_CDK8	cd07868	8e-19	1	284
STKc_JNK2	cd07876	6.9e-17	1	329
STKc_p38gamma_MAPK12	cd07880	8.4e-47	1	326
STKc_Nek6_Nek7	cd08224	1.1e-09	1	284
STKc_Nek6	cd08228	1.8e-06	1	266
STKc_Nek7	cd08229	1.3e-07	1	287
PTKc_Src_like	cd05034	2.2e-10	2	283
PTKc_ALK_LTK	cd05036	3.3e-07	2	236
PTKc_Jak_rpt2	cd05038	4.4e-08	2	290
PTKc_Musk	cd05050	5.5e-08	2	252
PTKc_FGFR	cd05053	3.4e-06	2	291
PTKc_PDGFR	cd05055	0.00022	2	235
PTKc_FAK	cd05056	1.8e-07	2	258
PTKc_EphR_A2	cd05063	4.8e-06	2	250
PTKc_DDR	cd05051	0.0005	2	286
PTKc_Jak1_rpt2	cd05079	8.2e-06	2	287
PTKc_Itk	cd05112	2.7e-09	2	253
PTKc_Tec_Rlk	cd05114	8.7e-08	2	254
STKc_phototropin_lik	cd05574	9.6e-07	2	302
STKc_ROCK_NDR_like	cd05573	8.2e-07	2	322
STKc_PKA	cd05580	3.5e-08	2	265
STKc_PDK1	cd05581	8.7e-16	2	284
STKc_DMPK_like	cd05597	0.0001	2	332
STKc_NDR_like	cd05599	0.00018	2	356
STKc_LATS	cd05598	0.00017	2	325
STKc_Sid2p_Dbf2p	cd05600	1e-05	2	384
STKc_CRIK	cd05601	3.2e-07	2	328
STKc_MAST	cd05609	2e-06	2	318
STKc_PRKX_like	cd05612	6.3e-07	2	300
STKc_LATS2	cd05626	0.0004	2	332
STKc_NDR1	cd05628	0.00038	2	311
STKc_NDR_like_fungal	cd05629	0.00011	2	384
PKc_MAPKK	cd06605	4.3e-11	2	288
STKc_TAO	cd06607	1.1e-07	2	318
STKc_myosinIII_like	cd06608	5.8e-10	2	284
STKc_MST3_like	cd06609	1.8e-09	2	307
STKc_OSR1_SPAK	cd06610	6.1e-12	2	284
STKc_MST1_2	cd06612	6.4e-12	2	284
STKc_PAK	cd06614	2.3e-13	2	290
PKc_MKK3_6	cd06617	1.8e-07	2	300
PKc_MKK7	cd06618	8.9e-07	2	330
PKc_MKK5	cd06619	0.00023	2	301
PKc_MAPKK_Pek1_like	cd06621	1e-07	2	290
PKc_MAPKK_PBS2_like	cd06622	7.3e-07	2	313
STKc_MEKK3_like	cd06625	4.4e-11	2	284
PKc_MAPKK_plant_like	cd06623	2.4e-13	2	289
PKc_MEK	cd06615	1.2e-07	2	301
STKc_TAO2	cd06634	2.5e-09	2	293
STKc_TAO3	cd06633	3.9e-06	2	285
STKc_MST4	cd06640	3.1e-06	2	305
STKc_MST3	cd06641	8.2e-06	2	305
STKc_STK25-YSK1	cd06642	1e-06	2	305
STKc_SLK	cd06643	9.9e-07	2	301
STKc_PAK_II	cd06648	1.4e-07	2	297
PKc_MEK2	cd06649	9.4e-06	2	341
STKc_MEKK2	cd06652	5e-05	2	264
STKc_MEKK3_like_1	cd06653	4.2e-06	2	284
STKc_PAK4	cd06657	0.00013	2	305
STKc_PAK5	cd06658	0.00072	2	298
PKc_MEK1	cd06650	9.5e-05	2	314
STKc_NAK1_like	cd06917	1.5e-07	2	304
STKc_CDKL	cd07833	1.7e-73	2	284
STKc_CdkB_plant	cd07837	3.5e-76	2	285
STKc_CDKL2_3	cd07846	8.8e-64	2	284
STKc_CDKL1_4	cd07847	3.3e-72	2	284
STKc_CDKL5	cd07848	9.7e-48	2	284
STKc_ERK1_2_like	cd07849	3.8e-44	2	322
STKc_p38	cd07851	1e-39	2	321
STKc_MAPK4_6	cd07854	1.8e-17	2	320
STKc_ERK5	cd07855	2.5e-32	2	310
STKc_Sty1_Hog1	cd07856	7.5e-33	2	311
STKc_CDK6	cd07862	9.1e-49	2	284
STKc_p38alpha_MAPK14	cd07877	7.3e-33	2	321
STKc_p38beta_MAPK11	cd07878	1.8e-31	2	326
STKc_p38delta_MAPK13	cd07879	3.1e-45	2	332
SPS1	COG0515	1.7e-66	2	462
PTKc_RET	cd05045	6.3e-05	3	264
PKc_STE	cd05122	4.2e-23	3	283
STKc_Yank1	cd05578	1.7e-12	3	284
STKc_MSK_N	cd05583	1.3e-05	3	314
STKc_cPKC	cd05587	3.2e-07	3	311
STKc_GRK4_like	cd05605	2.9e-08	3	314
STKc_MSK1_N	cd05613	0.00013	3	278
STKc_MSK2_N	cd05614	4e-05	3	349
STKc_cPKC_alpha	cd05615	1.9e-06	3	311
STKc_cPKC_beta	cd05616	2.7e-05	3	318
STKc_GRK4	cd05631	4.4e-05	3	305
STKc_MAPKKK	cd06606	4.5e-25	3	284
STKc_MAPKKK_Byr2_lik	cd06628	3.1e-22	3	284
STKc_MEKK1	cd06630	3e-09	3	285
STKc_YSK4	cd06631	1.2e-09	3	284
STKc_Cdc7_like	cd06627	1.1e-19	3	284
STKc_MEKK3	cd06651	3.5e-07	3	286
STKc_CCRK	cd07832	1.8e-84	3	285
STKc_MAPK	cd07834	2e-59	3	326
STKc_Pho85	cd07836	2.9e-77	3	284
STKc_CDK7	cd07841	5e-74	3	298
STKc_CDK8_like	cd07842	1.3e-41	3	284
STKc_CDK5	cd07839	8.9e-66	3	284
STKc_MPK1	cd07857	2.1e-38	3	319
STKc_TDY_MAPK_plant	cd07859	7.8e-53	3	337
STKc_CDK2_3	cd07860	4.3e-78	3	284
STKc_CDK1_euk	cd07861	7.1e-78	3	284
STKc_CDK4	cd07863	3.1e-58	3	284
STKc_NLK	cd07853	2.4e-19	3	357
STKc_Nek	cd08215	8.5e-21	3	284
STKc_Nek2	cd08217	2e-15	3	284
STKc_Nek1	cd08218	2.4e-15	3	250
STKc_Nek3	cd08219	6.4e-21	3	255
STKc_Nek8	cd08220	1.3e-09	3	284
STKc_Nek9	cd08221	4.8e-13	3	284
STKc_Nek11	cd08222	6.5e-09	3	284
STKc_Nek4	cd08223	4.8e-09	3	284
STKc_Nek5	cd08225	8.8e-13	3	284
STKc_Nek10	cd08528	2.7e-09	3	252
STKc_CNK2-like	cd08530	1e-11	3	284
STKc_FA2-like	cd08529	2.7e-10	3	284
PTKc_Axl_like	cd05035	3.3e-05	4	250
PTKc_Tyro3	cd05074	2.2e-05	4	259
PTKc_Axl	cd05075	0.00015	4	257
PTK_Ryk	cd05043	0.00016	4	286
STKc_CMGC	cd05118	3.7e-197	4	284
PTKc_Srm_Brk	cd05148	1.4e-08	4	286
STKc_PKN	cd05589	1.3e-07	4	370
PKc_MKK4	cd06616	1.2e-06	4	304
STKc_MAPKKK_Bck1_lik	cd06629	7.1e-13	4	284
STKc_MAP4K4_6	cd06636	0.0001	4	284
STKc_TNIK	cd06637	1.6e-05	4	253
STKc_STK10_LOK	cd06644	2.2e-06	4	303
STKc_CDK_like	cd07829	2.7e-113	4	284
STKc_MAK_like	cd07830	6.4e-231	4	284
STKc_MOK	cd07831	1.9e-105	4	284
STKc_CDK4_6_like	cd07838	4.3e-58	4	284
STKc_CDK1_like	cd07835	2.1e-77	4	284
STKc_CDK9_like	cd07840	3.6e-68	4	284
PTKc_Tec_like	cd05059	7e-12	5	235
PTKc_Yes	cd05069	2.2e-07	5	265
PTKc_Src	cd05071	3.5e-06	5	255
STKc_PAK6	cd06659	1.2e-06	5	304
PK_STRAD	cd08216	1.4e-07	5	309
STKc_GRK6	cd05630	7.3e-05	6	287
STKc_GRK5	cd05632	4.9e-06	6	269
PKc_MAPKK_Byr1_like	cd06620	6.1e-05	6	290
PTKc_Jak2_Jak3_rpt2	cd05081	3.3e-08	7	285
STKc_RSK_N	cd05582	2.5e-05	7	317
STKc_p70S6K	cd05584	6.7e-06	7	321
PTKc	cd00192	6.4e-11	8	283
PTKc_Ack_like	cd05040	9.6e-12	8	240
PTKc_Fes_like	cd05041	4.9e-08	8	236
PTKc_c-ros	cd05044	1.2e-05	8	236
PTKc_Aatyk	cd05042	4e-05	8	233
PTKc_Met_Ron	cd05058	0.00033	8	259
PTKc_Syk_like	cd05060	1.3e-07	8	215
PTKc_Fes	cd05084	5.8e-06	8	281
PTKc_Aatyk1_Aatyk3	cd05087	0.00065	8	262
PTKc_Syk	cd05116	2.4e-06	8	253
PTKc_Fer	cd05085	1e-05	8	236
STKc_PKC	cd05570	1.1e-09	8	331
STKc_PKB	cd05571	5.2e-10	8	366
STKc_SGK	cd05575	5.9e-06	8	356
STKc_aPKC	cd05588	1.2e-07	8	340
STKc_nPKC_eta	cd05590	8.2e-06	8	328
STKc_nPKC_epsilon	cd05591	2.2e-07	8	333
STKc_nPKC_theta_delt	cd05592	2.5e-06	8	341
STKc_PKB_gamma	cd05593	3.5e-06	8	322
STKc_PKB_alpha	cd05594	1.4e-07	8	364
STKc_PKB_beta	cd05595	4.7e-06	8	363
STKc_SGK1	cd05602	7.3e-05	8	351
STKc_SGK2	cd05603	5.4e-07	8	296
STKc_SGK3	cd05604	0.00022	8	324
STKc_aPKC_zeta	cd05617	5e-06	8	340
STKc_aPKC_iota	cd05618	1.1e-05	8	340
STKc_nPKC_theta	cd05619	2.2e-07	8	319
STKc_nPKC_delta	cd05620	0.00023	8	319
STKc_MEKK1_plant	cd06632	2.2e-14	8	284
PTKc_Zap-70	cd05115	2.4e-05	9	251
STKc_SLK_like	cd06611	7.2e-10	9	299
STKc_MEKK4	cd06626	4.9e-12	9	284
PKc	cd00180	4.3e-73	10	282
PTKc_Tie	cd05047	0.00079	10	263
STKc_AGC	cd05123	1.5e-14	10	284
STKc_cGK_PKG	cd05572	6.8e-10	10	240
STKc_GRK	cd05577	4.4e-09	10	292
STKc_MAST_like	cd05579	7.8e-15	10	285
STKc_YPK1_like	cd05585	5e-06	10	364
STKc_Sck1_like	cd05586	1.5e-05	10	372
STKc_beta_ARK	cd05606	1.4e-06	10	282
STKc_GRK7	cd05607	1.4e-06	10	252
STKc_GRK1	cd05608	1.4e-06	10	286
STKc_GRK3	cd05633	6.2e-05	10	279
STKc_CDC2L1	cd07843	3.2e-60	12	284
STKc_Rim15_like	cd05611	9.5e-05	13	285
Pkinase	pfam00069	6.1e-112	4	284
Pkinase_Tyr	pfam07714	1.7e-14	4	284
TyrKc	smart00219	1.2e-13	4	284
STYKc	smart00221	8.2e-92	4	284
S_TKc	smart00220	2.4e-101	14	284

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_066991	Disease	p.ARG166HIS	Retinitis pigmentosa 62 (RP62)
Swiss-Prot	VAR_042007	Polymorphism	p.ARG272PRO	N/A
Swiss-Prot	VAR_066990	Disease	p.ASN130HIS	Retinitis pigmentosa 62 (RP62)
Swiss-Prot	VAR_042008	Polymorphism	p.ASN384SER	N/A
Swiss-Prot	VAR_053932	Polymorphism	p.ASP329GLU	N/A
Swiss-Prot	VAR_066989	Disease	p.GLY27ARG	Retinitis pigmentosa 62 (RP62)
Swiss-Prot	VAR_066988	Disease	p.GLY13SER	Retinitis pigmentosa 62 (RP62)
Swiss-Prot	VAR_066992	Disease	p.ILE181THR	Retinitis pigmentosa 62 (RP62)
Swiss-Prot	VAR_042006	Polymorphism	p.ILE189VAL	N/A
Swiss-Prot	VAR_042010	Polymorphism	p.PHE550LEU	N/A
Swiss-Prot	VAR_066993	Polymorphism	p.PRO325LEU	N/A
dbSNP	rs567083	Polymorphism	p.PRO520SER	N/A
OMIM	154235.0005	Disease	p.ARG166HIS	RETINITIS PIGMENTOSA 62
OMIM	154235.0003	Disease	p.ASN130HIS	RETINITIS PIGMENTOSA 62
OMIM	154235.0004	Disease	p.GLY13SER	RETINITIS PIGMENTOSA 62
OMIM	154235.0002	Disease	p.GLY240TER	RETINITIS PIGMENTOSA 62

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258