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Results for the Protein: P37231
13432234

PPARG_HUMAN RecName: Full=Peroxisome proliferator-activated receptor gamma; Short=PPAR-gamma; AltName: Full=Nuclear receptor subfamily 1 group C member 3

Known Diseases associated with this Protein:
  COLON CANCER, SOMATIC
  LIPODYSTROPHY, FAMILIAL PARTIAL, 3 (FPLD3)
  LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
  OBESITY (OBESITY)
  OBESITY, SEVERE
13
6
10
1
8
Tips:
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PPARgamma_N - pfam12577
NR_DBD_LXR - cd07160
NR_DBD_DHR4_like - cd07168
NR_DBD_GCNF_like - cd07169
NR_DBD_PNR - cd06970
NR_DBD_TLX - cd07163
NR_DBD_VDR - cd06955
NR_DBD_ROR - cd06968
NR_DBD_RAR - cd06964
NR_DBD_ERR - cd07170
NR_DBD_TR2_like - cd06967
NR_DBD_AR - cd07173
NR_DBD_ER - cd07171
NR_DBD_REV_ERB - cd07166
NR_DBD_GR_PR - cd07172
zf-C4 - pfam00105
NR_DBD_NGFI-B - cd06969
NR_DBD_Ppar - cd06965
NR_DBD_EcR_like - cd06959
NR_DBD_TR - cd06961
ZnF_C4 - smart00399
2DBD_NR_DBD1 - cd07157
NR_DBD_EcR - cd07161
NR_DBD_Ppar_like - cd07158
NR_DBD_PXR - cd07162
2DBD_NR_DBD2 - cd07179
NR_DBD_Lrh-1_like - cd07167
NR_DBD_DmE78_like - cd07165
NR_DBD_VDR_like - cd07156
NR_DBD_PNR_like_1 - cd07164
NR_DBD_ER_like - cd07155
NR_DBD_COUP_TF - cd06958
NR_DBD_PNR_like_2 - cd06957
NR_DBD_like - cd06916
NR_DBD_HNF4A - cd06960
NR_DBD_RXR - cd06956
NR_DBD_GR_like - cd06963
NR_DBD_FXR - cd06962
NR_DBD_PNR_like - cd07154
NR_DBD_CAR - cd06966
NR_LBD_VDR - cd06933
NR_LBD_PXR_like - cd06934
NR_LBD_PPAR - cd06932
NR_LBD_LXR - cd06954
NR_LBD_ROR_like - cd06939
NR_LBD_DHR38_like - cd07072
NR_LBD_TR - cd06935
NR_LBD_NGFI-B - cd07348
NR_LBD_Nurr1_like - cd06945
NR_LBD_EcR - cd06938
NR_LBD_Ftz-F1_like - cd06944
NR_LBD_HNF4_like - cd06931
NR_LBD_ERR - cd06946
NR_LBD_ER_like - cd07068
NR_LBD_RAR - cd06937
NR_LBD_RXR_like - cd06943
NR_LBD_Fxr - cd06936
NR_LBD_Tlx_PNR_like - cd06950
NR_LBD_COUP-TF - cd06948
NR_LBD_REV_ERB - cd06940
NR_LBD_F1 - cd06929
NR_LBD_DmE78_like - cd06941
NR_LBD_Sex_1_like - cd06942
NR_LBD_F2 - cd06930
NR_LBD - cd06157
HOLI - smart00430
Hormone_recep - pfam00104


Swiss-Prot Protein: P37231
Identical to: NP_056953
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
NR_DBD_LXRcd071601.9e-18120218
NR_DBD_DHR4_likecd071682.6e-31128219
NR_DBD_VDRcd069555.9e-16131234
NR_DBD_PNRcd069704.8e-25131220
NR_DBD_TLXcd071637.1e-23131219
NR_DBD_GCNF_likecd071695.5e-29131219
NR_DBD_RORcd069682e-33132225
NR_DBD_RARcd069645.2e-32133216
NR_DBD_ERRcd071702.4e-20133229
NR_DBD_TR2_likecd069671.8e-31134219
NR_DBD_REV_ERBcd071661.1e-44134220
NR_DBD_ERcd071711.7e-21134214
NR_DBD_ARcd071732.6e-09134215
NR_DBD_GR_PRcd071726.2e-09135211
NR_DBD_NGFI-Bcd069692.3e-32137210
NR_DBD_EcR_likecd069593e-23138209
NR_DBD_TRcd069612.1e-33138221
NR_DBD_Pparcd069651.2e-57138221
2DBD_NR_DBD1cd071574.2e-14138219
NR_DBD_likecd069161.8e-43139209
NR_DBD_PNR_like_2cd069576e-23139218
NR_DBD_COUP_TFcd069585.4e-25139210
NR_DBD_RXRcd069569.4e-31139212
NR_DBD_HNF4Acd069604.3e-31139213
NR_DBD_FXRcd069621.6e-17139218
NR_DBD_GR_likecd069631.9e-12139210
NR_DBD_CARcd069664.7e-13139229
NR_DBD_PNR_likecd071544.2e-26139209
NR_DBD_ER_likecd071552.1e-23139212
NR_DBD_VDR_likecd071567.7e-25139209
NR_DBD_Ppar_likecd071587.8e-47139209
NR_DBD_EcRcd071611.8e-19139224
NR_DBD_PXRcd071621.2e-20139227
NR_DBD_PNR_like_1cd071641.3e-25139215
NR_DBD_DmE78_likecd071654.3e-41139218
NR_DBD_Lrh-1_likecd071679.1e-27139231
2DBD_NR_DBD2cd071791.8e-32139211
NR_LBD_VDRcd069332.1e-07203505
NR_LBD_PXR_likecd069341.3e-05236500
NR_LBD_PPARcd069323.5e-176237504
NR_LBD_LXRcd069542.4e-10240504
NR_LBD_ROR_likecd069391e-10251505
NR_LBD_DHR38_likecd070720.00047252505
NR_LBD_TRcd069352.9e-07255500
NR_LBD_NGFI-Bcd073487.4e-05261505
NR_LBD_EcRcd069384.7e-09268504
NR_LBD_Nurr1_likecd069450.00041268505
NR_LBD_Ftz-F1_likecd069440.00047273504
NR_LBD_HNF4_likecd069313e-07279500
NR_LBD_ERRcd069460.00031280503
NR_LBD_ER_likecd070682.9e-06281503
NR_LBD_RARcd069372e-11284503
NR_LBD_RXR_likecd069431.9e-08284482
NR_LBD_Fxrcd069369.9e-09286499
NR_LBD_Tlx_PNR_likecd069500.00026287490
NR_LBD_COUP-TFcd069480.00041290500
NR_LBD_REV_ERBcd069401.8e-27296486
NR_LBD_F1cd069292.5e-67307481
NR_LBD_DmE78_likecd069411.6e-24309502
NR_LBD_Sex_1_likecd069421.2e-08310498
NR_LBD_F2cd069302.1e-06310473
NR_LBDcd061573e-44311473
zf-C4pfam001051.1e-41137205
Hormone_receppfam001044.3e-33341500
PPARgamma_Npfam125771.3e-0867108
ZnF_C4smart003991.4e-35138206
HOLIsmart004301.9e-26317473

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_022701Diseasep.ARG425CYSLipodystrophy, familial partial, 3 (FPLD3)
Swiss-ProtVAR_010726Polymorphismp.ARG316HISN/A
Swiss-ProtVAR_010725Polymorphismp.GLN314PRON/A
Swiss-ProtVAR_022700Diseasep.PHE388LEULipodystrophy, familial partial, 3 (FPLD3)
dbSNPrs1801282 Polymorphismp.PRO12ALAN/A
Swiss-ProtVAR_016116Polymorphismp.PRO40ALAN/A
Swiss-ProtVAR_010724Diseasep.PRO113GLNObesity (OBESITY)
Swiss-ProtVAR_010728Polymorphismp.PRO495LEUN/A
Swiss-ProtVAR_010727Polymorphismp.VAL318METN/A
OMIM601487.0013 Diseasep.ARG425CYSLIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM601487.0006 Diseasep.ARG288HISCOLON CANCER, SOMATIC
OMIM601487.0015 Diseasep.ARG194TRPLIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM601487.0014 Diseasep.CYS190SERLIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM601487.0004 Diseasep.GLN286PROCOLON CANCER, SOMATIC
OMIM601487.0005 Diseasep.LYS319TERCOLON CANCER, SOMATIC
OMIM601487.0012 Diseasep.PHE388LEULIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM601487.0001 Diseasep.PRO115GLNOBESITY, SEVERE
OMIM601487.0007 Diseasep.PRO467LEULIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM601487.0008 Diseasep.VAL290METLIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3



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