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Results for the Protein: P11388
13959709

TOP2A_HUMAN RecName: Full=DNA topoisomerase 2-alpha; AltName: Full=DNA topoisomerase II, alpha isozyme

Known Diseases associated with this Protein:
  DNA TOPOISOMERASE II, RESISTANCE TO INHIBITION OF, BY AMSACRINE
1
6
1
3
3
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

GyrB - COG0187
HATPase_c - pfam02518
HATPase_c - smart00387
TOP2c - smart00433
HATPase_c - cd00075
TopoIIA_Trans_ScTopo - cd03481
DNA_gyraseB - pfam00204
TopoII_MutL_Trans - cd00329
TOPRIM_TopoIIA_like - cd01030
TOPRIM - cd00188
TOPRIM_TopoIIA - cd03365
TOPRIM_TopoIIA_GyrB - cd03366
GyrA - COG0188
TOP4c - smart00434
TOP4c - cd00187
DNA_topoisoIV - pfam00521
DTHCT - pfam08070


Swiss-Prot Protein: P11388
Identical to: NP_001058
   Default View:








Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
GyrBCOG01873.4e-9024680
HATPase_ccd000751.2e-0781221
TopoIIA_Trans_ScTopocd034818e-108265417
TopoII_MutL_Transcd003293.7e-21267382
TOPRIMcd001882.8e-14455572
TOPRIM_TopoIIA_likecd010301.7e-76455575
TOPRIM_TopoIIAcd033654e-91455575
TOPRIM_TopoIIA_GyrBcd033662.8e-23455577
GyrACOG01883e-116741492
TOP4ccd001874.1e-2327111174
HATPase_cpfam025184.8e-1976224
DNA_gyraseBpfam002042.4e-51266430
DNA_topoisoIVpfam005212.7e-2017131172
HATPase_csmart003871.1e-0576224
TOP2csmart0043380670
TOP4csmart004342e-2326931169
DTHCTpfam080703e-5014351523

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs11540720 Polymorphismp.ALA1515SERN/A
Swiss-ProtVAR_007532Polymorphismp.ARG450GLNN/A
Swiss-ProtVAR_007533Polymorphismp.ARG487LYSN/A
dbSNPrs34300454 Polymorphismp.GLY1386ASPN/A
dbSNPrs11656816 Polymorphismp.SER654ILEN/A
Swiss-ProtVAR_029245Polymorphismp.THR1324LYSN/A
OMIM126430.0001 Diseasep.ARG486LYSDNA TOPOISOMERASE II, RESISTANCE TO INHIBITION OF, BY AMSACRINE



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