Home News About DMDM Database Statistics Research Publications Contact  

Results for the Protein: P41235
148886624

HNF4A_HUMAN RecName: Full=Hepatocyte nuclear factor 4-alpha; Short=HNF-4-alpha; AltName: Full=Nuclear receptor subfamily 2 group A member 1; AltName: Full=Transcription factor 14; Short=TCF-14; AltName: Full=Transcription factor HNF-4

Known Diseases associated with this Protein:
  DIABETES MELLITUS, NON-INSULIN-DEPENDENT (NIDDM)
  MATURITY-ONSET DIABETES OF THE YOUNG 1 (MODY1)
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
  NONINSULIN-DEPENDENT DIABETES MELLITUS
8
4
5
1
6
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

NR_DBD_LXR - cd07160
NR_DBD_DHR4_like - cd07168
NR_DBD_TLX - cd07163
NR_DBD_GCNF_like - cd07169
NR_DBD_PNR - cd06970
NR_DBD_VDR - cd06955
NR_DBD_ROR - cd06968
NR_DBD_ERR - cd07170
NR_DBD_AR - cd07173
NR_DBD_ER - cd07171
NR_DBD_TR2_like - cd06967
NR_DBD_REV_ERB - cd07166
NR_DBD_GR_PR - cd07172
NR_DBD_RAR - cd06964
NR_DBD_EcR - cd07161
NR_DBD_FXR - cd06962
zf-C4 - pfam00105
2DBD_NR_DBD1 - cd07157
NR_DBD_NGFI-B - cd06969
NR_DBD_RXR - cd06956
NR_DBD_CAR - cd06966
ZnF_C4 - smart00399
NR_DBD_PXR - cd07162
NR_DBD_Ppar - cd06965
NR_DBD_EcR_like - cd06959
NR_DBD_TR - cd06961
NR_DBD_PNR_like_1 - cd07164
NR_DBD_Ppar_like - cd07158
NR_DBD_Lrh-1_like - cd07167
2DBD_NR_DBD2 - cd07179
NR_DBD_VDR_like - cd07156
NR_DBD_DmE78_like - cd07165
NR_DBD_PNR_like_2 - cd06957
NR_DBD_ER_like - cd07155
NR_DBD_like - cd06916
NR_DBD_COUP_TF - cd06958
NR_DBD_HNF4A - cd06960
NR_DBD_GR_like - cd06963
NR_DBD_PNR_like - cd07154
NR_LBD_PPAR - cd06932
NR_LBD_TR - cd06935
NR_LBD_EcR - cd06938
NR_LBD_ER - cd06949
NR_LBD_Nurr1_like - cd06945
NR_LBD_DHR38_like - cd07072
NR_LBD_Ftz-F1_like - cd06944
NR_LBD_Lrh-1 - cd07069
NR_LBD_RXR_like - cd06943
NR_LBD_SF-1 - cd07070
NR_LBD_HNF4_like - cd06931
NR_LBD_COUP-TF - cd06948
NR_LBD_ER_like - cd07068
NR_LBD_ERR - cd06946
NR_LBD_LXR - cd06954
NR_LBD_PXR_like - cd06934
NR_LBD_DHR4_like - cd06953
NR_LBD_RAR - cd06937
NR_LBD_TR2_like - cd06952
NR_LBD_AR - cd07073
NR_LBD_Tlx_PNR_like - cd06950
NR_LBD_Dax1 - cd07350
NR_LBD_Dax1_like - cd06951
NR_LBD_F1 - cd06929
NR_LBD_SHP - cd07349
NR_LBD_F2 - cd06930
NR_LBD_Sex_1_like - cd06942
NR_LBD - cd06157
HOLI - smart00430
Hormone_recep - pfam00104


Swiss-Prot Protein: P41235
Identical to: NP_000448
   Default View:










































Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
NR_DBD_LXRcd071602.3e-2439140
NR_DBD_VDRcd069551.4e-2452150
NR_DBD_RORcd069683.3e-2652147
NR_DBD_PNRcd069701.1e-3052142
NR_DBD_TLXcd071639.2e-3052140
NR_DBD_DHR4_likecd071681e-2852143
NR_DBD_GCNF_likecd071692.8e-2752141
NR_DBD_ERRcd071701.7e-1854152
NR_DBD_TR2_likecd069677e-3955141
NR_DBD_REV_ERBcd071662.6e-2355140
NR_DBD_ERcd071711.9e-2255136
NR_DBD_ARcd071733.4e-1655138
NR_DBD_RARcd069642.2e-3156138
NR_DBD_GR_PRcd071722.7e-1556133
NR_DBD_FXRcd069629.1e-2457140
NR_DBD_EcRcd071618.5e-2757148
NR_DBD_RXRcd069562e-3958134
NR_DBD_CARcd069667.2e-2158151
NR_DBD_NGFI-Bcd069691.6e-3758132
2DBD_NR_DBD1cd071578.6e-1258140
NR_DBD_EcR_likecd069593.2e-2759131
NR_DBD_TRcd069616.8e-3659143
NR_DBD_Pparcd069656.3e-2359137
NR_DBD_PXRcd071621.6e-2459141
NR_DBD_likecd069166.9e-4660131
NR_DBD_PNR_like_2cd069572.4e-3160140
NR_DBD_COUP_TFcd069585.2e-3460132
NR_DBD_HNF4Acd069604.3e-5260135
NR_DBD_GR_likecd069633.6e-1860132
NR_DBD_PNR_likecd071541.2e-3160131
NR_DBD_ER_likecd071552.7e-2460134
NR_DBD_VDR_likecd071569.4e-3060131
NR_DBD_Ppar_likecd071585.6e-2860131
NR_DBD_PNR_like_1cd071641.2e-3360137
NR_DBD_DmE78_likecd071652.6e-2660140
NR_DBD_Lrh-1_likecd071672.2e-2660155
2DBD_NR_DBD2cd071791.7e-2460133
NR_LBD_PPARcd069326.7e-0584373
NR_LBD_TRcd069354.9e-05131373
NR_LBD_EcRcd069384.4e-06133376
NR_LBD_Nurr1_likecd069452.4e-06146380
NR_LBD_ERcd069492.7e-07146383
NR_LBD_DHR38_likecd070720.00071147380
NR_LBD_Ftz-F1_likecd069448.5e-11148386
NR_LBD_RXR_likecd069431.3e-37149359
NR_LBD_Lrh-1cd070691.2e-05149379
NR_LBD_SF-1cd070702.7e-06149377
NR_LBD_HNF4_likecd069311.5e-167151373
NR_LBD_COUP-TFcd069482.2e-26151387
NR_LBD_PXR_likecd069340.00014152373
NR_LBD_ERRcd069462e-09152376
NR_LBD_LXRcd069540.00015152373
NR_LBD_ER_likecd070681.1e-12152382
NR_LBD_RARcd069370.00013154376
NR_LBD_DHR4_likecd069532e-07154363
NR_LBD_TR2_likecd069521.3e-08155373
NR_LBD_ARcd070730.00062156392
NR_LBD_Tlx_PNR_likecd069502.2e-14157363
NR_LBD_Dax1cd073501.1e-08159372
NR_LBD_Dax1_likecd069511.9e-10177372
NR_LBD_F1cd069296.6e-13181355
NR_LBD_SHPcd073492e-07181374
NR_LBD_F2cd069304.3e-61184347
NR_LBDcd061576.2e-49185347
NR_LBD_Sex_1_likecd069420.00076185395
zf-C4pfam001051.4e-4558127
Hormone_receppfam001044.6e-49215373
ZnF_C4smart003993.8e-3859128
HOLIsmart004309.2e-47191347

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_004668Diseasep.ARG136TRPMaturity-onset diabetes of the young 1 (MODY1)
Swiss-ProtVAR_010601Diseasep.GLU285GLNMaturity-onset diabetes of the young 1 (MODY1)
Swiss-ProtVAR_011785Polymorphismp.PRO445SERN/A
dbSNPrs1800961 Polymorphismp.THR139ILEN/A
Swiss-ProtVAR_004670Diseasep.VAL402ILEDiabetes mellitus, non-insulin-dependent (NIDDM)
Swiss-ProtVAR_062267Polymorphismp.VAL453ILEN/A
Swiss-ProtVAR_010600Polymorphismp.VAL264METN/A
OMIM600281.0002 Diseasep.ARG154TERMATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM600281.0003 Diseasep.ARG127TRPMATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM600281.0001 Diseasep.GLN268TERMATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM600281.0007 Diseasep.MET364ARGMATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM600281.0004 Diseasep.VAL393ILENONINSULIN-DEPENDENT DIABETES MELLITUS



   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258