Results for the protein: P36888

Results for the Protein: P36888

156630887

2322

FLT3

NCBI, UniProt

FLT3_HUMAN RecName: Full=Receptor-type tyrosine-protein kinase FLT3; AltName: Full=FL cytokine receptor; AltName: Full=Fetal liver kinase-2; Short=FLK-2; AltName: Full=Fms-like tyrosine kinase 3; Short=FLT-3; AltName: Full=Stem cell tyrosine kinase 1; Short=STK-1; AltName: CD_antigen=CD135; Flags: Precursor

Known Diseases associated with this Protein:
LEUKEMIA, ACUTE LYMPHOBLASTIC, SOMATIC, INCLUDED
LEUKEMIA, ACUTE MYELOID, SOMATIC

5

15

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4

11

Tips:

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Swiss-Prot Protein: P36888

Identical to: NP_004110

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_PDGFR	cd05055	2.7e-273	572	947
PTKc_PDGFR_alpha	cd05105	3.5e-141	572	949
PTKc_PDGFR_beta	cd05107	5.2e-136	572	948
PTKc_Kit	cd05104	2.8e-166	575	947
STKc_PAK	cd06614	6.4e-09	591	958
PTKc_FGFR1	cd05098	1.4e-87	593	954
PTKc_FGFR2	cd05101	2.9e-93	596	952
PTKc_FGFR	cd05053	2e-111	597	948
PTKc_FGFR4	cd05099	3e-89	597	965
PTKc_FGFR3	cd05100	1.4e-83	597	987
STKc_ASK	cd06624	0.00053	601	943
PTKc_VEGFR	cd05054	1e-129	602	950
PTKc_EGFR_like	cd05057	1.2e-50	602	957
PTKc_VEGFR3	cd05102	1e-131	602	950
PTKc_VEGFR2	cd05103	6.5e-128	602	951
PTKc_InsR_like	cd05032	1.1e-55	603	945
PTKc_Src_like	cd05034	1.2e-50	603	946
PTKc_ALK_LTK	cd05036	3.7e-50	603	945
PTKc_Csk_like	cd05039	4e-41	603	942
PTKc_Abl	cd05052	1.8e-53	603	947
PTKc_FAK	cd05056	2.8e-41	603	952
PTKc_InsR	cd05061	3.8e-40	603	955
PTKc_IGF-1R	cd05062	1.9e-37	603	945
PTKc_Lck_Blk	cd05067	1.3e-35	603	946
PTKc_Frk_like	cd05068	6.8e-50	603	946
PTKc_Yes	cd05069	2.1e-31	603	946
PTKc_Fyn_Yrk	cd05070	1.3e-30	603	946
PTKc_Src	cd05071	4.5e-31	603	948
PTKc_Hck	cd05073	1.2e-38	603	946
PTKc_Chk	cd05083	5.1e-42	603	946
PTKc_Csk	cd05082	1.4e-44	603	946
PTKc_Lyn	cd05072	2.7e-37	603	946
PTKc_Srm_Brk	cd05148	6.2e-42	603	946
PTK_CCK4	cd05046	1.6e-33	604	945
PTKc_Ror	cd05048	5e-42	604	946
PTKc_Musk	cd05050	2.7e-56	604	945
PTKc_DDR	cd05051	1.3e-35	604	945
PTKc_Trk	cd05049	2e-48	604	945
PTKc_EphR_A2	cd05063	8.7e-19	604	947
PTKc_EphR_A10	cd05064	2.8e-12	604	947
PTKc_Ror1	cd05090	8.7e-26	604	946
PTKc_TrkB	cd05093	1.8e-29	604	956
PTKc_TrkC	cd05094	1.2e-14	604	956
PTKc_Ror2	cd05091	1.4e-33	604	946
PTKc_DDR2	cd05095	5.2e-36	604	945
PTKc_DDR1	cd05096	2.9e-33	604	945
PTKc_DDR_like	cd05097	5.4e-32	604	945
PTKc_TrkA	cd05092	9.9e-38	604	949
STKc_SLK_like	cd06611	0.0003	604	949
PTKc_EphR	cd05033	7.8e-17	605	947
PTKc_Jak_rpt2	cd05038	2.5e-37	605	947
PTKc_EphR_B	cd05065	5.7e-17	605	947
PTKc_EphR_A	cd05066	2.6e-21	605	947
PTKc_Jak1_rpt2	cd05079	1.7e-13	605	947
PTKc_Tyk2_rpt2	cd05080	1.5e-12	605	948
PTKc_Jak2_Jak3_rpt2	cd05081	1.6e-16	605	951
PTKc_Tie2	cd05088	1.6e-49	605	965
PTKc_Tec_like	cd05059	3.2e-40	605	944
PTKc_HER2	cd05109	7.1e-28	605	957
PTKc_HER4	cd05110	2.5e-18	605	980
PTK_HER3	cd05111	4.3e-23	605	957
PTKc_Itk	cd05112	2.4e-33	605	944
PTKc_Btk_Bmx	cd05113	9.7e-45	605	944
PTKc_Tec_Rlk	cd05114	3.1e-37	606	944
STKc_myosinIII_like	cd06608	3.6e-07	606	943
STKc_MAP4K3_like	cd06613	6.8e-06	606	942
STKc_MST1_2	cd06612	1.5e-07	606	943
STKc_Nek6_Nek7	cd08224	0.00017	607	953
PTKc_Tie1	cd05089	4e-53	608	973
PTKc_EGFR	cd05108	1.1e-25	608	986
STKc_CMGC	cd05118	2.2e-07	608	936
STKc_PDK1	cd05581	2.2e-08	608	943
STKc_PKA	cd05580	0.00076	608	788
PKc_MAPKK	cd06605	4.2e-06	608	949
STKc_OSR1_SPAK	cd06610	1.9e-06	608	943
PKc_MAPKK_PBS2_like	cd06622	9.5e-05	608	973
STKc_MEKK3_like	cd06625	6.6e-05	608	945
PKc_MAPKK_plant_like	cd06623	3.5e-07	608	950
STKc_CDKL	cd07833	2e-05	608	936
STKc_CDK9_like	cd07840	1.1e-06	608	936
STKc_CDKL2_3	cd07846	6.2e-05	608	942
PTKc_RET	cd05045	3.5e-89	609	950
PKc_STE	cd05122	5.9e-10	609	942
STKc_MAPKKK	cd06606	1.2e-12	609	936
STKc_Cdc7_like	cd06627	6.1e-09	609	936
STKc_MEKK3	cd06651	0.00074	609	947
STKc_MAPK	cd07834	0.00044	609	978
STKc_CDK7	cd07841	0.00034	609	944
STKc_Nek5	cd08225	0.00029	609	943
PTKc_Axl_like	cd05035	5.4e-39	610	947
PTKc_Tyro3	cd05074	5.7e-29	610	947
PTKc_Axl	cd05075	2e-28	610	947
STKc_CDK_like	cd07829	4e-08	610	936
STKc_MAK_like	cd07830	1.3e-05	610	936
STKc_CDK8_like	cd07842	0.00077	611	955
STKc_MAPKKK_Bck1_lik	cd06629	1.5e-05	613	943
STKc_MEKK1_plant	cd06632	0.00051	613	913
STKc_YSK4	cd06631	5.3e-06	613	943
PTKc	cd00192	9.2e-150	614	944
PTK_Jak_rpt1	cd05037	9.2e-06	614	944
PTKc_Ack_like	cd05040	6.2e-31	614	945
PTKc_Fes_like	cd05041	6.8e-36	614	945
PTKc_Aatyk	cd05042	1.4e-12	614	945
PTKc_c-ros	cd05044	8.6e-53	614	945
PTKc_Tie	cd05047	1.5e-55	614	948
PTKc_Met_Ron	cd05058	5.4e-42	614	949
PTKc_Syk_like	cd05060	2.1e-31	614	948
PTKc_Fer	cd05085	9e-44	614	945
PTKc_Aatyk2	cd05086	8.9e-07	614	945
PTKc_Aatyk1_Aatyk3	cd05087	5.7e-10	614	945
PTKc_Fes	cd05084	9.5e-35	614	945
PTKc_Syk	cd05116	5.3e-24	614	944
STKc_Nek2	cd08217	2.1e-06	614	943
STKc_Nek	cd08215	9.3e-07	614	939
PKc	cd00180	4e-42	616	943
PTKc_Zap-70	cd05115	1.7e-25	616	948
STKc_AGC	cd05123	4.9e-07	616	942
STKc_Nek7	cd08229	9.8e-05	659	948
PTK_Jak1_rpt1	cd05077	0.00057	676	944
STKc_MAPKKK_Byr2_lik	cd06628	4.1e-06	676	943
STKc_Nek11	cd08222	0.00075	688	943
STKc_Nek3	cd08219	7.8e-05	700	945
STKc_Nek9	cd08221	0.00048	701	945
PTK_Ryk	cd05043	7e-18	703	947
STKc_CDK5	cd07839	0.001	706	970
PTK_Jak2_Jak3_rpt1	cd05078	3.8e-06	708	944
PKc_MKK4	cd06616	0.00018	729	966
PKc_MKK3_6	cd06617	0.00095	741	960
STKc_CDC2L1	cd07843	0.00043	741	936
STKc_FA2-like	cd08529	0.00036	767	943
ig	pfam00047	4.3e-09	265	332
Pkinase	pfam00069	3.6e-23	610	943
Pkinase_Tyr	pfam07714	3.2e-174	610	943
TyrKc	smart00219	1.9e-163	610	943
STYKc	smart00221	1e-58	610	916
S_TKc	smart00220	3.7e-29	620	943

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs74041526	Polymorphism	p.ALA988PRO	N/A
Swiss-Prot	VAR_042070	Polymorphism	p.ASP324ASN	N/A
Swiss-Prot	VAR_065681	Polymorphism	p.ASP835ASN	N/A
Swiss-Prot	VAR_065679	Polymorphism	p.ASP835GLU	N/A
dbSNP	rs12872889	Polymorphism	p.ASP7GLY	N/A
Swiss-Prot	VAR_065680	Polymorphism	p.ASP835HIS	N/A
Swiss-Prot	VAR_065683	Polymorphism	p.ASP835TYR	N/A
Swiss-Prot	VAR_042071	Polymorphism	p.ASP358VAL	N/A
Swiss-Prot	VAR_065682	Polymorphism	p.ASP835VAL	N/A
Swiss-Prot	VAR_061291	Polymorphism	p.ILE417LEU	N/A
Swiss-Prot	VAR_065684	Polymorphism	p.ILE836MET	N/A
dbSNP	rs1933437	Polymorphism	p.THR227MET	N/A
Swiss-Prot	VAR_042069	Polymorphism	p.VAL158ALA	N/A
dbSNP	rs35958982	Polymorphism	p.VAL557ILE	N/A
Swiss-Prot	VAR_054149	Polymorphism	p.VAL194MET	N/A
OMIM	136351.0005	Disease	p.ASP835ASN	LEUKEMIA, ACUTE MYELOID, SOMATIC
OMIM	136351.0006	Disease	p.ASP835GLU	LEUKEMIA, ACUTE MYELOID, SOMATIC
OMIM	136351.0004	Disease	p.ASP835HIS	LEUKEMIA, ACUTE MYELOID, SOMATIC
OMIM	136351.0007	Disease	p.ASP835TYR	LEUKEMIA, ACUTE MYELOID, SOMATIC\|\|LEUKEMIA, ACUTE LYMPHOBLASTIC, SOMATIC, INCLUDED
OMIM	136351.0003	Disease	p.ASP835VAL	LEUKEMIA, ACUTE MYELOID, SOMATIC\|\|LEUKEMIA, ACUTE LYMPHOBLASTIC, SOMATIC, INCLUDED

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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