Results for the protein: P51451

Results for the Protein: P51451

158936749

640

BLK

NCBI, UniProt

BLK_HUMAN RecName: Full=Tyrosine-protein kinase Blk; AltName: Full=B lymphocyte kinase; AltName: Full=p55-Blk

Known Diseases associated with this Protein:
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11

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Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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Swiss-Prot Protein: P51451

Identical to: NP_001706

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	5.8e-32	123	220
PTKc_VEGFR	cd05054	1.4e-26	123	497
PTKc_PDGFR_alpha	cd05105	2.2e-15	195	496
PTKc_PDGFR_beta	cd05107	1e-12	195	495
PTKc_CSF-1R	cd05106	2.6e-27	196	495
PTKc_PDGFR	cd05055	7.5e-21	201	494
PTKc_Kit	cd05104	4e-15	205	494
STKc_PAK5	cd06658	0.00014	215	502
STKc_PAK6	cd06659	8.5e-06	216	504
STKc_PAK4	cd06657	0.00044	217	504
STKc_myosinIIIB	cd06639	0.0001	218	496
STKc_TAO2	cd06634	1.1e-05	222	505
STKc_PAK_II	cd06648	5.4e-07	222	494
STKc_TAO1	cd06635	0.00014	223	504
STKc_myosinIIIA	cd06638	2.5e-07	223	491
STKc_PAK	cd06614	1.5e-14	224	497
PTKc_FGFR1	cd05098	2.4e-41	225	501
PTKc_FGFR2	cd05101	7.1e-40	225	501
STKc_SLK	cd06643	1.8e-05	226	505
STKc_p38	cd07851	1.8e-06	226	505
STKc_p38beta_MAPK11	cd07878	0.0003	226	505
STKc_p38gamma_MAPK12	cd07880	0.00049	226	505
PTK_Tyk2_rpt1	cd05076	1.7e-05	227	491
STKc_TAO	cd06607	4.9e-05	227	504
PTKc_FGFR	cd05053	6.3e-53	229	495
PTKc_Tie2	cd05088	1.5e-29	229	505
STKc_STK10_LOK	cd06644	6.8e-05	229	503
PTKc_FGFR4	cd05099	3.3e-44	230	504
PTKc_FGFR3	cd05100	9.4e-27	230	502
PKc_MKK7	cd06618	1.8e-08	230	503
STKc_ASK	cd06624	1.9e-08	230	495
STKc_MAP4K4_6	cd06636	2.4e-05	231	490
STKc_PAK1	cd06654	0.00048	231	504
STKc_PAK_I	cd06647	0.00018	232	502
STKc_PAK2	cd06655	0.00027	232	505
STKc_PAK3	cd06656	0.0005	232	505
STKc_CDK9	cd07865	6.7e-07	232	494
PTKc_EGFR_like	cd05057	1.6e-62	233	504
PTKc_VEGFR3	cd05102	4.1e-29	233	497
PTKc_VEGFR2	cd05103	7e-25	233	497
PTKc_InsR_like	cd05032	9.7e-63	234	492
PTKc_Src_like	cd05034	4.9e-202	234	493
PTKc_ALK_LTK	cd05036	3.6e-62	234	495
PTKc_Csk_like	cd05039	3.3e-95	234	493
PTKc_Abl	cd05052	1.1e-103	234	494
PTKc_FAK	cd05056	1.4e-80	234	498
PTKc_InsR	cd05061	1.9e-49	234	503
PTKc_Lck_Blk	cd05067	4.5e-190	234	493
PTKc_Yes	cd05069	5.6e-156	234	493
PTKc_Fyn_Yrk	cd05070	1e-161	234	493
PTKc_Src	cd05071	1.1e-157	234	495
PTKc_Lyn	cd05072	2.8e-177	234	493
PTKc_Hck	cd05073	9.9e-181	234	493
PTKc_Frk_like	cd05068	3.2e-142	234	493
PTKc_IGF-1R	cd05062	2.6e-53	234	491
PTKc_Csk	cd05082	6.4e-81	234	493
PTKc_Chk	cd05083	7.1e-80	234	493
PTKc_Tie1	cd05089	1.9e-35	234	499
PTKc_Srm_Brk	cd05148	1.1e-123	234	493
STKc_TNIK	cd06637	6.6e-07	234	494
STKc_ERK1_2_like	cd07849	7.8e-06	234	505
STKc_MAPK4_6	cd07854	4.8e-05	234	504
STKc_Sty1_Hog1	cd07856	0.0001	234	503
STKc_CDK12	cd07864	9.4e-08	234	503
PTK_CCK4	cd05046	8.7e-32	235	492
PTKc_Ror	cd05048	1.1e-44	235	493
PTKc_Trk	cd05049	1e-46	235	499
PTKc_Musk	cd05050	8.1e-48	235	492
PTKc_EphR_A2	cd05063	5.4e-69	235	494
PTKc_EphR_A10	cd05064	9.9e-62	235	494
PTKc_Ror1	cd05090	9.8e-43	235	493
PTKc_Ror2	cd05091	4.1e-38	235	493
PTKc_TrkA	cd05092	1.9e-48	235	492
PTKc_TrkB	cd05093	9.8e-40	235	502
PTKc_TrkC	cd05094	6e-25	235	502
PTKc_DDR2	cd05095	5.7e-41	235	492
PTKc_DDR1	cd05096	4.2e-29	235	492
PTKc_DDR	cd05051	5.7e-38	235	488
PTKc_DDR_like	cd05097	2.9e-36	235	492
STKc_SLK_like	cd06611	3e-06	235	496
PKc_MAPKK_Byr1_like	cd06620	7.6e-07	235	504
STKc_MAP4K5	cd06646	6.7e-06	235	491
PTKc_EphR	cd05033	6.9e-87	236	494
PTKc_Jak_rpt2	cd05038	2.2e-53	236	494
PTK_Ryk	cd05043	1.2e-22	236	497
PTKc_Tec_like	cd05059	7.4e-106	236	491
PTKc_EphR_B	cd05065	8.2e-68	236	494
PTKc_EphR_A	cd05066	6.3e-71	236	494
PTKc_Jak1_rpt2	cd05079	3.7e-32	236	494
PTKc_Tyk2_rpt2	cd05080	4.6e-24	236	495
PTKc_Jak2_Jak3_rpt2	cd05081	1e-37	236	494
PTKc_EGFR	cd05108	6.6e-32	236	505
PTKc_HER2	cd05109	3.9e-47	236	504
PTKc_HER4	cd05110	1.2e-34	236	504
PTKc_Itk	cd05112	1.5e-95	236	491
PTKc_Tec_Rlk	cd05114	9.2e-91	236	491
PTK_HER3	cd05111	4.4e-39	236	504
PTKc_Btk_Bmx	cd05113	1.4e-90	236	491
STKc_MAPK15	cd07852	2e-05	236	504
STKc_myosinIII_like	cd06608	5.1e-07	237	486
STKc_MST1_2	cd06612	3.6e-13	237	486
STKc_MAP4K3_like	cd06613	1.9e-10	237	490
STKc_MST4	cd06640	5.8e-07	237	501
STKc_MST3	cd06641	6.2e-07	237	505
STKc_STK25-YSK1	cd06642	6.2e-08	237	504
STKc_MAP4K3	cd06645	4.9e-06	237	490
STKc_PCTAIRE_like	cd07844	4.1e-07	237	502
STKc_PFTAIRE2	cd07870	2.2e-06	237	502
PKc_MKK4	cd06616	8.9e-06	238	503
STKc_MEKK2	cd06652	3.1e-06	238	485
STKc_MEKK3_like_1	cd06653	6.7e-08	238	492
STKc_PFTAIRE1	cd07869	7.4e-05	238	505
STKc_Nek6_Nek7	cd08224	1e-08	238	498
STKc_ROCK_NDR_like	cd05573	0.00023	239	502
STKc_phototropin_lik	cd05574	2.7e-05	239	472
STKc_PKA	cd05580	5.7e-05	239	501
STKc_PRKX_like	cd05612	0.00048	239	502
PKc_MAPKK	cd06605	1.5e-10	239	491
STKc_MST3_like	cd06609	1.4e-12	239	505
STKc_OSR1_SPAK	cd06610	8e-13	239	490
PKc_MEK	cd06615	1.7e-06	239	503
PKc_MKK3_6	cd06617	6.9e-08	239	504
PKc_MKK5	cd06619	0.0006	239	505
PKc_MAPKK_Pek1_like	cd06621	3.8e-07	239	490
PKc_MAPKK_PBS2_like	cd06622	2.8e-06	239	500
PKc_MAPKK_plant_like	cd06623	3.6e-12	239	491
STKc_CDKL	cd07833	1.5e-07	239	485
STKc_CdkB_plant	cd07837	2.9e-07	239	502
STKc_CDK10	cd07845	1.5e-06	239	484
STKc_CDKL2_3	cd07846	1.2e-07	239	494
STKc_CDKL1_4	cd07847	1.7e-06	239	502
STKc_CDK6	cd07862	0.00035	239	502
STKc_PCTAIRE3	cd07871	4.4e-06	239	502
STKc_PCTAIRE2	cd07872	2.5e-05	239	504
STKc_PCTAIRE1	cd07873	3.5e-05	239	505
STKc_Nek6	cd08228	1.5e-07	239	495
STKc_Nek7	cd08229	2.9e-09	239	495
SPS1	COG0515	1.4e-08	239	505
PTKc_RET	cd05045	7.5e-40	240	497
PKc_STE	cd05122	1e-13	240	485
STKc_MSK_N	cd05583	1e-05	240	505
STKc_GRK4_like	cd05605	2e-05	240	505
STKc_GRK6	cd05630	0.0008	240	505
STKc_GRK4	cd05631	0.00086	240	498
STKc_GRK5	cd05632	0.00028	240	505
STKc_MAPKKK	cd06606	8.6e-24	240	486
STKc_Cdc7_like	cd06627	9.2e-15	240	486
STKc_MEKK3	cd06651	1.3e-09	240	488
STKc_CCRK	cd07832	7.2e-10	240	495
STKc_Pho85	cd07836	5.8e-06	240	502
STKc_CDK5	cd07839	7.8e-06	240	494
STKc_CDK7	cd07841	1e-09	240	504
STKc_MAPK	cd07834	3e-08	240	493
STKc_CDK8_like	cd07842	6.4e-06	240	495
STKc_MPK1	cd07857	0.00018	240	493
STKc_CDK2_3	cd07860	4.7e-06	240	502
STKc_CDK1_euk	cd07861	4.2e-05	240	502
STKc_CDK4	cd07863	0.00048	240	502
STKc_BUR1	cd07866	5.8e-08	240	483
STKc_Nek	cd08215	1.7e-14	240	486
STKc_Nek1	cd08218	2e-06	240	495
STKc_Nek3	cd08219	1.4e-09	240	490
STKc_Nek8	cd08220	4e-07	240	490
STKc_Nek4	cd08223	1.5e-07	240	495
STKc_Nek5	cd08225	1.3e-07	240	495
STKc_Nek10	cd08528	1.5e-07	240	492
STKc_FA2-like	cd08529	4.4e-11	240	490
STKc_CNK2-like	cd08530	5.1e-07	240	491
PTKc_Tyro3	cd05074	2.7e-45	241	494
PTKc_Axl	cd05075	4.4e-36	241	494
STKc_CMGC	cd05118	3.7e-12	241	486
PTKc_Axl_like	cd05035	1.2e-46	241	494
STKc_PKN	cd05589	6.2e-05	241	504
STKc_MAPKKK_Bck1_lik	cd06629	1.5e-09	241	486
STKc_CDK_like	cd07829	3.2e-13	241	495
STKc_MAK_like	cd07830	5.2e-12	241	491
STKc_MOK	cd07831	1.4e-06	241	483
STKc_CDK1_like	cd07835	2.4e-06	241	502
STKc_CDK4_6_like	cd07838	2.6e-06	241	486
STKc_CDK9_like	cd07840	5.6e-13	241	486
STKc_Yank1	cd05578	7.6e-08	242	495
STKc_PDK1	cd05581	3e-10	242	494
STKc_MEKK4	cd06626	1.2e-09	242	486
STKc_MAPKKK_Byr2_lik	cd06628	4.5e-10	242	494
STKc_MEKK3_like	cd06625	3.6e-12	242	486
STKc_NAK1_like	cd06917	4.1e-08	242	498
STKc_CDC2L1	cd07843	2e-06	242	483
STKc_CRIK	cd05601	0.00034	243	503
STKc_Nek2	cd08217	2e-09	243	491
STKc_Nek11	cd08222	1.8e-06	243	491
STKc_Nek9	cd08221	9.6e-08	244	491
PTKc	cd00192	7.7e-118	245	491
PTK_Jak_rpt1	cd05037	2.4e-10	245	491
PTKc_Ack_like	cd05040	9.6e-68	245	492
PTKc_Fes_like	cd05041	1.7e-81	245	492
PTKc_Aatyk	cd05042	2.2e-12	245	492
PTKc_c-ros	cd05044	1.6e-56	245	492
PTKc_Met_Ron	cd05058	2.7e-51	245	496
PTKc_Syk_like	cd05060	3.9e-67	245	495
PTK_Jak1_rpt1	cd05077	1.3e-07	245	494
PTK_Jak2_Jak3_rpt1	cd05078	3e-09	245	491
PTKc_Fes	cd05084	4.3e-63	245	492
PTKc_Fer	cd05085	5.9e-65	245	492
PTKc_Aatyk1_Aatyk3	cd05087	4.9e-12	245	492
PTKc_Aatyk2	cd05086	3.8e-09	245	492
PTKc_Syk	cd05116	2.3e-55	245	495
STKc_PKC	cd05570	7.8e-08	245	495
STKc_nPKC_theta_delt	cd05592	0.00061	245	505
STKc_nPKC_theta	cd05619	2.9e-05	245	498
STKc_MEKK1	cd06630	6.5e-06	245	492
STKc_MEKK1_plant	cd06632	1.7e-11	245	486
PTKc_Zap-70	cd05115	3.7e-55	246	495
PKc	cd00180	5.6e-60	247	489
PTKc_Tie	cd05047	9.1e-43	247	495
STKc_AGC	cd05123	1.9e-08	247	486
STKc_cGK_PKG	cd05572	5.6e-07	247	490
STKc_GRK	cd05577	3.1e-05	247	505
STKc_MAST_like	cd05579	1.1e-07	247	491
STKc_GRK7	cd05607	6.2e-05	247	504
STKc_GRK1	cd05608	0.00055	247	505
STKc_YSK4	cd06631	1e-07	247	486
SH3_1	pfam00018	8.2e-19	64	110
SH2	pfam00017	6.5e-36	124	205
Pkinase	pfam00069	3.2e-39	241	489
SH3	smart00326	1.5e-19	59	116
SH3_2	pfam07653	9.8e-08	62	115
SH2	smart00252	6.4e-31	122	211
Pkinase_Tyr	pfam07714	9.1e-145	241	490
TyrKc	smart00219	1.1e-123	241	490
STYKc	smart00221	1.3e-56	241	486
S_TKc	smart00220	2.8e-44	251	494

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041673	Polymorphism	p.ALA71THR	N/A
Swiss-Prot	VAR_041672	Polymorphism	p.THR48ILE	N/A
OMIM	191305.0001	Disease	p.ALA71THR	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258