Home News About DMDM Database Statistics Research Publications Contact  

Results for the Protein: Q99759
160332306

M3K3_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 3; AltName: Full=MAPK/ERK kinase kinase 3; Short=MEK kinase 3; Short=MEKK 3
0
3
0
1
2
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

PB1 - smart00666
PB1 - pfam00564
PB1_Mekk2_3 - cd06405
PB1 - cd05992
PTKc_PDGFR_alpha - cd05105
STKc_ROCK2 - cd05621
STKc_ROCK - cd05596
STKc_ROCK1 - cd05622
STKc_PAK5 - cd06658
STKc_PAK6 - cd06659
STKc_myosinIIIB - cd06639
STKc_TAO2 - cd06634
STKc_PAK1 - cd06654
STKc_TAO - cd06607
STKc_PAK4 - cd06657
STKc_PAK2 - cd06655
STKc_PAK_I - cd06647
STKc_PAK3 - cd06656
STKc_PAK - cd06614
PKc_MKK7 - cd06618
STKc_myosinIIIA - cd06638
STKc_JNK - cd07850
STKc_MAP4K4_6 - cd06636
STKc_TAO1 - cd06635
PTKc_FGFR1 - cd05098
STKc_p38gamma_MAPK12 - cd07880
STKc_PAK_II - cd06648
STKc_CDK9 - cd07865
PTKc_FGFR2 - cd05101
STKc_TAO3 - cd06633
STKc_STK10_LOK - cd06644
STKc_p38 - cd07851
STKc_MAP4K5 - cd06646
STKc_MAP4K3 - cd06645
PTKc_Fyn_Yrk - cd05070
PTKc_Yes - cd05069
PTKc_Lck_Blk - cd05067
PTKc_DDR - cd05051
PTKc_Hck - cd05073
PTKc_FGFR4 - cd05099
STKc_ASK - cd06624
PTKc_Lyn - cd05072
STKc_TNIK - cd06637
PTKc_IGF-1R - cd05062
PTKc_EphR_A10 - cd05064
PTKc_Ror - cd05048
PTKc_InsR - cd05061
PTKc_Musk - cd05050
STKc_CDK10 - cd07845
STKc_myosinIII_like - cd06608
STKc_ERK5 - cd07855
PTKc_Csk_like - cd05039
PTKc_InsR_like - cd05032
STKc_BUR1 - cd07866
PTKc_Src - cd05071
PTKc_Jak_rpt2 - cd05038
STKc_TEY_MAPK_plant - cd07858
STKc_PFTAIRE2 - cd07870
STKc_PCTAIRE_like - cd07844
PTKc_Ror1 - cd05090
STKc_SLK - cd06643
STKc_STK25-YSK1 - cd06642
PTKc_Btk_Bmx - cd05113
PTKc_Tec_Rlk - cd05114
PTK_HER3 - cd05111
PKc_MAPKK_Byr1_like - cd06620
STKc_MAP4K3_like - cd06613
PTKc_Itk - cd05112
PTKc_EphR - cd05033
PTKc_EphR_A2 - cd05063
PTKc_EphR_A - cd05066
PTKc_ALK_LTK - cd05036
PTKc_EGFR - cd05108
PTKc_HER2 - cd05109
PTKc_HER4 - cd05110
PTKc_Tec_like - cd05059
STKc_MEKK3 - cd06651
STKc_ERK1_2_like - cd07849
STKc_MEKK3_like - cd06625
STKc_MEKK3_like_1 - cd06653
STKc_MEKK2 - cd06652
PKc_MKK5 - cd06619
PKc_MAPKK_plant_like - cd06623
PKc_MEK - cd06615
STKc_MAPKKK_Bck1_lik - cd06629
STKc_MST3_like - cd06609
STKc_Nek7 - cd08229
STKc_PRKX_like - cd05612
SPS1 - COG0515
STKc_CDC2L6 - cd07867
STKc_Sty1_Hog1 - cd07856
STKc_NAK1_like - cd06917
STKc_CDK8 - cd07868
PTKc_EphR_B - cd05065
PTKc_Csk - cd05082
PTKc_FAK - cd05056
PTKc_Abl - cd05052
PTK_Ryk - cd05043
STKc_MAST - cd05609
PTKc_Chk - cd05083
PTKc_Frk_like - cd05068
STKc_phototropin_lik - cd05574
PTKc_TrkA - cd05092
STKc_ROCK_NDR_like - cd05573
PTKc_TrkC - cd05094
STKc_PDK1 - cd05581
STKc_PKA - cd05580
STKc_CDKL5 - cd07848
STKc_MAPK4_6 - cd07854
STKc_CDK2_3 - cd07860
STKc_CDK1_euk - cd07861
STKc_CDKL1_4 - cd07847
STKc_TDY_MAPK_plant - cd07859
STKc_MPK1 - cd07857
STKc_CCRK - cd07832
STKc_CDK6 - cd07862
PKc_MEK1 - cd06650
STKc_MAPK - cd07834
STKc_Pho85 - cd07836
STKc_CDK5 - cd07839
STKc_CdkB_plant - cd07837
STKc_CDK7 - cd07841
STKc_Nek8 - cd08220
STKc_Nek5 - cd08225
STKc_Nek6_Nek7 - cd08224
STKc_Nek6 - cd08228
STKc_Nek10 - cd08528
PKc_MEK2 - cd06649
STKc_CNK2-like - cd08530
STKc_Nek4 - cd08223
STKc_Nek11 - cd08222
STKc_NLK - cd07853
STKc_PFTAIRE1 - cd07869
STKc_Nek - cd08215
STKc_Nek1 - cd08218
STKc_Nek9 - cd08221
STKc_Nek3 - cd08219
STKc_CDK4 - cd07863
STKc_GRK4 - cd05631
STKc_Yank1 - cd05578
PKc_STE - cd05122
PTKc_DDR_like - cd05097
STKc_MSK_N - cd05583
STKc_cPKC - cd05587
STKc_DMPK_like - cd05597
STKc_LATS - cd05598
PTKc_DDR1 - cd05096
PTKc_DDR2 - cd05095
PTK_CCK4 - cd05046
STKc_MEKK1_plant - cd06632
PTKc_RET - cd05045
PTKc_Trk - cd05049
PTKc_TrkB - cd05093
PTKc_FGFR - cd05053
STKc_GRK4_like - cd05605
PTKc_EGFR_like - cd05057
STKc_MEKK4 - cd06626
STKc_MAPKKK - cd06606
STKc_GRK5 - cd05632
STKc_Cdc7_like - cd06627
STKc_MEKK1 - cd06630
STKc_MSK1_N - cd05613
STKc_MAPKKK_Byr2_lik - cd06628
STKc_GRK6 - cd05630
STKc_YSK4 - cd06631
STKc_cPKC_alpha - cd05615
STKc_NDR_like_fungal - cd05629
STKc_MSK2_N - cd05614
STKc_MRCK_alpha - cd05623
STKc_cPKC_beta - cd05616
STKc_NDR1 - cd05628
STKc_MRCK_beta - cd05624
STKc_CDK4_6_like - cd07838
STKc_MAK_like - cd07830
STKc_CDK9_like - cd07840
STKc_CDK12 - cd07864
STKc_CDK1_like - cd07835
Pkinase_Tyr - pfam07714
STKc_MOK - cd07831
Pkinase - pfam00069
TyrKc - smart00219
STYKc - smart00221
STKc_CMGC - cd05118
PTKc_Tie1 - cd05089
STKc_CDK_like - cd07829
PTKc_Jak1_rpt2 - cd05079
PTKc_Axl - cd05075
PTKc_Tyro3 - cd05074
PTKc_Src_like - cd05034
PTKc_Srm_Brk - cd05148
STKc_MST3 - cd06641
STKc_MST4 - cd06640
PKc_MKK4 - cd06616
STKc_PKN - cd05589
PTKc_Axl_like - cd05035
PKc_MAPKK - cd06605
PTKc_Tyk2_rpt2 - cd05080
STKc_PCTAIRE1 - cd07873
PK_STRAD - cd08216
STKc_MAPK15 - cd07852
STKc_PCTAIRE2 - cd07872
STKc_CDK8_like - cd07842
STKc_PCTAIRE3 - cd07871
STKc_CDKL - cd07833
STKc_p70S6K - cd05584
PKc_MAPKK_Pek1_like - cd06621
STKc_SGK1 - cd05602
STKc_NDR_like - cd05599
STKc_CRIK - cd05601
STKc_PKB_alpha - cd05594
STKc_SGK2 - cd05603
STKc_PKB_gamma - cd05593
STKc_PKB_beta - cd05595
STKc_OSR1_SPAK - cd06610
STKc_Nek2 - cd08217
STKc_FA2-like - cd08529
PKc_MKK3_6 - cd06617
STKc_nPKC_theta_delt - cd05592
STKc_nPKC_theta - cd05619
STKc_Rim15_like - cd05611
STKc_nPKC_eta - cd05590
PTKc - cd00192
STKc_nPKC_epsilon - cd05591
PTKc_Tie - cd05047
PTKc_Syk_like - cd05060
PTK_Jak_rpt1 - cd05037
PTKc_Ack_like - cd05040
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Fes_like - cd05041
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Met_Ron - cd05058
PTKc_Syk - cd05116
PTKc_Aatyk1_Aatyk3 - cd05087
STKc_PKC - cd05570
STKc_PKB - cd05571
STKc_RSK_N - cd05582
STKc_SGK - cd05575
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Aatyk2 - cd05086
PTKc_Fes - cd05084
PTKc_Fer - cd05085
STKc_MST1_2 - cd06612
STKc_GRK3 - cd05633
STKc_CDKL2_3 - cd07846
STKc_beta_ARK - cd05606
STKc_SLK_like - cd06611
STKc_GRK1 - cd05608
PKc_MAPKK_PBS2_like - cd06622
PKc - cd00180
STKc_cGK_PKG - cd05572
STKc_AGC - cd05123
PTKc_Zap-70 - cd05115
STKc_GRK7 - cd05607
STKc_GRK - cd05577
STKc_MAST_like - cd05579
STKc_YPK1_like - cd05585
STKc_Sid2p_Dbf2p - cd05600
STKc_CDC2L1 - cd07843
S_TKc - smart00220
KIND - smart00750


Swiss-Prot Protein: Q99759
Identical to: NP_002392
   Default View:



































































































































































































































































Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PB1cd059924e-1545121
PB1_Mekk2_3cd064051e-5545123
PTKc_PDGFR_alphacd051050.00082258626
STKc_ROCKcd055963.2e-06320625
STKc_ROCK2cd056219.6e-06320626
STKc_ROCK1cd056220.00022320626
STKc_PAK5cd066582.5e-11334625
STKc_myosinIIIBcd066392.4e-18335623
STKc_PAK6cd066594.3e-12335624
STKc_TAOcd066071.5e-11339626
STKc_TAO2cd066346.7e-12339626
STKc_PAK1cd066541.2e-23339626
STKc_PAK_Icd066474.7e-33340626
STKc_PAK2cd066554.1e-23340625
STKc_PAK3cd066563.3e-22340625
STKc_PAK4cd066571.3e-08340626
STKc_PAKcd066142e-38341625
PKc_MKK7cd066188.1e-12343626
STKc_myosinIIIAcd066383.2e-24344622
PTKc_FGFR1cd050980.00011345624
STKc_TAO1cd066354.7e-11345623
STKc_MAP4K4_6cd066362.4e-29345622
STKc_JNKcd078500.00041345626
STKc_p38gamma_MAPK12cd078800.00027346626
STKc_PAK_IIcd066482.3e-16347625
STKc_CDK9cd078654.3e-10347622
PTKc_FGFR2cd051013.3e-05348624
STKc_TAO3cd066334.1e-08348626
STKc_STK10_LOKcd066443.9e-27349625
STKc_p38cd078516.9e-08349625
PTKc_DDRcd050516.1e-06350624
PTKc_Lck_Blkcd050671.3e-06350624
PTKc_Yescd050696.8e-07350623
PTKc_Fyn_Yrkcd050701e-05350623
PTKc_Hckcd050731.1e-07350621
STKc_MAP4K3cd066455.7e-32350621
STKc_MAP4K5cd066464e-36350621
PTKc_FGFR4cd050990.00023351625
STKc_ASKcd066242.2e-66353622
PTKc_Rorcd050484.8e-06354599
PTKc_Muskcd050501.7e-05354624
PTKc_InsRcd050617.8e-06354626
PTKc_IGF-1Rcd050621.3e-06354622
PTKc_EphR_A10cd050641.1e-05354626
PTKc_Lyncd050724.4e-08354621
STKc_TNIKcd066373e-29354622
STKc_myosinIII_likecd066081.2e-20355622
STKc_CDK10cd078455.2e-12355625
STKc_ERK5cd078554.1e-06355625
PTKc_InsR_likecd050321.2e-08356622
PTKc_Csk_likecd050391.1e-06356586
PTKc_Jak_rpt2cd050384.6e-14357625
PTKc_Srccd050711.2e-07357622
PTKc_Ror1cd050900.0002357614
STKc_SLKcd066434.6e-25357624
STKc_STK25-YSK1cd066429.7e-28357625
STKc_PCTAIRE_likecd078442.7e-09357622
STKc_TEY_MAPK_plantcd078584.4e-05357626
STKc_BUR1cd078663.5e-14357622
STKc_PFTAIRE2cd078706.7e-08357622
PTKc_ALK_LTKcd050367.7e-09358598
PTKc_EphRcd050331.4e-05358625
PTKc_EphR_A2cd050631.9e-06358625
PTKc_EphR_Acd050660.00019358625
PTKc_EGFRcd051080.00014358619
PTKc_HER2cd051093.3e-06358625
PTKc_HER4cd051100.00018358621
PTK_HER3cd051114.4e-07358606
PTKc_Itkcd051123.5e-11358622
PTKc_Btk_Bmxcd051131.6e-09358621
PTKc_Tec_Rlkcd051149.5e-09358621
STKc_MAP4K3_likecd066133.3e-44358621
PKc_MAPKK_Byr1_likecd066205.3e-14358622
PTKc_Tec_likecd050591.8e-09359604
STKc_MEKK3_likecd066251.7e-218359622
STKc_MEKK3cd066511.4e-247359624
STKc_MEKK2cd066521.4e-215359623
STKc_MEKK3_like_1cd066537.1e-204359622
STKc_ERK1_2_likecd078491.3e-08359626
PTK_Rykcd050435.7e-07360624
PTKc_Ablcd050521e-06360626
PTKc_FAKcd050561e-08360626
PTKc_EphR_Bcd050653.5e-05360625
PTKc_Frk_likecd050682e-09360624
PTKc_Cskcd050822.9e-06360620
PTKc_Chkcd050831.4e-05360623
PTKc_TrkAcd050927.2e-09360624
PTKc_TrkCcd050942.6e-06360626
STKc_ROCK_NDR_likecd055732.4e-12360626
STKc_phototropin_likcd055742.9e-09360626
STKc_PKAcd055803.9e-13360624
STKc_PDK1cd055814e-18360622
STKc_MASTcd056094.8e-08360625
STKc_PRKX_likecd056122e-10360625
STKc_MST3_likecd066092.2e-54360625
PKc_MEKcd066155.6e-13360625
PKc_MKK5cd066194.5e-07360625
PKc_MAPKK_plant_likecd066234e-36360624
STKc_MAPKKK_Bck1_likcd066291.3e-68360622
STKc_NAK1_likecd069173.9e-28360625
STKc_Sty1_Hog1cd078567.1e-07360626
STKc_CDC2L6cd078676.3e-05360622
STKc_CDK8cd078688.4e-05360622
STKc_Nek7cd082293.6e-17360622
SPS1COG05152.6e-34360625
PTKc_RETcd050456.6e-05361625
PTK_CCK4cd050461.7e-05361622
PTKc_Trkcd050494.2e-11361619
PTKc_EGFR_likecd050579.3e-07361606
PTKc_FGFRcd050530.00011361625
PTKc_TrkBcd050932.4e-08361619
PTKc_DDR2cd050955e-06361622
PTKc_DDR1cd050960.00085361624
PTKc_DDR_likecd050970.00011361624
PKc_STEcd051228.1e-67361621
STKc_Yank1cd055785.5e-13361622
STKc_MSK_Ncd055832.7e-09361625
STKc_cPKCcd055871.6e-05361626
STKc_LATScd055986.5e-06361625
STKc_DMPK_likecd055970.00032361626
STKc_GRK4_likecd056056.1e-08361626
STKc_MSK1_Ncd056132e-07361626
STKc_MSK2_Ncd056143e-06361625
STKc_cPKC_alphacd056154.5e-06361626
STKc_cPKC_betacd056167e-05361626
STKc_MRCK_alphacd056233.4e-05361626
STKc_MRCK_betacd056249.4e-05361625
STKc_NDR1cd056282.4e-05361626
STKc_NDR_like_fungalcd056290.00059361626
STKc_GRK6cd056302.7e-05361626
STKc_GRK4cd056314e-06361625
STKc_GRK5cd056321.3e-06361626
STKc_MAPKKKcd066064.4e-152361622
STKc_MEKK4cd066261.1e-74361622
STKc_Cdc7_likecd066271e-73361622
STKc_MAPKKK_Byr2_likcd066284.9e-98361622
STKc_MEKK1cd066305.4e-73361622
STKc_YSK4cd066312.1e-95361622
STKc_MEKK1_plantcd066325.6e-114361622
PKc_MEK2cd066499.5e-05361625
PKc_MEK1cd066505.1e-05361622
STKc_CCRKcd078322.9e-15361623
STKc_MAPKcd078343.1e-10361625
STKc_Pho85cd078366.3e-17361622
STKc_CdkB_plantcd078371e-12361623
STKc_CDK5cd078395.5e-11361622
STKc_CDK7cd078411.1e-15361625
STKc_CDKL1_4cd078476.7e-11361622
STKc_CDKL5cd078480.00029361622
STKc_MAPK4_6cd078544.8e-07361626
STKc_MPK1cd078571.5e-06361624
STKc_TDY_MAPK_plantcd078594.5e-05361626
STKc_CDK2_3cd078602.2e-16361622
STKc_CDK1_eukcd078611.7e-11361622
STKc_CDK6cd078621.1e-06361622
STKc_CDK4cd078638.4e-12361622
STKc_PFTAIRE1cd078690.00019361626
STKc_NLKcd078530.00031361626
STKc_Nekcd082151e-40361622
STKc_Nek1cd082182.7e-28361622
STKc_Nek3cd082197.7e-27361622
STKc_Nek8cd082203.3e-30361622
STKc_Nek9cd082217.5e-21361622
STKc_Nek11cd082221e-27361622
STKc_Nek4cd082231.5e-22361622
STKc_Nek6_Nek7cd082243.1e-18361626
STKc_Nek5cd082251.4e-28361622
STKc_Nek6cd082281.1e-17361626
STKc_Nek10cd085283.6e-09361622
STKc_CNK2-likecd085307.6e-14361622
PTKc_Src_likecd050341.1e-09362624
PTKc_Axl_likecd050353.1e-06362624
PTKc_Tyro3cd050742.2e-06362624
PTKc_Axlcd050750.00036362624
PTKc_Jak1_rpt2cd050794.6e-23362625
PTKc_Tie1cd050890.00095362625
STKc_CMGCcd051182.4e-17362622
PTKc_Srm_Brkcd051489e-09362619
STKc_PKNcd055891.1e-06362626
PKc_MKK4cd066164.3e-11362624
STKc_MST4cd066401.5e-24362625
STKc_MST3cd066411.7e-25362625
STKc_CDK_likecd078291.9e-19362622
STKc_MOKcd078316.8e-13362622
STKc_CDK1_likecd078357e-13362622
STKc_CDK4_6_likecd078381.1e-12362622
STKc_CDK9_likecd078401.1e-17362622
STKc_MAK_likecd078302.7e-13362622
STKc_CDK12cd078645.9e-12362622
PTKc_Tyk2_rpt2cd050805.4e-12363620
PKc_MAPKKcd066055e-20363626
STKc_p70S6Kcd055846.3e-06365626
PKc_MAPKK_Pek1_likecd066213.4e-17365625
STKc_CDKLcd078334.3e-13365622
STKc_CDK8_likecd078425.2e-11365622
STKc_MAPK15cd078529.1e-09365626
STKc_PCTAIRE3cd078711.2e-08365622
STKc_PCTAIRE2cd078727e-06365625
STKc_PCTAIRE1cd078735.5e-07365625
PK_STRADcd082162.5e-09365624
PTKccd001921.4e-18366622
PTK_Jak_rpt1cd050370.0005366604
PTKc_Ack_likecd050408.6e-12366618
PTKc_Fes_likecd050411.3e-10366622
PTKc_Aatykcd050421.3e-06366619
PTKc_c-roscd050445.3e-06366619
PTKc_Tiecd050470.00022366625
PTKc_Met_Roncd050582.3e-05366626
PTKc_Syk_likecd050601.7e-07366597
PTK_Jak2_Jak3_rpt1cd050780.00049366621
PTKc_Jak2_Jak3_rpt2cd050819.2e-12366625
PTKc_Fescd050843e-06366622
PTKc_Fercd050857.8e-07366622
PTKc_Aatyk2cd050869.8e-05366619
PTKc_Aatyk1_Aatyk3cd050875.6e-06366626
PTKc_Sykcd051162.8e-05366622
STKc_PKCcd055702e-10366625
STKc_PKBcd055711.3e-07366626
STKc_SGKcd055752e-05366626
STKc_RSK_Ncd055820.00028366624
STKc_nPKC_epsiloncd055919.9e-06366625
STKc_nPKC_theta_deltcd055922.3e-06366626
STKc_PKB_gammacd055931.2e-06366626
STKc_PKB_alphacd055947.6e-07366626
STKc_PKB_betacd055952e-06366626
STKc_CRIKcd056018.6e-09366626
STKc_SGK1cd056022.5e-05366624
STKc_NDR_likecd055991.2e-06366626
STKc_SGK2cd056036.6e-06366623
STKc_nPKC_etacd055900.00012366625
STKc_Rim15_likecd056113.9e-06366624
STKc_nPKC_thetacd056192.7e-07366626
STKc_OSR1_SPAKcd066101.7e-23366622
PKc_MKK3_6cd066172.7e-12366625
STKc_Nek2cd082177.7e-20366622
STKc_FA2-likecd085292e-17366622
STKc_beta_ARKcd056069.5e-08367625
STKc_GRK3cd056334.2e-06367626
STKc_MST1_2cd066123.4e-47367622
STKc_CDKL2_3cd078461.2e-11367622
PKccd001809.4e-78368620
PTKc_Zap-70cd051159.2e-06368622
STKc_AGCcd051231.3e-16368622
STKc_cGK_PKGcd055721.4e-14368623
STKc_GRKcd055778.2e-11368625
STKc_MAST_likecd055791.8e-18368621
STKc_YPK1_likecd055855e-06368626
STKc_Sid2p_Dbf2pcd056004.4e-07368623
STKc_GRK7cd056072.3e-06368625
STKc_GRK1cd056081.3e-08368624
STKc_SLK_likecd066113.2e-22368625
PKc_MAPKK_PBS2_likecd066222.5e-09368620
STKc_CDC2L1cd078439.8e-11371622
PB1pfam005645.4e-1944123
Pkinasepfam000692.4e-78362622
PB1smart006666.9e-1844121
Pkinase_Tyrpfam077141.9e-19362621
TyrKcsmart002191.9e-16362621
STYKcsmart002217.2e-85362622
S_TKcsmart002201e-94372622
KINDsmart007501.3e-08459624

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_037275Polymorphismp.ALA325GLYN/A
Swiss-ProtVAR_037276Polymorphismp.ALA435GLYN/A
dbSNPrs36109904 Polymorphismp.VAL281METN/A



   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258