Results for the protein: Q99759

Results for the Protein: Q99759

160332306

4215

MAP3K3

NCBI, UniProt

M3K3_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 3; AltName: Full=MAPK/ERK kinase kinase 3; Short=MEK kinase 3; Short=MEKK 3

			0 3 0 1 2

Tips:

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Swiss-Prot Protein: Q99759

Identical to: NP_002392

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PB1_Mekk2_3	cd06405	1e-55	45	123
PTKc_PDGFR_alpha	cd05105	0.00082	258	626
STKc_ROCK	cd05596	3.2e-06	320	625
STKc_ROCK2	cd05621	9.6e-06	320	626
STKc_ROCK1	cd05622	0.00022	320	626
STKc_PAK5	cd06658	2.5e-11	334	625
STKc_myosinIIIB	cd06639	2.4e-18	335	623
STKc_PAK6	cd06659	4.3e-12	335	624
STKc_TAO	cd06607	1.5e-11	339	626
STKc_TAO2	cd06634	6.7e-12	339	626
STKc_PAK1	cd06654	1.2e-23	339	626
STKc_PAK_I	cd06647	4.7e-33	340	626
STKc_PAK2	cd06655	4.1e-23	340	625
STKc_PAK3	cd06656	3.3e-22	340	625
STKc_PAK4	cd06657	1.3e-08	340	626
STKc_PAK	cd06614	2e-38	341	625
PKc_MKK7	cd06618	8.1e-12	343	626
STKc_myosinIIIA	cd06638	3.2e-24	344	622
PTKc_FGFR1	cd05098	0.00011	345	624
STKc_TAO1	cd06635	4.7e-11	345	623
STKc_MAP4K4_6	cd06636	2.4e-29	345	622
STKc_JNK	cd07850	0.00041	345	626
STKc_p38gamma_MAPK12	cd07880	0.00027	346	626
STKc_PAK_II	cd06648	2.3e-16	347	625
STKc_CDK9	cd07865	4.3e-10	347	622
PTKc_FGFR2	cd05101	3.3e-05	348	624
STKc_TAO3	cd06633	4.1e-08	348	626
STKc_STK10_LOK	cd06644	3.9e-27	349	625
STKc_p38	cd07851	6.9e-08	349	625
PTKc_DDR	cd05051	6.1e-06	350	624
PTKc_Lck_Blk	cd05067	1.3e-06	350	624
PTKc_Yes	cd05069	6.8e-07	350	623
PTKc_Fyn_Yrk	cd05070	1e-05	350	623
PTKc_Hck	cd05073	1.1e-07	350	621
STKc_MAP4K3	cd06645	5.7e-32	350	621
STKc_MAP4K5	cd06646	4e-36	350	621
PTKc_FGFR4	cd05099	0.00023	351	625
STKc_ASK	cd06624	2.2e-66	353	622
PTKc_Ror	cd05048	4.8e-06	354	599
PTKc_Musk	cd05050	1.7e-05	354	624
PTKc_InsR	cd05061	7.8e-06	354	626
PTKc_IGF-1R	cd05062	1.3e-06	354	622
PTKc_EphR_A10	cd05064	1.1e-05	354	626
PTKc_Lyn	cd05072	4.4e-08	354	621
STKc_TNIK	cd06637	3e-29	354	622
STKc_myosinIII_like	cd06608	1.2e-20	355	622
STKc_CDK10	cd07845	5.2e-12	355	625
STKc_ERK5	cd07855	4.1e-06	355	625
PTKc_InsR_like	cd05032	1.2e-08	356	622
PTKc_Csk_like	cd05039	1.1e-06	356	586
PTKc_Jak_rpt2	cd05038	4.6e-14	357	625
PTKc_Src	cd05071	1.2e-07	357	622
PTKc_Ror1	cd05090	0.0002	357	614
STKc_SLK	cd06643	4.6e-25	357	624
STKc_STK25-YSK1	cd06642	9.7e-28	357	625
STKc_PCTAIRE_like	cd07844	2.7e-09	357	622
STKc_TEY_MAPK_plant	cd07858	4.4e-05	357	626
STKc_BUR1	cd07866	3.5e-14	357	622
STKc_PFTAIRE2	cd07870	6.7e-08	357	622
PTKc_ALK_LTK	cd05036	7.7e-09	358	598
PTKc_EphR	cd05033	1.4e-05	358	625
PTKc_EphR_A2	cd05063	1.9e-06	358	625
PTKc_EphR_A	cd05066	0.00019	358	625
PTKc_EGFR	cd05108	0.00014	358	619
PTKc_HER2	cd05109	3.3e-06	358	625
PTKc_HER4	cd05110	0.00018	358	621
PTK_HER3	cd05111	4.4e-07	358	606
PTKc_Itk	cd05112	3.5e-11	358	622
PTKc_Btk_Bmx	cd05113	1.6e-09	358	621
PTKc_Tec_Rlk	cd05114	9.5e-09	358	621
STKc_MAP4K3_like	cd06613	3.3e-44	358	621
PKc_MAPKK_Byr1_like	cd06620	5.3e-14	358	622
PTKc_Tec_like	cd05059	1.8e-09	359	604
STKc_MEKK3_like	cd06625	1.7e-218	359	622
STKc_MEKK3	cd06651	1.4e-247	359	624
STKc_MEKK2	cd06652	1.4e-215	359	623
STKc_MEKK3_like_1	cd06653	7.1e-204	359	622
STKc_ERK1_2_like	cd07849	1.3e-08	359	626
PTK_Ryk	cd05043	5.7e-07	360	624
PTKc_Abl	cd05052	1e-06	360	626
PTKc_FAK	cd05056	1e-08	360	626
PTKc_EphR_B	cd05065	3.5e-05	360	625
PTKc_Frk_like	cd05068	2e-09	360	624
PTKc_Csk	cd05082	2.9e-06	360	620
PTKc_Chk	cd05083	1.4e-05	360	623
PTKc_TrkA	cd05092	7.2e-09	360	624
PTKc_TrkC	cd05094	2.6e-06	360	626
STKc_ROCK_NDR_like	cd05573	2.4e-12	360	626
STKc_phototropin_lik	cd05574	2.9e-09	360	626
STKc_PKA	cd05580	3.9e-13	360	624
STKc_PDK1	cd05581	4e-18	360	622
STKc_MAST	cd05609	4.8e-08	360	625
STKc_PRKX_like	cd05612	2e-10	360	625
STKc_MST3_like	cd06609	2.2e-54	360	625
PKc_MEK	cd06615	5.6e-13	360	625
PKc_MKK5	cd06619	4.5e-07	360	625
PKc_MAPKK_plant_like	cd06623	4e-36	360	624
STKc_MAPKKK_Bck1_lik	cd06629	1.3e-68	360	622
STKc_NAK1_like	cd06917	3.9e-28	360	625
STKc_Sty1_Hog1	cd07856	7.1e-07	360	626
STKc_CDC2L6	cd07867	6.3e-05	360	622
STKc_CDK8	cd07868	8.4e-05	360	622
STKc_Nek7	cd08229	3.6e-17	360	622
SPS1	COG0515	2.6e-34	360	625
PTKc_RET	cd05045	6.6e-05	361	625
PTK_CCK4	cd05046	1.7e-05	361	622
PTKc_Trk	cd05049	4.2e-11	361	619
PTKc_EGFR_like	cd05057	9.3e-07	361	606
PTKc_FGFR	cd05053	0.00011	361	625
PTKc_TrkB	cd05093	2.4e-08	361	619
PTKc_DDR2	cd05095	5e-06	361	622
PTKc_DDR1	cd05096	0.00085	361	624
PTKc_DDR_like	cd05097	0.00011	361	624
PKc_STE	cd05122	8.1e-67	361	621
STKc_Yank1	cd05578	5.5e-13	361	622
STKc_MSK_N	cd05583	2.7e-09	361	625
STKc_cPKC	cd05587	1.6e-05	361	626
STKc_LATS	cd05598	6.5e-06	361	625
STKc_DMPK_like	cd05597	0.00032	361	626
STKc_GRK4_like	cd05605	6.1e-08	361	626
STKc_MSK1_N	cd05613	2e-07	361	626
STKc_MSK2_N	cd05614	3e-06	361	625
STKc_cPKC_alpha	cd05615	4.5e-06	361	626
STKc_cPKC_beta	cd05616	7e-05	361	626
STKc_MRCK_alpha	cd05623	3.4e-05	361	626
STKc_MRCK_beta	cd05624	9.4e-05	361	625
STKc_NDR1	cd05628	2.4e-05	361	626
STKc_NDR_like_fungal	cd05629	0.00059	361	626
STKc_GRK6	cd05630	2.7e-05	361	626
STKc_GRK4	cd05631	4e-06	361	625
STKc_GRK5	cd05632	1.3e-06	361	626
STKc_MAPKKK	cd06606	4.4e-152	361	622
STKc_MEKK4	cd06626	1.1e-74	361	622
STKc_Cdc7_like	cd06627	1e-73	361	622
STKc_MAPKKK_Byr2_lik	cd06628	4.9e-98	361	622
STKc_MEKK1	cd06630	5.4e-73	361	622
STKc_YSK4	cd06631	2.1e-95	361	622
STKc_MEKK1_plant	cd06632	5.6e-114	361	622
PKc_MEK2	cd06649	9.5e-05	361	625
PKc_MEK1	cd06650	5.1e-05	361	622
STKc_CCRK	cd07832	2.9e-15	361	623
STKc_MAPK	cd07834	3.1e-10	361	625
STKc_Pho85	cd07836	6.3e-17	361	622
STKc_CdkB_plant	cd07837	1e-12	361	623
STKc_CDK5	cd07839	5.5e-11	361	622
STKc_CDK7	cd07841	1.1e-15	361	625
STKc_CDKL1_4	cd07847	6.7e-11	361	622
STKc_CDKL5	cd07848	0.00029	361	622
STKc_MAPK4_6	cd07854	4.8e-07	361	626
STKc_MPK1	cd07857	1.5e-06	361	624
STKc_TDY_MAPK_plant	cd07859	4.5e-05	361	626
STKc_CDK2_3	cd07860	2.2e-16	361	622
STKc_CDK1_euk	cd07861	1.7e-11	361	622
STKc_CDK6	cd07862	1.1e-06	361	622
STKc_CDK4	cd07863	8.4e-12	361	622
STKc_PFTAIRE1	cd07869	0.00019	361	626
STKc_NLK	cd07853	0.00031	361	626
STKc_Nek	cd08215	1e-40	361	622
STKc_Nek1	cd08218	2.7e-28	361	622
STKc_Nek3	cd08219	7.7e-27	361	622
STKc_Nek8	cd08220	3.3e-30	361	622
STKc_Nek9	cd08221	7.5e-21	361	622
STKc_Nek11	cd08222	1e-27	361	622
STKc_Nek4	cd08223	1.5e-22	361	622
STKc_Nek6_Nek7	cd08224	3.1e-18	361	626
STKc_Nek5	cd08225	1.4e-28	361	622
STKc_Nek6	cd08228	1.1e-17	361	626
STKc_Nek10	cd08528	3.6e-09	361	622
STKc_CNK2-like	cd08530	7.6e-14	361	622
PTKc_Src_like	cd05034	1.1e-09	362	624
PTKc_Axl_like	cd05035	3.1e-06	362	624
PTKc_Tyro3	cd05074	2.2e-06	362	624
PTKc_Axl	cd05075	0.00036	362	624
PTKc_Jak1_rpt2	cd05079	4.6e-23	362	625
PTKc_Tie1	cd05089	0.00095	362	625
STKc_CMGC	cd05118	2.4e-17	362	622
PTKc_Srm_Brk	cd05148	9e-09	362	619
STKc_PKN	cd05589	1.1e-06	362	626
PKc_MKK4	cd06616	4.3e-11	362	624
STKc_MST4	cd06640	1.5e-24	362	625
STKc_MST3	cd06641	1.7e-25	362	625
STKc_CDK_like	cd07829	1.9e-19	362	622
STKc_MOK	cd07831	6.8e-13	362	622
STKc_CDK1_like	cd07835	7e-13	362	622
STKc_CDK4_6_like	cd07838	1.1e-12	362	622
STKc_CDK9_like	cd07840	1.1e-17	362	622
STKc_MAK_like	cd07830	2.7e-13	362	622
STKc_CDK12	cd07864	5.9e-12	362	622
PTKc_Tyk2_rpt2	cd05080	5.4e-12	363	620
PKc_MAPKK	cd06605	5e-20	363	626
STKc_p70S6K	cd05584	6.3e-06	365	626
PKc_MAPKK_Pek1_like	cd06621	3.4e-17	365	625
STKc_CDKL	cd07833	4.3e-13	365	622
STKc_CDK8_like	cd07842	5.2e-11	365	622
STKc_MAPK15	cd07852	9.1e-09	365	626
STKc_PCTAIRE3	cd07871	1.2e-08	365	622
STKc_PCTAIRE2	cd07872	7e-06	365	625
STKc_PCTAIRE1	cd07873	5.5e-07	365	625
PK_STRAD	cd08216	2.5e-09	365	624
PTKc	cd00192	1.4e-18	366	622
PTK_Jak_rpt1	cd05037	0.0005	366	604
PTKc_Ack_like	cd05040	8.6e-12	366	618
PTKc_Fes_like	cd05041	1.3e-10	366	622
PTKc_Aatyk	cd05042	1.3e-06	366	619
PTKc_c-ros	cd05044	5.3e-06	366	619
PTKc_Tie	cd05047	0.00022	366	625
PTKc_Met_Ron	cd05058	2.3e-05	366	626
PTKc_Syk_like	cd05060	1.7e-07	366	597
PTK_Jak2_Jak3_rpt1	cd05078	0.00049	366	621
PTKc_Jak2_Jak3_rpt2	cd05081	9.2e-12	366	625
PTKc_Fes	cd05084	3e-06	366	622
PTKc_Fer	cd05085	7.8e-07	366	622
PTKc_Aatyk2	cd05086	9.8e-05	366	619
PTKc_Aatyk1_Aatyk3	cd05087	5.6e-06	366	626
PTKc_Syk	cd05116	2.8e-05	366	622
STKc_PKC	cd05570	2e-10	366	625
STKc_PKB	cd05571	1.3e-07	366	626
STKc_SGK	cd05575	2e-05	366	626
STKc_RSK_N	cd05582	0.00028	366	624
STKc_nPKC_epsilon	cd05591	9.9e-06	366	625
STKc_nPKC_theta_delt	cd05592	2.3e-06	366	626
STKc_PKB_gamma	cd05593	1.2e-06	366	626
STKc_PKB_alpha	cd05594	7.6e-07	366	626
STKc_PKB_beta	cd05595	2e-06	366	626
STKc_CRIK	cd05601	8.6e-09	366	626
STKc_SGK1	cd05602	2.5e-05	366	624
STKc_NDR_like	cd05599	1.2e-06	366	626
STKc_SGK2	cd05603	6.6e-06	366	623
STKc_nPKC_eta	cd05590	0.00012	366	625
STKc_Rim15_like	cd05611	3.9e-06	366	624
STKc_nPKC_theta	cd05619	2.7e-07	366	626
STKc_OSR1_SPAK	cd06610	1.7e-23	366	622
PKc_MKK3_6	cd06617	2.7e-12	366	625
STKc_Nek2	cd08217	7.7e-20	366	622
STKc_FA2-like	cd08529	2e-17	366	622
STKc_beta_ARK	cd05606	9.5e-08	367	625
STKc_GRK3	cd05633	4.2e-06	367	626
STKc_MST1_2	cd06612	3.4e-47	367	622
STKc_CDKL2_3	cd07846	1.2e-11	367	622
PKc	cd00180	9.4e-78	368	620
PTKc_Zap-70	cd05115	9.2e-06	368	622
STKc_AGC	cd05123	1.3e-16	368	622
STKc_cGK_PKG	cd05572	1.4e-14	368	623
STKc_GRK	cd05577	8.2e-11	368	625
STKc_MAST_like	cd05579	1.8e-18	368	621
STKc_YPK1_like	cd05585	5e-06	368	626
STKc_Sid2p_Dbf2p	cd05600	4.4e-07	368	623
STKc_GRK7	cd05607	2.3e-06	368	625
STKc_GRK1	cd05608	1.3e-08	368	624
STKc_SLK_like	cd06611	3.2e-22	368	625
PKc_MAPKK_PBS2_like	cd06622	2.5e-09	368	620
STKc_CDC2L1	cd07843	9.8e-11	371	622
PB1	pfam00564	5.4e-19	44	123
Pkinase	pfam00069	2.4e-78	362	622
PB1	smart00666	6.9e-18	44	121
Pkinase_Tyr	pfam07714	1.9e-19	362	621
TyrKc	smart00219	1.9e-16	362	621
STYKc	smart00221	7.2e-85	362	622
S_TKc	smart00220	1e-94	372	622
KIND	smart00750	1.3e-08	459	624

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_037275	Polymorphism	p.ALA325GLY	N/A
Swiss-Prot	VAR_037276	Polymorphism	p.ALA435GLY	N/A
dbSNP	rs36109904	Polymorphism	p.VAL281MET	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258