Results for the protein: P53350

Results for the Protein: P53350

1709658

5347

PLK1

NCBI, UniProt

PLK1_HUMAN RecName: Full=Serine/threonine-protein kinase PLK1; AltName: Full=Polo-like kinase 1; Short=PLK-1; AltName: Full=Serine/threonine-protein kinase 13; Short=STPK13

			0 8 0 0 8

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Swiss-Prot Protein: P53350

Identical to: NP_005021

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK1	cd05622	3.5e-08	16	370
STKc_CDKL5	cd07848	4.6e-05	18	305
STKc_ROCK2	cd05621	1.3e-08	20	369
STKc_JNK1	cd07875	0.00044	26	378
STKc_TAO1	cd06635	4.3e-08	27	345
STKc_myosinIIIB	cd06639	1.3e-10	29	306
STKc_PAK	cd06614	4.1e-22	32	314
STKc_TAO3	cd06633	1.2e-06	32	345
STKc_PAK5	cd06658	7.1e-09	32	324
STKc_PAK6	cd06659	2.2e-11	32	328
STKc_PAK4	cd06657	8.1e-10	33	326
STKc_p38alpha_MAPK14	cd07877	2e-07	33	350
STKc_JNK2	cd07876	4.2e-05	34	371
STKc_PAK1	cd06654	5.5e-09	36	336
STKc_CDK9	cd07865	1.4e-09	36	305
PTKc_FGFR2	cd05101	2.7e-05	37	312
STKc_TAO	cd06607	2.7e-08	37	345
STKc_TAO2	cd06634	8.7e-10	37	346
STKc_PAK2	cd06655	5.7e-10	37	337
STKc_PAK3	cd06656	7.2e-10	37	332
STKc_p38beta_MAPK11	cd07878	7.1e-07	37	350
STKc_p38delta_MAPK13	cd07879	2e-05	37	352
STKc_p38gamma_MAPK12	cd07880	1.6e-08	37	350
PTKc_PDGFR	cd05055	0.00019	38	304
STKc_MAP4K4_6	cd06636	2.5e-07	38	305
STKc_STK10_LOK	cd06644	1.3e-09	38	327
STKc_PAK_II	cd06648	6e-13	38	318
STKc_JNK	cd07850	1.4e-06	38	381
STKc_JNK3	cd07874	2.8e-05	38	371
STKc_p38	cd07851	1.8e-11	39	339
STKc_PAK_I	cd06647	1.8e-11	41	328
PTKc_FGFR1	cd05098	2.9e-05	42	314
PTKc_HER2	cd05109	1.8e-05	42	318
STKc_ASK	cd06624	5.8e-25	42	305
PTKc_FGFR	cd05053	8e-06	43	306
PTKc_EGFR_like	cd05057	1.6e-05	43	317
PTKc_FGFR3	cd05100	0.00034	43	343
PTKc_FGFR4	cd05099	3.3e-06	43	322
STKc_myosinIII_like	cd06608	1.2e-13	44	305
STKc_TNIK	cd06637	5.2e-09	44	305
STKc_MAP4K5	cd06646	2.7e-09	44	304
PTKc_EphR	cd05033	0.00019	45	305
PTKc_Itk	cd05112	1e-07	45	304
PTKc_Tec_Rlk	cd05114	1.1e-07	45	304
STKc_SLK_like	cd06611	8.3e-13	45	322
STKc_SLK	cd06643	1.1e-10	45	321
STKc_MAPK15	cd07852	4.4e-11	45	336
STKc_MST4	cd06640	3.3e-09	46	326
STKc_MST3	cd06641	3.4e-09	46	326
STKc_STK25-YSK1	cd06642	4.6e-15	46	326
STKc_ERK5	cd07855	7.8e-11	46	346
PTKc_Musk	cd05050	1.4e-05	47	302
PTKc_Lck_Blk	cd05067	0.00027	47	303
PTKc_Src	cd05071	5.5e-06	47	306
PTKc_Lyn	cd05072	3.8e-07	47	304
PTKc_Yes	cd05069	3.6e-07	47	303
PTKc_Ror1	cd05090	0.00051	47	303
PTKc_Tie2	cd05088	0.00065	47	332
PTKc_VEGFR2	cd05103	0.00036	47	307
STKc_myosinIIIA	cd06638	1.5e-10	47	305
PTKc_Src_like	cd05034	1.1e-09	48	303
PTKc_Srm_Brk	cd05148	5.8e-10	48	304
STKc_TEY_MAPK_plant	cd07858	4.9e-15	48	350
STKc_CDK12	cd07864	3.1e-10	48	305
PTKc_InsR_like	cd05032	4.6e-07	49	302
PTKc_ALK_LTK	cd05036	7.7e-07	49	307
PTKc_Jak_rpt2	cd05038	2.5e-09	49	308
PTK_CCK4	cd05046	0.00064	49	303
PTKc_Trk	cd05049	9e-06	49	302
PTKc_Abl	cd05052	7.9e-07	49	304
PTKc_FAK	cd05056	3.5e-09	49	308
PTKc_InsR	cd05061	4.9e-07	49	318
PTKc_IGF-1R	cd05062	1.1e-07	49	303
PTKc_EphR_A2	cd05063	9.9e-06	49	305
PTKc_EphR_A	cd05066	1.9e-05	49	305
PTKc_Frk_like	cd05068	3.2e-11	49	304
PTKc_Fyn_Yrk	cd05070	1.5e-05	49	303
PTKc_Hck	cd05073	1.2e-06	49	303
PTKc_Jak1_rpt2	cd05079	1.8e-05	49	306
PTKc_Csk	cd05082	5.4e-06	49	303
PTKc_TrkB	cd05093	4.9e-06	49	315
PTKc_TrkC	cd05094	1.2e-05	49	365
PTKc_TrkA	cd05092	3.8e-06	49	306
PTKc_VEGFR3	cd05102	0.00026	49	307
PTKc_EGFR	cd05108	0.00011	49	352
PTK_HER3	cd05111	5.7e-07	49	318
PTKc_Btk_Bmx	cd05113	3.6e-07	49	304
PTKc_HER4	cd05110	0.00032	49	345
STKc_MAP4K3_like	cd06613	1.1e-17	49	304
PKc_MKK7	cd06618	4.7e-08	49	331
PKc_MEK2	cd06649	0.0001	49	384
PKc_MEK1	cd06650	0.0009	49	385
STKc_PCTAIRE_like	cd07844	3.8e-09	49	305
STKc_BUR1	cd07866	7.5e-11	49	305
STKc_PFTAIRE1	cd07869	0.00026	49	319
STKc_PFTAIRE2	cd07870	9.6e-07	49	305
PTKc_Ror	cd05048	2.3e-05	50	259
PTKc_Tyk2_rpt2	cd05080	9.4e-09	50	310
STKc_MAP4K3	cd06645	1.9e-09	50	304
STKc_MEKK2	cd06652	6e-13	50	306
STKc_MEKK3_like_1	cd06653	7.9e-17	50	305
STKc_ERK1_2_like	cd07849	1.4e-09	50	345
STKc_Nek6_Nek7	cd08224	7.1e-14	50	308
PTKc_Tie1	cd05089	0.00059	51	333
STKc_phototropin_lik	cd05574	6.9e-15	51	318
STKc_ROCK_NDR_like	cd05573	1.8e-15	51	368
STKc_PKA	cd05580	2e-18	51	328
STKc_PDK1	cd05581	6e-41	51	305
STKc_LATS	cd05598	7.7e-11	51	375
STKc_DMPK_like	cd05597	2e-09	51	368
STKc_MAST	cd05609	8.7e-15	51	333
STKc_PRKX_like	cd05612	4.3e-23	51	344
STKc_MRCK_alpha	cd05623	4.5e-09	51	375
STKc_MRCK_beta	cd05624	3.9e-09	51	382
STKc_LATS1	cd05625	2.8e-07	51	374
STKc_LATS2	cd05626	1.8e-07	51	383
STKc_NDR2	cd05627	1.1e-07	51	373
STKc_NDR1	cd05628	4.7e-09	51	371
STKc_NDR_like_fungal	cd05629	5.5e-08	51	385
STKc_MST3_like	cd06609	1.4e-15	51	325
PKc_MEK	cd06615	1.6e-07	51	321
PKc_MKK3_6	cd06617	1.2e-08	51	323
PKc_MKK5	cd06619	0.00011	51	325
STKc_MEKK3_like	cd06625	4.8e-32	51	305
STKc_NAK1_like	cd06917	3.7e-10	51	315
STKc_CDKL2_3	cd07846	1.7e-09	51	305
STKc_CDKL1_4	cd07847	9.6e-14	51	305
STKc_Sty1_Hog1	cd07856	1.2e-09	51	344
STKc_CDK6	cd07862	0.00034	51	337
STKc_CdkB_plant	cd07837	3e-10	51	306
STKc_PCTAIRE2	cd07872	1.1e-07	51	333
STKc_PCTAIRE1	cd07873	3.1e-07	51	316
STKc_PCTAIRE3	cd07871	1.6e-07	51	305
STKc_Nek6	cd08228	4.8e-09	51	310
STKc_Nek7	cd08229	1.1e-10	51	308
SPS1	COG0515	5.2e-63	51	478
PTKc_RET	cd05045	0.00035	52	309
PTKc_EphR_B	cd05065	6e-05	52	305
PTKc_Jak2_Jak3_rpt2	cd05081	8.9e-08	52	306
PKc_STE	cd05122	1.2e-46	52	304
STKc_Yank1	cd05578	1.5e-27	52	305
STKc_cPKC	cd05587	8.1e-25	52	385
STKc_GRK4_like	cd05605	2.2e-19	52	334
STKc_MSK1_N	cd05613	4e-11	52	325
STKc_MSK2_N	cd05614	1.1e-13	52	371
STKc_cPKC_alpha	cd05615	2.4e-12	52	385
STKc_cPKC_beta	cd05616	3.7e-10	52	349
STKc_GRK6	cd05630	6.1e-10	52	329
STKc_GRK4	cd05631	1.4e-08	52	329
STKc_GRK5	cd05632	2.4e-09	52	329
STKc_MAPKKK	cd06606	9.7e-63	52	305
STKc_MEKK4	cd06626	2.3e-15	52	305
STKc_Cdc7_like	cd06627	3.8e-26	52	305
STKc_MAPKKK_Byr2_lik	cd06628	5.2e-33	52	305
STKc_MAPKKK_Bck1_lik	cd06629	7.3e-15	52	305
STKc_MEKK1	cd06630	5.2e-13	52	306
STKc_YSK4	cd06631	8.4e-15	52	305
STKc_MEKK1_plant	cd06632	6.4e-18	52	305
STKc_MEKK3	cd06651	2.9e-18	52	307
STKc_CCRK	cd07832	4.4e-14	52	306
STKc_Pho85	cd07836	6.6e-17	52	305
STKc_CDK5	cd07839	5.5e-08	52	305
STKc_CDK8_like	cd07842	2.6e-09	52	305
STKc_CDK7	cd07841	5.3e-16	52	315
STKc_MAPK	cd07834	4e-13	52	350
STKc_NLK	cd07853	9.4e-10	52	391
STKc_MAPK4_6	cd07854	1.3e-08	52	351
STKc_MPK1	cd07857	6.8e-10	52	346
STKc_TDY_MAPK_plant	cd07859	1.5e-09	52	350
STKc_CDK2_3	cd07860	3.8e-06	52	305
STKc_CDK1_euk	cd07861	1.9e-06	52	305
STKc_CDK4	cd07863	2.1e-05	52	305
STKc_Nek	cd08215	5.5e-49	52	305
STKc_Nek1	cd08218	2.2e-32	52	305
STKc_Nek3	cd08219	2e-28	52	305
STKc_Nek8	cd08220	2.4e-15	52	305
STKc_Nek9	cd08221	6.1e-14	52	305
STKc_Nek11	cd08222	9.7e-36	52	305
STKc_Nek4	cd08223	5e-24	52	305
STKc_Nek5	cd08225	7.1e-27	52	305
STKc_Nek10	cd08528	4.4e-09	52	302
STKc_FA2-like	cd08529	1.6e-14	52	305
STKc_CNK2-like	cd08530	2.7e-15	52	305
PTKc_Axl_like	cd05035	7.5e-06	53	306
PTKc_Tyro3	cd05074	3.5e-05	53	306
PTKc_Axl	cd05075	0.00051	53	307
STKc_CMGC	cd05118	1.1e-17	53	305
STKc_PKN	cd05589	2.9e-20	53	370
STKc_CDK_like	cd07829	6e-22	53	305
STKc_MAK_like	cd07830	6.4e-14	53	305
STKc_CDK1_like	cd07835	1e-08	53	305
STKc_CDK4_6_like	cd07838	3.2e-12	53	305
STKc_CDK9_like	cd07840	5.6e-17	53	305
PTK_Ryk	cd05043	1.9e-05	54	263
STKc_CRIK	cd05601	4.5e-09	54	352
PKc_MAPKK	cd06605	1.1e-08	54	309
PKc_MAPKK_plant_like	cd06623	6.4e-18	54	308
STKc_CDC2L6	cd07867	3e-05	54	305
STKc_CDK8	cd07868	0.00012	54	305
STKc_p70S6K	cd05584	2.3e-25	56	371
STKc_Sid2p_Dbf2p	cd05600	3e-09	56	382
PTKc	cd00192	5.3e-13	57	304
PTK_Jak_rpt1	cd05037	3.4e-05	57	301
PTKc_Ack_like	cd05040	2e-10	57	302
PTKc_Fes_like	cd05041	1.4e-08	57	305
PTKc_c-ros	cd05044	5.3e-07	57	302
PTKc_Tie	cd05047	0.001	57	301
PTKc_Met_Ron	cd05058	2.8e-06	57	309
PTKc_Fes	cd05084	7.3e-07	57	305
PTKc_Aatyk1_Aatyk3	cd05087	8.4e-05	57	305
PTKc_Fer	cd05085	6.1e-07	57	305
PTKc_Syk	cd05116	4.6e-06	57	306
STKc_PKC	cd05570	1.3e-18	57	370
STKc_PKB	cd05571	1e-28	57	375
STKc_SGK	cd05575	3.6e-10	57	376
STKc_RSK_N	cd05582	6.7e-27	57	369
STKc_MSK_N	cd05583	2.2e-15	57	327
STKc_aPKC	cd05588	8.8e-24	57	385
STKc_nPKC_eta	cd05590	2.7e-23	57	370
STKc_nPKC_theta_delt	cd05592	7.5e-27	57	386
STKc_PKB_gamma	cd05593	2e-11	57	365
STKc_PKB_alpha	cd05594	1.9e-15	57	376
STKc_PKB_beta	cd05595	5.9e-17	57	375
STKc_NDR_like	cd05599	2.4e-10	57	348
STKc_SGK2	cd05603	2.2e-15	57	385
STKc_SGK3	cd05604	5e-11	57	389
STKc_nPKC_epsilon	cd05591	5e-24	57	385
STKc_aPKC_zeta	cd05617	1.1e-12	57	385
STKc_aPKC_iota	cd05618	1.2e-10	57	371
STKc_nPKC_theta	cd05619	5.4e-16	57	386
STKc_nPKC_delta	cd05620	1.8e-10	57	364
STKc_SGK1	cd05602	7.6e-10	57	389
STKc_MOK	cd07831	6e-12	57	305
STKc_Nek2	cd08217	4e-17	57	305
PTKc_Chk	cd05083	5.2e-06	58	303
STKc_beta_ARK	cd05606	3.9e-12	58	323
STKc_GRK3	cd05633	9.5e-09	58	324
PKc	cd00180	1.6e-80	59	303
PTKc_Aatyk	cd05042	1.2e-05	59	302
PTK_Jak2_Jak3_rpt1	cd05078	4.9e-05	59	304
PTKc_Zap-70	cd05115	3.6e-05	59	309
STKc_AGC	cd05123	3.2e-46	59	305
STKc_cGK_PKG	cd05572	4.2e-24	59	308
STKc_GRK	cd05577	1e-13	59	323
STKc_MAST_like	cd05579	2.3e-19	59	307
STKc_YPK1_like	cd05585	3.7e-21	59	387
STKc_Sck1_like	cd05586	1.8e-09	59	425
STKc_GRK7	cd05607	2.6e-08	59	328
STKc_GRK1	cd05608	5.2e-18	59	330
STKc_MST1_2	cd06612	1.1e-18	59	305
PKc_MKK4	cd06616	0.00042	59	322
PKc_MAPKK_PBS2_like	cd06622	6.2e-07	59	354
STKc_OSR1_SPAK	cd06610	8.2e-16	60	305
STKc_CDK10	cd07845	1.2e-11	65	322
PK_STRAD	cd08216	2.9e-05	65	316
PKc_MAPKK_Pek1_like	cd06621	1.4e-06	66	319
STKc_CDC2L1	cd07843	1e-12	67	305
PTKc_Csk_like	cd05039	1.1e-06	68	306
STKc_Rim15_like	cd05611	1.2e-06	69	307
PKc_MAPKK_Byr1_like	cd06620	9.9e-06	69	312
PTKc_Syk_like	cd05060	6.8e-05	76	310
PTKc_Tec_like	cd05059	1.5e-07	83	304
STKc_CDKL	cd07833	1e-10	91	305
Pkinase	pfam00069	1.3e-86	53	305
POLO_box	pfam00659	1.5e-27	417	480
POLO_box	pfam00659	2.3e-32	515	584
Pkinase_Tyr	pfam07714	1.1e-17	53	304
TyrKc	smart00219	3.5e-15	53	304
STYKc	smart00221	4.5e-84	53	305
S_TKc	smart00220	5.4e-95	63	305
KIND	smart00750	2.2e-06	136	313

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041022	Polymorphism	p.ARG518HIS	N/A
Swiss-Prot	VAR_051661	Polymorphism	p.ARG599HIS	N/A
Swiss-Prot	VAR_041018	Polymorphism	p.ARG12LEU	N/A
Swiss-Prot	VAR_051659	Polymorphism	p.ASN297ASP	N/A
Swiss-Prot	VAR_041021	Polymorphism	p.LEU463HIS	N/A
Swiss-Prot	VAR_041019	Polymorphism	p.LEU261PHE	N/A
Swiss-Prot	VAR_041020	Polymorphism	p.LEU332VAL	N/A
Swiss-Prot	VAR_051660	Polymorphism	p.SER595LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258