Results for the protein: P10398

Results for the Protein: P10398

1730068

369

ARAF

NCBI, UniProt

ARAF_HUMAN RecName: Full=Serine/threonine-protein kinase A-Raf; AltName: Full=Proto-oncogene A-Raf; AltName: Full=Proto-oncogene A-Raf-1; AltName: Full=Proto-oncogene Pks

			0 3 0 0 3

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Swiss-Prot Protein: P10398

Identical to: NP_001645

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Raf_RBD	cd01816	1.1e-47	20	91
C1	cd00029	5.9e-15	99	144
PTKc_CSF-1R	cd05106	6e-05	201	572
PTKc_Kit	cd05104	5.6e-08	203	571
STKc_TAO1	cd06635	4.6e-08	275	600
PTKc_PDGFR_alpha	cd05105	2e-06	276	573
PTKc_PDGFR_beta	cd05107	0.00014	276	572
PTKc_DDR	cd05051	2.6e-09	278	572
PTKc_DDR2	cd05095	3.3e-08	278	569
STKc_MAP4K4_6	cd06636	1.5e-06	282	569
STKc_myosinIIIA	cd06638	2.2e-06	284	569
STKc_PAK6	cd06659	2.3e-08	284	592
STKc_PAK4	cd06657	0.00014	285	593
PKc_MKK5	cd06619	0.00013	286	585
STKc_PAK1	cd06654	4.6e-07	286	598
STKc_TAO3	cd06633	1.9e-06	287	588
STKc_PAK_I	cd06647	4.9e-07	287	596
STKc_PAK2	cd06655	9.2e-07	287	599
STKc_PAK3	cd06656	3.9e-07	287	603
PTKc_DDR1	cd05096	2.7e-06	288	569
STKc_TAO2	cd06634	1.9e-09	288	601
PTKc_PDGFR	cd05055	1.2e-10	289	571
STKc_PAK5	cd06658	1.4e-05	290	591
STKc_TAO	cd06607	1.3e-07	293	600
STKc_p38alpha_MAPK14	cd07877	0.0001	293	606
PTKc_FGFR4	cd05099	8.8e-10	294	582
STKc_myosinIIIB	cd06639	3e-07	294	570
PTKc_FGFR2	cd05101	6.6e-08	295	581
PKc_MKK7	cd06618	3.5e-08	295	576
STKc_p38beta_MAPK11	cd07878	0.00033	296	606
STKc_SLK	cd06643	4.5e-08	297	585
STKc_CDK9	cd07865	5.9e-05	297	560
PTKc_FGFR	cd05053	3.1e-11	298	575
PTKc_FGFR1	cd05098	6.5e-08	299	583
PTKc_FGFR3	cd05100	1.1e-06	299	601
STKc_ASK	cd06624	2.4e-11	299	569
STKc_STK10_LOK	cd06644	5.7e-07	299	585
STKc_JNK	cd07850	0.00055	299	605
STKc_MAP4K3	cd06645	1.9e-09	300	568
STKc_MAP4K5	cd06646	1.1e-09	300	568
STKc_CDK10	cd07845	4.9e-07	300	598
STKc_Sty1_Hog1	cd07856	5.3e-05	300	602
STKc_p38	cd07851	3.7e-06	301	606
PTKc_EGFR_like	cd05057	1.1e-16	302	578
PTKc_Tie2	cd05088	1.7e-09	302	597
PTKc_VEGFR3	cd05102	3.4e-07	302	573
PTKc_VEGFR2	cd05103	2.8e-07	302	573
STKc_PAK	cd06614	3.8e-14	302	578
STKc_CDK12	cd07864	2.8e-06	302	599
STKc_BUR1	cd07866	6.2e-05	302	560
PTKc_InsR_like	cd05032	8.5e-15	303	569
PTKc_ALK_LTK	cd05036	1.5e-14	303	569
PTKc_Csk_like	cd05039	2.2e-16	303	570
PTKc_Abl	cd05052	2.8e-28	303	571
PTKc_FAK	cd05056	1e-14	303	575
PTKc_InsR	cd05061	1e-12	303	579
PTKc_IGF-1R	cd05062	1.9e-11	303	569
PTKc_Lck_Blk	cd05067	8.8e-31	303	570
PTKc_Frk_like	cd05068	3.1e-48	303	570
PTKc_Yes	cd05069	9.6e-29	303	570
PTKc_Fyn_Yrk	cd05070	2.8e-34	303	570
PTKc_Src	cd05071	4.6e-29	303	572
PTKc_Lyn	cd05072	3.8e-27	303	570
PTKc_Hck	cd05073	1e-25	303	570
PTKc_Src_like	cd05034	5e-26	303	570
PTKc_Csk	cd05082	1.4e-20	303	570
PTKc_Chk	cd05083	1.3e-28	303	573
PTKc_Tie1	cd05089	7.7e-09	303	592
PTKc_Srm_Brk	cd05148	1.2e-17	303	573
STKc_TNIK	cd06637	2.6e-08	303	569
STKc_ERK5	cd07855	0.00052	303	601
STKc_TEY_MAPK_plant	cd07858	0.00032	303	606
STKc_PFTAIRE2	cd07870	6.1e-06	303	590
STKc_ERK1_2_like	cd07849	6.5e-06	303	596
PTK_CCK4	cd05046	4.9e-11	304	569
PTKc_Ror	cd05048	1.2e-14	304	570
PTKc_Trk	cd05049	5.9e-12	304	569
PTKc_Musk	cd05050	2.9e-12	304	569
PTKc_EphR_A2	cd05063	9.8e-26	304	571
PTKc_EphR_A10	cd05064	8.5e-17	304	574
PTKc_Ror1	cd05090	3e-09	304	570
PTKc_Ror2	cd05091	5e-09	304	570
PTKc_TrkA	cd05092	1.2e-07	304	579
PTKc_TrkB	cd05093	5.5e-07	304	583
PTKc_TrkC	cd05094	5.4e-05	304	599
PTKc_DDR_like	cd05097	3.3e-07	304	569
PKc_MAPKK_Byr1_like	cd06620	3.9e-06	304	581
PTKc_EphR	cd05033	2.9e-16	305	571
PTK_Ryk	cd05043	1.3e-10	305	574
PTKc_Tec_like	cd05059	1.1e-15	305	568
PTKc_EphR_B	cd05065	1.2e-27	305	571
PTKc_EphR_A	cd05066	3.7e-30	305	571
PTKc_HER2	cd05109	2.7e-11	305	578
PTK_HER3	cd05111	1.7e-12	305	578
PTKc_Itk	cd05112	8.6e-22	305	568
PTKc_Btk_Bmx	cd05113	3.1e-25	305	568
PTKc_Tec_Rlk	cd05114	5.1e-20	305	568
PTKc_HER4	cd05110	5.2e-09	305	603
PTKc_EGFR	cd05108	2e-10	305	606
STKc_SLK_like	cd06611	5.5e-09	305	572
STKc_myosinIII_like	cd06608	1.1e-10	306	570
STKc_MAP4K3_like	cd06613	1e-16	306	569
STKc_MST4	cd06640	1.5e-07	306	590
STKc_MST3	cd06641	1.2e-07	306	598
STKc_STK25-YSK1	cd06642	1.1e-07	306	598
STKc_PAK_II	cd06648	1.8e-07	306	582
STKc_MST1_2	cd06612	9.5e-16	307	574
STKc_MEKK3_like	cd06625	8.3e-12	307	569
STKc_MEKK3	cd06651	3.7e-09	307	563
STKc_MEKK2	cd06652	1e-05	307	566
STKc_MEKK3_like_1	cd06653	6.1e-09	307	569
PTKc_Jak_rpt2	cd05038	6.4e-16	308	571
STKc_phototropin_lik	cd05574	1.5e-05	308	568
STKc_PKA	cd05580	7.8e-07	308	584
STKc_PDK1	cd05581	1.2e-11	308	565
STKc_CRIK	cd05601	0.0003	308	602
STKc_MAST	cd05609	0.00069	308	606
STKc_PRKX_like	cd05612	3.7e-05	308	595
PKc_MAPKK	cd06605	4.1e-12	308	575
STKc_MST3_like	cd06609	4.3e-11	308	581
STKc_OSR1_SPAK	cd06610	7.3e-11	308	560
PKc_MKK4	cd06616	6.7e-09	308	598
PKc_MKK3_6	cd06617	2.7e-08	308	586
PKc_MAPKK_Pek1_like	cd06621	3.6e-07	308	579
PKc_MAPKK_PBS2_like	cd06622	4.3e-06	308	589
PKc_MAPKK_plant_like	cd06623	1.2e-10	308	556
PKc_MEK	cd06615	0.00053	308	598
STKc_CdkB_plant	cd07837	0.00037	308	592
STKc_CDC2L1	cd07843	0.001	308	586
STKc_PCTAIRE_like	cd07844	1.3e-06	308	590
STKc_CDKL2_3	cd07846	1.2e-05	308	570
STKc_CDKL1_4	cd07847	8.5e-08	308	600
STKc_MAPK4_6	cd07854	5.8e-06	308	602
STKc_PFTAIRE1	cd07869	0.00031	308	603
STKc_Nek6_Nek7	cd08224	2.8e-08	308	572
STKc_Nek6	cd08228	1.1e-05	308	572
STKc_Nek7	cd08229	9.1e-07	308	572
SPS1	COG0515	1.3e-17	308	602
PTKc_RET	cd05045	1.3e-08	309	573
PTKc_Jak1_rpt2	cd05079	1.3e-15	309	571
PKc_STE	cd05122	3e-16	309	564
STKc_Yank1	cd05578	4.4e-11	309	570
STKc_MSK_N	cd05583	6.1e-08	309	580
STKc_cPKC	cd05587	7e-06	309	606
STKc_GRK4_like	cd05605	7.8e-08	309	590
STKc_MSK1_N	cd05613	3.3e-06	309	580
STKc_MSK2_N	cd05614	1.6e-05	309	606
STKc_cPKC_alpha	cd05615	8.7e-06	309	606
STKc_GRK6	cd05630	3.4e-05	309	602
STKc_GRK4	cd05631	0.00017	309	590
STKc_GRK5	cd05632	0.00027	309	606
STKc_cPKC_beta	cd05616	0.00022	309	601
STKc_MAPKKK	cd06606	8e-26	309	560
STKc_Cdc7_like	cd06627	5.1e-15	309	559
STKc_YSK4	cd06631	8.3e-12	309	569
STKc_CCRK	cd07832	2.2e-07	309	591
STKc_MAPK	cd07834	2.1e-05	309	601
STKc_Pho85	cd07836	4.2e-07	309	590
STKc_CDK5	cd07839	4.4e-06	309	590
STKc_CDK7	cd07841	9.6e-09	309	595
STKc_NLK	cd07853	0.00059	309	606
STKc_MPK1	cd07857	4.8e-05	309	605
STKc_TDY_MAPK_plant	cd07859	0.00025	309	606
STKc_CDK1_euk	cd07861	0.00059	309	590
STKc_CDK4	cd07863	0.00018	309	590
STKc_CDK2_3	cd07860	0.00061	309	584
STKc_PCTAIRE3	cd07871	5.3e-06	309	591
STKc_PCTAIRE2	cd07872	0.00017	309	605
STKc_PCTAIRE1	cd07873	9.9e-05	309	603
STKc_Nek2	cd08217	2.9e-12	309	569
STKc_Nek1	cd08218	3.5e-21	309	569
STKc_Nek3	cd08219	5.5e-11	309	569
STKc_Nek5	cd08225	1.1e-16	309	569
STKc_Nek8	cd08220	3.5e-09	309	569
STKc_Nek4	cd08223	2.4e-12	309	569
STKc_Nek11	cd08222	1.5e-09	309	569
STKc_Nek10	cd08528	8.1e-08	309	569
STKc_FA2-like	cd08529	3.6e-13	309	574
STKc_CNK2-like	cd08530	3.8e-11	309	569
PTKc_Axl_like	cd05035	5.8e-09	310	571
PTKc_Tyro3	cd05074	8.5e-11	310	571
PTKc_Axl	cd05075	9.1e-07	310	571
PTKc_Jak2_Jak3_rpt2	cd05081	1.9e-20	310	571
STKc_PKN	cd05589	2.4e-05	310	600
STKc_MAPKKK_Bck1_lik	cd06629	4.2e-12	310	561
STKc_CDK1_like	cd07835	5.3e-05	310	590
PTKc_Tyk2_rpt2	cd05080	1.1e-10	311	572
STKc_CMGC	cd05118	8.4e-11	311	569
STKc_MEKK4	cd06626	2e-12	311	569
STKc_MAPKKK_Byr2_lik	cd06628	2e-19	311	569
STKc_NAK1_like	cd06917	3.5e-11	311	590
STKc_CDK_like	cd07829	1e-09	311	569
STKc_MAK_like	cd07830	3.7e-10	311	569
STKc_MOK	cd07831	2.9e-07	311	560
STKc_CDK4_6_like	cd07838	2.3e-05	311	560
STKc_CDK9_like	cd07840	8.1e-10	311	520
STKc_MAPK15	cd07852	0.00042	311	602
STKc_Nek	cd08215	7e-20	311	569
STKc_CDKL	cd07833	2.9e-05	312	565
STKc_RSK_N	cd05582	1.5e-05	313	605
STKc_p70S6K	cd05584	0.00042	313	606
PTKc	cd00192	3.6e-34	314	568
PTK_Jak_rpt1	cd05037	2.7e-08	314	568
PTKc_Ack_like	cd05040	1.2e-16	314	569
PTKc_Fes_like	cd05041	4e-18	314	569
PTKc_Aatyk	cd05042	5.9e-08	314	548
PTKc_c-ros	cd05044	1e-10	314	569
PTKc_Tie	cd05047	7.5e-09	314	572
PTKc_Met_Ron	cd05058	9.1e-25	314	573
PTKc_Syk_like	cd05060	1.3e-12	314	572
PTK_Jak1_rpt1	cd05077	1.5e-05	314	568
PTK_Jak2_Jak3_rpt1	cd05078	7.8e-06	314	568
PTKc_Fes	cd05084	1.1e-19	314	569
PTKc_Fer	cd05085	1.5e-14	314	569
PTKc_Aatyk1_Aatyk3	cd05087	9.9e-08	314	569
PTKc_Aatyk2	cd05086	7.3e-07	314	576
PTKc_Syk	cd05116	9e-09	314	576
STKc_PKC	cd05570	9.1e-08	314	589
STKc_PKB	cd05571	2.9e-06	314	602
STKc_SGK	cd05575	0.00022	314	605
STKc_aPKC	cd05588	0.00063	314	606
STKc_nPKC_epsilon	cd05591	3.6e-05	314	605
STKc_nPKC_theta_delt	cd05592	6.5e-06	314	606
STKc_PKB_gamma	cd05593	3.3e-05	314	605
STKc_PKB_alpha	cd05594	2e-05	314	601
STKc_PKB_beta	cd05595	9.6e-05	314	602
STKc_nPKC_eta	cd05590	0.00075	314	601
STKc_SGK1	cd05602	0.0007	314	606
STKc_SGK2	cd05603	4.1e-06	314	606
STKc_SGK3	cd05604	0.00075	314	606
STKc_aPKC_zeta	cd05617	0.00052	314	601
STKc_nPKC_theta	cd05619	4.4e-06	314	606
STKc_MEKK1	cd06630	3.5e-10	314	576
STKc_MEKK1_plant	cd06632	5.9e-12	314	565
PTKc_Zap-70	cd05115	4e-15	315	572
PKc	cd00180	1.2e-58	316	567
STKc_AGC	cd05123	7.9e-10	316	560
STKc_cGK_PKG	cd05572	3.9e-08	316	556
STKc_GRK	cd05577	9.1e-08	316	562
STKc_MAST_like	cd05579	1.6e-07	316	560
STKc_YPK1_like	cd05585	0.00026	316	604
STKc_GRK7	cd05607	4.4e-05	316	589
STKc_GRK1	cd05608	2.5e-06	316	589
STKc_beta_ARK	cd05606	5.3e-06	316	580
STKc_GRK3	cd05633	0.00031	316	597
STKc_Nek9	cd08221	5.6e-10	316	569
RBD	pfam02196	2e-36	19	91
C1_1	pfam00130	2.1e-15	99	147
Pkinase	pfam00069	1.1e-74	310	567
RBD	smart00455	4.5e-31	20	91
C1	smart00109	1.3e-12	99	144
Pkinase_Tyr	pfam07714	1.7e-60	310	567
TyrKc	smart00219	1e-45	310	567
STYKc	smart00221	3.7e-47	310	569
S_TKc	smart00220	1.8e-46	320	569
KIND	smart00750	0.0002	388	573

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040377	Polymorphism	p.GLU578ASP	N/A
Swiss-Prot	VAR_040376	Polymorphism	p.GLY331CYS	N/A
Swiss-Prot	VAR_040375	Polymorphism	p.MET98THR	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258