Results for the protein: P54760

Results for the Protein: P54760

19860819

2050

EPHB4

NCBI, UniProt

EPHB4_HUMAN RecName: Full=Ephrin type-B receptor 4; AltName: Full=Hepatoma transmembrane kinase; AltName: Full=Tyrosine-protein kinase TYRO11; Flags: Precursor

			0 10 0 1 9

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Swiss-Prot Protein: P54760

Identical to: NP_004435

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FN3	cd00063	9.5e-11	324	429
FN3	cd00063	6.7e-18	434	526
PTKc_VEGFR	cd05054	5.3e-18	486	881
PTKc_Kit	cd05104	2.5e-12	503	878
PTKc_PDGFR_beta	cd05107	3.8e-09	505	879
PTKc_PDGFR_alpha	cd05105	3.5e-12	505	880
PTKc_CSF-1R	cd05106	6.5e-13	578	879
PTKc_PDGFR	cd05055	1.3e-15	580	878
STKc_TAO1	cd06635	0.00085	593	910
STKc_myosinIIIA	cd06638	8.6e-05	594	879
STKc_myosinIIIB	cd06639	4.2e-05	594	879
STKc_PAK5	cd06658	1.6e-05	594	903
STKc_PAK6	cd06659	1.2e-08	594	909
STKc_p38beta_MAPK11	cd07878	0.00048	594	930
PTKc_FGFR1	cd05098	2.6e-30	595	885
PTKc_FGFR2	cd05101	1.3e-37	595	885
STKc_PAK4	cd06657	1.6e-05	595	922
STKc_PAK	cd06614	1.1e-10	596	887
STKc_PAK_II	cd06648	1.1e-08	596	878
STKc_JNK	cd07850	0.00016	597	939
STKc_TAO	cd06607	0.00026	598	889
STKc_TAO2	cd06634	7.5e-05	598	911
PTKc_FGFR4	cd05099	6.2e-39	599	898
PTKc_FGFR3	cd05100	3.3e-24	599	918
STKc_p38alpha_MAPK14	cd07877	0.00023	599	930
PTK_Tyk2_rpt1	cd05076	2.1e-06	600	875
STKc_PAK3	cd06656	0.0008	600	897
STKc_p38gamma_MAPK12	cd07880	6.2e-06	600	930
STKc_CDK9	cd07865	1.8e-05	601	909
PKc_MKK7	cd06618	1.3e-07	602	890
STKc_p38	cd07851	2.5e-06	602	930
STKc_Sty1_Hog1	cd07856	1.4e-05	603	945
PTKc_HER2	cd05109	8.6e-57	604	888
STKc_ASK	cd06624	2.6e-08	604	878
PTKc_HER4	cd05110	6.8e-46	605	903
STKc_MAP4K4_6	cd06636	0.00042	605	878
STKc_MAP4K3	cd06645	0.00012	605	882
STKc_PCTAIRE2	cd07872	0.00027	605	912
STKc_PCTAIRE1	cd07873	0.00037	605	921
STKc_MAP4K5	cd06646	0.00057	606	875
STKc_PCTAIRE_like	cd07844	1.1e-05	606	910
STKc_PCTAIRE3	cd07871	2.9e-05	606	899
PTKc_EGFR_like	cd05057	3.3e-68	607	887
PTKc_VEGFR3	cd05102	5.7e-20	607	881
PTKc_VEGFR2	cd05103	5.1e-14	607	881
PTKc_EGFR	cd05108	1.3e-49	607	924
PTK_HER3	cd05111	2.5e-46	607	888
STKc_CDK10	cd07845	8.4e-07	607	907
PTKc_ALK_LTK	cd05036	3e-55	608	876
PTKc_FAK	cd05056	1.1e-84	608	882
STKc_TNIK	cd06637	0.00014	608	876
STKc_CDK12	cd07864	6.5e-10	608	899
PTKc_InsR_like	cd05032	1.9e-66	609	876
PTKc_Src_like	cd05034	2.6e-91	609	877
PTKc_Csk_like	cd05039	9.1e-71	609	877
PTKc_Trk	cd05049	1.2e-64	609	876
PTKc_DDR	cd05051	5.7e-45	609	876
PTKc_Abl	cd05052	4.6e-83	609	878
PTKc_FGFR	cd05053	7.2e-40	609	879
PTKc_Musk	cd05050	4.9e-67	609	876
PTKc_InsR	cd05061	1.4e-49	609	889
PTKc_IGF-1R	cd05062	1.6e-48	609	876
PTKc_EphR_A2	cd05063	1.9e-176	609	878
PTKc_Lck_Blk	cd05067	2.6e-73	609	877
PTKc_Frk_like	cd05068	1.6e-93	609	877
PTKc_Yes	cd05069	1.5e-72	609	877
PTKc_Ror	cd05048	8.1e-61	609	877
PTKc_Fyn_Yrk	cd05070	5.7e-75	609	877
PTKc_Src	cd05071	1.9e-75	609	879
PTKc_EphR_A10	cd05064	2e-144	609	878
PTKc_Hck	cd05073	5.4e-75	609	877
PTKc_Lyn	cd05072	1.7e-72	609	877
PTKc_Csk	cd05082	2.1e-56	609	877
PTKc_Ror1	cd05090	1.8e-61	609	877
PTKc_Ror2	cd05091	8e-59	609	877
PTKc_TrkA	cd05092	1e-50	609	884
PTKc_TrkB	cd05093	3.7e-44	609	885
PTKc_DDR2	cd05095	7.1e-48	609	876
PTKc_DDR1	cd05096	7.4e-41	609	876
PTKc_DDR_like	cd05097	7.4e-53	609	876
PKc_MAPKK_Byr1_like	cd06620	1.2e-07	609	888
STKc_MST4	cd06640	5.9e-07	609	885
STKc_MST3	cd06641	2.1e-06	609	885
STKc_STK25-YSK1	cd06642	5.6e-07	609	885
STKc_SLK	cd06643	1.2e-06	609	892
STKc_STK10_LOK	cd06644	5.8e-06	609	894
STKc_ERK1_2_like	cd07849	8e-07	609	929
STKc_ERK5	cd07855	9e-05	609	945
STKc_TEY_MAPK_plant	cd07858	3.4e-06	609	946
PTKc_EphR	cd05033	1.2e-214	610	878
PTKc_Jak_rpt2	cd05038	1.4e-51	610	878
PTK_Ryk	cd05043	2.4e-24	610	878
PTKc_Tec_like	cd05059	4.2e-71	610	875
PTKc_EphR_B	cd05065	3.1e-227	610	878
PTKc_EphR_A	cd05066	3.3e-195	610	878
PTKc_Jak2_Jak3_rpt2	cd05081	6.8e-34	610	878
PTKc_Chk	cd05083	2.2e-66	610	877
PTKc_Tie2	cd05088	2.1e-36	610	901
PTKc_Itk	cd05112	2.4e-74	610	875
PTKc_Btk_Bmx	cd05113	1.3e-72	610	875
PTKc_Jak1_rpt2	cd05079	2.3e-38	610	878
PTKc_Tec_Rlk	cd05114	1.5e-72	610	875
PKc_MAPKK	cd06605	4.2e-09	610	872
PKc_MKK4	cd06616	1.5e-05	610	898
STKc_MAPK15	cd07852	4e-06	610	909
STKc_PFTAIRE2	cd07870	0.00031	610	903
PTK_CCK4	cd05046	3.1e-38	611	876
STKc_cPKC	cd05587	0.00018	611	940
STKc_MAP4K3_like	cd06613	2.4e-10	611	882
STKc_BUR1	cd07866	6.4e-08	611	867
STKc_ROCK_NDR_like	cd05573	0.00047	612	937
STKc_phototropin_lik	cd05574	2.7e-06	612	894
STKc_MST3_like	cd06609	1e-09	612	885
STKc_SLK_like	cd06611	6.8e-07	612	890
PKc_MKK3_6	cd06617	1.6e-06	612	892
STKc_MAPKKK_Bck1_lik	cd06629	2.8e-10	612	868
STKc_CDK6	cd07862	0.00017	612	904
PK_STRAD	cd08216	0.00013	612	880
STKc_Nek6_Nek7	cd08224	1.6e-08	612	879
STKc_Nek6	cd08228	7e-07	612	879
STKc_Nek7	cd08229	1.9e-09	612	879
STKc_PKA	cd05580	1.8e-06	613	909
STKc_MAST	cd05609	0.0004	613	934
STKc_PRKX_like	cd05612	1.7e-06	613	897
STKc_MAPKKK	cd06606	6.5e-18	613	868
STKc_OSR1_SPAK	cd06610	4.7e-09	613	870
PKc_MEK	cd06615	9.9e-06	613	920
PKc_MAPKK_PBS2_like	cd06622	1.3e-06	613	919
PKc_MAPKK_plant_like	cd06623	9.5e-12	613	883
STKc_MAPKKK_Byr2_lik	cd06628	9.8e-14	613	876
STKc_Cdc7_like	cd06627	2.9e-16	613	867
STKc_MEKK3_like_1	cd06653	4.9e-05	613	879
PKc_MKK5	cd06619	2.8e-05	613	902
STKc_NAK1_like	cd06917	8.4e-07	613	882
STKc_Pho85	cd07836	2.1e-06	613	899
STKc_CdkB_plant	cd07837	6.1e-06	613	900
STKc_CDK5	cd07839	5.1e-06	613	899
STKc_CDK7	cd07841	1.5e-06	613	885
STKc_CDKL1_4	cd07847	1.9e-05	613	921
STKc_CDK1_euk	cd07861	2.4e-05	613	899
STKc_CDK4	cd07863	3e-05	613	899
STKc_CDK2_3	cd07860	5.1e-05	613	899
STKc_Nek	cd08215	1e-13	613	870
STKc_Nek1	cd08218	2.9e-06	613	879
STKc_Nek8	cd08220	2e-06	613	878
STKc_Nek9	cd08221	2.5e-08	613	876
STKc_Nek4	cd08223	7.1e-07	613	878
STKc_Nek11	cd08222	1.8e-07	613	878
STKc_Nek10	cd08528	1.5e-06	613	876
SPS1	COG0515	6.9e-22	613	987
PTKc_RET	cd05045	2.4e-44	614	881
PTKc_Tyk2_rpt2	cd05080	1e-15	614	879
STKc_CMGC	cd05118	5.3e-09	614	899
PKc_STE	cd05122	1.6e-13	614	867
PTKc_TrkC	cd05094	2.5e-27	614	885
STKc_GRK4_like	cd05605	2.8e-05	614	902
STKc_MSK2_N	cd05614	0.00064	614	931
STKc_GRK6	cd05630	0.001	614	897
STKc_MSK_N	cd05583	0.00088	614	897
STKc_CDK_like	cd07829	4.8e-11	614	884
STKc_MAPK	cd07834	2.1e-07	614	926
STKc_CDK1_like	cd07835	3.4e-06	614	899
STKc_CDK4_6_like	cd07838	6.6e-05	614	857
STKc_CDKL2_3	cd07846	4.1e-05	614	867
STKc_NLK	cd07853	5.7e-05	614	971
STKc_MPK1	cd07857	2.1e-05	614	927
STKc_TDY_MAPK_plant	cd07859	1.3e-06	614	951
STKc_CDK9_like	cd07840	8.4e-11	614	884
STKc_Nek3	cd08219	1.9e-08	614	876
STKc_Nek5	cd08225	1.1e-05	614	879
PTKc_Axl_like	cd05035	4.8e-57	615	878
PTKc_Tyro3	cd05074	2.5e-51	615	878
PTKc_Axl	cd05075	4.7e-49	615	878
PTKc_Tie1	cd05089	1.7e-42	615	900
STKc_PKN	cd05589	5.8e-06	615	939
STKc_myosinIII_like	cd06608	4.1e-07	615	870
PKc_MAPKK_Pek1_like	cd06621	1.3e-06	615	891
STKc_CDC2L1	cd07843	9.1e-07	615	899
PTKc_Srm_Brk	cd05148	1.8e-73	616	877
STKc_Yank1	cd05578	2.6e-07	616	877
STKc_PDK1	cd05581	3e-08	616	867
STKc_CRIK	cd05601	5.8e-05	616	897
STKc_MST1_2	cd06612	5.9e-10	616	865
STKc_MEKK3_like	cd06625	1.8e-08	616	876
STKc_MEKK3	cd06651	2.6e-05	616	884
STKc_MOK	cd07831	0.00057	616	899
STKc_CCRK	cd07832	1.7e-07	616	868
STKc_CDKL	cd07833	0.00013	616	867
STKc_MAK_like	cd07830	2.5e-07	616	867
STKc_CDK8_like	cd07842	0.001	616	890
STKc_Nek2	cd08217	2.7e-07	616	870
STKc_FA2-like	cd08529	2.5e-07	616	874
STKc_CNK2-like	cd08530	1.2e-05	616	874
STKc_RSK_N	cd05582	3.4e-06	618	942
STKc_p70S6K	cd05584	7.6e-05	618	941
STKc_MEKK4	cd06626	2.3e-07	618	868
PTKc	cd00192	4.4e-126	619	875
PTK_Jak_rpt1	cd05037	3.3e-11	619	875
PTKc_Ack_like	cd05040	3.2e-67	619	876
PTKc_Fes_like	cd05041	1.9e-84	619	876
PTKc_Aatyk	cd05042	9.1e-15	619	876
PTKc_c-ros	cd05044	7.2e-65	619	876
PTKc_Tie	cd05047	8.1e-48	619	879
PTKc_Met_Ron	cd05058	7.8e-63	619	880
PTKc_Syk_like	cd05060	1.1e-83	619	879
PTK_Jak1_rpt1	cd05077	4.7e-10	619	875
PTK_Jak2_Jak3_rpt1	cd05078	8.9e-12	619	875
PTKc_Fes	cd05084	5.6e-73	619	876
PTKc_Fer	cd05085	1.7e-70	619	876
PTKc_Aatyk2	cd05086	1.2e-16	619	876
PTKc_Aatyk1_Aatyk3	cd05087	2.8e-19	619	876
PTKc_Syk	cd05116	3.1e-60	619	879
STKc_PKC	cd05570	3.6e-05	619	912
STKc_PKB	cd05571	2.2e-05	619	914
STKc_SGK	cd05575	0.00025	619	934
STKc_nPKC_eta	cd05590	0.00059	619	930
STKc_nPKC_epsilon	cd05591	0.00024	619	930
STKc_nPKC_theta_delt	cd05592	8.1e-05	619	941
STKc_PKB_alpha	cd05594	0.0002	619	915
STKc_SGK1	cd05602	0.00023	619	941
STKc_SGK2	cd05603	0.00019	619	937
STKc_nPKC_theta	cd05619	0.0003	619	941
STKc_PKB_gamma	cd05593	0.00061	619	912
STKc_YSK4	cd06631	3.1e-08	619	874
STKc_MEKK1_plant	cd06632	7.8e-11	619	870
PKc	cd00180	7.6e-54	621	874
PTKc_Zap-70	cd05115	4.6e-70	621	879
STKc_AGC	cd05123	1.9e-07	621	877
STKc_cGK_PKG	cd05572	1.6e-05	621	859
STKc_MAST_like	cd05579	1.1e-06	621	857
STKc_YPK1_like	cd05585	0.00025	621	928
STKc_GRK1	cd05608	0.001	621	901
STKc_GRK7	cd05607	0.00037	621	885
STKc_MEKK1	cd06630	2.5e-07	628	868
	cd00166	2.1e-19	906	969
Ephrin_lbd	pfam01404	4e-109	17	197
fn3	pfam00041	1.8e-10	325	414
fn3	pfam00041	7.2e-17	435	519
Pkinase	pfam00069	1.6e-39	615	874
SAM_1	pfam00536	2.9e-29	905	969
EPH_lbd	smart00615	3.1e-101	17	196
GCC2_GCC3	pfam07699	0.00037	258	304
FN3	smart00060	2.1e-08	324	415
FN3	smart00060	3.3e-14	434	516
Pkinase_Tyr	pfam07714	2e-141	615	874
TyrKc	smart00219	2.1e-136	615	874
STYKc	smart00221	4.3e-49	615	876
S_TKc	smart00220	5.3e-40	625	878
SAM_2	pfam07647	4.3e-24	904	969
SAM	smart00454	5.3e-24	904	971

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_042187	Polymorphism	p.ALA882THR	N/A
Swiss-Prot	VAR_042184	Polymorphism	p.ALA371VAL	N/A
Swiss-Prot	VAR_042186	Polymorphism	p.ARG678HIS	N/A
Swiss-Prot	VAR_042188	Polymorphism	p.ARG889TRP	N/A
Swiss-Prot	VAR_042185	Polymorphism	p.ASP576GLU	N/A
Swiss-Prot	VAR_042189	Polymorphism	p.GLU890ASP	N/A
dbSNP	rs114926839	Polymorphism	p.GLY382SER	N/A
Swiss-Prot	VAR_042183	Polymorphism	p.PRO346LEU	N/A
Swiss-Prot	VAR_042181	Polymorphism	p.PRO67LEU	N/A
Swiss-Prot	VAR_042182	Polymorphism	p.VAL113ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258