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Results for the Protein: Q03518
215273957

TAP1_HUMAN RecName: Full=Antigen peptide transporter 1; Short=APT1; AltName: Full=ATP-binding cassette sub-family B member 2; AltName: Full=Peptide supply factor 1; AltName: Full=Peptide transporter PSF1; Short=PSF-1; AltName: Full=Peptide transporter TAP1; AltName: Full=Peptide transporter involved in antigen processing 1; AltName: Full=Really interesting new gene 4 protein

Known Diseases associated with this Protein:
  TAP1 DEFICIENCY, SOMATIC
1
14
1
8
6
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

SunT - COG2274
COG4178 - COG4178
ArpD - COG4618
MdlB - COG1132
CydC - COG4987
PvdE - COG4615
CydD - COG4988
ABC_membrane - pfam00664
ATM1 - COG5265
Uup - COG0488
COG4172 - COG4172
COG1123 - COG1123
ABCC_SUR2 - cd03288
ModF - COG1119
ABCC_TAP - cd03248
PhnL - COG4778
Ttg2A - COG1127
PstB - COG1117
ABC_Mj1267_LivG_bran - cd03219
COG4181 - COG4181
PhnK - COG1101
HisP - COG4598
PhnK - COG4107
PotA - COG3842
CcmA - COG1131
ABC_Carb_Monos_II - cd03215
ZnuC - COG1121
SapF - COG4167
ProV - COG4175
AppF - COG4608
CbiO - COG1122
ABCC_NFT1 - cd03369
sufC - COG0396
ABCG_White - cd03234
ABCG_PDR_domain1 - cd03233
ABCG_EPDR - cd03213
ABCG_PDR_domain2 - cd03232
LivF - COG0410
TauB - COG1116
BtuD - COG4138
COG4586 - COG4586
COG3638 - COG3638
TagH - COG1134
DppF - COG1124
COG4136 - COG4136
ABCC_MRP_domain2 - cd03244
ABCC_bacteriocin_exp - cd03245
ABCC_Glucan_exporter - cd03254
FepC - COG1120
GlnQ - COG1126
SalX - COG1136
FtsE - COG2884
ABC_NikE_OppD_transp - cd03257
ABC_NatA_sodium_expo - cd03266
AbcC - COG1135
OpuBA - COG1125
ABC_MetN_methionine_ - cd03258
COG4619 - COG4619
TauB - COG4525
ThiQ - COG3840
NatA - COG4555
COG4559 - COG4559
CeuD - COG4604
DppD - COG0444
ABC_MalK_N - cd03301
ABC_FtsE_transporter - cd03292
CysA - COG1118
ArtP - COG4161
MalK - COG3839
CcmA - COG4133
ABC_PotA_N - cd03300
ABC_drug_resistance_ - cd03264
ABCC_Hemolysin - cd03252
ABCC_MsbA - cd03251
ABCC_MRP_domain1 - cd03250
ABC_MTABC3_MDL1_MDL2 - cd03249
ABCC_ATM1_transporte - cd03253
ABC_MJ0796_LolCDE_Ft - cd03255
ABC_ThiQ_thiamine_tr - cd03298
ABC_PstB_phosphate_t - cd03260
ABC_Carb_Solutes_lik - cd03259
ABC_PhnC_transporter - cd03256
ABCC_cytochrome_bd - cd03247
ABC_YhbG - cd03218
ABC_RNaseL_inhibitor - cd03222
ABCF_EF-3 - cd03221
ABC_KpsT_Wzt - cd03220
ABC_Carb_Monos_I - cd03216
ABCD_peroxisomal_ALD - cd03223
ABC_TM1139_LivF_bran - cd03224
ABC_DR_subfamily_A - cd03230
ABC_RNaseL_inhibitor - cd03236
ABC_Class3 - cd03229
ABCC_MRP_Like - cd03228
ABC_HisP_GlnQ - cd03262
ABC_Org_Solvent_Resi - cd03261
ABC_NrtD_SsuB_transp - cd03293
ABC_CysA_sulfate_imp - cd03296
ABC_OpuCA_Osmoprotec - cd03295
ABC_subfamily_A - cd03263
ABCC_SUR1_N - cd03290
ABC_Pro_Gly_Betaine - cd03294
ABC_putative_ATPase - cd03269
ABC_NatA_like - cd03267
ABC_BcrA_bacitracin_ - cd03268
ABCC_Protease_Secret - cd03246
ABC_cobalt_CbiO_doma - cd03225
ABC_cobalt_CbiO_doma - cd03226
ABC_Metallic_Cations - cd03235
ABC_ATPase - cd00267
ABC_Iron-Siderophore - cd03214
COG4674 - COG4674
LivG - COG0411
ABC_CcmA_heme_export - cd03231
ABC_ModC_like - cd03299
YhbG - COG1137
ABC_FeS_Assembly - cd03217
ABC_ModC_molybdenum_ - cd03297
ABC_DrrA - cd03265
AAA - smart00382
ABC_tran - pfam00005


Swiss-Prot Protein: Q03518
Identical to: NP_000584
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
MdlBCOG11322.1e-165230806
UupCOG04883.4e-05343796
COG1123COG11231.1e-11407808
ABCC_SUR2cd032881.3e-08469804
ModFCOG11192.2e-11541786
ABCC_TAPcd032485.5e-172552780
Ttg2ACOG11271.8e-09553808
PstBCOG11176.2e-10556797
ABC_Mj1267_LivG_brancd032192.7e-13557789
PhnKCOG11014.8e-07557759
ABC_Carb_Monos_IIcd032151.7e-09559780
CcmACOG11311.8e-20559802
ZnuCCOG11216.3e-12559804
ABCG_EPDRcd032135.9e-12560783
ABCG_PDR_domain2cd032322.3e-05560778
ABCG_PDR_domain1cd032331.9e-06560784
ABCG_Whitecd032345.3e-09560784
ABCC_NFT1cd033691e-10560786
sufCCOG03963.8e-07560806
LivFCOG04109.9e-14560799
TauBCOG11161.4e-11560807
DppFCOG11242.7e-13560808
CbiOCOG11225.8e-35560792
TagHCOG11344.7e-07560807
ABCC_MRP_domain2cd032442.7e-20561786
ABCC_bacteriocin_expcd032453.2e-46561783
ABCC_Glucan_exportercd032549.1e-70561794
FepCCOG11201.8e-12561804
GlnQCOG11263.4e-12561801
ABC_MetN_methionine_cd032582.4e-14562794
ABC_NikE_OppD_transpcd032575e-29562784
ABC_NatA_sodium_expocd032666.6e-10562784
DppDCOG04443.4e-07562808
OpuBACOG11253.5e-05562793
AbcCCOG11352.8e-10562802
SalXCOG11361.2e-15562786
ABC_Carb_Monos_Icd032168.3e-14563783
ABC_KpsT_Wztcd032205.7e-09563784
ABCF_EF-3cd032218.4e-10563779
ABC_RNaseL_inhibitorcd032220.00015563805
ABCD_peroxisomal_ALDcd032231.8e-09563780
ABC_TM1139_LivF_brancd032241.5e-14563792
ABCC_MRP_Likecd032284.6e-98563779
ABC_Class3cd032299.7e-30563779
ABC_RNaseL_inhibitorcd032360.00048563797
ABC_DR_subfamily_Acd032306.8e-28563780
ABC_YhbGcd032181.2e-07563794
ABCC_cytochrome_bdcd032471.4e-41563784
ABC_MTABC3_MDL1_MDL2cd032492.3e-85563803
ABCC_MRP_domain1cd032503.3e-17563779
ABCC_MsbAcd032511.7e-55563800
ABCC_Hemolysincd032523.2e-67563803
ABCC_ATM1_transportecd032533e-44563803
ABC_MJ0796_LolCDE_Ftcd032555.9e-14563780
ABC_PhnC_transportercd032566.2e-11563796
ABC_Carb_Solutes_likcd032593.4e-15563784
ABC_PstB_phosphate_tcd032603e-19563789
ABC_Org_Solvent_Resicd032612.6e-13563802
ABC_HisP_GlnQcd032621.4e-13563780
ABC_subfamily_Acd032631.5e-12563790
ABC_drug_resistance_cd032641e-10563784
ABC_NatA_likecd032674.1e-08563784
ABCC_Protease_Secretcd032464.6e-37563780
ABC_BcrA_bacitracin_cd032681.9e-09563784
ABC_putative_ATPasecd032697.6e-10563784
ABCC_SUR1_Ncd032907.5e-08563779
ABC_NrtD_SsuB_transpcd032932.7e-18563790
ABC_Pro_Gly_Betainecd032941.4e-10563800
ABC_OpuCA_Osmoproteccd032953.4e-09563806
ABC_CysA_sulfate_impcd032961.4e-17563804
ABC_ThiQ_thiamine_trcd032985.4e-10563784
ABC_PotA_Ncd033001.3e-11563750
ABC_MalK_Ncd033015.2e-12563784
ABC_FtsE_transportercd032921.7e-12563780
CysACOG11187.6e-07563808
ABC_ATPasecd002672.2e-59564779
ABC_Iron-Siderophorecd032143.3e-21564784
ABC_cobalt_CbiO_domacd032263.6e-13564781
ABC_cobalt_CbiO_domacd032252e-29564779
ABC_Metallic_Cationscd032351.8e-12564783
ABC_CcmA_heme_exportcd032313e-08574781
LivGCOG04114.2e-12574788
ABC_ModC_likecd032991.1e-08575792
ABC_FeS_Assemblycd032172.1e-05577795
ABC_DrrAcd032652.6e-09577790
ABC_ModC_molybdenum_cd032972.1e-11577784
YhbGCOG11372.1e-06577799
SunTCOG22746e-66104804
COG4178COG41780.00065207792
ArpDCOG46188.1e-15224807
CydCCOG49871.2e-12233803
PvdECOG46158e-07234794
CydDCOG49881.6e-25246804
ABC_membranepfam006645.5e-71247518
ATM1COG52652.1e-39304802
COG4172COG41722.3e-06384807
PhnLCOG47787.9e-05553769
PhnKCOG41075.1e-05557807
COG4181COG41812.5e-10557784
HisPCOG45985.3e-07557804
PotACOG38424.7e-09558808
SapFCOG41672.1e-10559801
ProVCOG41750.00076559793
AppFCOG46082.3e-12559808
COG3638COG36382.6e-08560790
BtuDCOG41387.4e-05560802
COG4586COG45860.00041560806
COG4136COG41361.2e-06561783
FtsECOG28845.3e-12562788
ThiQCOG38407.9e-10562803
TauBCOG45259.8e-09562808
NatACOG45554.6e-11562806
COG4559COG45592.5e-07562808
CeuDCOG46040.00046562798
COG4619COG46194.8e-12562791
MalKCOG38398.3e-09563801
CcmACOG41331.4e-09563783
ArtPCOG41611.3e-08563803
COG4674COG46746.3e-05571788
ABC_tranpfam000056.7e-39605731
AAAsmart003821.6e-33590794

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs2127679 Polymorphismp.ALA430VALN/A
dbSNPrs1057149 Polymorphismp.ARG708GLNN/A
Swiss-ProtVAR_013173Polymorphismp.ARG719GLNN/A
dbSNPrs1135216 Polymorphismp.ASP697GLYN/A
Swiss-ProtVAR_047514Polymorphismp.GLN768ARGN/A
dbSNPrs57640466 Polymorphismp.GLY77ARGN/A
dbSNPrs2228110 Polymorphismp.GLY479CYSN/A
dbSNPrs1057141 Polymorphismp.ILE393VALN/A
Swiss-ProtVAR_048137Polymorphismp.LEU170VALN/A
Swiss-ProtVAR_016801Polymorphismp.PRO67SERN/A
Swiss-ProtVAR_048138Polymorphismp.SER346PHEN/A
dbSNPrs41561219 Polymorphismp.VAL578ILEN/A
Swiss-ProtVAR_060987Polymorphismp.VAL304LEUN/A
dbSNPrs41550019 Polymorphismp.VAL518LEUN/A
OMIM170260.0003 Diseasep.ARG659GLNTAP1 DEFICIENCY, SOMATIC



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