Results for the protein: Q96PY6

Results for the Protein: Q96PY6

22256934

4750

NEK1

NCBI, UniProt

NEK1_HUMAN RecName: Full=Serine/threonine-protein kinase Nek1; AltName: Full=Never in mitosis A-related kinase 1; Short=NimA-related protein kinase 1; AltName: Full=Renal carcinoma antigen NY-REN-55

Known Diseases associated with this Protein:
SHORT RIB-POLYDACTYLY SYNDROME 2A (SRPS2A)
SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIA

4

12

2

0

14

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

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Swiss-Prot Protein: Q96PY6

Identical to: NP_036356

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_Jak_rpt2	cd05038	2.8e-09	1	261
PTKc_Csk_like	cd05039	3.5e-06	1	259
PTKc_Ror	cd05048	5.9e-06	1	234
PTKc_Trk	cd05049	1.8e-08	1	255
PTKc_DDR	cd05051	0.00097	1	255
PTKc_Abl	cd05052	1.3e-08	1	257
PTKc_EGFR_like	cd05057	7.7e-06	1	269
PTKc_InsR	cd05061	2.5e-07	1	275
PTKc_IGF-1R	cd05062	1.1e-07	1	254
PTKc_EphR_A2	cd05063	4.9e-06	1	257
PTKc_Frk_like	cd05068	1.3e-12	1	265
PTKc_Fyn_Yrk	cd05070	5.7e-07	1	256
PTKc_Lyn	cd05072	4.6e-08	1	256
PTKc_Jak1_rpt2	cd05079	3.5e-06	1	277
PTKc_Tyk2_rpt2	cd05080	8.8e-09	1	264
PTKc_Csk	cd05082	1.8e-07	1	259
PTKc_Chk	cd05083	9.4e-11	1	261
PTKc_Tie1	cd05089	3.1e-06	1	281
PTKc_Lck_Blk	cd05067	7.4e-06	1	256
PTKc_TrkB	cd05093	1.3e-06	1	267
PTKc_TrkC	cd05094	2.4e-05	1	322
PTKc_DDR2	cd05095	0.00013	1	258
PTKc_FGFR1	cd05098	0.00024	1	270
PTKc_FGFR2	cd05101	0.00056	1	273
PTKc_EGFR	cd05108	0.00015	1	311
PTKc_HER2	cd05109	8.7e-06	1	269
PTK_HER3	cd05111	1.5e-05	1	269
PTKc_Btk_Bmx	cd05113	2.5e-10	1	257
PTKc_HER4	cd05110	0.00032	1	274
PTKc_FGFR3	cd05100	0.0006	1	306
PTKc_FGFR4	cd05099	2.3e-05	1	278
STKc_ROCK	cd05596	1.9e-05	1	323
STKc_ROCK1	cd05622	8.5e-05	1	322
STKc_ROCK2	cd05621	7.1e-06	1	323
STKc_MST1_2	cd06612	5e-22	1	258
STKc_MAP4K3_like	cd06613	8.6e-34	1	257
STKc_ASK	cd06624	1.8e-27	1	258
STKc_myosinIIIA	cd06638	3.2e-10	1	258
STKc_MAP4K3	cd06645	3.2e-20	1	257
STKc_PAK_I	cd06647	2.1e-17	1	278
STKc_MAP4K5	cd06646	6.4e-19	1	257
STKc_myosinIIIB	cd06639	1.2e-10	1	259
STKc_PAK1	cd06654	1.7e-10	1	280
STKc_PAK3	cd06656	2.4e-11	1	282
STKc_PAK5	cd06658	1.2e-08	1	275
STKc_PAK2	cd06655	3.4e-11	1	281
STKc_PAK6	cd06659	3.7e-12	1	283
STKc_PCTAIRE_like	cd07844	2e-18	1	282
STKc_CDK10	cd07845	1.6e-11	1	281
STKc_JNK	cd07850	5e-07	1	340
STKc_MAPK15	cd07852	7.6e-10	1	283
STKc_TEY_MAPK_plant	cd07858	1.4e-08	1	326
STKc_CDK12	cd07864	6.2e-12	1	258
STKc_CDK9	cd07865	5.5e-12	1	258
STKc_PFTAIRE1	cd07869	5.1e-06	1	268
STKc_PCTAIRE3	cd07871	9.7e-11	1	283
STKc_PCTAIRE2	cd07872	4.9e-09	1	306
STKc_PCTAIRE1	cd07873	6.5e-08	1	269
STKc_JNK1	cd07875	0.00038	1	344
STKc_JNK2	cd07876	1.5e-05	1	364
STKc_p38gamma_MAPK12	cd07880	6.8e-07	1	318
STKc_BUR1	cd07866	4.5e-11	1	258
STKc_PFTAIRE2	cd07870	2e-08	1	299
STKc_JNK3	cd07874	3.8e-05	1	377
STKc_Nek6_Nek7	cd08224	5.1e-62	1	264
STKc_Nek6	cd08228	1.4e-53	1	264
STKc_Nek7	cd08229	2.4e-53	1	264
PTKc_ALK_LTK	cd05036	2.6e-08	2	259
PTKc_Src_like	cd05034	2e-08	2	256
PTKc_FGFR	cd05053	2.4e-05	2	267
PTKc_FAK	cd05056	1.8e-09	2	264
PTKc_EphR_A10	cd05064	2e-05	2	262
PTKc_EphR_A	cd05066	3.1e-06	2	262
PTKc_Yes	cd05069	5.9e-08	2	256
PTKc_Src	cd05071	7.6e-08	2	258
PTKc_Hck	cd05073	3e-08	2	256
PTKc_Jak2_Jak3_rpt2	cd05081	3.6e-08	2	266
PTKc_DDR_like	cd05097	0.00011	2	260
PTKc_Tec_Rlk	cd05114	6.8e-09	2	257
PTKc_Itk	cd05112	2.2e-10	2	257
PTKc_Srm_Brk	cd05148	1.6e-07	2	258
STKc_ROCK_NDR_like	cd05573	8.8e-13	2	278
STKc_phototropin_lik	cd05574	1.1e-11	2	266
STKc_PDK1	cd05581	3.9e-29	2	266
STKc_DMPK_like	cd05597	3.9e-09	2	325
STKc_PKA	cd05580	7.7e-18	2	283
STKc_MAST	cd05609	2.1e-09	2	316
STKc_PRKX_like	cd05612	5.4e-11	2	284
STKc_LATS	cd05598	4.6e-08	2	330
STKc_MRCK_alpha	cd05623	1e-08	2	312
STKc_MRCK_beta	cd05624	3.9e-08	2	325
STKc_LATS1	cd05625	1.4e-05	2	325
STKc_NDR1	cd05628	8.4e-08	2	325
STKc_NDR_like_fungal	cd05629	5.3e-08	2	325
STKc_NDR2	cd05627	7e-06	2	339
STKc_LATS2	cd05626	7.2e-06	2	330
PKc_MAPKK	cd06605	2.4e-16	2	264
STKc_TAO	cd06607	7.6e-10	2	286
STKc_OSR1_SPAK	cd06610	8.9e-21	2	258
STKc_MST3_like	cd06609	3.9e-23	2	278
STKc_myosinIII_like	cd06608	1.8e-16	2	258
STKc_PAK	cd06614	2.4e-23	2	271
PKc_MEK	cd06615	6.5e-09	2	270
PKc_MKK7	cd06618	5.4e-11	2	273
PKc_MKK5	cd06619	5e-05	2	283
PKc_MAPKK_Pek1_like	cd06621	2.5e-15	2	270
PKc_MAPKK_plant_like	cd06623	1.7e-23	2	264
PKc_MAPKK_PBS2_like	cd06622	2.7e-09	2	315
STKc_TAO1	cd06635	1.1e-08	2	286
STKc_MST4	cd06640	2.4e-19	2	278
STKc_STK25-YSK1	cd06642	4.9e-18	2	278
STKc_SLK	cd06643	6.1e-19	2	276
PKc_MKK3_6	cd06617	4.5e-10	2	271
STKc_MST3	cd06641	4.7e-20	2	278
STKc_TAO2	cd06634	5.6e-11	2	287
PKc_MEK2	cd06649	4.4e-05	2	338
PKc_MEK1	cd06650	0.00012	2	301
STKc_MEKK2	cd06652	3.3e-11	2	259
STKc_MEKK3_like_1	cd06653	3.8e-12	2	258
STKc_PAK4	cd06657	3.9e-10	2	277
STKc_TAO3	cd06633	6.3e-07	2	286
PKc_MAPKK_Byr1_like	cd06620	7.1e-08	2	266
STKc_PAK_II	cd06648	1.8e-15	2	270
STKc_NAK1_like	cd06917	3.5e-17	2	280
STKc_CDKL	cd07833	3.1e-12	2	258
STKc_CdkB_plant	cd07837	1.6e-11	2	259
STKc_CDC2L1	cd07843	4.6e-11	2	258
STKc_CDKL2_3	cd07846	2.7e-11	2	276
STKc_CDKL1_4	cd07847	2.2e-26	2	294
STKc_CDKL5	cd07848	1.6e-07	2	276
STKc_ERK1_2_like	cd07849	2.2e-08	2	285
STKc_p38	cd07851	1.4e-09	2	304
STKc_ERK5	cd07855	2.8e-09	2	295
STKc_CDK6	cd07862	7.1e-07	2	300
STKc_p38alpha_MAPK14	cd07877	1.7e-06	2	318
STKc_p38beta_MAPK11	cd07878	2.7e-05	2	323
STKc_p38delta_MAPK13	cd07879	0.00019	2	318
STKc_Sty1_Hog1	cd07856	2e-06	2	306
SPS1	COG0515	3.8e-65	2	435
PTKc_EphR	cd05033	3.1e-06	3	258
PTKc_Musk	cd05050	9.3e-07	3	255
PTKc_EphR_B	cd05065	1.5e-05	3	262
PTKc_RET	cd05045	3.8e-05	3	269
PTKc_Ror2	cd05091	0.00037	3	259
PTKc_Ror1	cd05090	4.4e-05	3	259
PTKc_Tie2	cd05088	2.2e-06	3	282
PKc_STE	cd05122	3.9e-49	3	257
STKc_Yank1	cd05578	2.1e-22	3	258
STKc_MSK_N	cd05583	2.6e-12	3	268
STKc_cPKC	cd05587	4.7e-14	3	331
STKc_GRK4_like	cd05605	4.3e-16	3	293
STKc_MSK1_N	cd05613	5.4e-10	3	277
STKc_MSK2_N	cd05614	4.9e-11	3	304
STKc_cPKC_alpha	cd05615	2.3e-10	3	315
STKc_cPKC_beta	cd05616	8.3e-08	3	331
STKc_GRK6	cd05630	9.8e-09	3	289
STKc_GRK4	cd05631	1.1e-08	3	279
STKc_GRK5	cd05632	4e-09	3	274
STKc_MAPKKK	cd06606	2.6e-56	3	258
STKc_MEKK4	cd06626	3.2e-18	3	258
STKc_MAPKKK_Byr2_lik	cd06628	8e-36	3	258
STKc_MAPKKK_Bck1_lik	cd06629	2.2e-12	3	258
STKc_MEKK1	cd06630	1.3e-11	3	259
STKc_YSK4	cd06631	4.2e-13	3	258
STKc_Cdc7_like	cd06627	2.2e-23	3	258
STKc_MEKK3	cd06651	2.6e-20	3	260
STKc_CCRK	cd07832	1.4e-13	3	259
STKc_MAPK	cd07834	2.2e-11	3	274
STKc_CDK7	cd07841	2.2e-17	3	271
STKc_CDK8_like	cd07842	1.2e-12	3	258
STKc_Pho85	cd07836	2.7e-15	3	276
STKc_NLK	cd07853	1.3e-07	3	394
STKc_MAPK4_6	cd07854	7.4e-08	3	316
STKc_CDK5	cd07839	3.3e-11	3	258
STKc_MPK1	cd07857	3.3e-08	3	291
STKc_TDY_MAPK_plant	cd07859	2.2e-08	3	339
STKc_CDK2_3	cd07860	1.6e-17	3	258
STKc_CDK1_euk	cd07861	9.8e-16	3	289
STKc_CDK4	cd07863	1.1e-07	3	283
STKc_Nek	cd08215	8e-182	3	258
STKc_Nek2	cd08217	1.2e-89	3	258
STKc_Nek1	cd08218	5e-208	3	258
STKc_Nek3	cd08219	1e-135	3	258
STKc_Nek9	cd08221	5.3e-109	3	258
STKc_Nek11	cd08222	4.5e-75	3	258
STKc_Nek4	cd08223	6.8e-116	3	258
STKc_Nek5	cd08225	7.4e-156	3	258
STKc_Nek8	cd08220	9.1e-102	3	258
STKc_FA2-like	cd08529	7.1e-103	3	258
STKc_Nek10	cd08528	2.3e-47	3	255
PTK_CCK4	cd05046	1.1e-05	4	260
PTKc_Tyro3	cd05074	3.9e-06	4	260
PTKc_TrkA	cd05092	2.1e-06	4	264
STKc_CMGC	cd05118	1.5e-23	4	258
STKc_PKN	cd05589	1.6e-10	4	314
PKc_MKK4	cd06616	5.2e-10	4	277
STKc_MAP4K4_6	cd06636	1.9e-13	4	258
STKc_TNIK	cd06637	4.4e-14	4	258
STKc_STK10_LOK	cd06644	2.6e-22	4	278
STKc_MOK	cd07831	1.3e-15	4	258
STKc_MAK_like	cd07830	1.9e-17	4	258
STKc_CDK1_like	cd07835	3.4e-20	4	281
STKc_CDK4_6_like	cd07838	3.3e-12	4	258
STKc_CDK9_like	cd07840	2.2e-18	4	258
STKc_CDK_like	cd07829	9.7e-23	4	258
PTKc_Axl_like	cd05035	2.8e-06	5	257
PTK_Ryk	cd05043	9e-05	5	211
PTKc_Axl	cd05075	0.00046	5	257
PK_STRAD	cd08216	1.4e-07	5	272
STKc_MEKK3_like	cd06625	9.3e-27	6	258
STKc_MEKK1_plant	cd06632	4.6e-30	6	258
PK_STRAD_beta	cd08226	0.001	6	322
PTKc_Tec_like	cd05059	7.6e-10	7	259
STKc_RSK_N	cd05582	1.3e-27	7	315
STKc_p70S6K	cd05584	1.1e-24	7	318
STKc_NDR_like	cd05599	7.7e-07	7	284
STKc_Sid2p_Dbf2p	cd05600	0.00012	7	282
STKc_Rim15_like	cd05611	6.6e-07	7	252
PK_STRAD_alpha	cd08227	0.00099	7	358
STKc_CNK2-like	cd08530	9.3e-84	7	258
PTKc	cd00192	1.5e-18	8	257
PTKc_Ack_like	cd05040	1e-09	8	259
PTKc_Fes_like	cd05041	2.2e-08	8	258
PTKc_Aatyk	cd05042	1.4e-06	8	255
PTKc_c-ros	cd05044	1.2e-07	8	258
PTKc_Tie	cd05047	4e-06	8	263
PTKc_Met_Ron	cd05058	2e-05	8	264
PTKc_Syk_like	cd05060	1.9e-05	8	263
PTKc_Fes	cd05084	1.4e-07	8	259
PTKc_Fer	cd05085	5.8e-06	8	259
PTKc_Aatyk2	cd05086	8.1e-08	8	255
PTKc_Aatyk1_Aatyk3	cd05087	8.8e-06	8	257
PTKc_Syk	cd05116	7.2e-06	8	258
STKc_PKB	cd05571	4.2e-23	8	324
STKc_PKC	cd05570	4.4e-12	8	300
STKc_SGK	cd05575	6.6e-11	8	316
STKc_nPKC_eta	cd05590	7.4e-14	8	331
STKc_nPKC_epsilon	cd05591	8.2e-12	8	323
STKc_nPKC_theta_delt	cd05592	5.4e-18	8	318
STKc_PKB_alpha	cd05594	5.9e-15	8	319
STKc_PKB_beta	cd05595	2.3e-14	8	318
STKc_aPKC	cd05588	7.6e-10	8	350
STKc_PKB_gamma	cd05593	9.2e-12	8	306
STKc_SGK1	cd05602	7.5e-10	8	322
STKc_SGK3	cd05604	2.5e-16	8	318
STKc_aPKC_zeta	cd05617	1.2e-08	8	360
STKc_SGK2	cd05603	9e-13	8	323
STKc_aPKC_iota	cd05618	4.4e-07	8	310
STKc_nPKC_theta	cd05619	3.7e-10	8	318
STKc_nPKC_delta	cd05620	2e-05	8	311
PTKc_Zap-70	cd05115	1.3e-05	9	261
STKc_CDC2L6	cd07867	3e-06	9	319
STKc_CDK8	cd07868	9e-06	9	289
PKc	cd00180	5.1e-85	10	256
STKc_AGC	cd05123	3.7e-42	10	251
STKc_cGK_PKG	cd05572	9.4e-17	10	261
STKc_GRK	cd05577	3.3e-11	10	273
STKc_MAST_like	cd05579	4.1e-18	10	254
STKc_YPK1_like	cd05585	1.6e-19	10	317
STKc_Sck1_like	cd05586	2.7e-15	10	368
STKc_CRIK	cd05601	1.2e-10	10	301
STKc_beta_ARK	cd05606	2.5e-09	10	273
STKc_GRK1	cd05608	1.3e-13	10	283
STKc_GRK7	cd05607	4.9e-10	10	278
STKc_GRK3	cd05633	2.8e-07	10	275
STKc_SLK_like	cd06611	7.7e-17	10	273
Pkinase	pfam00069	5.2e-85	4	258
Pkinase_Tyr	pfam07714	1.1e-17	4	258
TyrKc	smart00219	1.8e-19	4	257
STYKc	smart00221	3.4e-88	4	258
S_TKc	smart00220	9.2e-94	14	258
KIND	smart00750	3.7e-06	92	266

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040903	Polymorphism	p.ALA294PRO	N/A
Swiss-Prot	VAR_046486	Polymorphism	p.ALA598THR	N/A
Swiss-Prot	VAR_040905	Polymorphism	p.ALA463VAL	N/A
Swiss-Prot	VAR_040904	Polymorphism	p.ARG355GLY	N/A
Swiss-Prot	VAR_061743	Polymorphism	p.ASN717LYS	N/A
Swiss-Prot	VAR_046489	Polymorphism	p.ASP1180ASN	N/A
Swiss-Prot	VAR_046488	Polymorphism	p.GLN883GLU	N/A
Swiss-Prot	VAR_051651	Polymorphism	p.GLU724GLY	N/A
Swiss-Prot	VAR_040901	Polymorphism	p.GLU25LYS	N/A
Swiss-Prot	VAR_069617	Disease	p.GLY145ARG	Short rib-polydactyly syndrome 2A (SRPS2A)
Swiss-Prot	VAR_040900	Polymorphism	p.ILE10PHE	N/A
Swiss-Prot	VAR_069618	Disease	p.LEU253SER	Short rib-polydactyly syndrome 2A (SRPS2A)
Swiss-Prot	VAR_040902	Polymorphism	p.LEU76VAL	N/A
Swiss-Prot	VAR_040906	Polymorphism	p.LYS745ASN	N/A
OMIM	604588.0001	Disease	p.ARG127TER	SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIA
OMIM	604588.0004	Disease	p.GLY145ARG	SHORT RIB-POLYDACTYLY SYNDROME, TYPE IIA

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258