Results for the protein: NP

Results for the Protein: NP_001138728

223671883

51135

IRAK4

NCBI

interleukin-1 receptor-associated kinase 4 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
IRAK4 DEFICIENCY

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Tips:

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RefSeq Protein: NP_001138728

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_VEGFR3	cd05102	0.00039	4	333
STKc_JNK	cd07850	0.00045	30	333
STKc_PAK5	cd06658	3.8e-05	35	330
STKc_PAK6	cd06659	5.9e-08	36	336
STKc_TAO1	cd06635	5.4e-06	37	332
STKc_PAK1	cd06654	4.4e-07	37	333
STKc_TAO3	cd06633	2.9e-05	40	331
PTKc_EGFR_like	cd05057	1.7e-08	41	336
STKc_PAK	cd06614	2.9e-16	42	326
STKc_MAP4K4_6	cd06636	1.3e-05	42	309
STKc_PAK_I	cd06647	1.8e-06	42	335
STKc_PAK_II	cd06648	1.5e-09	42	334
STKc_PAK2	cd06655	6.1e-06	42	334
STKc_PAK3	cd06656	7.8e-07	42	335
STKc_PAK4	cd06657	5.7e-06	42	335
PTK_CCK4	cd05046	1.6e-07	43	332
PTKc_FGFR1	cd05098	1.7e-06	43	332
STKc_myosinIIIB	cd06639	1.2e-05	44	336
STKc_p38	cd07851	9.4e-06	44	335
STKc_Sty1_Hog1	cd07856	5.7e-06	46	308
STKc_BUR1	cd07866	3.8e-09	46	307
PTKc_PDGFR	cd05055	4.8e-06	47	334
PTKc_FGFR2	cd05101	4.4e-06	47	336
STKc_TAO	cd06607	3.4e-06	47	332
STKc_ASK	cd06624	1.7e-08	47	335
STKc_myosinIIIA	cd06638	4.3e-07	47	335
STKc_STK10_LOK	cd06644	3.4e-07	47	336
PTKc_EphR_A10	cd05064	1.2e-07	48	334
PTKc_Ror2	cd05091	7.6e-08	48	333
PKc_MKK7	cd06618	1.7e-08	48	336
STKc_TAO2	cd06634	3.9e-06	48	332
STKc_MAP4K3	cd06645	2.4e-07	48	331
STKc_MAP4K5	cd06646	2.3e-06	48	331
PKc_MEK2	cd06649	0.0004	48	336
STKc_CDK10	cd07845	9.3e-10	48	323
PTKc_FGFR3	cd05100	0.00046	49	312
PTKc_FGFR4	cd05099	1.1e-06	49	336
STKc_myosinIII_like	cd06608	1e-08	49	290
PTKc_HER2	cd05109	4.7e-06	50	328
PTK_HER3	cd05111	6e-08	50	325
STKc_MAPK15	cd07852	2.3e-06	50	334
PTKc_EGFR	cd05108	5.6e-05	51	336
PTKc_HER4	cd05110	1.9e-06	51	334
STKc_CDK9	cd07865	2.1e-07	52	306
STKc_Nek6_Nek7	cd08224	1.2e-07	53	335
PTKc_ALK_LTK	cd05036	9.9e-12	54	332
STKc_ROCK_NDR_like	cd05573	8.6e-06	54	324
STKc_PKA	cd05580	1.2e-05	54	305
STKc_PDK1	cd05581	4.1e-10	54	314
STKc_CRIK	cd05601	1.5e-05	54	336
STKc_PRKX_like	cd05612	0.00024	54	334
PKc_MAPKK_Byr1_like	cd06620	5.2e-10	54	335
PKc_MAPKK_plant_like	cd06623	1.2e-14	54	328
STKc_SLK	cd06643	2.4e-08	54	335
STKc_CDKL5	cd07848	0.0002	54	335
PTKc_Musk	cd05050	5.2e-11	55	332
PTKc_DDR	cd05051	7.3e-10	55	332
PTKc_Trk	cd05049	1.3e-13	55	332
PTKc_InsR	cd05061	3.9e-08	55	335
PTKc_Frk_like	cd05068	2.4e-25	55	333
PTKc_Lyn	cd05072	2.4e-14	55	333
PTKc_Csk	cd05082	1.3e-14	55	333
PTKc_Tie2	cd05088	1e-08	55	336
PTKc_TrkC	cd05094	1e-07	55	336
PTKc_DDR2	cd05095	1.3e-09	55	332
PTKc_DDR_like	cd05097	4.4e-09	55	332
PTKc_Itk	cd05112	4.5e-14	55	331
STKc_TNIK	cd06637	1.1e-06	55	309
STKc_PCTAIRE2	cd07872	0.00012	55	330
STKc_PCTAIRE1	cd07873	4.3e-05	55	322
PTKc_InsR_like	cd05032	1.1e-10	56	332
PTKc_EphR	cd05033	1.5e-11	56	334
PTKc_Jak_rpt2	cd05038	3.2e-12	56	330
PTKc_FGFR	cd05053	3.6e-09	56	335
PTKc_Tec_like	cd05059	5.5e-13	56	331
PTKc_EphR_B	cd05065	6.2e-08	56	334
PTKc_EphR_A	cd05066	4.6e-07	56	334
PTKc_Jak1_rpt2	cd05079	9.1e-06	56	334
PTKc_Tyk2_rpt2	cd05080	6.9e-09	56	335
PTKc_Jak2_Jak3_rpt2	cd05081	2.2e-09	56	334
PTKc_Chk	cd05083	1.9e-20	56	333
PTKc_Btk_Bmx	cd05113	1.1e-10	56	331
PKc_MKK4	cd06616	6.2e-08	56	330
STKc_ERK1_2_like	cd07849	3.3e-05	56	336
STKc_PCTAIRE_like	cd07844	1.3e-06	56	334
STKc_MAPK4_6	cd07854	0.00035	56	334
STKc_CDK12	cd07864	3.2e-09	56	313
STKc_PFTAIRE2	cd07870	4.7e-06	56	334
STKc_PCTAIRE3	cd07871	1.1e-05	56	331
PTKc_EphR_A2	cd05063	8.3e-13	57	334
PKc_MAPKK_PBS2_like	cd06622	6.6e-06	57	316
STKc_MST4	cd06640	1.8e-07	57	334
STKc_MST3	cd06641	3.1e-07	57	334
STKc_STK25-YSK1	cd06642	2e-08	57	322
STKc_NLK	cd07853	0.00095	57	336
PTKc_Src_like	cd05034	3e-16	58	289
PTKc_Csk_like	cd05039	1.5e-15	58	333
PTK_Ryk	cd05043	0.00033	58	279
PTKc_Ror	cd05048	6.6e-13	58	333
PTKc_Abl	cd05052	6.7e-15	58	334
PTKc_IGF-1R	cd05062	2.3e-08	58	332
PTKc_Fyn_Yrk	cd05070	3.3e-13	58	333
PTKc_Ror1	cd05090	9.1e-10	58	333
PTKc_TrkA	cd05092	6e-09	58	332
PTKc_TrkB	cd05093	1.8e-08	58	336
PTKc_FAK	cd05056	9.5e-07	58	336
PTKc_Srm_Brk	cd05148	3.5e-11	58	333
STKc_SLK_like	cd06611	2.6e-08	58	332
STKc_CDKL2_3	cd07846	6.1e-08	58	335
STKc_CDKL1_4	cd07847	8.6e-09	58	335
STKc_Nek8	cd08220	1.9e-06	58	330
PTKc_Lck_Blk	cd05067	8.7e-20	59	333
PTKc_Yes	cd05069	5.6e-11	59	333
PTKc_Src	cd05071	1.1e-09	59	335
PTKc_Hck	cd05073	2.4e-11	59	333
PTKc_DDR1	cd05096	2.6e-07	59	332
PTKc_Tec_Rlk	cd05114	3.1e-11	59	331
STKc_PKN	cd05589	0.00036	59	336
STKc_GRK4_like	cd05605	1.7e-06	59	336
STKc_GRK6	cd05630	0.0002	59	336
STKc_GRK5	cd05632	2.1e-05	59	336
PKc_MKK5	cd06619	0.00059	59	334
PK_STRAD	cd08216	1.6e-06	59	332
STKc_Nek9	cd08221	4.6e-08	59	331
STKc_MAPKKK	cd06606	1.1e-20	60	335
STKc_Cdc7_like	cd06627	7.4e-15	60	281
STKc_MEKK3_like	cd06625	1.6e-13	60	335
STKc_MEKK3	cd06651	1.1e-09	60	309
STKc_MEKK3_like_1	cd06653	7.2e-08	60	310
SPS1	COG0515	7.2e-17	60	336
STKc_CDK8_like	cd07842	7.4e-06	62	322
STKc_CDC2L1	cd07843	6.4e-07	62	316
PTKc_RET	cd05045	3.6e-08	63	336
STKc_MAPKKK_Byr2_lik	cd06628	1.6e-15	63	313
STKc_MAPKKK_Bck1_lik	cd06629	2.1e-10	63	305
STKc_Pho85	cd07836	2.2e-07	63	335
STKc_CDK4_6_like	cd07838	0.00011	63	290
STKc_CDK7	cd07841	1.4e-11	63	321
STKc_Nek1	cd08218	1.8e-05	63	330
STKc_Nek11	cd08222	3.9e-06	63	313
STKc_Nek4	cd08223	6.2e-06	63	334
PTKc_Axl_like	cd05035	2.9e-08	65	334
PTKc_Tyro3	cd05074	8.5e-06	65	334
PTKc_Axl	cd05075	2.1e-05	65	334
PTKc_Tie1	cd05089	2.4e-08	65	336
PKc_STE	cd05122	9.7e-16	65	334
STKc_MEKK4	cd06626	4.2e-11	65	275
STKc_MEKK1	cd06630	5.5e-09	65	334
STKc_YSK4	cd06631	1.3e-10	65	313
STKc_MEKK1_plant	cd06632	2.5e-12	65	308
STKc_MEKK2	cd06652	7.2e-07	65	308
STKc_MAK_like	cd07830	6.2e-10	65	331
STKc_CCRK	cd07832	2.2e-11	65	335
STKc_Nek6	cd08228	2e-06	65	335
STKc_Nek7	cd08229	6.8e-07	65	335
PTKc	cd00192	4.5e-33	66	331
PTK_Jak_rpt1	cd05037	0.00021	66	334
PTKc_Ack_like	cd05040	5.7e-14	66	332
PTKc_Fes_like	cd05041	3.8e-16	66	332
PTKc_Aatyk	cd05042	9.6e-07	66	332
PTKc_Tie	cd05047	1.7e-09	66	335
PTKc_Met_Ron	cd05058	1.1e-12	66	336
PTKc_Syk_like	cd05060	1.9e-09	66	335
PTK_Jak2_Jak3_rpt1	cd05078	5.9e-06	66	331
PTKc_Fes	cd05084	7.4e-13	66	332
PTKc_Fer	cd05085	2e-09	66	332
PTKc_Aatyk2	cd05086	0.00053	66	332
PTKc_Aatyk1_Aatyk3	cd05087	0.00016	66	332
PTKc_c-ros	cd05044	2.9e-09	66	332
STKc_CMGC	cd05118	1.9e-11	66	331
PTKc_Syk	cd05116	4.6e-07	66	335
STKc_PKB	cd05571	9.6e-05	66	336
STKc_MSK_N	cd05583	0.00028	66	321
STKc_PKB_alpha	cd05594	0.00065	66	335
PKc_MAPKK	cd06605	4.2e-12	66	328
STKc_MST3_like	cd06609	2e-11	66	294
STKc_OSR1_SPAK	cd06610	2.4e-13	66	335
STKc_MAP4K3_like	cd06613	7e-13	66	334
PKc_MEK	cd06615	1.5e-08	66	333
PKc_MKK3_6	cd06617	5.5e-08	66	332
PKc_MAPKK_Pek1_like	cd06621	1.4e-11	66	330
STKc_CDK_like	cd07829	2.5e-11	66	307
STKc_MOK	cd07831	9e-05	66	307
STKc_CDKL	cd07833	2.9e-08	66	335
STKc_CDK1_like	cd07835	4.1e-07	66	334
STKc_MAPK	cd07834	9.4e-07	66	333
STKc_CdkB_plant	cd07837	1.1e-07	66	332
STKc_CDK5	cd07839	7.8e-06	66	335
STKc_CDK9_like	cd07840	7.8e-12	66	316
STKc_CDK2_3	cd07860	3e-06	66	334
STKc_CDK1_euk	cd07861	8.5e-06	66	332
STKc_CDK4	cd07863	0.00052	66	334
STKc_Nek	cd08215	3.2e-15	66	332
STKc_Nek2	cd08217	1.6e-07	66	332
STKc_Nek3	cd08219	1e-06	66	313
STKc_Nek5	cd08225	2.1e-05	66	323
STKc_Nek10	cd08528	5e-06	66	332
STKc_FA2-like	cd08529	3.8e-11	66	335
STKc_CNK2-like	cd08530	9e-08	66	335
PTKc_Zap-70	cd05115	1.6e-06	67	335
STKc_nPKC_theta	cd05619	0.00013	67	336
STKc_MST1_2	cd06612	2e-13	67	275
PKc	cd00180	4.5e-72	68	333
STKc_AGC	cd05123	1.1e-08	68	329
STKc_PKC	cd05570	1.4e-05	68	334
STKc_cGK_PKG	cd05572	1.4e-06	68	300
STKc_GRK	cd05577	3.3e-07	68	322
STKc_MAST_like	cd05579	2e-11	68	299
STKc_beta_ARK	cd05606	2.6e-05	68	336
STKc_GRK7	cd05607	1.6e-05	68	325
STKc_GRK1	cd05608	1.2e-07	68	336
STKc_GRK4	cd05631	1.4e-05	68	336
STKc_GRK3	cd05633	0.00011	68	326
STKc_NAK1_like	cd06917	3.7e-10	68	313
STKc_Yank1	cd05578	5e-09	69	330
Pkinase	pfam00069	5.5e-46	62	330
Pkinase_Tyr	pfam07714	9.1e-42	61	330
TyrKc	smart00219	9.4e-44	62	330
STYKc	smart00221	7e-47	62	332
S_TKc	smart00220	7.9e-46	72	334
KIND	smart00750	4.4e-05	144	336

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs4251545	Polymorphism	p.ALA304THR	N/A
OMIM	606883.0002	Disease	p.GLN169TER	IRAK4 DEFICIENCY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258