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Results for the Protein: P08183
238054374

MDR1_HUMAN RecName: Full=Multidrug resistance protein 1; AltName: Full=ATP-binding cassette sub-family B member 1; AltName: Full=P-glycoprotein 1; AltName: CD_antigen=CD243

Known Diseases associated with this Protein:
  COLCHICINE RESISTANCE
1
26
1
4
22
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

SunT - COG2274
COG4178 - COG4178
MdlB - COG1132
ABC_membrane - pfam00664
CydD - COG4988
CydC - COG4987
ATM1 - COG5265
COG1123 - COG1123
COG4172 - COG4172
ABCC_SUR2 - cd03288
ABCC_CFTR1 - cd03291
COG4586 - COG4586
ModF - COG1119
TagH - COG1134
ABCC_TAP - cd03248
PstB - COG1117
YhbG - COG1137
PhnK - COG4107
HisP - COG4598
COG4181 - COG4181
PotA - COG3842
Ttg2A - COG1127
COG3845 - COG3845
ProV - COG4175
PhnL - COG4778
CcmA - COG1131
MalK - COG3839
DppF - COG1124
ABCG_White - cd03234
ABCC_NFT1 - cd03369
ABCG_PDR_domain1 - cd03233
ABCG_PDR_domain2 - cd03232
ABCG_EPDR - cd03213
sufC - COG0396
Uup - COG0488
CbiO - COG1122
MglA - COG1129
ZnuC - COG1121
TauB - COG1116
COG3638 - COG3638
ABCC_CFTR2 - cd03289
CcmA - COG4133
GlnQ - COG1126
FepC - COG1120
ABCC_Glucan_exporter - cd03254
ABCC_bacteriocin_exp - cd03245
COG4152 - COG4152
ABCC_MRP_domain2 - cd03244
CysA - COG1118
AppF - COG4608
FtsE - COG2884
ThiQ - COG3840
ArtP - COG4161
LivF - COG0410
ABC_NikE_OppD_transp - cd03257
SalX - COG1136
ABC_MetN_methionine_ - cd03258
ABC_RNaseL_inhibitor - cd03236
ABC_CysA_sulfate_imp - cd03296
AbcC - COG1135
OpuBA - COG1125
DppD - COG0444
ABC_ThiQ_thiamine_tr - cd03298
ABC_OpuCA_Osmoprotec - cd03295
ABC_ModC_like - cd03299
NatA - COG4555
ABC_Pro_Gly_Betaine - cd03294
CeuD - COG4604
COG4619 - COG4619
ABC_MalK_N - cd03301
ABC_NrtD_SsuB_transp - cd03293
ABCC_Protease_Secret - cd03246
ABCC_cytochrome_bd - cd03247
ABCC_MsbA - cd03251
ABC_FtsE_transporter - cd03292
ABCC_MRP_Like - cd03228
ABC_BcrA_bacitracin_ - cd03268
ABCD_peroxisomal_ALD - cd03223
ABC_TM1139_LivF_bran - cd03224
ABC_Class3 - cd03229
ABCC_MRP_domain1 - cd03250
ABC_NatA_like - cd03267
ABC_NatA_sodium_expo - cd03266
ABC_Carb_Solutes_lik - cd03259
ABC_PhnC_transporter - cd03256
ABC_MJ0796_LolCDE_Ft - cd03255
ABCC_ATM1_transporte - cd03253
ABC_Org_Solvent_Resi - cd03261
ABC_drug_resistance_ - cd03264
ABCC_Hemolysin - cd03252
ABC_HisP_GlnQ - cd03262
ABC_subfamily_A - cd03263
ABCF_EF-3 - cd03221
ABC_DR_subfamily_A - cd03230
ABC_MTABC3_MDL1_MDL2 - cd03249
ABC_Mj1267_LivG_bran - cd03219
ABCC_SUR1_N - cd03290
ABC_PstB_phosphate_t - cd03260
ABC_YhbG - cd03218
ABC_FeS_Assembly - cd03217
ABC_Carb_Monos_I - cd03216
ABC_cobalt_CbiO_doma - cd03225
ABC_cobalt_CbiO_doma - cd03226
ABC_Iron-Siderophore - cd03214
ABC_ATPase - cd00267
ABC_Metallic_Cations - cd03235
ABC_RNaseL_inhibitor - cd03237
ABC_UvrA_II - cd03271
ABC_DrrA - cd03265
ModC - COG4148
ABC_ModC_molybdenum_ - cd03297
AAA - smart00382
ABC_tran - pfam00005
ArpD - COG4618
PvdE - COG4615
SapF - COG4167
TauB - COG4525
ABC_putative_ATPase - cd03269
COG4136 - COG4136
PhnK - COG1101
ABC_RNaseL_inhibitor - cd03222
ABC_KpsT_Wzt - cd03220
ABC_PotA_N - cd03300
ABC_Carb_Monos_II - cd03215
ABC_CcmA_heme_export - cd03231
ABC_UvrA - cd03238
COG4674 - COG4674
LivG - COG0411
BtuD - COG4138
COG4559 - COG4559


Swiss-Prot Protein: P08183
Identical to: NP_000918
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
MdlBCOG11323.9e-18631632
COG1123COG11231.5e-12197636
ABCC_SUR2cd032886.7e-21318630
ABCC_CFTR1cd032919.2e-08358655
ModFCOG11192.5e-13370612
TagHCOG11344.6e-08372633
ABCC_TAPcd032487.4e-85385606
PstBCOG11177.4e-16385623
YhbGCOG11372.6e-10385625
Ttg2ACOG11274.6e-13387636
CcmACOG11313.2e-38388715
ABCG_EPDRcd032133.5e-14389610
ABCG_PDR_domain2cd032323e-08389610
ABCG_PDR_domain1cd032334.9e-08389610
ABCG_Whitecd032341.6e-11389610
ABCC_NFT1cd033697.9e-19389612
sufCCOG03961.3e-12389630
UupCOG04881e-06389829
TauBCOG11162.3e-14389638
DppFCOG11245.1e-22389625
ZnuCCOG11215e-12389640
MglACOG11294.7e-08389764
CbiOCOG11221.9e-39389637
ABCC_MRP_domain2cd032442.9e-61390612
ABCC_bacteriocin_expcd032452.3e-68390610
ABCC_Glucan_exportercd032549e-117390620
ABCC_CFTR2cd032891e-12390660
CysACOG11181.3e-13390714
FepCCOG11202.8e-17390641
GlnQCOG11262.6e-20390627
ABC_RNaseL_inhibitorcd032360.00018391624
ABC_MetN_methionine_cd032581.4e-20391620
ABC_NikE_OppD_transpcd032573.2e-32391610
ABC_CysA_sulfate_impcd032961.3e-15391633
LivFCOG04108.5e-14391628
DppDCOG04443.4e-12391669
OpuBACOG11252.5e-13391739
AbcCCOG11352.4e-16391675
SalXCOG11364.2e-32391613
ABC_Carb_Monos_Icd032166.8e-20392609
ABC_FeS_Assemblycd032172e-10392622
ABC_YhbGcd032183.3e-09392620
ABC_Mj1267_LivG_brancd032195.1e-15392621
ABCF_EF-3cd032211.4e-08392605
ABCD_peroxisomal_ALDcd032234.8e-11392606
ABC_TM1139_LivF_brancd032242.9e-16392618
ABC_Class3cd032291.5e-44392605
ABC_DR_subfamily_Acd032301.1e-38392606
ABCC_MRP_Likecd032286.3e-123392605
ABCC_Protease_Secretcd032463.4e-61392606
ABCC_cytochrome_bdcd032479.7e-56392610
ABCC_MsbAcd032511.3e-127392626
ABCC_MRP_domain1cd032508.3e-19392605
ABCC_ATM1_transportecd032532.2e-113392629
ABC_MJ0796_LolCDE_Ftcd032551.9e-27392606
ABC_PhnC_transportercd032568.6e-17392622
ABC_Carb_Solutes_likcd032591.6e-26392610
ABC_Org_Solvent_Resicd032611.4e-17392621
ABC_drug_resistance_cd032642.1e-11392610
ABC_subfamily_Acd032631.7e-13392616
ABC_HisP_GlnQcd032621e-20392606
ABCC_Hemolysincd032528.3e-103392629
ABC_NatA_sodium_expocd032663.2e-11392610
ABC_NatA_likecd032679.3e-08392603
ABC_BcrA_bacitracin_cd032689.8e-11392610
ABC_PstB_phosphate_tcd032601.4e-38392615
ABC_MTABC3_MDL1_MDL2cd032491.3e-177392629
ABCC_SUR1_Ncd032902e-15392605
ABC_FtsE_transportercd032921.5e-17392597
ABC_NrtD_SsuB_transpcd032932.4e-20392605
ABC_Pro_Gly_Betainecd032944.7e-17392626
ABC_OpuCA_Osmoproteccd032951.9e-15392621
ABC_ThiQ_thiamine_trcd032983.9e-10392610
ABC_ModC_likecd032998.9e-14392626
ABC_MalK_Ncd033012.6e-13392610
ABC_ATPasecd002671.9e-65393605
ABC_Iron-Siderophorecd032143.9e-20393610
ABC_cobalt_CbiO_domacd032255.9e-45393605
ABC_cobalt_CbiO_domacd032266.6e-15393607
ABC_Metallic_Cationscd032354.8e-13393609
ABC_RNaseL_inhibitorcd032370.00018401620
ABC_UvrA_IIcd032711e-05405612
ABC_DrrAcd032651.2e-12406616
ABC_ModC_molybdenum_cd032977.2e-12408610
MdlBCOG11322.3e-1716941277
ABCC_SUR2cd032882.7e-279641277
ABCC_CFTR1cd032919.7e-079951280
ModFCOG11191.1e-129971257
ABCC_TAPcd032482e-10010261251
CcmACOG11318.5e-2110271280
PstBCOG11171.7e-1310281276
Ttg2ACOG11271.1e-1210281280
ABC_putative_ATPasecd032693.4e-1010311255
ABCG_EPDRcd032137.7e-1310321255
ABCG_Whitecd032341.8e-0910321255
TauBCOG11168.7e-1310321277
DppFCOG11245.7e-1710321270
CbiOCOG11225.7e-3710321269
ABCC_MRP_domain2cd032445.3e-5810331257
ABCC_bacteriocin_expcd032455.3e-6310331255
ABCC_Glucan_exportercd032548.2e-11610331265
ABCC_CFTR2cd032891.3e-0710331280
FepCCOG11201.9e-1310331276
GlnQCOG11263.9e-1610331272
ABC_MetN_methionine_cd032581e-1810341265
ABC_NikE_OppD_transpcd032572.1e-2510341255
ABC_CysA_sulfate_impcd032966.1e-2110341275
PhnKCOG11011.4e-0910341262
SalXCOG11365.6e-2710341257
ABCF_EF-3cd032219.2e-0910351250
ABC_RNaseL_inhibitorcd032220.0001110351269
ABCD_peroxisomal_ALDcd032232.4e-1110351251
ABC_KpsT_Wztcd032203.2e-1110351255
ABC_Class3cd032296.9e-4110351250
ABC_DR_subfamily_Acd032301.1e-2810351251
ABCC_MRP_Likecd032281.6e-11310351250
ABCC_cytochrome_bdcd032477.3e-5810351255
ABCC_MsbAcd032514.9e-12110351271
ABCC_MRP_domain1cd032503.1e-1810351250
ABCC_ATM1_transportecd032539.9e-10810351274
ABC_MJ0796_LolCDE_Ftcd032552.7e-1610351251
ABC_Carb_Solutes_likcd032591.5e-2410351255
ABC_Org_Solvent_Resicd032616.2e-1610351266
ABC_subfamily_Acd032631.2e-1210351261
ABC_HisP_GlnQcd032621.3e-1710351251
ABCC_Hemolysincd032522e-9510351274
ABC_PstB_phosphate_tcd032601.8e-3510351260
ABC_MTABC3_MDL1_MDL2cd032495e-17810351274
ABCC_SUR1_Ncd032903.3e-1410351250
ABC_FtsE_transportercd032921e-1510351251
ABC_NrtD_SsuB_transpcd032934.4e-2010351259
ABC_OpuCA_Osmoproteccd032951.2e-1410351279
ABC_ThiQ_thiamine_trcd032985.8e-1110351255
ABC_PotA_Ncd033007.1e-1610351260
ABC_MalK_Ncd033017.8e-1310351255
ABC_ATPasecd002671.7e-5910361250
ABC_Iron-Siderophorecd032144.5e-1410361255
ABC_cobalt_CbiO_domacd032256.4e-3810361250
ABC_cobalt_CbiO_domacd032263.6e-1710361252
ABC_Metallic_Cationscd032358.1e-1310361255
ABCC_NFT1cd033692.3e-2310361257
ABC_Carb_Monos_IIcd032153.7e-1210381251
ABC_CcmA_heme_exportcd032313.5e-0810391252
ABCC_Protease_Secretcd032465.4e-6410401251
ABC_UvrAcd032382.9e-0510451255
ABC_ModC_likecd032994e-1410471266
ABC_Carb_Monos_Icd032161.3e-1710481254
LivGCOG04118.7e-1310481256
ABC_ModC_molybdenum_cd032971.3e-1210491255
SunTCOG22742.1e-7712630
COG4178COG41780.0002118619
ABC_membranepfam006641.8e-9351348
CydDCOG49882.6e-3463634
CydCCOG49877.1e-13105629
ATM1COG52651.9e-74147628
COG4172COG41723.4e-08206635
COG4586COG45863.9e-07366708
PhnKCOG41073.5e-05386633
HisPCOG45981.5e-17386631
PotACOG38421.8e-14387702
COG4181COG41811.7e-12387610
COG3845COG38451.8e-05388798
ProVCOG41757.3e-09388692
PhnLCOG47787.3e-09388600
COG3638COG36385.8e-15389644
MalKCOG38396.1e-15389703
CcmACOG41339.3e-08390606
COG4152COG41527.3e-06390678
FtsECOG28843.9e-14391614
ThiQCOG38407.1e-11391629
ArtPCOG41612.4e-19391629
AppFCOG46081.1e-15391657
NatACOG45556.2e-15392635
CeuDCOG46042e-07392624
COG4619COG46195.4e-16392620
ModCCOG41482.2e-06406699
ABC_tranpfam000051.7e-39434559
SunTCOG22742.8e-646331275
ArpDCOG46182.5e-176761278
PvdECOG46153.7e-097011265
CydCCOG49879.3e-137011274
CydDCOG49884.1e-307101280
ABC_membranepfam006645.8e-85715991
ATM1COG52654.1e-727721273
SapFCOG41675.2e-0810271280
TauBCOG45256.2e-1210271279
HisPCOG45981.1e-1310291274
PhnKCOG41071.3e-0510311279
COG4136COG41368.2e-0810331260
FtsECOG28841.7e-1310341259
ThiQCOG38403.1e-1210341274
ArtPCOG41611.2e-1310341274
NatACOG45557.1e-1510351279
COG4619COG46193e-1510351262
COG4674COG46742.4e-0610461259
BtuDCOG41381.1e-0510491280
COG4559COG45595.7e-0710521280
ABC_tranpfam000052.3e-3610771204
AAAsmart003821.1e-39419611
AAAsmart003822.9e-3410621250

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_055424Polymorphismp.ALA80GLUN/A
Swiss-ProtVAR_055426Polymorphismp.ALA599THRN/A
Swiss-ProtVAR_015004Polymorphismp.ALA999THRN/A
Swiss-ProtVAR_022278Polymorphismp.ARG593CYSN/A
Swiss-ProtVAR_055427Polymorphismp.ARG669CYSN/A
dbSNPrs9282564 Polymorphismp.ASN21ASPN/A
Swiss-ProtVAR_055423Polymorphismp.ASN44SERN/A
Swiss-ProtVAR_015005Polymorphismp.GLN1107PRON/A
Swiss-ProtVAR_018351Polymorphismp.GLU108LYSN/A
Swiss-ProtVAR_022277Polymorphismp.GLU566LYSN/A
Swiss-ProtVAR_015002Polymorphismp.GLY185VALN/A
Swiss-ProtVAR_055425Polymorphismp.ILE261VALN/A
Swiss-ProtVAR_055429Polymorphismp.ILE829VALN/A
Swiss-ProtVAR_022279Polymorphismp.ILE836VALN/A
Swiss-ProtVAR_035737Polymorphismp.LYS887ASNN/A
Swiss-ProtVAR_018352Polymorphismp.MET986VALN/A
Swiss-ProtVAR_015001Polymorphismp.PHE103LEUN/A
Swiss-ProtVAR_022276Polymorphismp.PHE17LEUN/A
Swiss-ProtVAR_022280Polymorphismp.PRO1051ALAN/A
dbSNPrs2032582 Polymorphismp.SER893ALAN/A
Swiss-ProtVAR_015003Polymorphismp.SER400ASNN/A
dbSNPrs2229109 Polymorphismp.SER400ILEN/A
dbSNPrs2229107 Polymorphismp.SER1141THRN/A
Swiss-ProtVAR_013362Polymorphismp.SER893THRN/A
Swiss-ProtVAR_018353Polymorphismp.VAL1251ILEN/A
Swiss-ProtVAR_055428Polymorphismp.VAL801METN/A
OMIM171050.0001 Diseasep.GLY185VALCOLCHICINE RESISTANCE



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