Results for the protein: P49327

Results for the Protein: P49327

269849686

2194

FASN

NCBI, UniProt

FAS_HUMAN RecName: Full=Fatty acid synthase; Includes: RecName: Full=[Acyl-carrier-protein] S-acetyltransferase; Includes: RecName: Full=[Acyl-carrier-protein] S-malonyltransferase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase; Includes: RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Includes: RecName: Full=Enoyl-[acyl-carrier-protein] reductase; Includes: RecName: Full=Oleoyl-[acyl-carrier-protein] hydrolase

			0 4 0 1 3

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Swiss-Prot Protein: P49327

Identical to: NP_004095

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PKS	cd00833	7.4e-188	2	404
KAS_I_II	cd00834	2.7e-23	2	404
elong_cond_enzymes	cd00828	7.2e-38	2	404
decarbox_cond_enzyme	cd00825	9.6e-36	3	404
cond_enzymes	cd00327	2.3e-32	7	404
CLF	cd00832	3.9e-06	26	404
FabD	COG0331	3.6e-06	489	799
Tdh	COG1063	0.00028	1502	1856
MDR_yhdh_yhfp	cd05280	0.00084	1514	1856
AdhP	COG1064	1.5e-07	1526	1858
p53_inducible_oxidor	cd05276	2.4e-19	1529	1854
QOR1	cd08241	4.7e-19	1529	1855
RTN4I1	cd08248	2.9e-07	1529	1855
Zn_ADH4	cd08258	0.00085	1529	1817
enoyl_reductase_like	cd08249	3.6e-09	1529	1856
Qor	COG0604	2.9e-36	1529	1856
QOR2	cd05286	5.7e-12	1530	1856
MDR_like_2	cd05289	4.3e-11	1530	1854
MDR9	cd08274	2.4e-08	1530	1856
MDR8	cd08273	1.3e-10	1530	1855
zeta_crystallin	cd08253	1.2e-13	1531	1856
MDR3	cd08275	7.1e-18	1532	1856
ETR	cd08290	7.2e-06	1533	1856
Zn_ADH_like1	cd08266	3.8e-15	1535	1856
MDR1	cd08267	5.6e-13	1536	1854
crotonyl_coA_red	cd08246	9.6e-05	1539	1856
PGDH	cd05288	2.7e-09	1542	1854
Mgc45594_like	cd08250	1.9e-06	1542	1855
Zn_ADH5	cd08259	2.3e-09	1543	1855
MDR7	cd08276	5.3e-13	1543	1856
MDR2	cd08268	3.7e-15	1544	1856
MDR4	cd08270	3.3e-05	1544	1856
MDR5	cd08271	1.9e-09	1546	1856
iditol_2_DH_like	cd08235	0.00012	1547	1855
AST1_like	cd08247	6.5e-06	1548	1856
sorbitol_DH	cd05285	1.8e-05	1549	1856
MDR6	cd08272	5e-16	1549	1856
MDR_enoyl_red	cd08244	0.00038	1550	1856
ETR_like	cd05282	2.2e-09	1551	1855
polyketide_synthase	cd08251	1.4e-15	1553	1854
THR_DH_like	cd08239	0.00044	1559	1856
enoyl_red	cd05195	2e-127	1560	1854
MDR	cd05188	2e-42	1561	1814
FDH_like	cd05278	6.9e-06	1565	1856
quinone_oxidoreducta	cd08243	5.8e-06	1577	1855
Zn_ADH6	cd08260	1.1e-06	1577	1856
AL_MDR	cd08252	0.00017	1588	1855
Zn_ADH7	cd08261	0.00051	1589	1856
FabG	COG1028	0.00028	1880	2140
COG3321	COG3321	1.4e-152	1	1212
ketoacyl-synt	pfam00109	1.2e-94	1	239
Ketoacyl-synt_C	pfam02801	3e-52	243	360
Acyl_transf_1	pfam00698	1.7e-166	493	810
COG2130	COG2130	4.8e-07	1538	1858
ADH_zinc_N	pfam00107	1.1e-20	1679	1816
adh_short	pfam00106	4.5e-64	1885	2053
PP-binding	pfam00550	1.2e-11	2125	2194
COG3319	COG3319	1.2e-13	2242	2509
Thioesterase	pfam00975	3.8e-80	2242	2501
PKS_KS	smart00825	1.2e-178	4	414
PKS_AT	smart00827	1e-60	494	902
PKS_DH	smart00826	3e-05	838	1008
Methyltransf_11	pfam08241	0.0001	1243	1344
Methyltransf_12	pfam08242	6.8e-12	1243	1342
PKS_ER	smart00829	1.7e-140	1563	1854
PKS_KR	smart00822	1e-58	1885	2065
KR	pfam08659	3.2e-56	1886	2066
PKS_PP	smart00823	8e-15	2074	2182

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_055480	Polymorphism	p.ARG1694HIS	N/A
Swiss-Prot	VAR_055481	Polymorphism	p.ILE1888VAL	N/A
dbSNP	rs2228306	Polymorphism	p.VAL2005ALA	N/A
Swiss-Prot	VAR_055479	Polymorphism	p.VAL1483ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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