Results for the protein: Q9UQB9

Results for the Protein: Q9UQB9

27805738

6795

AURKC

NCBI, UniProt

AURKC_HUMAN RecName: Full=Aurora kinase C; AltName: Full=Aurora 3; AltName: Full=Aurora/IPL1-related kinase 3; Short=ARK-3; Short=Aurora-related kinase 3; AltName: Full=Aurora/IPL1/Eg2 protein 2; AltName: Full=Serine/threonine-protein kinase 13; AltName: Full=Serine/threonine-protein kinase aurora-C

Known Diseases associated with this Protein:
SPERMATOGENIC FAILURE 5

1

3

1

0

3

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: Q9UQB9

Identical to: NP_001015878

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	4.9e-09	5	309
STKc_ROCK1	cd05622	4.9e-08	6	309
STKc_PAK5	cd06658	2.4e-08	14	309
STKc_PAK1	cd06654	1.4e-08	16	309
STKc_PAK4	cd06657	7e-09	16	308
STKc_PAK6	cd06659	1e-14	16	309
STKc_TAO3	cd06633	7.5e-06	17	309
STKc_PAK_I	cd06647	4.7e-15	17	309
STKc_PAK_II	cd06648	7.5e-15	17	305
STKc_PAK3	cd06656	5.5e-09	17	309
STKc_myosinIIIA	cd06638	8.4e-10	20	293
STKc_TAO1	cd06635	5e-07	22	306
PTKc_FGFR1	cd05098	2.9e-05	23	307
STKc_JNK2	cd07876	0.00076	23	308
PTKc_FGFR2	cd05101	6.2e-06	26	307
STKc_MAP4K4_6	cd06636	3.7e-07	26	293
STKc_PAK	cd06614	1.8e-20	27	305
STKc_myosinIIIB	cd06639	4.4e-10	27	294
STKc_JNK	cd07850	1.7e-05	27	307
STKc_CDK9	cd07865	1.8e-11	28	293
STKc_p38gamma_MAPK12	cd07880	6.2e-05	28	309
PTKc_FGFR4	cd05099	1.4e-05	30	309
STKc_PAK2	cd06655	8.5e-09	31	309
STKc_TAO	cd06607	4.6e-08	32	309
PKc_MKK7	cd06618	3.7e-11	32	309
STKc_TAO2	cd06634	1.4e-07	32	307
STKc_STK10_LOK	cd06644	1.3e-16	32	309
STKc_MAP4K5	cd06646	1.5e-08	33	292
STKc_CDK10	cd07845	4.1e-13	33	303
STKc_p38alpha_MAPK14	cd07877	5.2e-05	33	303
PTK_CCK4	cd05046	9.2e-07	34	290
PTKc_EGFR_like	cd05057	1.7e-06	35	296
PTKc_Tie2	cd05088	1.7e-08	35	309
PTKc_EGFR	cd05108	0.00041	35	309
PTKc_HER2	cd05109	0.00041	35	303
PTK_HER3	cd05111	0.00021	35	295
STKc_MAP4K3	cd06645	2e-09	35	292
STKc_p38	cd07851	9.4e-09	35	309
STKc_p38beta_MAPK11	cd07878	0.00076	35	309
PTKc_ALK_LTK	cd05036	4.9e-11	36	293
PTKc_FAK	cd05056	2.2e-10	36	300
STKc_ASK	cd06624	7.2e-17	36	293
STKc_TNIK	cd06637	5.1e-09	36	293
PTKc_Ror	cd05048	1.6e-06	37	292
PTKc_Trk	cd05049	4.2e-10	37	290
PTKc_Abl	cd05052	1.3e-08	37	295
PTKc_InsR	cd05061	3.2e-05	37	298
PTKc_IGF-1R	cd05062	1.4e-05	37	290
PTKc_EphR_A10	cd05064	6.9e-05	37	300
PTKc_Lck_Blk	cd05067	1.2e-05	37	304
PTKc_Frk_like	cd05068	2.1e-08	37	295
PTKc_Fyn_Yrk	cd05070	7.2e-05	37	291
PTKc_Lyn	cd05072	5.6e-07	37	291
PTKc_Hck	cd05073	5e-07	37	291
PTKc_Csk	cd05082	9.9e-05	37	295
PTKc_Ror1	cd05090	2.2e-05	37	296
PTKc_Ror2	cd05091	0.0001	37	292
PTKc_TrkA	cd05092	1.7e-07	37	299
PTKc_TrkB	cd05093	1.3e-06	37	306
PTKc_TrkC	cd05094	5.9e-05	37	303
PKc_MEK2	cd06649	5.8e-06	37	307
PKc_MEK1	cd06650	3.3e-06	37	308
STKc_TEY_MAPK_plant	cd07858	8e-06	37	309
STKc_CDK12	cd07864	6.4e-15	37	293
PTKc_InsR_like	cd05032	1.5e-08	38	290
PTK_Ryk	cd05043	0.00047	38	251
PTKc_Csk_like	cd05039	9.9e-06	38	261
PTKc_FGFR	cd05053	3.8e-08	38	295
PTKc_EphR_B	cd05065	2.8e-05	38	295
PTKc_EphR_A	cd05066	1.2e-05	38	295
PTKc_EphR	cd05033	4.2e-07	38	297
PTKc_Chk	cd05083	0.00044	38	291
PTKc_Itk	cd05112	1.3e-08	38	292
PTKc_Btk_Bmx	cd05113	1.9e-09	38	292
PTKc_Tec_Rlk	cd05114	1.9e-08	38	292
PKc_MKK4	cd06616	3.7e-08	38	308
PKc_MAPKK_Byr1_like	cd06620	2.2e-11	38	305
STKc_SLK	cd06643	1.3e-14	38	307
STKc_ERK5	cd07855	3.2e-08	38	308
PTKc_EphR_A2	cd05063	5.9e-05	39	292
STKc_MAP4K3_like	cd06613	1.6e-17	39	292
STKc_CDC2L1	cd07843	1.7e-12	39	293
STKc_PCTAIRE_like	cd07844	4.8e-21	39	293
STKc_Sty1_Hog1	cd07856	6.2e-08	39	305
STKc_BUR1	cd07866	5.1e-12	39	293
STKc_PFTAIRE1	cd07869	5.1e-07	39	305
STKc_PFTAIRE2	cd07870	3.3e-09	39	293
STKc_PCTAIRE3	cd07871	1.5e-10	39	293
STKc_PCTAIRE2	cd07872	5e-09	39	309
STKc_PCTAIRE1	cd07873	4.6e-09	39	303
PTKc_Tec_like	cd05059	1.3e-09	40	274
PTKc_Tie1	cd05089	4.1e-08	40	309
STKc_myosinIII_like	cd06608	4.4e-15	40	293
STKc_MAPK15	cd07852	9.2e-11	40	307
STKc_Nek6_Nek7	cd08224	1.1e-14	40	297
STKc_Nek6	cd08228	6.1e-09	40	293
STKc_Nek7	cd08229	1.3e-10	40	297
PTKc_Src_like	cd05034	3.2e-09	41	287
PTKc_Musk	cd05050	5.4e-09	41	290
PTKc_Srm_Brk	cd05148	5.1e-10	41	295
STKc_ROCK_NDR_like	cd05573	1.9e-19	41	309
STKc_phototropin_lik	cd05574	6.7e-18	41	300
STKc_PKA	cd05580	1.3e-40	41	307
STKc_PDK1	cd05581	2.1e-61	41	293
STKc_DMPK_like	cd05597	9e-10	41	309
STKc_NDR_like	cd05599	6.9e-14	41	301
STKc_Sid2p_Dbf2p	cd05600	3.9e-12	41	309
STKc_CRIK	cd05601	1.3e-13	41	309
STKc_LATS	cd05598	7.2e-09	41	309
STKc_MAST	cd05609	1.4e-16	41	309
STKc_PRKX_like	cd05612	3.7e-39	41	309
STKc_MRCK_alpha	cd05623	9.7e-10	41	309
STKc_MRCK_beta	cd05624	1.7e-09	41	309
STKc_LATS2	cd05626	9.1e-05	41	309
STKc_NDR2	cd05627	3e-08	41	309
STKc_NDR1	cd05628	2.4e-10	41	309
STKc_NDR_like_fungal	cd05629	2.8e-07	41	309
PKc_MAPKK	cd06605	3.6e-15	41	298
STKc_MST3_like	cd06609	4.6e-19	41	308
STKc_OSR1_SPAK	cd06610	1.5e-16	41	293
STKc_SLK_like	cd06611	3.5e-14	41	307
STKc_MST1_2	cd06612	1.4e-15	41	293
PKc_MKK3_6	cd06617	1e-12	41	309
PKc_MEK	cd06615	4.4e-12	41	307
PKc_MKK5	cd06619	1.1e-06	41	305
PKc_MAPKK_Pek1_like	cd06621	4.2e-13	41	301
PKc_MAPKK_PBS2_like	cd06622	1.8e-09	41	304
PKc_MAPKK_plant_like	cd06623	8.3e-31	41	298
STKc_MEKK3_like	cd06625	1.2e-14	41	293
STKc_MST4	cd06640	1.1e-09	41	308
STKc_MST3	cd06641	3.3e-09	41	308
STKc_STK25-YSK1	cd06642	2.6e-10	41	309
STKc_MEKK2	cd06652	1.1e-07	41	294
STKc_MEKK3_like_1	cd06653	1.4e-09	41	293
STKc_CdkB_plant	cd07837	1.6e-12	41	294
STKc_CDKL1_4	cd07847	1.8e-20	41	293
STKc_CDKL5	cd07848	1.4e-07	41	293
STKc_ERK1_2_like	cd07849	6.7e-08	41	308
STKc_CDKL	cd07833	4.9e-14	41	293
STKc_CDK6	cd07862	3e-06	41	293
STKc_CDKL2_3	cd07846	1.2e-10	41	293
SPS1	COG0515	4.6e-47	41	308
PTKc_RET	cd05045	0.00012	42	295
PTKc_DDR	cd05051	0.00026	42	295
PKc_STE	cd05122	6.7e-50	42	292
STKc_Yank1	cd05578	1.4e-32	42	293
STKc_MSK_N	cd05583	1.7e-38	42	306
STKc_cPKC	cd05587	2.1e-19	42	309
STKc_GRK4_like	cd05605	4.3e-12	42	308
STKc_MSK1_N	cd05613	5.3e-27	42	306
STKc_MSK2_N	cd05614	2.5e-15	42	309
STKc_cPKC_alpha	cd05615	8.7e-12	42	309
STKc_cPKC_beta	cd05616	4.8e-10	42	309
STKc_GRK6	cd05630	6.9e-08	42	308
STKc_GRK4	cd05631	7e-09	42	308
STKc_GRK5	cd05632	4e-08	42	308
STKc_MAPKKK	cd06606	4.7e-38	42	293
STKc_Cdc7_like	cd06627	8.2e-22	42	293
STKc_MAPKKK_Byr2_lik	cd06628	3.7e-26	42	293
STKc_MEKK1	cd06630	3.3e-12	42	294
STKc_YSK4	cd06631	1.2e-10	42	293
STKc_MEKK3	cd06651	1.4e-10	42	295
STKc_CCRK	cd07832	6.6e-19	42	294
STKc_MAPK	cd07834	7.5e-12	42	309
STKc_Pho85	cd07836	6.6e-22	42	293
STKc_CDK5	cd07839	5e-12	42	293
STKc_CDK7	cd07841	4.4e-16	42	308
STKc_CDK8_like	cd07842	1.7e-10	42	293
STKc_NLK	cd07853	0.00023	42	309
STKc_MPK1	cd07857	5.3e-08	42	305
STKc_TDY_MAPK_plant	cd07859	6.2e-05	42	309
STKc_CDK2_3	cd07860	3.5e-18	42	293
STKc_CDK1_euk	cd07861	2.9e-20	42	293
STKc_CDK4	cd07863	2.8e-09	42	293
STKc_Nek	cd08215	1.9e-31	42	293
STKc_Nek2	cd08217	9.7e-18	42	293
STKc_Nek1	cd08218	6.6e-27	42	293
STKc_Nek3	cd08219	9e-20	42	293
STKc_Nek8	cd08220	1.2e-17	42	293
STKc_Nek9	cd08221	3.2e-13	42	293
STKc_Nek11	cd08222	6.9e-12	42	293
STKc_Nek4	cd08223	4.1e-13	42	293
STKc_Nek5	cd08225	5e-27	42	293
STKc_Nek10	cd08528	1.2e-10	42	290
STKc_FA2-like	cd08529	1.3e-15	42	293
STKc_CNK2-like	cd08530	1.4e-14	42	293
PTKc_Axl_like	cd05035	1.2e-06	43	288
PTKc_Jak_rpt2	cd05038	9.6e-10	43	292
PTKc_Yes	cd05069	7.5e-05	43	296
PTKc_Src	cd05071	0.00064	43	297
PTKc_Axl	cd05075	0.00026	43	296
PTKc_Jak1_rpt2	cd05079	9.6e-05	43	308
PTKc_Tyro3	cd05074	2.9e-06	43	296
PTKc_Tyk2_rpt2	cd05080	3.4e-05	43	309
PTKc_Jak2_Jak3_rpt2	cd05081	1.6e-07	43	309
STKc_CMGC	cd05118	6.1e-18	43	293
STKc_PKN	cd05589	1.4e-19	43	309
STKc_LATS1	cd05625	6.4e-05	43	301
STKc_MAPKKK_Bck1_lik	cd06629	1.6e-12	43	293
STKc_CDK_like	cd07829	4.3e-21	43	293
STKc_MAK_like	cd07830	1.8e-14	43	293
STKc_CDK1_like	cd07835	5e-18	43	293
STKc_CDK4_6_like	cd07838	1.4e-12	43	293
STKc_CDK9_like	cd07840	1.9e-17	43	293
STKc_MAPK4_6	cd07854	1.2e-05	43	308
STKc_CDC2L6	cd07867	1.4e-07	43	293
STKc_CDK8	cd07868	4.2e-07	43	293
PTKc_Aatyk	cd05042	5.8e-05	44	276
PK_STRAD	cd08216	2.6e-05	44	307
STKc_p70S6K	cd05584	3.6e-19	46	309
STKc_MEKK4	cd06626	6.8e-14	46	293
STKc_MEKK1_plant	cd06632	5.5e-16	46	293
PTKc	cd00192	1.2e-13	47	292
PTK_Jak_rpt1	cd05037	2.6e-05	47	292
PTKc_Ack_like	cd05040	6.2e-11	47	293
PTKc_c-ros	cd05044	9.3e-07	47	290
PTKc_Fes_like	cd05041	7.1e-12	47	295
PTKc_Met_Ron	cd05058	0.00012	47	297
PTKc_Syk_like	cd05060	3e-07	47	293
PTK_Jak2_Jak3_rpt1	cd05078	0.00021	47	292
PTKc_Fes	cd05084	2.8e-08	47	293
PTKc_Aatyk2	cd05086	0.00024	47	294
PTKc_Syk	cd05116	7.8e-08	47	293
STKc_PKC	cd05570	7.3e-20	47	308
STKc_PKB	cd05571	7.7e-21	47	309
STKc_SGK	cd05575	3.6e-16	47	309
STKc_RSK_N	cd05582	1.1e-17	47	309
STKc_aPKC	cd05588	2.2e-10	47	309
STKc_nPKC_eta	cd05590	5e-24	47	308
STKc_nPKC_epsilon	cd05591	2.8e-20	47	309
STKc_nPKC_theta_delt	cd05592	6.1e-18	47	308
STKc_PKB_gamma	cd05593	9.7e-12	47	309
STKc_PKB_alpha	cd05594	4.5e-13	47	308
STKc_PKB_beta	cd05595	2e-13	47	309
STKc_SGK1	cd05602	3.3e-10	47	309
STKc_SGK2	cd05603	2.8e-16	47	309
STKc_SGK3	cd05604	3.4e-10	47	309
STKc_aPKC_zeta	cd05617	3.1e-10	47	309
STKc_aPKC_iota	cd05618	3.6e-09	47	309
STKc_nPKC_theta	cd05619	1.9e-12	47	309
STKc_nPKC_delta	cd05620	1.1e-06	47	308
STKc_MOK	cd07831	2e-12	47	293
STKc_Rim15_like	cd05611	1.9e-11	48	292
PKc	cd00180	6.9e-82	49	291
PTKc_Tie	cd05047	6.5e-08	49	302
PTKc_Fer	cd05085	3.8e-08	49	293
PTKc_Zap-70	cd05115	6.5e-08	49	296
STKc_AGC	cd05123	2.5e-64	49	293
STKc_cGK_PKG	cd05572	1.1e-45	49	300
STKc_GRK	cd05577	5.8e-12	49	307
STKc_MAST_like	cd05579	1.2e-22	49	292
STKc_YPK1_like	cd05585	7.5e-27	49	309
STKc_Sck1_like	cd05586	4.4e-09	49	309
STKc_beta_ARK	cd05606	3.2e-10	49	307
STKc_GRK7	cd05607	7.2e-09	49	307
STKc_GRK1	cd05608	2e-12	49	307
STKc_GRK3	cd05633	3.2e-08	49	308
STKc_NAK1_like	cd06917	2.4e-16	49	301
Pkinase	pfam00069	1.6e-82	43	293
Pkinase_Tyr	pfam07714	7.2e-19	43	288
TyrKc	smart00219	4.7e-17	43	291
STYKc	smart00221	5.3e-88	43	293
S_TKc	smart00220	1.3e-94	53	293
KIND	smart00750	1.2e-06	130	301

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040386	Polymorphism	p.GLU148GLN	N/A
Swiss-Prot	VAR_040385	Polymorphism	p.GLY52GLU	N/A
Swiss-Prot	VAR_040387	Polymorphism	p.HIS244GLN	N/A
OMIM	603495.0002	Disease	p.CYS229TYR	SPERMATOGENIC FAILURE 5

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258