Results for the protein: P24723

Results for the Protein: P24723

281185512

5583

PRKCH

NCBI, UniProt

KPCL_HUMAN RecName: Full=Protein kinase C eta type; AltName: Full=PKC-L; AltName: Full=nPKC-eta

Known Diseases associated with this Protein:
CEREBRAL INFARCTION, SUSCEPTIBILITY TO

1

10

1

2

8

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: P24723

Identical to: NP_006246

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
C2C_Tricalbin-like	cd04045	0.00069	10	130
C2	cd00030	4.6e-17	12	124
C1	cd00029	3.3e-15	172	222
C1	cd00029	1.9e-19	246	295
STKc_ROCK2	cd05621	7.9e-39	313	678
STKc_ROCK	cd05596	3.1e-52	314	678
STKc_ROCK1	cd05622	5.2e-44	314	679
STKc_JNK1	cd07875	0.00097	323	680
STKc_TAO1	cd06635	2.9e-05	325	641
STKc_TAO3	cd06633	0.00015	329	657
STKc_PAK5	cd06658	5.4e-09	330	625
STKc_PAK4	cd06657	1.5e-12	332	636
STKc_PAK6	cd06659	9e-11	332	638
STKc_PAK	cd06614	2.4e-17	333	623
STKc_PAK_II	cd06648	1.4e-12	333	631
STKc_JNK2	cd07876	5e-05	335	656
STKc_myosinIIIA	cd06638	4.5e-09	336	614
STKc_PAK1	cd06654	9.6e-10	336	644
STKc_MAP4K4_6	cd06636	1e-06	337	614
STKc_PAK_I	cd06647	1.9e-11	337	636
STKc_PAK2	cd06655	1e-09	337	639
STKc_PAK3	cd06656	2.5e-10	337	638
STKc_p38alpha_MAPK14	cd07877	0.00013	337	657
STKc_JNK	cd07850	1.9e-05	338	677
STKc_p38	cd07851	2e-08	340	646
STKc_myosinIIIB	cd06639	7e-10	341	615
PTKc_FGFR	cd05053	0.00015	342	609
PTKc_FGFR4	cd05099	4e-05	342	630
PKc_MKK7	cd06618	3.3e-10	342	637
STKc_CDK9	cd07865	3.5e-08	342	614
PTKc_FGFR1	cd05098	0.00086	343	605
STKc_TAO2	cd06634	8.7e-06	343	656
STKc_p38beta_MAPK11	cd07878	0.00028	343	676
STKc_p38gamma_MAPK12	cd07880	1.2e-06	343	683
STKc_TAO	cd06607	2.7e-06	345	657
STKc_STK10_LOK	cd06644	5.7e-14	345	635
STKc_MAP4K5	cd06646	5e-09	345	613
STKc_MAP4K3	cd06645	1.8e-11	345	613
STKc_ASK	cd06624	4.5e-16	346	614
STKc_TNIK	cd06637	2.5e-08	346	614
PTKc_EGFR_like	cd05057	2.5e-05	347	600
PTK_HER3	cd05111	0.0003	347	615
STKc_CDK10	cd07845	8.4e-10	347	633
PTKc_ALK_LTK	cd05036	7.4e-08	348	590
PTKc_FAK	cd05056	1.9e-06	348	608
STKc_ERK5	cd07855	6.4e-07	348	652
STKc_CDK12	cd07864	7.9e-10	348	614
PTK_CCK4	cd05046	0.00089	349	603
PTKc_Ror	cd05048	0.00034	349	600
PTKc_Trk	cd05049	9.5e-05	349	611
PTKc_Abl	cd05052	7.4e-07	349	608
PTKc_InsR	cd05061	3.3e-05	349	619
PTKc_EphR_A10	cd05064	4.8e-05	349	613
PTKc_Lck_Blk	cd05067	0.00015	349	619
PTKc_Frk_like	cd05068	5.1e-08	349	607
PTKc_Hck	cd05073	4.7e-05	349	604
PTKc_Src	cd05071	0.00085	349	614
PTKc_Csk	cd05082	2.9e-06	349	607
PTKc_Lyn	cd05072	1.2e-06	349	604
PTKc_Ror1	cd05090	0.0008	349	625
PTKc_TrkA	cd05092	0.00042	349	615
PTKc_TrkB	cd05093	0.00028	349	616
PTKc_DDR_like	cd05097	0.00023	349	623
PTKc_Fyn_Yrk	cd05070	7e-05	349	604
STKc_SLK	cd06643	7.3e-11	349	632
PKc_MEK2	cd06649	3.7e-06	349	680
PKc_MEK1	cd06650	6.5e-05	349	683
PTKc_InsR_like	cd05032	2.7e-07	350	602
PTKc_EphR	cd05033	2.5e-05	350	589
PTKc_Jak_rpt2	cd05038	2.9e-07	350	610
PTKc_Csk_like	cd05039	3.8e-06	350	584
PTKc_EphR_B	cd05065	6.1e-05	350	608
PTKc_EphR_A	cd05066	0.00024	350	608
PTKc_Chk	cd05083	1.7e-05	350	616
PTKc_Tie2	cd05088	1e-06	350	624
PTKc_Itk	cd05112	5.6e-07	350	607
PTKc_Btk_Bmx	cd05113	5.2e-10	350	601
PTKc_Tec_Rlk	cd05114	4e-08	350	605
PKc_MKK4	cd06616	1.2e-07	350	636
PKc_MAPKK_Byr1_like	cd06620	1.5e-07	350	620
STKc_TEY_MAPK_plant	cd07858	3.6e-06	350	683
PTKc_TrkC	cd05094	0.00039	351	657
STKc_MST1_2	cd06612	2.3e-14	351	614
STKc_MAP4K3_like	cd06613	3.1e-15	351	613
STKc_PCTAIRE_like	cd07844	1.8e-08	351	644
STKc_PFTAIRE2	cd07870	1.6e-06	351	648
STKc_PCTAIRE2	cd07872	1.9e-05	351	647
STKc_PCTAIRE1	cd07873	1.9e-05	351	659
PTKc_Tec_like	cd05059	5.4e-08	352	601
PTKc_Tie1	cd05089	2.5e-06	352	623
STKc_SLK_like	cd06611	2.2e-13	352	628
STKc_CDC2L1	cd07843	1.4e-09	352	614
STKc_MAPK15	cd07852	5.2e-09	352	645
STKc_BUR1	cd07866	4.4e-09	352	614
STKc_PFTAIRE1	cd07869	8.8e-05	352	640
STKc_PCTAIRE3	cd07871	1.9e-06	352	648
STKc_Nek6_Nek7	cd08224	3e-09	352	609
STKc_Nek6	cd08228	1e-07	352	609
STKc_Nek7	cd08229	2.4e-09	352	612
PTKc_Src_like	cd05034	2.3e-06	353	600
PTKc_Musk	cd05050	1.5e-05	353	611
PTKc_Srm_Brk	cd05148	6.5e-07	353	584
STKc_ROCK_NDR_like	cd05573	1.7e-75	353	677
STKc_phototropin_lik	cd05574	1.3e-59	353	640
STKc_PKA	cd05580	4.5e-121	353	647
STKc_PDK1	cd05581	3.9e-81	353	614
STKc_DMPK_like	cd05597	6.5e-64	353	677
STKc_LATS	cd05598	1.7e-39	353	675
STKc_NDR_like	cd05599	6.9e-26	353	675
STKc_Sid2p_Dbf2p	cd05600	5.1e-23	353	676
STKc_CRIK	cd05601	7e-55	353	677
STKc_MAST	cd05609	9.5e-70	353	645
STKc_PRKX_like	cd05612	6.6e-86	353	646
STKc_MRCK_alpha	cd05623	3e-50	353	678
STKc_MRCK_beta	cd05624	4.6e-55	353	677
STKc_LATS2	cd05626	1.1e-24	353	675
STKc_NDR2	cd05627	8.3e-34	353	680
STKc_NDR1	cd05628	2.9e-31	353	680
STKc_NDR_like_fungal	cd05629	4.7e-44	353	682
PKc_MAPKK	cd06605	4e-13	353	619
STKc_myosinIII_like	cd06608	2.1e-11	353	614
STKc_MST3_like	cd06609	5.1e-16	353	631
STKc_OSR1_SPAK	cd06610	3e-14	353	614
PKc_MEK	cd06615	1.3e-09	353	681
PKc_MKK3_6	cd06617	4.3e-08	353	633
PKc_MKK5	cd06619	1.3e-05	353	639
PKc_MAPKK_Pek1_like	cd06621	2.7e-10	353	623
PKc_MAPKK_PBS2_like	cd06622	9.1e-09	353	652
PKc_MAPKK_plant_like	cd06623	4.5e-18	353	619
STKc_MEKK3_like	cd06625	3.6e-15	353	614
STKc_MST4	cd06640	1.3e-08	353	636
STKc_MST3	cd06641	2.7e-08	353	620
STKc_STK25-YSK1	cd06642	5.5e-09	353	636
STKc_MEKK3_like_1	cd06653	1.1e-09	353	614
STKc_MEKK2	cd06652	1.5e-07	353	615
STKc_NAK1_like	cd06917	1.4e-12	353	623
STKc_CDKL	cd07833	5.5e-13	353	614
STKc_CdkB_plant	cd07837	6.4e-13	353	615
STKc_CDKL2_3	cd07846	1.9e-10	353	672
STKc_CDKL1_4	cd07847	2.4e-14	353	644
STKc_CDKL5	cd07848	1.7e-06	353	614
STKc_ERK1_2_like	cd07849	2e-05	353	656
STKc_CDK6	cd07862	2.4e-05	353	627
SPS1	COG0515	5.2e-58	353	682
PTKc_RET	cd05045	0.00092	354	592
PKc_STE	cd05122	3.1e-33	354	613
STKc_Yank1	cd05578	1.5e-70	354	614
STKc_MSK_N	cd05583	2.2e-96	354	633
STKc_cPKC	cd05587	6.2e-177	354	678
STKc_GRK4_like	cd05605	2.7e-66	354	635
STKc_MSK1_N	cd05613	2.9e-72	354	633
STKc_MSK2_N	cd05614	7.6e-92	354	679
STKc_cPKC_alpha	cd05615	8.3e-162	354	678
STKc_cPKC_beta	cd05616	4.3e-165	354	678
STKc_GRK6	cd05630	8.4e-53	354	635
STKc_GRK4	cd05631	8.1e-61	354	635
STKc_GRK5	cd05632	2.1e-58	354	635
STKc_MAPKKK	cd06606	1.1e-39	354	614
STKc_Cdc7_like	cd06627	2.3e-17	354	614
STKc_MEKK3	cd06651	2.1e-10	354	616
STKc_CCRK	cd07832	3.8e-13	354	615
STKc_MAPK	cd07834	2.2e-10	354	652
STKc_Pho85	cd07836	8.4e-09	354	644
STKc_CDK5	cd07839	1.1e-07	354	614
STKc_CDK7	cd07841	9.8e-13	354	623
STKc_CDK8_like	cd07842	3.7e-07	354	614
STKc_NLK	cd07853	0.00011	354	674
STKc_MAPK4_6	cd07854	4e-05	354	645
STKc_MPK1	cd07857	5.4e-08	354	652
STKc_TDY_MAPK_plant	cd07859	3.8e-08	354	673
STKc_CDK2_3	cd07860	3.1e-11	354	614
STKc_CDK4	cd07863	8.5e-07	354	614
STKc_CDK1_euk	cd07861	2.1e-13	354	648
STKc_Nek	cd08215	8e-35	354	614
STKc_Nek2	cd08217	2.1e-14	354	614
STKc_Nek1	cd08218	9.1e-24	354	614
STKc_Nek3	cd08219	3.6e-23	354	608
STKc_Nek8	cd08220	1e-10	354	609
STKc_Nek9	cd08221	1.6e-12	354	614
STKc_Nek11	cd08222	9.7e-16	354	614
STKc_Nek4	cd08223	1.9e-17	354	614
STKc_Nek5	cd08225	2.6e-27	354	614
STKc_Nek10	cd08528	1.3e-09	354	608
STKc_FA2-like	cd08529	2.5e-15	354	600
STKc_CNK2-like	cd08530	2.7e-14	354	614
PTKc_Axl_like	cd05035	5.2e-05	355	609
PTKc_Tyro3	cd05074	2.8e-06	355	608
PTKc_Jak1_rpt2	cd05079	0.00033	355	648
PTKc_Tyk2_rpt2	cd05080	1.6e-07	355	643
PTKc_Jak2_Jak3_rpt2	cd05081	5.1e-08	355	626
STKc_CMGC	cd05118	2.6e-15	355	614
STKc_PKN	cd05589	6.1e-165	355	677
STKc_LATS1	cd05625	2.1e-27	355	675
STKc_MAPKKK_Bck1_lik	cd06629	2.3e-14	355	614
STKc_CDK_like	cd07829	9.2e-19	355	614
STKc_MAK_like	cd07830	5.2e-14	355	614
STKc_MOK	cd07831	5.5e-13	355	614
STKc_CDK1_like	cd07835	8.7e-09	355	644
STKc_CDK4_6_like	cd07838	6.6e-12	355	614
STKc_CDK9_like	cd07840	8.3e-13	355	614
STKc_Sty1_Hog1	cd07856	4.3e-06	355	678
PTKc_Yes	cd05069	0.0002	356	604
STKc_MAPKKK_Byr2_lik	cd06628	1.7e-21	356	614
STKc_YSK4	cd06631	1.6e-11	356	614
PK_STRAD	cd08216	0.00011	356	633
STKc_RSK_N	cd05582	3.1e-90	358	677
STKc_p70S6K	cd05584	2.8e-102	358	679
STKc_Rim15_like	cd05611	1.2e-19	358	620
PTKc	cd00192	1.8e-13	359	609
PTKc_Ack_like	cd05040	1.7e-08	359	591
PTKc_Fes_like	cd05041	3.5e-10	359	602
PTK_Ryk	cd05043	0.0001	359	581
PTKc_c-ros	cd05044	0.00019	359	607
PTKc_Tie	cd05047	3.3e-05	359	605
PTKc_Met_Ron	cd05058	1.7e-05	359	610
PTKc_Syk_like	cd05060	3.9e-05	359	594
PTK_Jak2_Jak3_rpt1	cd05078	0.00076	359	598
PTKc_Fes	cd05084	1.4e-07	359	606
PTKc_Fer	cd05085	2.7e-07	359	608
PTKc_Syk	cd05116	5.3e-06	359	614
STKc_PKC	cd05570	1.5e-266	359	677
STKc_PKB	cd05571	1.4e-130	359	679
STKc_SGK	cd05575	1.3e-121	359	677
STKc_aPKC	cd05588	1.6e-143	359	678
STKc_nPKC_eta	cd05590	1.2e-268	359	678
STKc_nPKC_epsilon	cd05591	6.1e-214	359	678
STKc_nPKC_theta_delt	cd05592	4.3e-169	359	679
STKc_PKB_gamma	cd05593	4.5e-111	359	682
STKc_PKB_alpha	cd05594	5.8e-114	359	680
STKc_PKB_beta	cd05595	2.6e-116	359	679
STKc_SGK1	cd05602	1.2e-96	359	679
STKc_SGK3	cd05604	2.2e-107	359	679
STKc_SGK2	cd05603	3e-105	359	678
STKc_aPKC_zeta	cd05617	3.3e-130	359	678
STKc_aPKC_iota	cd05618	1.3e-127	359	678
STKc_nPKC_theta	cd05619	1.4e-160	359	679
STKc_nPKC_delta	cd05620	1.5e-151	359	679
STKc_MEKK4	cd06626	2e-12	359	614
STKc_MEKK1_plant	cd06632	2.8e-14	359	614
STKc_MEKK1	cd06630	1.6e-10	359	615
STKc_beta_ARK	cd05606	1.3e-49	360	634
STKc_GRK3	cd05633	4e-42	360	635
PKc	cd00180	2.6e-74	361	612
PTKc_Aatyk	cd05042	0.0004	361	588
PTKc_Zap-70	cd05115	7.4e-05	361	614
STKc_AGC	cd05123	1.1e-133	361	614
STKc_GRK	cd05577	4e-69	361	634
STKc_YPK1_like	cd05585	5.5e-110	361	676
STKc_Sck1_like	cd05586	9.7e-85	361	676
STKc_MAST_like	cd05579	8.4e-67	361	619
STKc_cGK_PKG	cd05572	4.5e-72	361	621
STKc_GRK7	cd05607	7.5e-61	361	634
STKc_GRK1	cd05608	1.7e-65	361	634
C2	pfam00168	2.3e-16	12	102
C1_1	pfam00130	1e-20	172	225
C1_1	pfam00130	1.2e-22	246	298
Pkinase	pfam00069	2.3e-84	355	614
Pkinase_C	pfam00433	2.1e-17	634	680
C2	smart00239	1.8e-12	11	117
C1	smart00109	1.5e-14	172	222
C1	smart00109	6.4e-18	246	295
Pkinase_Tyr	pfam07714	1.5e-16	355	600
TyrKc	smart00219	5.3e-14	355	600
STYKc	smart00221	4.9e-90	355	614
S_TKc	smart00220	8.1e-103	365	614
S_TK_X	smart00133	9.2e-26	615	678

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_042312	Polymorphism	p.ALA19VAL	N/A
Swiss-Prot	VAR_042314	Polymorphism	p.ARG149GLN	N/A
Swiss-Prot	VAR_042315	Polymorphism	p.ARG359GLN	N/A
Swiss-Prot	VAR_060736	Polymorphism	p.ASP497TYR	N/A
dbSNP	rs35561533	Polymorphism	p.ASP645VAL	N/A
Swiss-Prot	VAR_042313	Polymorphism	p.LYS65ARG	N/A
Swiss-Prot	VAR_042318	Polymorphism	p.PRO612SER	N/A
Swiss-Prot	VAR_042316	Polymorphism	p.THR575ALA	N/A
Swiss-Prot	VAR_042317	Polymorphism	p.THR594ILE	N/A
dbSNP	rs2230500	Polymorphism	p.VAL374ILE	N/A
OMIM	605437.0001	Disease	p.VAL374ILE	CEREBRAL INFARCTION, SUSCEPTIBILITY TO

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258