Results for the protein: NP

Results for the Protein: NP_001165601

287326432

3055

HCK

NCBI

tyrosine-protein kinase HCK isoform c [Homo sapiens]

			0 2 0 2 0

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RefSeq Protein: NP_001165601

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	5.1e-38	142	240
PTKc_CSF-1R	cd05106	6.5e-37	212	515
PTKc_PDGFR_alpha	cd05105	5.2e-17	215	516
PTKc_PDGFR	cd05055	5.4e-30	221	514
PTKc_PDGFR_beta	cd05107	2.9e-18	222	515
PTKc_Kit	cd05104	3.7e-23	225	514
STKc_PAK_I	cd06647	0.00026	229	522
STKc_myosinIIIB	cd06639	2.6e-05	231	516
STKc_PAK5	cd06658	0.00079	235	522
STKc_TAO1	cd06635	0.00021	237	524
STKc_PAK6	cd06659	8.7e-06	238	524
PTK_Tyk2_rpt1	cd05076	8.4e-07	240	511
STKc_TAO	cd06607	5.8e-05	242	524
PTKc_FGFR1	cd05098	1.5e-49	243	521
STKc_PAK	cd06614	5e-13	243	524
STKc_myosinIIIA	cd06638	4.6e-07	243	511
STKc_MAP4K4_6	cd06636	7.8e-05	244	510
STKc_PAK1	cd06654	0.00011	244	524
PTKc_FGFR3	cd05100	1.9e-33	245	524
STKc_PAK2	cd06655	0.00012	245	525
STKc_PAK3	cd06656	0.00019	245	525
PTKc_FGFR4	cd05099	1.7e-52	248	524
STKc_STK10_LOK	cd06644	1.4e-05	249	521
PTKc_FGFR	cd05053	2.8e-62	250	515
PTKc_FGFR2	cd05101	1.8e-44	250	521
PKc_MKK7	cd06618	1.2e-08	250	523
STKc_TAO2	cd06634	2.5e-05	250	524
STKc_p38	cd07851	1.1e-05	250	525
STKc_CDK9	cd07865	3.6e-07	250	514
STKc_PFTAIRE1	cd07869	0.00015	250	518
STKc_SLK_like	cd06611	4.4e-08	251	516
STKc_PAK_II	cd06648	2e-07	251	510
STKc_ASK	cd06624	1.3e-09	252	514
PTKc_VEGFR	cd05054	7.4e-32	253	517
PTKc_EGFR_like	cd05057	1.6e-58	253	518
PTKc_VEGFR3	cd05102	4e-34	253	517
PTKc_VEGFR2	cd05103	1.1e-30	253	517
PTK_HER3	cd05111	2.1e-38	253	524
STKc_MAP4K3	cd06645	2.2e-05	253	510
STKc_Sty1_Hog1	cd07856	3.2e-05	253	523
STKc_PCTAIRE2	cd07872	0.00011	253	524
PTKc_InsR_like	cd05032	7.7e-73	254	512
PTKc_ALK_LTK	cd05036	1.1e-61	254	512
PTKc_Csk_like	cd05039	2.6e-97	254	513
PTKc_Src_like	cd05034	2.5e-220	254	513
PTKc_Abl	cd05052	9e-111	254	514
PTKc_FAK	cd05056	2.3e-85	254	518
PTKc_InsR	cd05061	6.5e-54	254	521
PTKc_IGF-1R	cd05062	2.6e-55	254	511
PTKc_Lck_Blk	cd05067	1.2e-190	254	513
PTKc_Frk_like	cd05068	1.1e-149	254	513
PTKc_Yes	cd05069	4.4e-169	254	513
PTKc_Fyn_Yrk	cd05070	2.7e-170	254	513
PTKc_Src	cd05071	1.1e-165	254	515
PTKc_Lyn	cd05072	1e-203	254	513
PTKc_Hck	cd05073	2e-232	254	513
PTKc_Chk	cd05083	8.4e-84	254	513
PTKc_Csk	cd05082	6.4e-83	254	513
PTKc_EGFR	cd05108	1.2e-27	254	525
PTKc_HER2	cd05109	8.3e-38	254	524
PTKc_HER4	cd05110	6.5e-30	254	522
PTKc_Srm_Brk	cd05148	2e-129	254	513
STKc_TNIK	cd06637	2.3e-06	254	514
STKc_ERK1_2_like	cd07849	3.2e-06	254	523
STKc_MAPK4_6	cd07854	0.00025	254	525
STKc_CDK12	cd07864	2.5e-09	254	522
STKc_PFTAIRE2	cd07870	1.5e-05	254	525
PTK_CCK4	cd05046	7e-34	255	512
PTKc_Ror	cd05048	6.4e-43	255	513
PTKc_Trk	cd05049	1.5e-47	255	512
PTKc_Musk	cd05050	9.8e-56	255	512
PTKc_DDR	cd05051	5.6e-38	255	512
PTKc_EphR_A2	cd05063	2.4e-78	255	514
PTKc_EphR_A10	cd05064	1.4e-62	255	514
PTKc_Ror1	cd05090	1.6e-40	255	513
PTKc_TrkA	cd05092	4e-50	255	512
PTKc_TrkB	cd05093	1.8e-42	255	522
PTKc_Ror2	cd05091	7.8e-39	255	513
PTKc_DDR2	cd05095	1.3e-41	255	512
PTKc_DDR1	cd05096	7.9e-30	255	512
PTKc_DDR_like	cd05097	2.3e-38	255	512
PTKc_TrkC	cd05094	1.3e-29	255	522
PKc_MAPKK_Byr1_like	cd06620	4.5e-06	255	514
STKc_SLK	cd06643	7.8e-06	255	525
STKc_MAP4K5	cd06646	4.6e-05	255	511
PTKc_EphR	cd05033	3e-95	256	514
PTKc_Jak_rpt2	cd05038	4.7e-63	256	514
PTK_Ryk	cd05043	7.2e-24	256	517
PTKc_EphR_B	cd05065	2e-78	256	514
PTKc_EphR_A	cd05066	3.9e-79	256	514
PTKc_Tec_like	cd05059	5.2e-98	256	511
PTKc_Jak1_rpt2	cd05079	2.9e-46	256	514
PTKc_Tie2	cd05088	1.6e-34	256	521
PTKc_Itk	cd05112	4e-90	256	511
PTKc_Btk_Bmx	cd05113	6.2e-89	256	511
PTKc_Tec_Rlk	cd05114	3.3e-88	256	511
STKc_MAPK15	cd07852	3.7e-06	256	524
STKc_BUR1	cd07866	3.3e-07	256	503
STKc_myosinIII_like	cd06608	5.7e-08	257	506
STKc_MST1_2	cd06612	2.7e-12	257	514
STKc_MAP4K3_like	cd06613	8.9e-11	257	511
STKc_MST4	cd06640	2.3e-06	257	525
STKc_MST3	cd06641	1.2e-06	257	525
STKc_STK25-YSK1	cd06642	4.6e-07	257	525
STKc_PCTAIRE_like	cd07844	1.2e-06	257	522
PKc_MKK4	cd06616	6.3e-06	258	523
PKc_MAPKK_PBS2_like	cd06622	7.8e-06	258	513
STKc_MEKK2	cd06652	3.5e-05	258	505
STKc_MEKK3_like_1	cd06653	1e-07	258	512
STKc_CDK10	cd07845	4.9e-06	258	525
STKc_CdkB_plant	cd07837	2.1e-08	258	523
STKc_Nek6_Nek7	cd08224	3.1e-10	258	515
PTKc_Tie1	cd05089	2.3e-39	259	525
STKc_ROCK_NDR_like	cd05573	0.00056	259	522
STKc_phototropin_lik	cd05574	2.4e-05	259	518
STKc_PDK1	cd05581	2e-10	259	514
STKc_PKA	cd05580	2.5e-06	259	506
STKc_CRIK	cd05601	0.00029	259	522
STKc_PRKX_like	cd05612	6.4e-05	259	522
PKc_MAPKK	cd06605	3.9e-10	259	511
STKc_MST3_like	cd06609	5.4e-11	259	525
STKc_OSR1_SPAK	cd06610	8.3e-12	259	503
PKc_MEK	cd06615	5e-06	259	523
PKc_MKK3_6	cd06617	2e-07	259	515
PKc_MKK5	cd06619	0.00025	259	524
PKc_MAPKK_Pek1_like	cd06621	4.1e-07	259	510
PKc_MAPKK_plant_like	cd06623	4.2e-14	259	511
STKc_Pho85	cd07836	4.4e-05	259	525
STKc_CDK2_3	cd07860	3.4e-05	259	522
STKc_CDK1_euk	cd07861	0.00012	259	525
STKc_Nek1	cd08218	1.2e-09	259	515
STKc_Nek6	cd08228	8.8e-09	259	515
STKc_Nek7	cd08229	1.4e-11	259	515
SPS1	COG0515	1.3e-10	259	525
PTKc_RET	cd05045	2.3e-54	260	517
PKc_STE	cd05122	9e-16	260	505
STKc_MSK_N	cd05583	7.9e-05	260	525
STKc_GRK4_like	cd05605	5.9e-05	260	525
STKc_GRK4	cd05631	0.00072	260	518
STKc_GRK5	cd05632	0.00072	260	525
STKc_MAPKKK	cd06606	1.4e-28	260	504
STKc_Cdc7_like	cd06627	1.7e-18	260	503
STKc_MAPKKK_Byr2_lik	cd06628	1.8e-16	260	514
STKc_MEKK3	cd06651	5.8e-08	260	508
STKc_CCRK	cd07832	1.7e-08	260	515
STKc_MAPK	cd07834	6.2e-07	260	523
STKc_CDK7	cd07841	6.8e-11	260	525
STKc_CDK8_like	cd07842	1.1e-05	260	514
STKc_NLK	cd07853	0.001	260	524
STKc_MPK1	cd07857	2.5e-06	260	513
STKc_Nek	cd08215	7e-16	260	511
STKc_Nek4	cd08223	1.9e-09	260	515
STKc_Nek5	cd08225	8.3e-12	260	515
STKc_Nek3	cd08219	6e-11	260	510
STKc_Nek10	cd08528	9.6e-07	260	512
STKc_FA2-like	cd08529	3.3e-12	260	510
STKc_CNK2-like	cd08530	3.3e-09	260	510
PTKc_Axl_like	cd05035	2.5e-56	261	514
PTKc_Tyro3	cd05074	2e-51	261	514
PTKc_Axl	cd05075	4.8e-45	261	514
PTKc_Tyk2_rpt2	cd05080	1.5e-35	261	515
PTKc_Jak2_Jak3_rpt2	cd05081	2.1e-45	261	514
STKc_PKN	cd05589	1.6e-05	261	522
STKc_CDK_like	cd07829	4.7e-14	261	515
STKc_MAK_like	cd07830	9.5e-14	261	513
STKc_MOK	cd07831	9.4e-07	261	503
STKc_CDK4_6_like	cd07838	5.2e-05	261	506
STKc_Yank1	cd05578	7.1e-08	262	515
STKc_MEKK3_like	cd06625	3e-11	262	512
STKc_MEKK4	cd06626	3.7e-11	262	506
STKc_NAK1_like	cd06917	2.9e-08	262	522
STKc_CDK1_like	cd07835	6.3e-06	262	522
STKc_CDK5	cd07839	6.4e-06	262	522
STKc_CDK9_like	cd07840	9.5e-12	262	506
STKc_CDKL1_4	cd07847	1.4e-05	262	522
STKc_PCTAIRE3	cd07871	8.7e-05	262	522
STKc_PCTAIRE1	cd07873	0.00047	262	518
PK_STRAD	cd08216	0.00018	262	512
STKc_Nek8	cd08220	1.8e-06	262	510
STKc_Nek11	cd08222	7.2e-09	263	515
STKc_RSK_N	cd05582	0.00069	264	525
STKc_CDKL	cd07833	1.2e-06	264	503
STKc_CDC2L1	cd07843	1.8e-06	264	506
STKc_CDKL2_3	cd07846	7.5e-07	264	514
PTKc	cd00192	3.5e-121	265	511
PTK_Jak_rpt1	cd05037	2.9e-10	265	511
PTKc_Fes_like	cd05041	1.8e-88	265	512
PTKc_Aatyk	cd05042	2.8e-14	265	512
PTKc_c-ros	cd05044	2.1e-63	265	512
PTKc_Tie	cd05047	1.6e-45	265	515
PTKc_Ack_like	cd05040	1.4e-77	265	512
PTKc_Met_Ron	cd05058	4e-58	265	516
PTKc_Syk_like	cd05060	2.1e-72	265	515
PTK_Jak1_rpt1	cd05077	1.5e-08	265	511
PTK_Jak2_Jak3_rpt1	cd05078	1.1e-09	265	511
PTKc_Fes	cd05084	5.2e-66	265	512
PTKc_Fer	cd05085	1.1e-76	265	512
PTKc_Aatyk2	cd05086	6.9e-11	265	512
PTKc_Aatyk1_Aatyk3	cd05087	1.4e-17	265	512
PTKc_Syk	cd05116	3.2e-58	265	515
STKc_CMGC	cd05118	1.3e-12	265	506
STKc_PKC	cd05570	5.7e-08	265	515
STKc_nPKC_theta	cd05619	3.5e-05	265	525
STKc_MEKK1	cd06630	1.4e-07	265	504
STKc_MEKK1_plant	cd06632	6.1e-12	265	506
STKc_Nek2	cd08217	2.7e-09	265	509
PTKc_Zap-70	cd05115	3.8e-57	266	515
PKc	cd00180	9e-69	267	510
STKc_AGC	cd05123	5.2e-10	267	514
STKc_cGK_PKG	cd05572	6.1e-09	267	510
STKc_GRK	cd05577	0.00044	267	515
STKc_MAST_like	cd05579	4.6e-08	267	512
STKc_GRK7	cd05607	9.9e-05	267	524
STKc_GRK1	cd05608	0.00041	267	525
STKc_YSK4	cd06631	2.7e-09	267	514
STKc_Nek9	cd08221	7.4e-06	267	510
STKc_MAPKKK_Bck1_lik	cd06629	9.5e-11	268	504
SH3_1	pfam00018	8.5e-22	83	129
SH2	pfam00017	1.1e-42	143	225
Pkinase	pfam00069	1.5e-40	261	510
SH3	smart00326	5.4e-21	78	135
SH3_2	pfam07653	2.2e-06	81	134
SH2	smart00252	1.3e-34	141	231
Pkinase_Tyr	pfam07714	1e-151	261	510
TyrKc	smart00219	6.4e-131	261	510
STYKc	smart00221	1e-57	261	506
S_TKc	smart00220	3.2e-51	271	514

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs114505022	Polymorphism	p.ALA369THR	N/A
dbSNP	rs17093828	Polymorphism	p.PRO501GLN	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258