Results for the protein: Q9NZJ5

Results for the Protein: Q9NZJ5

296439367

9451

EIF2AK3

NCBI, UniProt

E2AK3_HUMAN RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3; AltName: Full=PRKR-like endoplasmic reticulum kinase; AltName: Full=Pancreatic eIF2-alpha kinase; Short=HsPEK; Flags: Precursor

Known Diseases associated with this Protein:
WOLCOTT-RALLISON SYNDROME
WOLCOTT-RALLISON SYNDROME (WRS)

3

6

2

4

3

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: Q9NZJ5

Identical to: NP_004827

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_FGFR4	cd05099	0.00022	794	1094
STKc_Nek8	cd08220	1.2e-05	794	1077
PTKc_FAK	cd05056	0.00097	795	1085
STKc_PAK6	cd06659	6.4e-05	796	1099
SPS1	COG0515	2.8e-06	798	1116
PKc	cd00180	1.6e-25	799	1075
STKc_Nek4	cd08223	8.2e-06	800	1077
STKc_Nek6_Nek7	cd08224	3.8e-08	802	1080
STKc_Nek6	cd08228	1.9e-07	804	1080
STKc_Nek10	cd08528	7.4e-06	804	1079
STKc_MAPKKK_Byr2_lik	cd06628	0.00012	806	1077
PTKc_Tec_Rlk	cd05114	0.00094	808	1076
PTKc_Itk	cd05112	0.001	808	1076
STKc_GRK1	cd05608	0.00075	808	1097
STKc_CDK1_like	cd07835	0.00086	808	1111
STKc_CDK10	cd07845	1.4e-05	811	1083
PTKc_Frk_like	cd05068	0.00015	812	1080
PTKc_Hck	cd05073	0.00029	812	1080
STKc_CDC2L1	cd07843	0.0004	813	1077
STKc_MSK_N	cd05583	8.7e-05	814	1097
PTKc_Abl	cd05052	0.00089	815	1081
PTKc_Btk_Bmx	cd05113	0.0005	816	1076
STKc_Nek7	cd08229	4.8e-09	816	1080
STKc_CdkB_plant	cd07837	3.6e-08	819	1078
STKc_CDKL1_4	cd07847	0.00051	819	1106
PTKc_Jak2_Jak3_rpt2	cd05081	0.00092	820	1076
STKc_SLK_like	cd06611	4e-06	820	1094
STKc_PAK_II	cd06648	0.00024	820	1076
STKc_Nek3	cd08219	4.4e-08	820	1077
PKc_STE	cd05122	1.2e-09	822	1068
STKc_MAP4K3_like	cd06613	4.6e-06	822	1077
STKc_MEKK3_like	cd06625	1e-05	822	1077
STKc_MEKK3	cd06651	0.00018	822	1080
STKc_Nek1	cd08218	6.6e-06	823	1077
STKc_Nek5	cd08225	0.001	823	1077
STKc_CMGC	cd05118	4.4e-08	824	1077
STKc_Nek11	cd08222	0.00015	824	1077
PKc_MKK7	cd06618	0.00013	826	1090
STKc_Nek	cd08215	3.9e-15	826	1077
PTKc_Ack_like	cd05040	0.00021	835	1077
STKc_Nek9	cd08221	3.2e-08	835	1077
PKc_MKK3_6	cd06617	0.0002	838	1096
STKc_MAK_like	cd07830	4.5e-07	840	1077
STKc_PAK	cd06614	1.9e-10	844	1086
STKc_OSR1_SPAK	cd06610	2.5e-08	847	1077
PTKc	cd00192	2.3e-05	849	1073
STKc_cGK_PKG	cd05572	2e-06	849	1084
STKc_CCRK	cd07832	1.9e-06	849	1094
PTKc_Jak_rpt2	cd05038	0.0002	856	1079
STKc_CNK2-like	cd08530	2.5e-06	859	1077
STKc_FA2-like	cd08529	5.3e-07	862	1077
PTKc_Src_like	cd05034	0.00018	864	1080
STKc_PDK1	cd05581	1.9e-08	866	1077
STKc_MAPKKK	cd06606	1.8e-08	866	1069
PKc_MAPKK_Byr1_like	cd06620	0.00016	866	1092
STKc_BUR1	cd07866	0.00092	866	1077
STKc_p38	cd07851	0.00087	867	1105
STKc_GRK	cd05577	0.00016	868	1084
STKc_MOK	cd07831	3.9e-05	868	1077
STKc_CDKL	cd07833	1.4e-05	869	1077
STKc_CDK7	cd07841	3e-06	869	1092
STKc_MST3_like	cd06609	0.00013	870	1087
PKc_MAPKK_Pek1_like	cd06621	0.00029	870	1077
PKc_MAPKK_plant_like	cd06623	8e-07	870	1074
STKc_Nek2	cd08217	6.1e-09	870	1077
PKc_MAPKK	cd06605	4.6e-05	873	1068
STKc_MST1_2	cd06612	3.5e-05	873	1071
STKc_CDK_like	cd07829	2.6e-07	873	1077
STKc_CDK9_like	cd07840	2.8e-06	873	1077
STKc_MEKK4	cd06626	2.3e-06	874	1077
STKc_MAPK	cd07834	0.00018	874	1106
STKc_AGC	cd05123	9.2e-09	881	1077
STKc_ROCK_NDR_like	cd05573	1.3e-06	881	1116
STKc_Yank1	cd05578	7.1e-07	881	1078
STKc_MAPKKK_Bck1_lik	cd06629	3e-05	881	1078
STKc_Cdc7_like	cd06627	1.7e-05	882	1069
STKc_Sid2p_Dbf2p	cd05600	0.00031	885	1089
STKc_MAPK15	cd07852	1.6e-05	886	1108
STKc_NAK1_like	cd06917	8.5e-05	889	1085
STKc_MAST_like	cd05579	3.8e-08	890	1082
Pkinase	pfam00069	7.5e-12	797	1077
STYKc	smart00221	2.8e-11	795	1077
S_TKc	smart00220	6.4e-16	823	1077
Pkinase_Tyr	pfam07714	1.1e-05	843	1075
TyrKc	smart00219	1.7e-07	849	1075
KIND	smart00750	2.2e-05	895	1103

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs1805165	Polymorphism	p.ALA704SER	N/A
Swiss-Prot	VAR_011408	Disease	p.ARG588GLN	Wolcott-Rallison syndrome (WRS)
Swiss-Prot	VAR_040477	Polymorphism	p.ASP566VAL	N/A
dbSNP	rs13045	Polymorphism	p.GLN166ARG	N/A
dbSNP	rs75385605	Polymorphism	p.ILE586LEU	N/A
Swiss-Prot	VAR_040478	Polymorphism	p.PRO716LEU	N/A
dbSNP	rs867529	Polymorphism	p.SER136CYS	N/A
OMIM	604032.0002	Disease	p.ARG587GLN	WOLCOTT-RALLISON SYNDROME
OMIM	604032.0005	Disease	p.GLU331TER	WOLCOTT-RALLISON SYNDROME

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258