Results for the protein: Q9P2K8

Results for the Protein: Q9P2K8

296439368

440275

EIF2AK4

NCBI, UniProt

E2AK4_HUMAN RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 4; AltName: Full=GCN2-like protein

			0 10 0 3 7

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Swiss-Prot Protein: Q9P2K8

Identical to: NP_001013725

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_PAK1	cd06654	1.9e-05	275	558
PTKc	cd00192	4.9e-08	276	538
STKc_PAK2	cd06655	5.4e-05	276	559
STKc_PAK3	cd06656	8.6e-06	276	569
STKc_myosinIIIB	cd06639	8.7e-05	278	540
STKc_MAPKKK_Byr2_lik	cd06628	3.1e-16	279	539
STKc_myosinIIIA	cd06638	7.1e-06	279	539
PTKc_Jak_rpt2	cd05038	7.9e-05	280	549
STKc_CDK1_like	cd07835	0.00033	280	587
STKc_MEKK3_like	cd06625	2.9e-12	281	539
STKc_MEKK1_plant	cd06632	1.7e-11	281	539
STKc_MAPKKK_Bck1_lik	cd06629	1.8e-10	282	539
PKc_MAPKK_PBS2_like	cd06622	8.5e-05	284	568
STKc_STK10_LOK	cd06644	2.8e-05	284	558
STKc_SLK	cd06643	9e-08	287	556
STKc_MEKK2	cd06652	7.5e-06	287	540
STKc_MEKK3_like_1	cd06653	1.1e-06	287	539
STKc_CDK4	cd07863	2.4e-05	288	584
SPS1	COG0515	1.1e-14	288	701
PTKc_Ror	cd05048	0.00048	289	511
STKc_Cdc7_like	cd06627	1.9e-14	289	539
STKc_MEKK3	cd06651	4.1e-09	289	541
PTKc_Fes_like	cd05041	3.5e-07	290	539
PTKc_Frk_like	cd05068	0.00045	290	538
PTKc_Btk_Bmx	cd05113	0.00043	290	538
STKc_PRKX_like	cd05612	0.00015	290	561
PKc_MEK	cd06615	1.4e-05	290	621
PTKc_InsR_like	cd05032	0.00059	295	541
STKc_ASK	cd06624	2.1e-09	295	539
STKc_Nek6	cd08228	0.00017	295	545
STKc_MSK2_N	cd05614	0.00018	296	590
PKc	cd00180	1.1e-33	300	537
PTKc_Fes	cd05084	4.2e-05	301	539
PTKc_Fer	cd05085	7.4e-05	303	539
PTKc_Srm_Brk	cd05148	9e-05	307	539
PTK_Ryk	cd05043	0.00038	308	539
PTKc_Csk	cd05082	0.00055	308	537
STKc_YPK1_like	cd05585	0.00027	311	588
STKc_aPKC	cd05588	0.00062	311	618
PTKc_Src_like	cd05034	9.4e-05	313	538
PTKc_Chk	cd05083	6.3e-05	313	540
PKc_STE	cd05122	3e-11	314	538
PKc_MKK7	cd06618	6.5e-06	314	563
STKc_MEKK4	cd06626	4.8e-12	316	539
STKc_MEKK1	cd06630	2e-07	316	540
STKc_YSK4	cd06631	2.3e-11	316	539
STKc_MAPKKK	cd06606	1.3e-17	318	539
PTKc_Ack_like	cd05040	2.1e-05	320	535
STKc_SLK_like	cd06611	1.9e-07	322	550
PKc_MKK4	cd06616	0.00063	324	565
PKc_MAPKK	cd06605	7.8e-10	328	544
STKc_CDK4_6_like	cd07838	2.6e-07	328	539
PKc_MAPKK_Pek1_like	cd06621	6.3e-08	331	547
PKc_MAPKK_plant_like	cd06623	1.2e-09	331	544
PKc_MKK3_6	cd06617	3.5e-06	345	553
STKc_BUR1	cd07866	5e-05	584	1001
STKc_Nek	cd08215	1.7e-16	589	1001
STKc_Nek2	cd08217	2.1e-10	589	1001
PKc	cd00180	9.4e-37	596	999
STKc_AGC	cd05123	8.2e-11	596	1001
STKc_TAO2	cd06634	3.6e-05	689	1037
STKc_PAK6	cd06659	0.00014	696	1029
STKc_JNK2	cd07876	0.00073	698	1032
SPS1	COG0515	2.7e-19	706	1171
STKc_CdkB_plant	cd07837	2.8e-06	707	1002
STKc_JNK3	cd07874	0.0005	708	1032
STKc_TEY_MAPK_plant	cd07858	0.0003	709	1076
STKc_TAO1	cd06635	0.00012	713	1036
STKc_TAO	cd06607	5.7e-05	716	1036
STKc_NAK1_like	cd06917	3.4e-08	718	1019
STKc_PAK	cd06614	7.2e-13	720	1015
STKc_MAPK4_6	cd07854	3e-05	720	1030
STKc_TNIK	cd06637	0.00022	721	1001
STKc_TDY_MAPK_plant	cd07859	0.00031	722	1079
STKc_CDK12	cd07864	0.00011	727	1001
STKc_PCTAIRE2	cd07872	6.6e-05	727	1038
STKc_PCTAIRE_like	cd07844	0.00025	729	1019
STKc_PCTAIRE3	cd07871	0.00051	729	1019
STKc_MAP4K3	cd06645	5.8e-06	730	1000
STKc_MAP4K5	cd06646	3.6e-06	730	1000
STKc_JNK	cd07850	0.00078	731	1083
STKc_MAST	cd05609	4.5e-05	732	1048
STKc_STK25-YSK1	cd06642	4.7e-07	732	1022
STKc_MST3	cd06641	3.3e-06	732	1022
STKc_cPKC	cd05587	0.00058	733	1049
STKc_Nek11	cd08222	2.9e-05	733	1001
STKc_Nek6_Nek7	cd08224	7.9e-05	733	1008
STKc_MAP4K3_like	cd06613	2.2e-10	734	1000
STKc_MST4	cd06640	1e-06	735	1022
STKc_nPKC_theta_delt	cd05592	7.6e-05	737	1071
STKc_nPKC_theta	cd05619	7.9e-05	737	1050
STKc_MSK_N	cd05583	0.00019	738	1025
STKc_CDK5	cd07839	0.00017	738	1001
STKc_Nek1	cd08218	9e-06	738	1001
STKc_Nek5	cd08225	4.4e-06	738	1001
STKc_Nek7	cd08229	0.00019	738	1001
PTKc_Aatyk	cd05042	0.00036	739	998
PTKc_Aatyk2	cd05086	0.00049	739	1001
STKc_CDC2L1	cd07843	8.3e-06	740	1001
STKc_Nek10	cd08528	8.9e-06	740	1003
STKc_CMGC	cd05118	1.3e-09	741	1001
STKc_CCRK	cd07832	8.6e-08	741	1002
STKc_MAST_like	cd05579	6.1e-10	742	993
STKc_MAPKKK_Byr2_lik	cd06628	4.1e-07	742	1001
STKc_Nek3	cd08219	5.6e-10	742	1001
STKc_Nek4	cd08223	6e-05	742	1001
STKc_PKB	cd05571	3e-05	743	1071
STKc_PKC	cd05570	7.7e-05	743	1031
STKc_PKN	cd05589	0.00082	743	1059
STKc_PKB_gamma	cd05593	0.00046	743	1074
STKc_GRK4_like	cd05605	0.00087	743	1043
STKc_myosinIII_like	cd06608	1.5e-06	743	1001
STKc_Nek8	cd08220	5.1e-06	743	1001
STKc_Nek9	cd08221	4.5e-09	743	1001
STKc_p38	cd07851	9e-06	745	1024
STKc_phototropin_lik	cd05574	1.9e-06	747	1014
STKc_CDK10	cd07845	1.9e-06	751	1006
STKc_MST3_like	cd06609	1.2e-08	755	1019
STKc_CDK9	cd07865	0.0004	755	1001
STKc_PDK1	cd05581	1.2e-11	757	1001
STKc_PKA	cd05580	7.2e-05	757	1045
STKc_MST1_2	cd06612	8.4e-10	757	1001
STKc_cGK_PKG	cd05572	2.1e-05	758	999
STKc_FA2-like	cd08529	2.6e-11	758	1001
STKc_CDK7	cd07841	3.1e-07	759	1012
STKc_CNK2-like	cd08530	5.9e-09	759	1001
STKc_CDK8_like	cd07842	0.0001	760	1001
STKc_Sty1_Hog1	cd07856	0.00029	760	1034
STKc_CDK9_like	cd07840	4.3e-09	761	1001
STKc_ERK1_2_like	cd07849	0.00011	761	1037
STKc_ERK5	cd07855	3.1e-05	761	1022
STKc_PAK_II	cd06648	6.3e-06	765	1019
STKc_MAK_like	cd07830	9.3e-07	765	1001
STKc_OSR1_SPAK	cd06610	1.7e-10	766	1001
STKc_CDK_like	cd07829	2.4e-09	767	1001
STKc_MOK	cd07831	5.5e-06	769	1001
PKc_MAPKK_Byr1_like	cd06620	0.0002	771	1015
STKc_CDKL2_3	cd07846	0.00043	772	1001
STKc_ROCK_NDR_like	cd05573	5.5e-08	775	1048
STKc_CRIK	cd05601	0.00055	775	1048
STKc_NDR_like	cd05599	3.2e-05	775	1048
STKc_CDKL	cd07833	5.6e-07	777	1001
STKc_MPK1	cd07857	0.00019	777	1014
STKc_NLK	cd07853	7.6e-05	785	1099
STKc_GRK	cd05577	1.5e-05	789	1008
STKc_Yank1	cd05578	4.9e-09	796	1006
STKc_MAPK	cd07834	5.1e-07	796	1034
STKc_MAPK15	cd07852	3.2e-09	800	1035
HisS	COG0124	2.4e-11	1053	1491
HisRS-like_core	cd00773	1.5e-10	1060	1386
HisRS_anticodon	cd00859	1.3e-05	1396	1487
Pkinase	pfam00069	7.5e-11	297	539
Pkinase	pfam00069	6.9e-21	743	1001
RWD	pfam05773	4.8e-32	18	134
RWD	smart00591	4.8e-34	26	137
STYKc	smart00221	8.1e-07	286	539
S_TKc	smart00220	1.3e-11	291	539
Pkinase_Tyr	pfam07714	2.1e-08	590	1000
TyrKc	smart00219	4.2e-08	590	1000
STYKc	smart00221	6.8e-31	590	1001
S_TKc	smart00220	1.6e-33	600	1001

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040480	Polymorphism	p.ARG166TRP	N/A
Swiss-Prot	VAR_040482	Polymorphism	p.ASP872VAL	N/A
Swiss-Prot	VAR_040487	Polymorphism	p.GLN1406HIS	N/A
dbSNP	rs2307105	Polymorphism	p.GLU556GLY	N/A
dbSNP	rs35602605	Polymorphism	p.GLY1306CYS	N/A
Swiss-Prot	VAR_040479	Polymorphism	p.HIS137ARG	N/A
Swiss-Prot	VAR_040483	Polymorphism	p.HIS939TYR	N/A
dbSNP	rs2291627	Polymorphism	p.ILE441LEU	N/A
Swiss-Prot	VAR_040486	Polymorphism	p.LYS1336ARG	N/A
Swiss-Prot	VAR_040484	Polymorphism	p.THR1060ARG	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258