Results for the protein: NP

Results for the Protein: NP_001171914

296939600

65125

WNK1

NCBI

serine/threonine-protein kinase WNK1 isoform 4 [Homo sapiens]

Known Diseases associated with this Protein:
NEUROPATHY, HEREDITARY SENSORY, TYPE II
VARIANT OF UNKNOWN SIGNIFICANCE

5

9

5

9

0

Tips:

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RefSeq Protein: NP_001171914

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_TAO1	cd06635	4.6e-09	182	515
STKc_TAO3	cd06633	3.3e-07	188	515
STKc_p38alpha_MAPK14	cd07877	6.9e-05	193	526
STKc_JNK1	cd07875	0.00023	196	562
STKc_PAK5	cd06658	1.5e-06	197	494
STKc_MAP4K4_6	cd06636	1.5e-07	197	479
STKc_JNK2	cd07876	3.8e-05	198	560
STKc_PAK1	cd06654	9.9e-10	199	503
STKc_PAK_I	cd06647	2.9e-17	200	501
STKc_PAK2	cd06655	1e-09	200	497
STKc_PAK3	cd06656	1.3e-10	200	505
STKc_PAK	cd06614	1.5e-20	202	493
STKc_PAK_II	cd06648	1.8e-11	202	490
STKc_MSK1_N	cd05613	0.00019	203	491
STKc_myosinIIIB	cd06639	3.7e-08	203	480
PTKc_EGFR_like	cd05057	4.2e-08	204	491
STKc_PAK4	cd06657	7.7e-07	204	496
STKc_PAK6	cd06659	4.5e-09	204	500
STKc_p38gamma_MAPK12	cd07880	5.2e-06	204	546
STKc_JNK3	cd07874	0.00025	205	571
STKc_p38beta_MAPK11	cd07878	0.00058	205	553
PTKc_Abl	cd05052	9.2e-08	206	478
PTKc_Ror1	cd05090	0.001	206	482
PTKc_DDR2	cd05095	9e-05	206	481
PKc_MKK7	cd06618	1.3e-08	206	512
STKc_TAO2	cd06634	8.3e-10	206	518
STKc_TAO	cd06607	1.2e-08	206	517
STKc_JNK	cd07850	1.9e-05	206	558
STKc_p38	cd07851	1.2e-07	206	514
STKc_CDK9	cd07865	5.1e-07	206	479
PTKc_ALK_LTK	cd05036	1.2e-07	210	481
PTK_CCK4	cd05046	1.6e-05	211	481
PTKc_Ror2	cd05091	0.00035	211	480
STKc_MAP4K5	cd06646	3.1e-08	211	478
STKc_MAP4K3	cd06645	3.1e-08	211	478
PTK_Ryk	cd05043	0.0008	212	431
PTKc_Lyn	cd05072	1.2e-06	212	477
PTKc_EGFR	cd05108	3e-07	212	506
PTK_HER3	cd05111	1.2e-06	212	491
PTKc_HER2	cd05109	5.3e-08	212	491
STKc_ASK	cd06624	2.7e-26	212	479
STKc_BUR1	cd07866	1.5e-08	212	479
STKc_PCTAIRE2	cd07872	8.6e-07	213	529
STKc_PCTAIRE1	cd07873	1.4e-05	213	511
STKc_CDK12	cd07864	1.5e-09	213	479
PTKc_InsR_like	cd05032	6.9e-09	214	475
PTKc_FAK	cd05056	3.2e-08	214	483
PTKc_IGF-1R	cd05062	1.3e-05	214	479
PTKc_FGFR	cd05053	0.00028	214	479
PTKc_Csk	cd05082	2e-05	214	477
STKc_TNIK	cd06637	1.9e-08	214	479
STKc_myosinIIIA	cd06638	5.4e-09	214	479
STKc_PCTAIRE_like	cd07844	2.5e-09	214	509
STKc_TEY_MAPK_plant	cd07858	3.2e-08	214	550
STKc_PFTAIRE2	cd07870	5.7e-06	214	479
STKc_PCTAIRE3	cd07871	8.4e-08	214	509
PTKc_Musk	cd05050	0.00016	215	476
PTKc_Tie2	cd05088	0.00027	215	500
STKc_MST4	cd06640	2.7e-08	215	500
STKc_STK25-YSK1	cd06642	2.5e-10	215	497
STKc_SLK	cd06643	7.8e-11	215	494
STKc_MEKK2	cd06652	7.3e-10	215	480
STKc_MEKK3_like_1	cd06653	1.8e-16	215	479
STKc_MST3	cd06641	1.5e-08	215	497
PTKc_Jak_rpt2	cd05038	1.8e-09	216	483
STKc_DMPK_like	cd05597	0.00013	216	546
STKc_PDK1	cd05581	1.1e-15	216	479
STKc_NDR_like_fungal	cd05629	0.00089	216	551
PKc_MEK2	cd06649	2.4e-05	216	511
PKc_MEK1	cd06650	9.8e-05	216	547
PTKc_Src_like	cd05034	1.4e-08	217	478
PTKc_Tec_like	cd05059	1.3e-10	217	478
PTKc_InsR	cd05061	1.2e-05	217	484
PTKc_EphR_A2	cd05063	2.7e-05	217	478
PTKc_EphR_A10	cd05064	9.5e-05	217	478
PTKc_EphR_B	cd05065	6.8e-06	217	479
PTKc_EphR_A	cd05066	2.2e-05	217	478
PTKc_Fyn_Yrk	cd05070	5.2e-06	217	482
PTKc_Frk_like	cd05068	6.5e-14	217	478
PTKc_EphR	cd05033	2.3e-07	217	478
PTKc_Jak1_rpt2	cd05079	2.1e-06	217	483
PTKc_Tyk2_rpt2	cd05080	1.2e-06	217	484
PTKc_Chk	cd05083	8.8e-06	217	482
PTKc_Jak2_Jak3_rpt2	cd05081	1.4e-09	217	481
PTKc_TrkA	cd05092	8.1e-06	217	481
PTKc_TrkC	cd05094	0.00011	217	535
PTKc_Btk_Bmx	cd05113	4.9e-10	217	478
PTKc_Tec_Rlk	cd05114	5.3e-09	217	478
PTKc_Itk	cd05112	4e-10	217	478
STKc_MSK_N	cd05583	1.5e-05	217	498
STKc_cPKC	cd05587	6.2e-06	217	547
STKc_MSK2_N	cd05614	0.00032	217	548
STKc_cPKC_beta	cd05616	0.0004	217	548
PKc_MAPKK_Byr1_like	cd06620	1.4e-07	217	493
STKc_MAPK15	cd07852	6.2e-06	217	522
STKc_ROCK_NDR_like	cd05573	4.8e-08	218	527
STKc_MAST	cd05609	7e-07	218	527
STKc_MST3_like	cd06609	6.7e-14	218	497
STKc_NAK1_like	cd06917	5.6e-12	218	488
STKc_CdkB_plant	cd07837	2e-10	218	480
STKc_CDK10	cd07845	1.4e-07	218	482
STKc_CDKL2_3	cd07846	6.2e-09	218	479
STKc_CDKL1_4	cd07847	4.4e-09	218	517
SPS1	COG0515	1.5e-49	218	667
PTKc_Ror	cd05048	6.4e-06	219	438
PTKc_Trk	cd05049	1.2e-06	219	476
PTKc_Lck_Blk	cd05067	3.8e-06	219	477
PTKc_Yes	cd05069	4.6e-07	219	477
PTKc_Src	cd05071	9.1e-06	219	484
PTKc_Hck	cd05073	3.3e-06	219	477
PTKc_TrkB	cd05093	6.6e-05	219	490
PTKc_HER4	cd05110	1.1e-06	219	508
STKc_PKA	cd05580	2.5e-09	219	498
STKc_GRK4_like	cd05605	4.3e-07	219	520
STKc_PRKX_like	cd05612	4e-07	219	504
STKc_GRK6	cd05630	5.8e-05	219	520
STKc_GRK5	cd05632	0.00015	219	495
STKc_GRK4	cd05631	0.00014	219	495
PKc_MKK3_6	cd06617	9.9e-11	219	498
PKc_MKK5	cd06619	1.2e-06	219	510
PKc_MEK	cd06615	3.2e-10	219	491
STKc_Cdc7_like	cd06627	9.3e-20	219	479
STKc_MAPKKK_Byr2_lik	cd06628	7.7e-24	219	479
STKc_YSK4	cd06631	1.1e-14	219	479
STKc_STK10_LOK	cd06644	6.3e-09	219	497
STKc_MEKK1	cd06630	7e-13	219	480
STKc_Pho85	cd07836	3.8e-10	219	504
STKc_CDK7	cd07841	4.4e-10	219	490
STKc_CDK5	cd07839	4.1e-08	219	479
STKc_CDK2_3	cd07860	8.2e-07	219	479
STKc_CDK6	cd07862	0.00047	219	479
STKc_CDK1_euk	cd07861	2.6e-06	219	509
STKc_Nek1	cd08218	7.4e-19	219	479
STKc_Nek9	cd08221	7.2e-09	219	479
STKc_Nek11	cd08222	1.6e-15	219	479
STKc_Nek8	cd08220	4.4e-12	219	479
STKc_CMGC	cd05118	4.2e-12	220	479
PKc_MKK4	cd06616	8e-10	220	502
STKc_CDK_like	cd07829	1.1e-16	220	479
STKc_CDK1_like	cd07835	1.9e-07	220	504
STKc_NLK	cd07853	7.1e-05	220	550
STKc_CDK9_like	cd07840	1.3e-10	220	479
STKc_PFTAIRE1	cd07869	0.00016	220	491
STKc_MAPK	cd07834	2.6e-08	220	512
STKc_Nek6_Nek7	cd08224	8.3e-12	220	482
STKc_Nek6	cd08228	3e-14	220	482
STKc_Nek7	cd08229	1.2e-12	220	482
PTKc_RET	cd05045	0.00037	221	481
PTKc_DDR	cd05051	0.00095	221	481
PTKc_Tyro3	cd05074	5.1e-05	221	481
PTKc_Tie1	cd05089	0.00029	221	501
PTKc_Axl_like	cd05035	1.5e-05	221	478
STKc_p70S6K	cd05584	7.3e-06	221	548
STKc_PKN	cd05589	4.8e-06	221	546
STKc_cPKC_alpha	cd05615	0.00015	221	528
PKc_MAPKK	cd06605	1.2e-12	221	483
STKc_MAP4K3_like	cd06613	6e-16	221	478
PKc_MAPKK_PBS2_like	cd06622	4.3e-10	221	543
STKc_MOK	cd07831	5e-09	221	479
STKc_Nek4	cd08223	3.4e-24	221	479
PTKc_Srm_Brk	cd05148	6.5e-08	222	478
PKc_STE	cd05122	2e-26	222	478
STKc_Yank1	cd05578	1.9e-13	222	479
STKc_MAPKKK	cd06606	4e-48	222	479
STKc_OSR1_SPAK	cd06610	6.7e-13	222	479
STKc_myosinIII_like	cd06608	5.8e-13	222	479
STKc_CDKL	cd07833	5.9e-07	222	479
STKc_CCRK	cd07832	1e-10	222	480
STKc_CDK8_like	cd07842	3.9e-07	222	479
STKc_TDY_MAPK_plant	cd07859	9.5e-07	222	545
STKc_MPK1	cd07857	4.8e-05	222	521
STKc_CDK4	cd07863	1.1e-07	222	479
PK_STRAD	cd08216	1.9e-05	222	491
STKc_Nek	cd08215	5.3e-26	222	479
STKc_Nek5	cd08225	5.8e-16	222	479
STKc_Nek2	cd08217	7.9e-18	222	479
STKc_Nek3	cd08219	1.5e-11	222	479
STKc_Nek10	cd08528	5.3e-07	222	482
STKc_FA2-like	cd08529	3.1e-15	222	478
STKc_CNK2-like	cd08530	7e-13	222	479
STKc_CRIK	cd05601	2.4e-06	223	527
STKc_MST1_2	cd06612	8.1e-15	223	479
PKc_MAPKK_plant_like	cd06623	1.3e-16	223	484
STKc_MAK_like	cd07830	6e-13	223	479
STKc_ERK1_2_like	cd07849	2.8e-05	223	521
STKc_ERK5	cd07855	7.5e-05	223	507
STKc_Sty1_Hog1	cd07856	2.2e-06	223	544
STKc_MAPK4_6	cd07854	2.1e-05	223	508
STKc_CDC2L6	cd07867	0.00019	223	517
STKc_CDK8	cd07868	0.0003	223	509
STKc_MEKK4	cd06626	2.2e-16	224	479
STKc_CDC2L1	cd07843	5.1e-06	224	479
PTKc	cd00192	3.6e-16	225	478
PTK_Jak_rpt1	cd05037	0.00051	225	475
PTKc_Fes_like	cd05041	3.7e-10	225	479
PTKc_Aatyk	cd05042	3.7e-06	225	476
PTKc_Ack_like	cd05040	5.3e-13	225	481
PTKc_Zap-70	cd05115	2.3e-05	225	479
PTKc_Syk	cd05116	3.3e-06	225	479
PTKc_Syk_like	cd05060	9.1e-08	225	461
PTK_Jak2_Jak3_rpt1	cd05078	0.00028	226	474
PTKc_Fes	cd05084	6.5e-07	226	479
STKc_SLK_like	cd06611	7.4e-11	226	492
STKc_CDK4_6_like	cd07838	3e-10	226	479
PKc	cd00180	2e-75	227	477
PTKc_c-ros	cd05044	1.8e-07	227	476
PTKc_Met_Ron	cd05058	0.00047	227	483
PTKc_Fer	cd05085	4.4e-07	227	479
STKc_AGC	cd05123	4.9e-14	227	479
STKc_PKB	cd05571	1e-07	227	531
STKc_cGK_PKG	cd05572	3.4e-12	227	482
STKc_PKC	cd05570	3.4e-09	227	527
STKc_RSK_N	cd05582	1.7e-05	227	546
STKc_SGK	cd05575	1.8e-06	227	546
STKc_Sck1_like	cd05586	7.8e-06	227	587
STKc_aPKC	cd05588	7.9e-07	227	547
STKc_nPKC_eta	cd05590	2.6e-05	227	547
STKc_PKB_gamma	cd05593	9e-06	227	546
STKc_PKB_alpha	cd05594	4.8e-07	227	560
STKc_PKB_beta	cd05595	1.4e-05	227	563
STKc_nPKC_theta_delt	cd05592	8.1e-09	227	549
STKc_SGK1	cd05602	1.8e-05	227	548
STKc_beta_ARK	cd05606	9.4e-08	227	499
STKc_YPK1_like	cd05585	2.7e-07	227	545
STKc_GRK7	cd05607	7.7e-07	227	499
STKc_GRK1	cd05608	1.3e-09	227	493
STKc_aPKC_zeta	cd05617	4.4e-06	227	547
STKc_nPKC_theta	cd05619	5.5e-08	227	549
STKc_MAST_like	cd05579	6.4e-10	227	484
STKc_SGK3	cd05604	0.00058	227	555
STKc_SGK2	cd05603	2e-06	227	566
STKc_GRK	cd05577	8.7e-09	227	494
STKc_GRK3	cd05633	1.3e-06	227	500
STKc_aPKC_iota	cd05618	0.00015	227	547
STKc_nPKC_epsilon	cd05591	6.6e-07	227	548
STKc_MEKK3_like	cd06625	1.1e-25	227	479
STKc_MAPKKK_Bck1_lik	cd06629	6.4e-12	227	479
STKc_MEKK1_plant	cd06632	7.2e-19	227	479
STKc_MEKK3	cd06651	8.6e-16	227	481
STKc_phototropin_lik	cd05574	1.5e-05	230	497
PKc_MAPKK_Pek1_like	cd06621	7.8e-08	242	489
Pkinase	pfam00069	8.7e-58	221	479
Pkinase_Tyr	pfam07714	1.1e-23	221	479
TyrKc	smart00219	8.8e-20	221	479
STYKc	smart00221	6.1e-65	221	479
S_TKc	smart00220	3.1e-66	231	479
KIND	smart00750	1.4e-06	307	487
OSR1_C	pfam12202	2.4e-20	500	537

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs11554421	Polymorphism	p.ALA141THR	N/A
dbSNP	rs117016551	Polymorphism	p.ARG2205CYS	N/A
dbSNP	rs34728563	Polymorphism	p.ILE509THR	N/A
dbSNP	rs61736905	Polymorphism	p.ILE694THR	N/A
dbSNP	rs12828016	Polymorphism	p.MET2068ILE	N/A
dbSNP	rs17755373	Polymorphism	p.PRO2083LEU	N/A
dbSNP	rs11833299	Polymorphism	p.THR674ALA	N/A
dbSNP	rs2286007	Polymorphism	p.THR665ILE	N/A
dbSNP	rs956868	Polymorphism	p.THR1316PRO	N/A
OMIM	605232.0007	Disease	p.ARG290TER	NEUROPATHY, HEREDITARY SENSORY, TYPE II
OMIM	605232.0005	Disease	p.GLN315TER	NEUROPATHY, HEREDITARY SENSORY, TYPE II
OMIM	605232.0009	Disease	p.GLN73TER	NEUROPATHY, HEREDITARY SENSORY, TYPE II
OMIM	605232.0012	Disease	p.ILE1172MET	VARIANT OF UNKNOWN SIGNIFICANCE
OMIM	605232.0013	Disease	p.SER2047ASN	VARIANT OF UNKNOWN SIGNIFICANCE

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258