Results for the protein: Q15831

Results for the Protein: Q15831

3024670

6794

STK11

NCBI, UniProt

STK11_HUMAN RecName: Full=Serine/threonine-protein kinase STK11; AltName: Full=Liver kinase B1; Short=LKB1; Short=hLKB1; AltName: Full=Renal carcinoma antigen NY-REN-19; Flags: Precursor

Known Diseases associated with this Protein:
  MELANOMA, MALIGNANT, SOMATIC
  PANCREATIC CANCER, SOMATIC
  PEUTZ-JEGHERS SYNDROME
  PEUTZ-JEGHERS SYNDROME (PJS)
  TESTICULAR GERM CELL TUMOR (TGCT)
  TESTICULAR TUMOR, SOMATIC

20

37

13

1

43

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

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Swiss-Prot Protein: Q15831

Identical to: NP_000446

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	2.2e-08	2	383
STKc_ROCK1	cd05622	4.7e-07	2	382
STKc_PAK5	cd06658	1.3e-05	19	327
STKc_PAK6	cd06659	1.3e-08	20	337
STKc_PAK_I	cd06647	9.1e-09	23	330
STKc_PAK3	cd06656	7.3e-08	23	333
STKc_PAK4	cd06657	8.7e-06	24	333
STKc_p38	cd07851	3.2e-09	26	342
STKc_JNK3	cd07874	9.5e-07	27	367
STKc_JNK2	cd07876	7.7e-08	27	350
PTKc_FGFR1	cd05098	2.6e-05	29	313
PTKc_FGFR4	cd05099	9.5e-06	29	327
STKc_PAK_II	cd06648	4.5e-09	30	323
STKc_ERK5	cd07855	2.7e-11	30	347
PTKc_FGFR2	cd05101	2.8e-05	31	318
STKc_TAO3	cd06633	1.1e-05	31	355
STKc_PAK1	cd06654	8.3e-08	31	331
STKc_ASK	cd06624	6.2e-12	32	309
STKc_MAP4K4_6	cd06636	0.00014	32	309
STKc_PAK2	cd06655	8.2e-08	32	333
STKc_JNK	cd07850	3.4e-06	32	349
STKc_p38alpha_MAPK14	cd07877	1e-06	33	342
STKc_PAK	cd06614	2.5e-16	35	322
STKc_myosinIIIB	cd06639	5.7e-07	35	310
STKc_p38beta_MAPK11	cd07878	6.5e-07	35	342
STKc_p38delta_MAPK13	cd07879	6.4e-05	35	381
STKc_p38gamma_MAPK12	cd07880	3.6e-07	35	381
PTK_CCK4	cd05046	0.00076	36	291
PTKc_FAK	cd05056	3.3e-09	36	308
PTKc_Lck_Blk	cd05067	0.00026	36	309
PTKc_Frk_like	cd05068	5e-09	36	308
PTKc_Fyn_Yrk	cd05070	9.2e-06	36	308
PTKc_Lyn	cd05072	4.2e-06	36	308
PTKc_Hck	cd05073	6.1e-05	36	309
STKc_STK10_LOK	cd06644	6.7e-09	36	322
STKc_CDK9	cd07865	6.8e-10	36	309
PKc_MKK7	cd06618	1.2e-07	37	325
STKc_STK25-YSK1	cd06642	5.5e-07	37	333
STKc_JNK1	cd07875	9.6e-07	37	357
PTKc_FGFR3	cd05100	0.00027	38	365
STKc_TAO1	cd06635	2.3e-06	38	347
PTKc_TrkB	cd05093	4.6e-05	39	319
PTKc_Btk_Bmx	cd05113	4.7e-06	39	308
STKc_TAO	cd06607	8e-07	39	355
STKc_TAO2	cd06634	1.2e-07	39	350
STKc_MAP4K5	cd06646	1.5e-07	39	308
PTKc_Src_like	cd05034	9.6e-09	40	308
PTKc_InsR_like	cd05032	1.2e-06	41	305
PTKc_Trk	cd05049	2.5e-06	41	311
PTKc_FGFR	cd05053	5.1e-05	41	307
PTKc_EphR_A10	cd05064	0.00096	41	313
PTKc_EGFR_like	cd05057	0.00082	41	301
PTKc_TrkA	cd05092	3.8e-05	41	311
STKc_phototropin_lik	cd05574	1.2e-11	41	328
STKc_MST4	cd06640	1.3e-06	41	333
STKc_MAP4K3	cd06645	7.7e-07	41	308
STKc_CDK10	cd07845	9.7e-15	41	326
PTKc_Ror1	cd05090	1.6e-06	42	308
PTKc_Ror2	cd05091	3.5e-06	42	308
PTKc_EGFR	cd05108	0.00013	42	362
STKc_TNIK	cd06637	7.5e-06	42	309
PTKc_Csk	cd05082	1.2e-05	43	307
STKc_myosinIIIA	cd06638	1.4e-07	43	309
STKc_ERK1_2_like	cd07849	3.1e-09	43	350
STKc_MAPK4_6	cd07854	1.2e-06	43	350
STKc_TEY_MAPK_plant	cd07858	9e-12	43	381
STKc_CDK12	cd07864	5.7e-14	43	309
PTKc_ALK_LTK	cd05036	3.1e-06	44	309
PTKc_Met_Ron	cd05058	2.2e-05	44	313
PTKc_Yes	cd05069	2.5e-06	44	312
PTKc_Src	cd05071	6.5e-06	44	310
PTKc_DDR2	cd05095	0.00052	44	311
STKc_BUR1	cd07866	6.4e-13	44	309
STKc_MAP4K3_like	cd06613	1.5e-13	45	308
STKc_PCTAIRE_like	cd07844	2.2e-13	45	309
STKc_Sty1_Hog1	cd07856	9.1e-09	45	339
PTKc_EphR_B	cd05065	0.001	46	313
PTKc_Jak1_rpt2	cd05079	5.4e-06	46	313
PTKc_Chk	cd05083	1.6e-07	46	312
STKc_PFTAIRE1	cd07869	1.9e-05	46	358
STKc_PFTAIRE2	cd07870	1.6e-08	46	341
STKc_PCTAIRE3	cd07871	3.2e-09	46	309
STKc_PCTAIRE2	cd07872	2.6e-07	46	330
STKc_PCTAIRE1	cd07873	2.5e-07	46	324
STKc_Nek6_Nek7	cd08224	2.7e-11	46	312
STKc_Nek6	cd08228	4.1e-09	46	312
STKc_Nek7	cd08229	7.6e-11	46	314
PTKc_Abl	cd05052	3e-08	47	313
PTKc_IGF-1R	cd05062	4.2e-05	47	305
PTKc_InsR	cd05061	0.00016	47	322
PTKc_DDR_like	cd05097	0.00017	47	311
PTKc_Itk	cd05112	3e-05	47	307
PTKc_Tec_Rlk	cd05114	2.6e-05	47	308
STKc_ROCK_NDR_like	cd05573	6.8e-11	47	365
STKc_PKA	cd05580	3.4e-14	47	357
STKc_DMPK_like	cd05597	5.7e-07	47	395
STKc_LATS	cd05598	0.0001	47	386
STKc_MAST	cd05609	2.9e-10	47	364
STKc_MRCK_alpha	cd05623	3.2e-06	47	396
STKc_MRCK_beta	cd05624	2e-06	47	395
STKc_LATS1	cd05625	0.0007	47	386
STKc_NDR1	cd05628	0.00031	47	367
STKc_PRKX_like	cd05612	1.2e-10	47	333
STKc_myosinIII_like	cd06608	2.6e-09	47	309
STKc_MST3_like	cd06609	4.2e-10	47	333
STKc_OSR1_SPAK	cd06610	2.9e-10	47	309
PKc_MKK5	cd06619	0.00019	47	345
PKc_MAPKK_PBS2_like	cd06622	1.9e-07	47	344
PKc_MAPKK_Pek1_like	cd06621	2.6e-09	47	321
STKc_MST3	cd06641	1.3e-06	47	333
STKc_MEKK2	cd06652	7.9e-08	47	310
STKc_NAK1_like	cd06917	6.4e-10	47	312
STKc_CDKL	cd07833	8.2e-13	47	309
STKc_CdkB_plant	cd07837	7.1e-14	47	310
STKc_CDKL2_3	cd07846	3.5e-10	47	309
STKc_CDKL1_4	cd07847	1e-09	47	341
STKc_CDKL5	cd07848	7.3e-07	47	309
STKc_CDK6	cd07862	1e-05	47	309
SPS1	COG0515	5.6e-52	47	430
PTKc_RET	cd05045	2.5e-05	48	312
PTKc_Ror	cd05048	2.2e-07	48	308
PTKc_Musk	cd05050	4.7e-06	48	306
PTKc_Tyk2_rpt2	cd05080	4.6e-08	48	314
PTKc_Jak2_Jak3_rpt2	cd05081	3.8e-07	48	310
PKc_STE	cd05122	1.1e-17	48	308
STKc_Yank1	cd05578	1.7e-15	48	309
STKc_cPKC	cd05587	1.1e-12	48	368
STKc_MSK_N	cd05583	3.2e-09	48	326
STKc_GRK4_like	cd05605	2.2e-09	48	328
STKc_MSK1_N	cd05613	1.1e-08	48	326
STKc_MSK2_N	cd05614	9.4e-09	48	369
STKc_cPKC_alpha	cd05615	1.1e-09	48	361
STKc_cPKC_beta	cd05616	2e-08	48	368
STKc_GRK6	cd05630	1.6e-06	48	328
STKc_GRK4	cd05631	2.7e-06	48	328
STKc_GRK5	cd05632	2.1e-06	48	328
STKc_MAPKKK	cd06606	2.9e-31	48	309
PKc_MAPKK_plant_like	cd06623	2e-15	48	316
STKc_Cdc7_like	cd06627	1.8e-16	48	309
STKc_MAPKKK_Byr2_lik	cd06628	1.4e-22	48	309
STKc_MAPKKK_Bck1_lik	cd06629	9.2e-11	48	309
STKc_MEKK1	cd06630	3.6e-09	48	310
STKc_MEKK1_plant	cd06632	5.9e-14	48	309
STKc_YSK4	cd06631	2.1e-10	48	309
STKc_MEKK3	cd06651	4.6e-10	48	311
STKc_MEKK3_like_1	cd06653	1.4e-08	48	316
STKc_CCRK	cd07832	3.7e-15	48	310
STKc_MAPK	cd07834	1.6e-12	48	339
STKc_Pho85	cd07836	1.8e-15	48	309
STKc_CDK5	cd07839	9e-12	48	309
STKc_CDK7	cd07841	7.7e-15	48	326
STKc_CDK8_like	cd07842	4.5e-11	48	309
STKc_TDY_MAPK_plant	cd07859	1.7e-07	48	382
STKc_CDK2_3	cd07860	1.2e-19	48	309
STKc_CDK1_euk	cd07861	1.4e-15	48	309
STKc_CDK4	cd07863	4.5e-09	48	309
STKc_MPK1	cd07857	5.2e-10	48	343
STKc_Nek	cd08215	1.9e-25	48	309
STKc_Nek2	cd08217	1.2e-13	48	309
STKc_Nek1	cd08218	7.4e-27	48	309
STKc_Nek3	cd08219	4.1e-19	48	309
STKc_Nek8	cd08220	6.2e-09	48	309
STKc_Nek9	cd08221	3.8e-09	48	309
STKc_Nek11	cd08222	1.1e-18	48	309
STKc_Nek4	cd08223	3.3e-20	48	309
STKc_Nek5	cd08225	2.3e-20	48	309
STKc_Nek10	cd08528	4.8e-07	48	309
STKc_FA2-like	cd08529	7.6e-12	48	309
STKc_CNK2-like	cd08530	2.9e-13	48	309
PTKc_Axl_like	cd05035	5.3e-05	49	310
PTKc_Jak_rpt2	cd05038	5.9e-08	49	307
PTKc_Tyro3	cd05074	1.3e-05	49	311
PTKc_Axl	cd05075	0.00057	49	311
STKc_CMGC	cd05118	6.3e-16	49	309
PTKc_Srm_Brk	cd05148	1.4e-09	49	308
STKc_PDK1	cd05581	9e-25	49	309
STKc_PKN	cd05589	5.2e-09	49	367
STKc_CRIK	cd05601	1.3e-08	49	356
STKc_MST1_2	cd06612	8.2e-14	49	309
PKc_MKK4	cd06616	4.8e-06	49	323
STKc_MEKK3_like	cd06625	1.1e-14	49	309
STKc_CDK_like	cd07829	6.7e-20	49	309
STKc_MAK_like	cd07830	1.1e-15	49	309
STKc_MOK	cd07831	1.9e-13	49	309
STKc_CDK1_like	cd07835	8e-20	49	309
STKc_CDK4_6_like	cd07838	2e-13	49	309
STKc_CDK9_like	cd07840	2.5e-17	49	309
PTKc_Csk_like	cd05039	0.00015	50	309
STKc_SLK_like	cd06611	1.5e-10	50	317
STKc_SLK	cd06643	1.1e-09	50	320
STKc_CDC2L6	cd07867	3.2e-05	50	346
STKc_CDK8	cd07868	0.00017	50	309
STKc_p70S6K	cd05584	2.4e-09	52	369
PKc_MAPKK	cd06605	1.7e-10	52	315
PKc_MKK3_6	cd06617	1.5e-08	52	324
PKc_MEK	cd06615	2.2e-05	52	337
STKc_MEKK4	cd06626	5.1e-15	52	309
PTKc	cd00192	1.1e-11	53	308
PTK_Jak_rpt1	cd05037	0.00023	53	307
PTKc_Ack_like	cd05040	1.7e-12	53	309
PTKc_Fes_like	cd05041	5.9e-08	53	309
PTKc_Aatyk	cd05042	0.00048	53	326
PTKc_c-ros	cd05044	9.5e-05	53	307
PTKc_Tie	cd05047	0.001	53	313
PTKc_Syk_like	cd05060	1.3e-06	53	305
PTKc_Fes	cd05084	3.1e-07	53	309
PTKc_Fer	cd05085	4.8e-06	53	309
PTKc_Syk	cd05116	1.4e-06	53	310
STKc_PKC	cd05570	4.9e-13	53	363
STKc_PKB	cd05571	2.6e-12	53	382
STKc_SGK	cd05575	4e-08	53	385
STKc_RSK_N	cd05582	1.3e-06	53	389
STKc_aPKC	cd05588	1.3e-08	53	373
STKc_nPKC_eta	cd05590	1.7e-09	53	368
STKc_nPKC_epsilon	cd05591	1.2e-10	53	373
STKc_nPKC_theta_delt	cd05592	3.9e-14	53	369
STKc_PKB_gamma	cd05593	5.6e-10	53	396
STKc_PKB_alpha	cd05594	8e-11	53	395
STKc_PKB_beta	cd05595	8.9e-09	53	371
STKc_SGK1	cd05602	2.9e-06	53	374
STKc_SGK2	cd05603	2.1e-09	53	393
STKc_aPKC_zeta	cd05617	2.2e-08	53	369
STKc_aPKC_iota	cd05618	1.5e-06	53	384
STKc_nPKC_theta	cd05619	3.5e-11	53	369
STKc_nPKC_delta	cd05620	5.3e-07	53	369
STKc_SGK3	cd05604	6e-06	53	369
PKc_MAPKK_Byr1_like	cd06620	6.2e-06	53	333
STKc_CDC2L1	cd07843	1.6e-10	53	309
STKc_beta_ARK	cd05606	6.6e-07	54	324
STKc_GRK3	cd05633	1.2e-05	54	321
PKc	cd00180	4.5e-73	55	307
PTKc_Tec_like	cd05059	3e-06	55	290
PTKc_Zap-70	cd05115	1.5e-06	55	312
STKc_AGC	cd05123	1.2e-23	55	309
STKc_cGK_PKG	cd05572	2.1e-12	55	312
STKc_MAST_like	cd05579	4e-16	55	314
STKc_YPK1_like	cd05585	1.9e-09	55	390
STKc_Sck1_like	cd05586	4.7e-08	55	433
STKc_Sid2p_Dbf2p	cd05600	6.5e-07	55	388
STKc_GRK7	cd05607	1.7e-06	55	327
STKc_GRK1	cd05608	1.4e-11	55	327
STKc_GRK	cd05577	3e-10	55	327
STKc_NLK	cd07853	1.3e-07	55	382
STKc_NDR_like	cd05599	4.4e-05	56	367
STKc_Rim15_like	cd05611	0.00032	58	311
STKc_MAPK15	cd07852	2.6e-10	78	348
Pkinase	pfam00069	1.4e-63	49	309
Pkinase_Tyr	pfam07714	3.7e-16	49	307
TyrKc	smart00219	2.6e-14	49	309
STYKc	smart00221	5e-72	49	309
S_TKc	smart00220	1.8e-79	59	309

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_065643	Polymorphism	p.ALA205THR	N/A
Swiss-Prot	VAR_065630	Polymorphism	p.ARG86GLY	N/A
Swiss-Prot	VAR_007922	Disease	p.ARG297LYS	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_041139	Polymorphism	p.ARG87LYS	N/A
Swiss-Prot	VAR_065639	Polymorphism	p.ASN181GLU	N/A
Swiss-Prot	VAR_007921	Disease	p.ASP194ASN	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_065644	Polymorphism	p.ASP208ASN	N/A
Swiss-Prot	VAR_065637	Polymorphism	p.ASP176TYR	N/A
Swiss-Prot	VAR_033141	Polymorphism	p.ASP194TYR	N/A
Swiss-Prot	VAR_065654	Polymorphism	p.ASP277TYR	N/A
Swiss-Prot	VAR_065640	Polymorphism	p.ASP194VAL	N/A
Swiss-Prot	VAR_065631	Polymorphism	p.GLN123ARG	N/A
Swiss-Prot	VAR_065634	Polymorphism	p.GLN170PRO	N/A
Swiss-Prot	VAR_065642	Polymorphism	p.GLU199GLN	N/A
Swiss-Prot	VAR_065628	Disease	p.GLU16GLY	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_065627	Polymorphism	p.GLU14LYS	N/A
Swiss-Prot	VAR_065641	Polymorphism	p.GLU199LYS	N/A
Swiss-Prot	VAR_065647	Polymorphism	p.GLU223VAL	N/A
Swiss-Prot	VAR_033139	Polymorphism	p.GLY135ARG	N/A
Swiss-Prot	VAR_033140	Disease	p.GLY163ASP	Testicular germ cell tumor (TGCT)
Swiss-Prot	VAR_065645	Polymorphism	p.GLY215ASP	N/A
Swiss-Prot	VAR_065635	Polymorphism	p.GLY171SER	N/A
Swiss-Prot	VAR_065636	Polymorphism	p.HIS174ARG	N/A
Swiss-Prot	VAR_065638	Polymorphism	p.ILE177ASN	N/A
Swiss-Prot	VAR_065651	Polymorphism	p.LEU245ARG	N/A
Swiss-Prot	VAR_065656	Polymorphism	p.LEU285GLN	N/A
Swiss-Prot	VAR_065633	Polymorphism	p.LEU160PRO	N/A
Swiss-Prot	VAR_006202	Disease	p.LEU67PRO	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_065649	Polymorphism	p.PHE231LEU	N/A
dbSNP	rs59912467	Polymorphism	p.PHE354LEU	N/A
Swiss-Prot	VAR_065632	Polymorphism	p.PHE157SER	N/A
Swiss-Prot	VAR_065657	Polymorphism	p.PRO314HIS	N/A
Swiss-Prot	VAR_065655	Polymorphism	p.PRO281LEU	N/A
Swiss-Prot	VAR_065658	Polymorphism	p.PRO324LEU	N/A
Swiss-Prot	VAR_033144	Disease	p.PRO315SER	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_065646	Polymorphism	p.SER216PHE	N/A
Swiss-Prot	VAR_065650	Polymorphism	p.SER232PRO	N/A
Swiss-Prot	VAR_065660	Polymorphism	p.THR367MET	N/A
Swiss-Prot	VAR_065648	Polymorphism	p.THR230PRO	N/A
Swiss-Prot	VAR_065652	Polymorphism	p.THR250PRO	N/A
Swiss-Prot	VAR_033142	Disease	p.TRP239CYS	Peutz-Jeghers syndrome (PJS)
Swiss-Prot	VAR_033138	Polymorphism	p.TYR49ASP	N/A
Swiss-Prot	VAR_065653	Polymorphism	p.TYR272HIS	N/A
Swiss-Prot	VAR_065629	Polymorphism	p.VAL66MET	N/A
OMIM	602216.0013	Disease	p.ASP194TYR	MELANOMA, MALIGNANT, SOMATIC
OMIM	602216.0018	Disease	p.GLU170TER	MELANOMA, MALIGNANT, SOMATIC
OMIM	602216.0010	Disease	p.GLU57TER	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0020	Disease	p.GLY135ARG	MELANOMA, MALIGNANT, SOMATIC
OMIM	602216.0011	Disease	p.GLY163ASP	TESTICULAR TUMOR, SOMATIC
OMIM	602216.0008	Disease	p.LEU67PRO	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0006	Disease	p.LYS84TER	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0024	Disease	p.PHE354LEU	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0021	Disease	p.TRP239CYS	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0019	Disease	p.TYR49ASP	MELANOMA, MALIGNANT, SOMATIC
OMIM	602216.0023	Disease	p.TYR246TER	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0002	Disease	p.TYR253TER	PEUTZ-JEGHERS SYNDROME
OMIM	602216.0015	Disease	p.TYR36TER	PANCREATIC CANCER, SOMATIC

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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